Schlüter, Oliver M.

[["dc.bibliographiccitation.artnumber","5400"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Babaev, Olga"],["dc.contributor.author","Cruces-Solis, Hugo"],["dc.contributor.author","Piletti Chatain, Carolina"],["dc.contributor.author","Hammer, Matthieu"],["dc.contributor.author","Wenger, Sally"],["dc.contributor.author","Ali, Heba"],["dc.contributor.author","Karalis, Nikolaos"],["dc.contributor.author","de Hoz, Livia"],["dc.contributor.author","Schlüter, Oliver M."],["dc.contributor.author","Yanagawa, Yuchio"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Taschenberger, Holger"],["dc.contributor.author","Brose, Nils"],["dc.contributor.author","Krueger-Burg, Dilja"],["dc.date.accessioned","2019-07-09T11:50:16Z"],["dc.date.available","2019-07-09T11:50:16Z"],["dc.date.issued","2018"],["dc.description.abstract","Abnormalities in synaptic inhibition play a critical role in psychiatric disorders, and accordingly, it is essential to understand the molecular mechanisms linking components of the inhibitory postsynapse to psychiatrically relevant neural circuits and behaviors. Here we study the role of IgSF9b, an adhesion protein that has been associated with affective disorders, in the amygdala anxiety circuitry. We show that deletion of IgSF9b normalizes anxiety-related behaviors and neural processing in mice lacking the synapse organizer Neuroligin-2 (Nlgn2), which was proposed to complex with IgSF9b. This normalization occurs through differential effects of Nlgn2 and IgSF9b at inhibitory synapses in the basal and centromedial amygdala (CeM), respectively. Moreover, deletion of IgSF9b in the CeM of adult Nlgn2 knockout mice has a prominent anxiolytic effect. Our data place IgSF9b as a key regulator of inhibition in the amygdala and indicate that IgSF9b-expressing synapses in the CeM may represent a target for anxiolytic therapies."],["dc.identifier.doi","10.1038/s41467-018-07762-1"],["dc.identifier.pmid","30573727"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15897"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59736"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/49"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/213342/EU//AIMS"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P10: Rekrutierung und Verankerung von Neurotransmitterrezeptoren an GABAergen Synapsen - Zellbiologie und molekulare Mechanismen"],["dc.relation.issn","2041-1723"],["dc.relation.workinggroup","RG Brose"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","612"],["dc.subject.mesh","Amygdala"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Anxiety Disorders"],["dc.subject.mesh","Cell Adhesion Molecules, Neuronal"],["dc.subject.mesh","Membrane Proteins"],["dc.subject.mesh","Mice"],["dc.subject.mesh","Mice, Knockout"],["dc.subject.mesh","Nerve Tissue Proteins"],["dc.subject.mesh","RNA Interference"],["dc.subject.mesh","Synapses"],["dc.subject.mesh","Synaptic Transmission"],["dc.title","IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Neural Circuits"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","El Hady, Ahmed"],["dc.contributor.author","Afshar, Ghazaleh"],["dc.contributor.author","Bröking, Kai"],["dc.contributor.author","Schlüter, Oliver M."],["dc.contributor.author","Geisel, Theo"],["dc.contributor.author","Stühmer, Walter"],["dc.contributor.author","Wolf, Fred"],["dc.date.accessioned","2017-09-07T11:45:38Z"],["dc.date.available","2017-09-07T11:45:38Z"],["dc.date.issued","2013"],["dc.description.abstract","Synchronized bursting is found in many brain areas and has also been implicated in the pathophysiology of neuropsychiatric disorders such as epilepsy, Parkinson’s disease, and schizophrenia. Despite extensive studies of network burst synchronization, it is insufficiently understood how this type of network wide synchronization can be strengthened, reduced, or even abolished. We combined electrical recording using multi-electrode array with optical stimulation of cultured channelrhodopsin-2 transducted hippocampal neurons to study and manipulate network burst synchronization. We found low frequency photo-stimulation protocols that are sufficient to induce potentiation of network bursting, modifying bursting dynamics, and increasing interneuronal synchronization. Surprisingly, slowly fading-in light stimulation, which substantially delayed and reduced light-driven spiking, was at least as effective in reorganizing network dynamics as much stronger pulsed light stimulation. Our study shows that mild stimulation protocols that do not enforce particular activity patterns onto the network can be highly effective inducers of network-level plasticity."],["dc.identifier.doi","10.3389/fncir.2013.00167"],["dc.identifier.fs","599562"],["dc.identifier.gro","3151828"],["dc.identifier.pmid","24155695"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10702"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8658"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","public"],["dc.notes.submitter","chake"],["dc.relation.issn","1662-5110"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.subject.mesh","Action Potentials"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Hippocampus"],["dc.subject.mesh","Models, Neurological"],["dc.subject.mesh","Nerve Net"],["dc.subject.mesh","Neurons"],["dc.subject.mesh","Optogenetics"],["dc.subject.mesh","Rats"],["dc.subject.mesh","Rats, Wistar"],["dc.title","Optogenetic stimulation effectively enhances intrinsically generated network synchrony"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]