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Hildebrandt, Belinda
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Hildebrandt, Belinda
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Hildebrandt, Belinda
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Hildebrandt, B.
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2009Conference Abstract [["dc.bibliographiccitation.journal","Leukemia Research"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Germing, U."],["dc.contributor.author","Hildebrandt, B."],["dc.contributor.author","Symeonidis, Argiris"],["dc.contributor.author","Cermak, J."],["dc.contributor.author","Pfeilstoecker, Michael"],["dc.contributor.author","Noesslinger, T."],["dc.contributor.author","Sekkeres, M."],["dc.contributor.author","Maciejewski, Andrzej J."],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Schlenk, Richard F."],["dc.contributor.author","Schanz, J."],["dc.contributor.author","Seymour, J."],["dc.contributor.author","Kenealy, M."],["dc.contributor.author","Koeppler, H."],["dc.contributor.author","Luebbert, Michael"],["dc.contributor.author","Platzbecker, Uwe"],["dc.contributor.author","Valent, Peter"],["dc.contributor.author","Blum, S."],["dc.contributor.author","Ottmann, Oliver G."],["dc.contributor.author","Goetze, K."],["dc.contributor.author","Stauder, Reinhard"],["dc.contributor.author","Kreuzer, Karl Anton"],["dc.contributor.author","Aul, Carlo"],["dc.contributor.author","Kuendgen, A."],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.date.accessioned","2018-11-07T08:30:27Z"],["dc.date.available","2018-11-07T08:30:27Z"],["dc.date.issued","2009"],["dc.format.extent","S74"],["dc.identifier.isi","000266759600107"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16895"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.publisher.place","Oxford"],["dc.relation.conference","10th International Symposium on Myelodysplastic Syndromes"],["dc.relation.eventlocation","Patras, GREECE"],["dc.relation.issn","0145-2126"],["dc.title","Survival, prognostic factors, and leukemic transformation in a multicenter study of 241 patients with MDS and del(5q)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS2012Journal Article [["dc.bibliographiccitation.firstpage","1286"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Leukemia"],["dc.bibliographiccitation.lastpage","1292"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Germing, U."],["dc.contributor.author","Lauseker, Michael"],["dc.contributor.author","Hildebrandt, B."],["dc.contributor.author","Symeonidis, Argiris"],["dc.contributor.author","Cermak, J."],["dc.contributor.author","Fenaux, Pierre"],["dc.contributor.author","Kelaidi, C."],["dc.contributor.author","Pfeilstoecker, Michael"],["dc.contributor.author","Noesslinger, T."],["dc.contributor.author","Sekeres, Mikkael A."],["dc.contributor.author","Maciejewski, Andrzej J."],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Schanz, J."],["dc.contributor.author","Seymour, J."],["dc.contributor.author","Kenealy, M."],["dc.contributor.author","Weide, Rudolf"],["dc.contributor.author","Luebbert, Michael"],["dc.contributor.author","Platzbecker, Uwe"],["dc.contributor.author","Valent, Peter"],["dc.contributor.author","Goetze, K."],["dc.contributor.author","Stauder, Reinhard"],["dc.contributor.author","Blum, S."],["dc.contributor.author","Kreuzer, K-A"],["dc.contributor.author","Schlenk, Richard F."],["dc.contributor.author","Ganser, Arnold"],["dc.contributor.author","Hofmann, W-K"],["dc.contributor.author","Aul, Carlo"],["dc.contributor.author","Krieger, Otto"],["dc.contributor.author","Kuendgen, A."],["dc.contributor.author","Haas, Rainer"],["dc.contributor.author","Hasford, Joerg"],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.date.accessioned","2018-11-07T09:09:41Z"],["dc.date.available","2018-11-07T09:09:41Z"],["dc.date.issued","2012"],["dc.description.abstract","Myelodysplastic syndromes (MDS) with del(5q) are considered to have a benign course of the disease. In order to address the issue of the propensity