Bayer, Thomas A.

[["dc.bibliographiccitation.artnumber","5451"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Curdt, Nadine"],["dc.contributor.author","Schmitt, Franziska W."],["dc.contributor.author","Bouter, Caroline"],["dc.contributor.author","Iseni, Trendelina"],["dc.contributor.author","Weile, Hanna C."],["dc.contributor.author","Altunok, Berfin"],["dc.contributor.author","Beindorff, Nicola"],["dc.contributor.author","Bayer, Thomas A."],["dc.contributor.author","Cooke, Matthew B."],["dc.contributor.author","Bouter, Yvonne"],["dc.date.accessioned","2022-05-02T08:02:10Z"],["dc.date.available","2022-05-02T08:02:10Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Spatial disorientation is one of the earliest symptoms in Alzheimer’s disease and allocentric deficits can already be detected in the asymptomatic preclinical stages of the disease. The Morris Water Maze (MWM) is used to study spatial learning in rodent models. Here we investigated the spatial memory of female 3, 7 and 12 month-old Alzheimer Tg4-42 mice in comparison to wild-type control animals. Conventional behavior analysis of escape latencies and quadrant preference revealed spatial memory and reference memory deficits in female 7 and 12 month-old Tg4-42 mice. In contrast, conventional analysis of the MWM indicated an intact spatial memory in 3 month-old Tg4-42 mice. However, a detailed analysis of the swimming strategies demonstrated allocentric-specific memory deficits in 3 month-old Tg4-42 mice before the onset of severe memory deficits. Furthermore, we could show that the spatial reference memory deficits in aged Tg4-42 animals are caused by the lack of allocentric and spatial strategies. Analyzing search strategies in the MWM allows to differentiate between hippocampus-dependent allocentric and hippocampus-independent egocentric search strategies. The spatial navigation impairments in young Tg4-42 mice are well in line with the hypometabolism and synaptic deficits in the hippocampus. Therefore, analyzing search strategies in the Tg4-42 model can be a powerful tool for preclinical drug testing and identifying early therapeutic successes."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1038/s41598-022-09270-1"],["dc.identifier.pii","9270"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107247"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-561"],["dc.relation.eissn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Search strategy analysis of Tg4-42 Alzheimer Mice in the Morris Water Maze reveals early spatial navigation deficits"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","11159"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","23"],["dc.contributor.affiliation","Schleicher, Eva Maria; 1Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Bayer, Thomas A.; 1Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Iseni, Trendelina; 1Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Ott, Frederik Wilhelm; 1Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Wagner, Jannek Moritz; 1Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Viotti, Julio S.; 4Institute of Anatomy and Embryology, University Medical Center Goettingen, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Dresbach, Thomas; 4Institute of Anatomy and Embryology, University Medical Center Goettingen, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.affiliation","Bouter, Yvonne; 1Department of Psychiatry and Psychotherapy, Division of Molecular Psychiatry, University Medical Center, Georg-August University, 37075 Goettingen, Germany"],["dc.contributor.author","Schleicher, Eva Maria"],["dc.contributor.author","Bayer, Thomas A."],["dc.contributor.author","Iseni, Trendelina"],["dc.contributor.author","Ott, Frederik Wilhelm"],["dc.contributor.author","Wagner, Jannek Moritz"],["dc.contributor.author","Viotti, Julio S."],["dc.contributor.author","Dresbach, Thomas"],["dc.contributor.author","Bouter, Yvonne"],["dc.contributor.editor","Dal Maschio, Marco"],["dc.contributor.editor","Miletto Petrazzini, Maria Elena"],["dc.date.accessioned","2022-11-01T10:17:26Z"],["dc.date.available","2022-11-01T10:17:26Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:13:02Z"],["dc.description.abstract","The presynaptic protein Mover/TPRGL/SVAP30 is absent in Drosophila and C. elegans and differentially expressed in synapses in the rodent brain, suggesting that it confers specific functions to subtypes of presynaptic terminals. In order to investigate how the absence of this protein affects behavior and learning, Mover knockout mice (KO) were subjected to a series of established learning tests. To determine possible behavioral and cognitive alterations, male and female 8-week-old KO and C57Bl/6J wildtype (WT) control mice were tested in a battery of memory and anxiety tests. Testing included the cross maze, novel object recognition test (NOR), the Morris water maze (MWM), the elevated plus maze (EPM), and the open field test (OF). Mover KO mice showed impaired recognition memory in the NOR test, and decreased anxiety behavior in the OF and the EPM. Mover KO did not lead to changes in working memory in the cross maze or spatial reference memory in the MWM. However, a detailed analysis of the swimming strategies demonstrated allocentric-specific memory deficits in male KO mice. Our data indicate that Mover appears to control synaptic properties associated with specific forms of memory formation and behavior, suggesting that it has a modulatory role in synaptic transmission."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3390/ijms231911159"],["dc.identifier.pii","ijms231911159"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116810"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-605"],["dc.publisher","MDPI"],["dc.relation.eissn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.title","Ablation of the Presynaptic Protein Mover Impairs Learning Performance and Decreases Anxiety Behavior in Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]