Moldrich, Gabriella

[["dc.bibliographiccitation.firstpage","1305"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Neurochemical Research"],["dc.bibliographiccitation.lastpage","1309"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Unzicker, Christian"],["dc.contributor.author","Erberich, Heike"],["dc.contributor.author","Moldrich, Gabriella"],["dc.contributor.author","Woldt, Helge"],["dc.contributor.author","Bulla, Jan"],["dc.contributor.author","Mechoulam, Raphael"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Sirén, Anna-Leena"],["dc.date.accessioned","2017-09-07T11:46:33Z"],["dc.date.available","2017-09-07T11:46:33Z"],["dc.date.issued","2005"],["dc.description.abstract","Endothelin (ETB)-receptors mediate anti-apoptotic actions. Lack of functional ETB-receptors leads to increased neuronal apoptosis in the hippocampus. The increased apoptosis must be compensated by other mechanisms, however, as ETB-deficient rats display normal overall brain morphology. To illuminate on brain plasticity in ETB-receptor deficiency, we studied the expression and function of another neuroprotective system, the cannabinoid CB1-receptors, in ETB-deficient hippocampus. We show that CB1 expression in hippocampus increases postnatally in all rats but that the increase in CB1-receptor expression is significantly higher in ETB-deficient compared to wildtype littermates. Neuronal apoptosis decreases during brain maturation but remains on a significantly higher level in the ETB-deficient compared to wildtype dentate. When investigating survival of hippocampal neurons in culture, we found significant protection against hypoxia-induced cell death with CB1-analogs (noladin, (9-tetrahydrocannabinol) only in ETB-deficient neurons. We suggest that CB1-receptor upregulation in the ETB-mutant hippocampus reflects an attempt to compensate for the lack of ETB-receptors."],["dc.identifier.doi","10.1007/s11064-005-8802-3"],["dc.identifier.gro","3150522"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7294"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.subject","Cannabis; CB1; endocannabinoid system; noladin; tetrahydrocannabinol; THC; endothelin; ETB; apoptosis; hippocampus; dentate gyrus; neuronal culture; Wistar-Imamichi rat; spotting lethal rat; hypoxia; neuroprotection; immunohistochemistry; Western blot"],["dc.title","Hippocampal cannabinoid-1 receptor upregulation upon endothelin-B receptor deficiency: A neuroprotective substitution effect?"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]