of those patients to progress to acute myeloid leukemia (AML), data on 381 untreated patients with MDS and del(5q) characterized by low or intermediate I International Prognostic Scoring System (IPSS) risk score were collected from nine centers and registries. Median survival of the entire group was 74 months. Transfusion-dependent patients had a median survival of 44 months vs 97 months for transfusion-independent patients (P<0.0001). Transfusion need at diagnosis was the most important patient characteristic for survival. Of the 381 patients, 48 (12.6%) progressed to AML. The cumulative progression rate calculated using the Kaplan-Meier method was 4.9% at 2 years and 17.6% at 5 years. Factors associated with the risk of AML transformation were high-risk World Health Organization adapted Prognostic Scoring System (WPSS) score, marrow blast count >5% and red-cell transfusion dependency at diagnosis. In conclusion, patients with MDS and del(5q) are facing a considerable risk of AML transformation. More detailed cytogenetic and molecular studies may help to identify the patients at risk of progression."],["dc.description.sponsorship","Celgene"],["dc.identifier.doi","10.1038/leu.2011.391"],["dc.identifier.isi","000305081000016"],["dc.identifier.pmid","22289990"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26315"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0887-6924"],["dc.title","Survival, prognostic factors and rates of leukemic transformation in 381 untreated patients with MDS and del(5q): A multicenter study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS2011Conference Abstract [["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Germing, U."],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Aul, Carlo"],["dc.contributor.author","Kuendgen, A."],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Schanz, J."],["dc.contributor.author","Pfeilstoecker, Michael"],["dc.contributor.author","Noesslinger, T."],["dc.contributor.author","Platzbecker, Uwe"],["dc.contributor.author","Goetze, K."],["dc.contributor.author","Luebbert, Michael"],["dc.contributor.author","Blum, S."],["dc.contributor.author","Hildebrandt, B."],["dc.contributor.author","Valent, Peter"],["dc.contributor.author","Krieger, Otto"],["dc.contributor.author","Stauder, Reinhard"],["dc.contributor.author","Hofmann, W-K"],["dc.contributor.author","Braess, J."],["dc.contributor.author","Schulte, K."],["dc.contributor.author","Kreutzer, K-A"],["dc.contributor.author","Buesche, Guntram"],["dc.contributor.author","Kreipe, Hans"],["dc.contributor.author","Stadler, M."],["dc.contributor.author","Ganser, Arnold"],["dc.contributor.author","Schlenk, Richard F."],["dc.contributor.author","Meckenstock, G."],["dc.contributor.author","Bug, G."],["dc.contributor.author","Rune, Gabriele M."],["dc.contributor.author","Haas, Rainer"],["dc.contributor.author","Tuechler, Heinz"],["dc.contributor.author","Lauseker, Michael"],["dc.contributor.author","Hasford, Joerg"],["dc.contributor.author","Gattermann, Norbert"],["dc.date.accessioned","2018-11-07T08:52:20Z"],["dc.date.available","2018-11-07T08:52:20Z"],["dc.date.issued","2011"],["dc.format.extent","288"],["dc.identifier.isi","000295160600773"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22143"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","Data from the German-Austrian-Suisse MDS registry (D-A-CH MDS registry)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS2014Conference Abstract [["dc.bibliographiccitation.firstpage","235"],["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.lastpage","236"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Platzbecker, Uwe"],["dc.contributor.author","Mueller-Thomas, Catharina"],["dc.contributor.author","Goetze, K."],["dc.contributor.author","Germing, U."],["dc.contributor.author","Bruemmendorf, Tim Hendrik"],["dc.contributor.author","Nolte, F."],["dc.contributor.author","Hofmann, W-K"],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Luebbert, Michael"],["dc.contributor.author","Greenberg, Peter