Klinker, Florian

[["dc.bibliographiccitation.firstpage","351"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neurochemistry"],["dc.bibliographiccitation.lastpage","362"],["dc.bibliographiccitation.volume","136"],["dc.contributor.author","Zschuentzsch, Jana"],["dc.contributor.author","Zhang, Y."],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Makosch, Gregor"],["dc.contributor.author","Klinge, Lars"],["dc.contributor.author","Malzahn, Doerthe"],["dc.contributor.author","Brinkmeier, Heinrich"],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Schmidt, Jens"],["dc.date.accessioned","2018-11-07T10:21:27Z"],["dc.date.available","2018-11-07T10:21:27Z"],["dc.date.issued","2016"],["dc.description.abstract","Duchenne muscular dystrophy (DMD) is a severe hereditary myopathy. Standard treatment by glucocorticosteroids is limited because of numerous side effects. The aim of this study was to test immunomodulation by human immunoglobulin G (IgG) as treatment in the experimental mouse model (mdx) of DMD. 2g/kg human IgG compared to human albumin was injected intraperitoneally in mdx mice at the age of 3 and 7weeks. Advanced voluntary wheel running parameters were recorded continuously. At the age of 11 weeks, animals were killed so that blood, diaphragm, and lower limb muscles could be removed for quantitative PCR, histological analysis and exvivo muscle contraction tests. IgG compared to albumin significantly improved the voluntary running performance and reduced muscle fatigability in an exvivo muscle contraction test. Upon IgG treatment, serum creatine kinase values were diminished and mRNA expression levels of relevant inflammatory markers were reduced in the diaphragm and limb muscles. Macrophage infiltration and myopathic damage were significantly ameliorated in the quadriceps muscle. Collectively, this study demonstrates that, in the early disease course of mdx mice, human IgG improves the running performance and diminishes myopathic damage and inflammation in the muscle. Therefore, IgG may be a promising approach for treatment of DMD."],["dc.identifier.doi","10.1111/jnc.13269"],["dc.identifier.isi","000367956800015"],["dc.identifier.pmid","26230042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42093"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1471-4159"],["dc.relation.issn","0022-3042"],["dc.title","Treatment with human immunoglobulin G improves the early disease course in a mouse model of Duchenne muscular dystrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9-10"],["dc.bibliographiccitation.journal","Neuromuscular Disorders"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Zschuentzsch, Jana"],["dc.contributor.author","Zhang, Y."],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Jouvenal, P."],["dc.contributor.author","Tiburcy, Malte"],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Brinkmeier, Heinrich"],["dc.contributor.author","Schmidt, J."],["dc.date.accessioned","2018-11-07T09:34:35Z"],["dc.date.available","2018-11-07T09:34:35Z"],["dc.date.issued","2014"],["dc.format.extent","819"],["dc.identifier.doi","10.1016/j.nmd.2014.06.097"],["dc.identifier.isi","000342870200094"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32201"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.publisher.place","Oxford"],["dc.relation.conference","19th International Congress of the World-Muscle-Society"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","1873-2364"],["dc.relation.issn","0960-8966"],["dc.title","Assessment of outcome measures for dystrophin deficient mice"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","177"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of Neuroimmunology"],["dc.bibliographiccitation.lastpage","178"],["dc.bibliographiccitation.volume","253"],["dc.contributor.author","Zschuentzsch, Jana"],["dc.contributor.author","Weller, Charlotte"],["dc.contributor.author","Zhang, Y."],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Makosch, Gregor"],["dc.contributor.author","Klinge, Lars"],["dc.contributor.author","Metselaar, Josbert M."],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Brinkmeier, Heinrich"],["dc.contributor.author","Schmidt, Jens"],["dc.date.accessioned","2018-11-07T09:02:18Z"],["dc.date.available","2018-11-07T09:02:18Z"],["dc.date.issued","2012"],["dc.identifier.isi","000312764800478"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24650"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","11th International Congress of Neuroimmunology (ISNI)"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","0165-5728"],["dc.title","Human IgG but not liposomal prednisolone improves the early clinical course of mdx mice as model for Duchenne muscular dystrophy"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","132"],["dc.bibliographiccitation.journal","Clinical & Experimental Immunology"],["dc.bibliographiccitation.lastpage","133"],["dc.bibliographiccitation.volume","178"],["dc.contributor.author","Zschuentzsch, Jana"],["dc.contributor.author","Jouvenal, P."],["dc.contributor.author","Zhang, Y."],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Tiburcy, Malte"],["dc.contributor.author","Malzahn, D."],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Brinkmeier, Heinrich"],["dc.contributor.author","Schmidt, J."],["dc.date.accessioned","2018-11-07T09:31:49Z"],["dc.date.available","2018-11-07T09:31:49Z"],["dc.date.issued","2014"],["dc.description.sponsorship","CSL Behring; Aktion Benni Co."],["dc.identifier.doi","10.1111/cei.12541"],["dc.identifier.isi","000346976700053"],["dc.identifier.pmid","25546792"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31616"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2249"],["dc.relation.issn","0009-9104"],["dc.title","Human immunoglobulin G for experimental treatment of Duchenne muscular dystrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]