Djukic, Marija

[["dc.bibliographiccitation.firstpage","57"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Current Opinion in Infectious Diseases"],["dc.bibliographiccitation.lastpage","68"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Seele, Jana"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Eiffert, Helmut"],["dc.date.accessioned","2020-12-10T18:20:12Z"],["dc.date.available","2020-12-10T18:20:12Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1097/QCO.0000000000000418"],["dc.identifier.issn","0951-7375"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75478"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Pharmacokinetics and pharmacodynamics of antibiotics in central nervous system infections"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","504"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Infectious Diseases"],["dc.bibliographiccitation.lastpage","509"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Jomrich, Nina"],["dc.contributor.author","Kellner, Silvia"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2018-11-07T09:55:09Z"],["dc.date.available","2018-11-07T09:55:09Z"],["dc.date.issued","2015"],["dc.description.abstract","Colonization of the pharynx by Streptococcus pneumoniae was studied in 185 in-hospital geriatric patients (median age 81 years) from 29 March 2011 to 22 June 2011. Swabs were plated on blood agar plates. Colonies with a morphology suggesting S. pneumoniae were further analyzed. Surprisingly, pneumococci were not found in any of the samples. Pneumococci chronically colonizing the pharynx of elderly people may be much rarer than previously thought and probably are not the source of pneumococcal pneumonia in old age."],["dc.description.sponsorship","European Commission [CAREPNEUMO] [223111]; Sparkasse Gottingen"],["dc.identifier.doi","10.3109/00365548.2015.1007476"],["dc.identifier.isi","000357737700011"],["dc.identifier.pmid","25746605"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36688"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.relation.issn","2374-4243"],["dc.relation.issn","2374-4235"],["dc.title","Absence of Streptococcus pneumoniae in pharyngeal swabs of geriatric inpatients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","630"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","636"],["dc.bibliographiccitation.volume","259"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Neubieser, Katja"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Schmidt, Holger"],["dc.date.accessioned","2018-11-07T09:11:41Z"],["dc.date.available","2018-11-07T09:11:41Z"],["dc.date.issued","2012"],["dc.description.abstract","Presence of BB-specific antibodies in the cerebrospinal fluid (CSF) with evidence of their intrathecal production in conjunction with the white cell count in the CSF and typical clinical symptoms is the traditional diagnostic gold standard of Lyme neuroborreliosis (LNB). Few data are available on the CSF lactate concentration in European adults with the diagnosis of acute LNB. The objective of the study was to investigate the CSF changes during acute LNB. Routine CSF parameters [leukocyte count, protein, lactate and albumin concentrations, CSF/serum quotients of albumin (Q(Alb)), IgG, IgA and IgM, and oligoclonal IgG bands] and the Borrelia burgdorferi (BB)-specific antibody index were retrospectively studied in relation to the clinical presentation in patients diagnosed with acute LNB. A total of 118 patients with LNB were categorized into the following groups according to their symptoms at presentation; group 1: polyradiculoneuritis (Bannwarth's syndrome), group 2: isolated facial palsy and group 3: predominantly meningitic course of the disease. In addition to the CSF of patients with acute LNB, CSF of 19 patients with viral meningitis (VM) and 3 with neurolues (NL) were analyzed. There were 97 patients classified with definite LNB, and 21 as probable LNB. Neck stiffness and fever were reported by 15.3% of patients. Most of these patients were younger than 50 years. Polyradiculoneuritis was frequently found in patients older than 50 years. Lymphopleocytosis was found in all patients. Only 5 patients had a CSF lactate >= 3.5 mmol/l, and the mean CSF lactate level was not elevated (2.1 +/- A 0.6 mmol/l). The patients with definite LNB had significantly higher lactate levels than patients with probable LNB. Elevated lactate levels were accompanied by fever and headache. In the Reiber nomograms, intrathecal immunoglobulin synthesis was found for IgM in 70.2% followed by IgG in 19.5%. Isoelectric focussing detected an intrathecal IgG synthesis in 83 patients (70.3%). Elevated BB AIs in the CSF were found in 97 patients (82.2%). Patients with VM showed lower CSF protein concentration and CSF/serum quotients of albumin than LNB patients. In acute LNB, all patients had elevated cerebrospinal fluid (CSF) leukocyte counts. In