Buttler, Kerstin

[["dc.bibliographiccitation.firstpage","220"],["dc.bibliographiccitation.lastpage","229"],["dc.contributor.author","Wilting, Jörg"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Rössler, Jochen"],["dc.contributor.author","Norgall, Susanne"],["dc.contributor.author","Schweigerer, Lothar"],["dc.contributor.author","Weich, Herbert A."],["dc.contributor.author","Papoutsi, Maria"],["dc.contributor.editor","Chadwick, Derek J."],["dc.contributor.editor","Goode, Jamie"],["dc.date.accessioned","2021-06-02T10:44:30Z"],["dc.date.available","2021-06-02T10:44:30Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1002/9780470319413.ch17"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87064"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","John Wiley & Sons, Ltd"],["dc.publisher.place","Chichester, UK"],["dc.relation.eisbn","978-0-470-31941-3"],["dc.relation.isbn","978-0-470-03428-6"],["dc.relation.ispartof","Vascular Development"],["dc.title","Embryonic Development and Malformation of Lymphatic Vessels"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4581"],["dc.bibliographiccitation.issue","34"],["dc.bibliographiccitation.journal","Current Medicinal Chemistry"],["dc.bibliographiccitation.lastpage","4592"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Wilting, J."],["dc.contributor.author","Becker, J."],["dc.contributor.author","Buttler, K."],["dc.contributor.author","Weich, H."],["dc.date.accessioned","2021-06-01T10:48:33Z"],["dc.date.available","2021-06-01T10:48:33Z"],["dc.date.issued","2009"],["dc.description.abstract","Inflammation is a local or systemic tissue reaction caused by external or internal stimuli with the objective to remove the noxa, inhibit its further dissemination and eventually repair damaged tissue. Blood vessels and perivascular connective tissue are important regulators of the inflammatory process. After a short initial ischemic phase, inflamed tissue is characterized by hyperaemia and increased permeability of capillaries. Therefore, blood vessels have been in the focus of inflammation research for quite some time, whereas lymphatic vessels have been neglected. Their reactivity is not immediately obvious, and, their identification within the tissue has hardly been possible until lymphatic endothelial cell (LEC)-specific molecules have been identified a few years ago. This has opened up the possibility to study lymphatics in normal and diseased tissues, and to isolate LECs for transcriptome and proteome analyses. Initial studies now provide evidence that lymphatics are not just a passive route for circulating lymphocytes, but seem to be directly involved in both the induction and the resolution of inflammation. This review provides a summary on the basics of inflammation, the structure of lymphatics and their molecular markers, human inflammation-associated diseases and their relation to lymphatics, animal models to study the interaction of lymphatics and inflammation, and finally inflammation-associated molecules expressed in LECs. The integration of lymphatics into inflammation research opens up an exciting new field with great clinical potential."],["dc.identifier.doi","10.2174/092986709789760751"],["dc.identifier.isi","000271382900006"],["dc.identifier.pmid","19903150"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85979"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Bentham Science Publ Ltd"],["dc.relation.issn","0929-8673"],["dc.relation.issn","1875-533X"],["dc.title","Lymphatics and Inflammation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","365"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","376"],["dc.bibliographiccitation.volume","381"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Becker, Jürgen"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Wilting, Jörg"],["dc.date.accessioned","2021-06-01T10:49:58Z"],["dc.date.available","2021-06-01T10:49:58Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1016/j.ydbio.2013.06.028"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86479"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0012-1606"],["dc.title","Maldevelopment of dermal lymphatics in Wnt5a-knockout-mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","17"],["dc.bibliographiccitation.lastpage","24"],["dc.contributor.author","Wilting, Jörg"],["dc.contributor.author","Papoutsi, Maria"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Becker, Jürgen"],["dc.contributor.editor","Rosen, Steven T."],["dc.contributor.editor","Leong, Stanley P. L."],["dc.date.accessioned","2021-06-02T10:44:20Z"],["dc.date.available","2021-06-02T10:44:20Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1007/978-0-387-69219-7_2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87003"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Springer US"],["dc.publisher.place","Boston, MA"],["dc.relation.eisbn","978-0-387-69219-7"],["dc.relation.isbn","978-0-387-69218-0"],["dc.relation.ispartof","Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy"],["dc.title","Embryonic Development of the Lymphovascular System and Tumor Lymphangiogenesis"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","112"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Pediatric Research"],["dc.bibliographiccitation.lastpage","117"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Becker, Jürgen"],["dc.contributor.author","Wang, Baigang"],["dc.contributor.author","Pavlakovic, Helena"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Wilting, Jörg"],["dc.date.accessioned","2021-06-01T10:48:09Z"],["dc.date.available","2021-06-01T10:48:09Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1203/PDR.0b013e3181e5bc0f"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85842"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1530-0447"],["dc.relation.issn","0031-3998"],["dc.title","Homeobox