L."],["dc.contributor.author","Bennett, John M."],["dc.contributor.author","Sole, Francesco"],["dc.contributor.author","Mallo, Mar"],["dc.contributor.author","Slovak, Marilyn L."],["dc.contributor.author","Ohyashiki, Kazuma"],["dc.contributor.author","Le Beau, Michelle M."],["dc.contributor.author","Tuechler, Heinz"],["dc.contributor.author","Pfeilstoecker, Michael"],["dc.contributor.author","Noesslinger, T."],["dc.contributor.author","Hildebrandt, B."],["dc.contributor.author","Shirneshan, Katayoon"],["dc.contributor.author","Aul, Carlo"],["dc.contributor.author","Stauder, Reinhard"],["dc.contributor.author","Sperr, Wolfgang R."],["dc.contributor.author","Valent, Peter"],["dc.contributor.author","Fonatsch, Christa"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Schanz, J."],["dc.date.accessioned","2018-11-07T09:34:15Z"],["dc.date.available","2018-11-07T09:34:15Z"],["dc.date.issued","2014"],["dc.identifier.isi","000343816900574"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32137"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","Is IPSS/IPSS-R cytogenetic classification possible from peripheral blood in MDS patients? Comparative results from a prospective German diagnostic study with the data set of an international collaboration"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS2011Conference Abstract [["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Schanz, J."],["dc.contributor.author","Kessels, S."],["dc.contributor.author","Haferlach, Claudia"],["dc.contributor.author","Bardi, Georgia"],["dc.contributor.author","Gourgouveli, E."],["dc.contributor.author","Slovak, Marilyn L."],["dc.contributor.author","Johansson, Bertil"],["dc.contributor.author","Ohyashiki, Kazuma"],["dc.contributor.author","Sole, Francesco"],["dc.contributor.author","Eclache, V."],["dc.contributor.author","Wimzal, Friedrich"],["dc.contributor.author","Pfeilstoecker, Michael"],["dc.contributor.author","Noesslinger, T."],["dc.contributor.author","Fonatsch, Christa"],["dc.contributor.author","Luebbert, Michael"],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Stauder, Reinhard"],["dc.contributor.author","Krieger, Otto"],["dc.contributor.author","Prescher, Gabriele"],["dc.contributor.author","Hildebrandt, B."],["dc.contributor.author","Greenberg, Peter L."],["dc.contributor.author","Le Beau, Michelle M."],["dc.contributor.author","Bennett, John M."],["dc.contributor.author","Germing, U."],["dc.contributor.author","Haase, Detlef"],["dc.date.accessioned","2018-11-07T08:52:14Z"],["dc.date.available","2018-11-07T08:52:14Z"],["dc.date.issued","2011"],["dc.format.extent","8"],["dc.identifier.isi","000295160600019"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22119"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","Characterization and prognostic significance of cytogenetically unrelated clones in myelodysplastic syndromes and acute myeloid leukemia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS2005Conference Abstract [["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Blood"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Steidl, Christian"],["dc.contributor.author","Schabla, R."],["dc.contributor.author","Germing, U."],["dc.contributor.author","Hildebrandt, B."],["dc.contributor.author","Noesslinger, T."],["dc.contributor.author","Pfeilstoecker, Michael"],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Kunzmann, R."],["dc.contributor.author","Haas, P."],["dc.contributor.author","Luebbert, Michael"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Haase, Detlef"],["dc.date.accessioned","2018-11-07T10:54:14Z"],["dc.date.available","2018-11-07T10:54:14Z"],["dc.date.issued","2005"],["dc.format.extent","711A"],["dc.identifier.isi","000233426004378"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49521"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Hematology"],["dc.publisher.place","Washington"],["dc.relation.conference","47th Annual Meeting of the American-Society-of-Hematology"],["dc.relation.eventlocation","Atlanta, GA"],["dc.relation.issn","0006-4971"],["dc.title","Sequential cytogenetic analyses of 577 patients with myelodysplastic syndromes: Correlations between initial karyotype, cytogenetic dynamics, and clinical course."