contrast to infections by other bacteria, CSF lactate was lower than 3.5 mmol/l in all but 5 patients. The CSF findings did not differ between polyradiculoneuritis, facial palsy, and meningitis. The CSF in LNB patients strongly differed from CSF in VM patients with respect to protein concentration and the CSF/serum albumin quotient."],["dc.identifier.doi","10.1007/s00415-011-6221-8"],["dc.identifier.isi","000302489400004"],["dc.identifier.pmid","21898139"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8098"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26777"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","547"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.lastpage","555"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Djukic, M."],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Nau, R."],["dc.contributor.author","von Steinbuechel, Nicole"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Schmidt, H."],["dc.date.accessioned","2018-11-07T08:57:47Z"],["dc.date.available","2018-11-07T08:57:47Z"],["dc.date.issued","2011"],["dc.description.abstract","Background and purpose: Studies addressing the diagnostic relevance of anti-Borrelia burgdorferi (BB) serum antibodies in patients with non-specific symptoms and suspected chronic Lyme neuroborreliosis (LNB) are scarce. Methods: In this study, we enrolled within 1 year 122 patients with suspected chronic LNB. One hundred and fourteen patients had previously tested positive for BB. All patients had previously received antibiotic treatment. Each patient received a clinical examination and measurement of BB-specific antibodies. The diagnosis of neuroborreliosis was made according to the national guidelines of the German Society of Neurology. Nine patients had acute borreliosis. One of the nine met the criteria of acute LNB. Of the remaining 113 patients, 85 patients underwent a lumbar puncture. Ten seronegative subjects without lumbar puncture were also considered. In 61.8% of these 95 patients the quality of life, of sleep, mood, and anxiety were assessed. Results: Of 95 patients, 25.3% had symptoms without a somatic cause or evidence of borreliosis, 38.9% had a well-defined illness unrelated to BB infection, and 29.5% suffered from symptoms without a detectable somatic cause, displaying antibodies against BB. Six patients were grouped as post-LNB syndrome. Most common symptoms in all categories were arthralgia, myalgia, dysaesthesia, depressive mood and chronic fatigue. Conclusion: Patients with persistent symptoms with elevated serum antibodies against BB but without signs of cerebrospinal fluid inflammation require further diagnostic examinations to exclude ongoing infection and to avoid co-infections and other treatable conditions (e.g. autoimmune diseases). One patient with acute LNB, who was treated with ceftriaxone for 3 weeks suffered from LNB with new headaches and persistent symptoms 6 months later. These data should encourage further studies with new experimental parameters."],["dc.identifier.doi","10.1111/j.1468-1331.2010.03229.x"],["dc.identifier.isi","000288503600007"],["dc.identifier.pmid","20977545"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23484"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1351-5101"],["dc.title","The diagnostic spectrum in patients with suspected chronic Lyme neuroborreliosis - the experience from one year of a university hospital's Lyme neuroborreliosis outpatients clinic"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","AKTUELLE NEUROLOGIE"],["dc.bibliographiccitation.lastpage","15"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Djukic, M."],["dc.contributor.author","Nau, R."],["dc.contributor.author","Eiffert, Helmut"],["dc.date.accessioned","2018-11-07T09:28:28Z"],["dc.date.available","2018-11-07T09:28:28Z"],["dc.date.issued","2013"],["dc.description.abstract","Neuroborreliosis is a nervous system infection caused by Borrelia burgdorferi sensu lato. Lyme disease is the most frequent tick-borne infectious disease in Europe affecting the skin, joints, heart, nervous system and rarely the eyes. Since the discovery of the causative pathogen Borrelia burgdorferi 30 years ago, the rapid accumulation of knowledge about this disease has resulted in well-evaluated clinical and microbiological diagnostic guidelines. Today, neuroborreliosis can generally be diagnosed and treated successfully. Progress in microbiological research has led to improved serological tests with higher sensitivity and new approaches for early diagnosis of Lyme disease. Erythema migrans is the most frequent manifestation of Borrelia infection. It is diagnosed clinically. Neuroborreliosis is diagnosed by the combination of typical neurological symptoms, cerebrospinal fluid pleocytosis and Borrelia-specific antibodies produced intrathecally. In adults, erythema migrans is treated with doxycycline, in children with