Transcription Factor Prox1 in Sympathetic Ganglia of Vertebrate Embryos: Correlation With Human Stage 4s Neuroblastoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2952"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Developmental Dynamics"],["dc.bibliographiccitation.lastpage","2961"],["dc.bibliographiccitation.volume","236"],["dc.contributor.author","Kasten, Philipp"],["dc.contributor.author","Schnoeink, Gerrit"],["dc.contributor.author","Bergmann, Astrid"],["dc.contributor.author","Papoutsi, Maria"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Roessler, Jochen"],["dc.contributor.author","Weich, Herbert A."],["dc.contributor.author","Wilting, Joerg"],["dc.date.accessioned","2018-11-07T10:57:58Z"],["dc.date.available","2018-11-07T10:57:58Z"],["dc.date.issued","2007"],["dc.description.abstract","Lymphangioma is a disfiguring malformation of early childhood. A mouse lymphangioma model has been established by injecting Freund's incomplete adjuvant (FIA) intraperitoneally, but has not been compared with the human disease. We show that, in accordance with studies from the 1960s, the mouse model represents an oil-granuloma, made up of CD45-positive leukocytes and invaded by blood and lymph vessels. Several markers of lymphatic endothelial cells are expressed in both mouse and human, like CD31, Prox1, podoplanin, and Lyve-1. However, the human disease affects all parts of the lymphovascular tree. We observed convolutes of lymphatic capillaries, irregularly formed collectors with signs of disintegration, and large lymph cysts. We observed VEGFR-2 and -3 expression in both blood vessels and lymphatics of the patients, whereas in mouse VEGFR-2 was confined to activated blood vessels. The experimental mouse FIA model represents a vascularized oil-granuloma rather than a lymphangioma and reflects the complexity of human lymphangioma only partially."],["dc.description.sponsorship","NICHD NIH HHS [N01-HD-6-2915]"],["dc.identifier.doi","10.1002/dvdy.21298"],["dc.identifier.isi","000250192100025"],["dc.identifier.pmid","17879316"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50377"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","1058-8388"],["dc.title","Similarities and differences of human and experimental mouse lymphangiomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","761"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Angiogenesis"],["dc.bibliographiccitation.lastpage","762"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Badar, Muhammad"],["dc.contributor.author","Seiffart, V."],["dc.contributor.author","Laggies, Sandra"],["dc.contributor.author","Gross, G."],["dc.contributor.author","Weich, Herbert A."],["dc.contributor.author","Wilting, J."],["dc.date.accessioned","2018-11-07T09:38:16Z"],["dc.date.available","2018-11-07T09:38:16Z"],["dc.date.issued","2014"],["dc.identifier.isi","000338213400154"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33034"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Dordrecht"],["dc.relation.issn","1573-7209"],["dc.relation.issn","0969-6970"],["dc.title","De novo hem- and lymphangiogenesis by endothelial progenitor and mesenchymal stem cells in immunocompetent mice"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","43"],["dc.bibliographiccitation.journal","BMC Developmental Biology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Ezaki, Taichi"],["dc.contributor.author","Wilting, Joerg"],["dc.date.accessioned","2018-11-07T11:15:59Z"],["dc.date.available","2018-11-07T11:15:59Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: The data on the embryonic origin of lymphatic endothelial cells (LECs) from either deep embryonic veins or mesenchymal (or circulating) lymphangioblasts presently available remain inconsistent. In various vertebrates, markers for LECs are first expressed in specific segments of embryonic veins arguing for a venous origin of lymph vessels. Very recently, studies on the mouse have strongly supported this view. However, in the chick, we have observed a dual origin of LECs from veins and from mesodermal lymphangioblasts. Additionally, in murine embryos we have detected mesenchymal cells that co-express LEC markers and the pan-leukocyte marker CD45. Here, we have characterized the mesoderm of murine embryos with LEC markers Prox1, Lyve-1 and LA102 in combination with macrophage markers CD11b and F4/80. Results: We observed cells co-expressing both types of markers (e. g. Prox1 - Lyve-1 - F4/80 triple-positive) located in the mesoderm, immediately adjacent to, and within lymph vessels. Our proliferation studies with Ki-67 antibodies showed high proliferative capacities of both the Lyve-1-positive LECs of lymph sacs/lymphatic sprouts and the Lyve-1-positive mesenchymal cells. Conclusion: Our data argue for a dual origin of LECs in the mouse, although the primary source of embryonic LECs may reside in specific embryonic veins and mesenchymal lymphangioblasts integrated secondarily into lymph vessels. The impact of a dual source of LECs for ontogenetic, phylogenetic and pathological lymphangiogenesis is discussed."],["dc.identifier.doi","10.1186/1471-213X-8-43"],["dc.identifier.isi","000255933200001"],["dc.identifier.pmid","18430230"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54489"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-213X"],["dc.title","Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1513"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Cellular