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS2008Conference Abstract [["dc.bibliographiccitation.firstpage","284"],["dc.bibliographiccitation.journal","HAEMATOLOGICA-THE HEMATOLOGY JOURNAL"],["dc.bibliographiccitation.lastpage","285"],["dc.bibliographiccitation.volume","93"],["dc.contributor.author","Kuendgen, A. K."],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Blum, S."],["dc.contributor.author","Fischer, S."],["dc.contributor.author","Platzbecker, Uwe"],["dc.contributor.author","Schlenk, Richard F."],["dc.contributor.author","Hildebrandt, B."],["dc.contributor.author","Valent, Peter"],["dc.contributor.author","Stadler, M."],["dc.contributor.author","Stauder, Reinhard"],["dc.contributor.author","Krieger, Otto"],["dc.contributor.author","Goetze, K."],["dc.contributor.author","Hofmann, Wolf-Karsten"],["dc.contributor.author","Ganser, Arnold"],["dc.contributor.author","Mende, Claudia"],["dc.contributor.author","Haas, Rainer"],["dc.contributor.author","Gattermann, Norbert"],["dc.contributor.author","Germing, U."],["dc.date.accessioned","2018-11-07T11:14:29Z"],["dc.date.available","2018-11-07T11:14:29Z"],["dc.date.issued","2008"],["dc.identifier.isi","000263430200709"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54132"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ferrata Storti Foundation"],["dc.publisher.place","Pavia"],["dc.relation.conference","13th Congress of the European-Hematology-Association"],["dc.relation.eventlocation","Copenhagen, DENMARK"],["dc.relation.issn","0390-6078"],["dc.title","CLINICAL AND PROGNOSTIC CHARACTERISTICS OF 484 PATIENTS WITH THERAPY-RELATED MYELODYSPLASTIC SYNDROME (T-MDS) OR ACUTE MYELOID LEUKEMIA (T-AML)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS2010Conference Abstract [["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Ganster, Christina"],["dc.contributor.author","Schanz, J."],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Shimeshan, K."],["dc.contributor.author","Sole, Francesco"],["dc.contributor.author","Hildebrandt, B."],["dc.contributor.author","Slovak, Marilyn L."],["dc.contributor.author","Ohyashiki, Kazuma"],["dc.contributor.author","Steidl, Christian"],["dc.contributor.author","Fonatsch, Christa"],["dc.contributor.author","Noesslinger, T."],["dc.contributor.author","Valent, Peter"],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Aul, Carlo"],["dc.contributor.author","Luebbert, Michael"],["dc.contributor.author","Stauder, Reinhard"],["dc.contributor.author","Krieger, Otto"],["dc.contributor.author","Le Beau, Michelle M."],["dc.contributor.author","Bennett, Jeffrey L."],["dc.contributor.author","Greenberg, Peter L."],["dc.contributor.author","Germing, U."],["dc.contributor.author","Haase, Detlef"],["dc.date.accessioned","2018-11-07T08:38:51Z"],["dc.date.available","2018-11-07T08:38:51Z"],["dc.date.issued","2010"],["dc.format.extent","224"],["dc.identifier.isi","000282988401186"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18856"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","Loss of the Y Chromosome in MDS: Clonal abnormality or age-related accident?"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details WOS2004Conference Abstract [["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Blood"],["dc.bibliographiccitation.volume","104"],["dc.contributor.author","Noesslinger, T."],["dc.contributor.author","Germing, U."],["dc.contributor.author","Hildebrandt, B."],["dc.contributor.author","Strupp, C."],["dc.contributor.author","Aivado, M."],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Schanz, J."],["dc.contributor.author","Wimazal, F."],["dc.contributor.author","Sperr, Wolfgang