Schilling, Arndt Friedrich

[["dc.bibliographiccitation.firstpage","681"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Engineering in Life Sciences"],["dc.bibliographiccitation.lastpage","698"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Fattahi, Ehsan"],["dc.contributor.author","Taheri, Shahed"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Becker, Thomas"],["dc.contributor.author","Pörtner, Ralf"],["dc.date.accessioned","2022-12-01T08:31:00Z"],["dc.date.available","2022-12-01T08:31:00Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1002/elsc.202100128"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118042"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","1618-2863"],["dc.relation.issn","1618-0240"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Generation and evaluation of input values for computational analysis of transport processes within tissue cultures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Immunology"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Rösch, Gundula"],["dc.contributor.author","Muschter, Dominique"],["dc.contributor.author","Taheri, Shahed"],["dc.contributor.author","El Bagdadi, Karima"],["dc.contributor.author","Dorn, Christoph"],["dc.contributor.author","Meurer, Andrea"],["dc.contributor.author","Zaucke, Frank"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Grässel, Susanne"],["dc.contributor.author","Straub, Rainer H."],["dc.contributor.author","Jenei-Lanzl, Zsuzsa"],["dc.date.accessioned","2022-04-01T10:00:50Z"],["dc.date.available","2022-04-01T10:00:50Z"],["dc.date.issued","2022"],["dc.description.abstract","Purpose Recent studies demonstrated a contribution of adrenoceptors (ARs) to osteoarthritis (OA) pathogenesis. Several AR subtypes are expressed in joint tissues and the β2-AR subtype seems to play a major role during OA progression. However, the importance of β2-AR has not yet been investigated in knee OA. Therefore, we examined the development of knee OA in β2-AR-deficient ( Adrb2 -/- ) mice after surgical OA induction. Methods OA was induced by destabilization of the medial meniscus (DMM) in male wildtype (WT) and Adrb2 -/- mice. Cartilage degeneration and synovial inflammation were evaluated by histological scoring. Subchondral bone remodeling was analyzed using micro-CT. Osteoblast (alkaline phosphatase - ALP) and osteoclast (cathepsin K - CatK) activity were analyzed by immunostainings. To evaluate β2-AR deficiency-associated effects, body weight, sympathetic tone (splenic norepinephrine (NE) via HPLC) and serum leptin levels (ELISA) were determined. Expression of the second major AR, the α2-AR, was analyzed in joint tissues by immunostaining. Results WT and Adrb2 -/- DMM mice developed comparable changes in cartilage degeneration and synovial inflammation. Adrb2 -/- DMM mice displayed elevated calcified cartilage and subchondral bone plate thickness as well as increased epiphyseal BV/TV compared to WTs, while there were no significant differences in Sham animals. In the subchondral bone of Adrb2 -/- mice, osteoblasts activity increased and osteoclast activity deceased. Adrb2 -/- mice had significantly higher body weight and fat mass compared to WT mice. Serum leptin levels increased in Adrb2 -/- DMM compared to WT DMM without any difference between the respective Shams. There was no difference in the development of meniscal ossicles and osteophytes or in the subarticular trabecular microstructure between Adrb2 -/- and WT DMM as well as Adrb2 -/- and WT Sham mice. Number of α2-AR-positive cells was lower in Adrb2 -/- than in WT mice in all analyzed tissues and decreased in both Adrb2 -/- and WT over time. Conclusion We propose that the increased bone mass in Adrb2 -/- DMM mice was not only due to β2-AR deficiency but to a synergistic effect of OA and elevated leptin concentrations. Taken together, β2-AR plays a major role in OA-related subchondral bone remodeling and is thus an attractive target for the exploration of novel therapeutic avenues."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.identifier.doi","10.3389/fimmu.2021.801505"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105526"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1664-3224"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","115181"],["dc.bibliographiccitation.journal","Bone"],["dc.bibliographiccitation.volume","133"],["dc.contributor.author","Muschter, Dominique"],["dc.contributor.author","Fleischhauer, Lutz"],["dc.contributor.author","Taheri, Shahed"],["dc.contributor.author","Schilling, Arndt F."],["dc.contributor.author","Clausen-Schaumann, Hauke"],["dc.contributor.author","Grässel, Susanne"],["dc.date.accessioned","2020-12-10T14:22:41Z"],["dc.date.available","2020-12-10T14:22:41Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.bone.2019.115181"],["dc.identifier.issn","8756-3282"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71693"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Calcified Tissue International"],["dc.contributor.author","Taheri, Shahed"],["dc.contributor.author","Yoshida, Takashi"],["dc.contributor.author","Böker, Kai O."],["dc.contributor.author","Foerster, Robert H."],["dc.contributor.author","Jochim, Lina"],["dc.contributor.author","Flux, Anna Lena"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Schilling, Arndt Friedrich"],["dc.date.accessioned","2021-06-01T09:42:49Z"],["dc.date.available","2021-06-01T09:42:49Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract The interplay between articular cartilage (AC) and subchondral bone (SB) plays a pivotal role in cartilage homeostasis and functionality. As direct connective pathways between the two are poorly understood, we examined the location-dependent characteristics of the 3D microchannel network within the SB that connects the basal cartilage layer to the bone marrow (i.e. cartilage-bone marrow microchannel connectors; CMMC). 43 measuring points were defined on five human cadaveric femoral heads with no signs of osteoarthritis (OA) (age ≤ 60), and cartilage-bone cylinders with diameters of 2.00 mm were extracted for high-resolution scanning ( n  = 215). The micro-CT data were categorized into three groups (load-bearing region: LBR, n  = 60; non-load-bearing region: NLBR, n  = 60; and the peripheral rim: PR, n  = 95) based on a gait analysis estimation of the joint reaction force (young, healthy cohort with no signs of OA). At the AC-SB interface, the number of CMMC in the LBR was 1.8 times and 2.2 times higher compared to the NLBR, and the PR, respectively. On the other hand, the median Feret size of the CMMC were smallest in the LBR (55.2 µm) and increased in the NLBR (73.5 µm; p  = 0.043) and the PR (89.1 µm; p  = 0.043). AC thickness was positively associated with SB thickness (Pearson's r  = 0.48; p  < 1e-13), CMMC number. ( r  = 0.46; p  < 1e-11), and circularity index ( r  = 0.61; p  < 1e-38). In conclusion, our data suggest that regional differences in the microchannel architecture of SB might reflect regional differences in loading."],["dc.identifier.doi","10.1007/s00223-021-00864-x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85362"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1432-0827"],["dc.relation.issn","0171-967X"],["dc.title","Investigating the Microchannel Architectures Inside the Subchondral Bone in Relation to Estimated Hip Reaction Forces on the Human Femoral Head"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]