and Molecular Life Sciences"],["dc.bibliographiccitation.lastpage","1527"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Badar, Muhammad"],["dc.contributor.author","Seiffart, Virginia"],["dc.contributor.author","Laggies, Sandra"],["dc.contributor.author","Gross, Gerhard"],["dc.contributor.author","Wilting, Joerg"],["dc.contributor.author","Weich, Herbert A."],["dc.date.accessioned","2018-11-07T09:42:13Z"],["dc.date.available","2018-11-07T09:42:13Z"],["dc.date.issued","2014"],["dc.description.abstract","Cellular pro-angiogenic therapies may be applicable for the treatment of peripheral vascular diseases. Interactions between mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) may provide such a treatment option. With the exception of some studies in man, experiments have only been performed in immunodeficient mice and rats. We studied an immunocompetent syngeneic mouse model. We isolated MSCs from bone marrow and EPCs from the lung of adult C57/Bl.6 mice and co-injected them in Matrigel subcutaneously in adult C57/Bl.6 mice. We demonstrate development of both blood vessels and lymphatics. Grafted EPCs integrated into the lining of the two vessel types, whereas MSCs usually did not incorporate into the vessel wall. Injections of each separate cell type did not, or hardly, reveal de novo angiogenesis. The release of VEGF-A by MSCs has been shown before, but its inhibitors, e.g., soluble VEGF receptors, have not been studied. We performed qualitative and quantitative studies of the proteins released by EPCs, MSCs, and cocultures of the cells. Despite the secretion of VEGF inhibitors (sVEGFR-1, sVEGFR-2) by EPCs, VEGF-A was secreted by MSCs at bioavailable amounts (350 pg/ml). We confirm the secretion of PlGF, FGF-1, MCP-1, and PDGFs by EPCs/MSCs and suggest functions for VEGF-B, amphiregulin, fractalkine, CXCL10, and CXCL16 during MSC-induced hem- and lymphangiogenesis. We assume that lymphangiogenesis is induced indirectly by growth factors from immigrating leukocytes, which we found in close association with the lymphatic networks. Inflammatory responses to the cellular markers GFP and cell-tracker red (CMPTX) used for tracing of EPCs or MSCs were not observed. Our studies demonstrate the feasibility of pro-angiogenic/lymphangiogenic therapies in immunocompetent animals and indicate new MSC/EPC-derived angiogenic factors."],["dc.identifier.doi","10.1007/s00018-013-1460-8"],["dc.identifier.isi","000333125800012"],["dc.identifier.pmid","23995988"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33906"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Basel"],["dc.relation.issn","1420-9071"],["dc.relation.issn","1420-682X"],["dc.title","De novo hem- and lymphangiogenesis by endothelial progenitor and mesenchymal stem cells in immunocompetent mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","451"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","459"],["dc.bibliographiccitation.volume","305"],["dc.contributor.author","Wilting, Joerg"],["dc.contributor.author","Buttler, Kerstin"],["dc.contributor.author","Schulte, Inga"],["dc.contributor.author","Papoutsi, Maria"],["dc.contributor.author","Schweigerer, Lothar L."],["dc.contributor.author","Maenner, Joerg"],["dc.date.accessioned","2018-11-07T11:02:22Z"],["dc.date.available","2018-11-07T11:02:22Z"],["dc.date.issued","2007"],["dc.description.abstract","The mass of the myocardium and endocardium of the vertebrate heart derive from the heart-forming fields of the lateral plate mesoderm. Further components of the mature heart such as the epicardium, cardiac interstitium and coronary blood vessels originate from a primarily extracardiac progenitor cell population: the proepicardium (PE). The coronary blood vessels are accompanied by lymph vessels, suggesting a common origin of the two vessel types. However, the origin of cardiac lymphatics has not been studied yet. We have grafted PE of HH-stage 17 (day 3) quail embryos hetero- and hornotopically into chick embryos, which were re-incubated until day 15. Double staining with the quail endothelial cell (EC) marker QH1 and the lymphendothelial marker Prox1 shows that the PE of avian embryos delivers hernangioblasts but not lymphangioblasts. We have never observed quail ECs in lymphatics of the chick host. However, one exception was a large lymphatic trunk at the base of the chick heart, indicating a lympho-venous anastomosis and a 'homing' mechanism of venous ECs into the lymphatic trunk. Cardiac lymphatics grow from the base toward the apex of the heart. In murine embryos, we observed a basal to apical gradient of scattered Lyve-(+)/ CD31(+)/CD45(+) cells in the subepicardium at ernbryonic day 12.5, indicating a contribution of immigrating lymphangioblasts to the cardiac lymphatic system. Our studies show that coronary blood and lymph vessels are derived from different sources, but grow in close association with each other. (c) 2007 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","NICHD NIH HHS [N01-HD-6-2915]"],["dc.identifier.doi","10.1016/j.ydbio.2007.02.026"],["dc.identifier.isi","000246461000007"],["dc.identifier.pmid","17383624"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51369"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","The proepicardium delivers hemangioblasts but not lymphangioblasts to the developing heart"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]