R."],["dc.contributor.author","Peter, V."],["dc.contributor.author","Michael, L."],["dc.contributor.author","Krieger, Otto"],["dc.contributor.author","Gattermann, Norbert"],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Tuchler, H."],["dc.contributor.author","Haas, Rainer"],["dc.contributor.author","Aul, Carlo"],["dc.contributor.author","Pfeilstocker, M."],["dc.date.accessioned","2018-11-07T10:43:53Z"],["dc.date.available","2018-11-07T10:43:53Z"],["dc.date.issued","2004"],["dc.identifier.isi","000225127501451"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47149"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Hematology"],["dc.publisher.place","Washington"],["dc.relation.conference","46th Annual Meeting of the American-Society-of-Hematology"],["dc.relation.eventlocation","San Diego, CA"],["dc.title","The influence of age and gender on the prognostic impact of karytoypic subgroups in myelodysplastic syndromes - a multicenter analysis."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]Details WOS2013Journal Article [["dc.bibliographiccitation.firstpage","1988"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Leukemia"],["dc.bibliographiccitation.lastpage","1995"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Schanz, J."],["dc.contributor.author","Tuechler, Heinz"],["dc.contributor.author","Sole, Francesco"],["dc.contributor.author","Mallo, Mar"],["dc.contributor.author","Luno, Elisa"],["dc.contributor.author","Cervera, J."],["dc.contributor.author","Grau, Javier"],["dc.contributor.author","Hildebrandt, B."],["dc.contributor.author","Slovak, Marilyn L."],["dc.contributor.author","Ohyashiki, Kazuma"],["dc.contributor.author","Steidl, Christian"],["dc.contributor.author","Fonatsch, Christa"],["dc.contributor.author","Pfeilstoecker, Michael"],["dc.contributor.author","Noesslinger, T."],["dc.contributor.author","Valent, Peter"],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Aul, Carlo"],["dc.contributor.author","Luebbert, Michael"],["dc.contributor.author","Stauder, Reinhard"],["dc.contributor.author","Krieger, Otto"],["dc.contributor.author","Le Beau, Michelle M."],["dc.contributor.author","Bennett, John M."],["dc.contributor.author","Greenberg, Peter L."],["dc.contributor.author","Germing, U."],["dc.contributor.author","Haase, Detlef"],["dc.date.accessioned","2018-11-07T09:19:23Z"],["dc.date.available","2018-11-07T09:19:23Z"],["dc.date.issued","2013"],["dc.description.abstract","Monosomal karyotype (MK) is associated with an adverse prognosis in patients in acute myeloid leukemia (AML). This study analyzes the prognostic impact of MK in a cohort of primary, untreated patients with myelodysplastic syndromes (MDS). A total of 431 patients were extracted from an international database. To analyze whether MK is an independent prognostic marker in MDS, cytogenetic and clinical data were explored in uni- and multivariate models regarding overall survival (OS) as well as AML-free survival. In all, 204/431 (47.3%) patients with MK were identified. Regarding OS, MK was prognostically significant in patients with <= 4 abnormalities only. In highly complex karyotypes (>= 5 abnormalities), MK did not separate prognostic subgroups (median OS 4.9 months in MK+ vs 5.6 months in patients without MK, P = 0.832). Based on the number of abnormalities, MK-positive karyotypes (MK+) split into different prognostic subgroups (MK+ and 2 abnormalities: OS 13.4 months, MK+ and 3 abnormalities: 8.0 months, MK+ and 4 abnormalities: 7.9 months and MK+ and >= 5 abnormalities: 4.9 months; P < 0.01). In multivariate analyses, MK was not an independent prognostic factor. Our data support the hypothesis that a high number of complex abnormalities, associated with an instable clone, define the subgroup with the worst prognosis in MDS, independent of MK."],["dc.identifier.doi","10.1038/leu.2013.187"],["dc.identifier.isi","000325642600005"],["dc.identifier.pmid","23787396"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28624"],["dc.notes.status","zu prĂĽfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1476-5551"],["dc.relation.issn","0887-6924"],["dc.title","Monosomal karyotype in MDS: explaining the poor prognosis?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]Details DOI PMID PMC WOS