amoxicillin. Standard treatment of neuroborreliosis is ceftriaxone or cefotaxime i.v. Recent studies show similar efficacy of oral doxycycline in early neuroborreliosis. An appropriate antibiotic treatment eliminates the pathogen effectively. Repeated episodes of acute manifestations of Lyme disease in treated patients are probably due to reinfection and not to relapse. Only in a small proportion of treated patients is recovery from neuroborrelioses incomplete. In addition to neurological residual sequelae recent studies have detected persistent neuropsychological deficits in a small subgroup of patients. Conversely, when borreliosis is suspected by patients suffering from non-specific symptoms, a thorough clinical and laboratory assessment is required to identify other underlying diseases."],["dc.identifier.doi","10.1055/s-0032-1332850"],["dc.identifier.isi","000315182600002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30782"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0302-4350"],["dc.title","Update Neuroborreliosis - New and Proven Options"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","52"],["dc.bibliographiccitation.journal","Zeitschrift für Gerontologie und Geriatrie"],["dc.bibliographiccitation.lastpage","53"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Nau, R."],["dc.contributor.author","Ribes, Sandra"],["dc.contributor.author","Djukic, M."],["dc.contributor.author","Redlich, Sandra"],["dc.contributor.author","Eiffert, Helmut"],["dc.date.accessioned","2018-11-07T09:36:20Z"],["dc.date.available","2018-11-07T09:36:20Z"],["dc.date.issued","2014"],["dc.identifier.isi","000359603600171"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32593"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1435-1269"],["dc.relation.issn","0948-6704"],["dc.title","Strategies for Increasing the Resistance of the central Nervous System against bacterial Infections"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","215"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Expert Review of Anti-infective Therapy"],["dc.bibliographiccitation.lastpage","231"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Tauber, Simone C."],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Gossner, Johannes"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2021-04-14T08:23:02Z"],["dc.date.available","2021-04-14T08:23:02Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1080/14787210.2020.1812384"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80782"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1744-8336"],["dc.relation.issn","1478-7210"],["dc.title","Sepsis-associated encephalopathy and septic encephalitis: an update"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1079"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Expert Review of Anti-infective Therapy"],["dc.bibliographiccitation.lastpage","1095"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Eiffert, Helmut"],["dc.date.accessioned","2018-11-07T09:19:23Z"],["dc.date.available","2018-11-07T09:19:23Z"],["dc.date.issued","2013"],["dc.description.abstract","Bacterial meningitis remains a disease with high mortality and long-term morbidity. Outcome critically depends on the rapid initiation of effective antibiotic therapy. Since a further increase of the incidence of pathogens resistant to antibacterials can be expected both in community-acquired and nosocomial bacterial meningitis, the choice of an optimum initial empirical antibiotic regimen will gain significance. In this context, the use of antibiotics which are bactericidal but do not lyse bacteria, may emerge as a therapeutic option. Conversely, the role of corticosteroids, which decrease the entry of hydrophilic antibacterials into the cerebrospinal fluid, as adjunctive therapy will probably decline as a consequence of the increasing antibiotic resistance of bacteria causing meningitis. Consequent vaccination of all children at present is the most efficient manner to reduce disease burden."],["dc.identifier.doi","10.1586/14787210.2013.839381"],["dc.identifier.isi","000325546200013"],["dc.identifier.pmid","24073921"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28620"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis Ltd"],["dc.relation.issn","1744-8336"],["dc.relation.issn","1478-7210"],["dc.title","Bacterial meningitis: new therapeutic approaches"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","325"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neurocritical Care"],["dc.bibliographiccitation.lastpage","329"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Djukic, M."],["dc.contributor.author","Bottcher, T."],["dc.contributor.author","Wellmer, A."],["dc.contributor.author","Gerber, Joachim"],["dc.contributor.author","Brocke, V. V."],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Nau, R."],["dc.date.accessioned","2018-11-07T08:44:15Z"],["dc.date.available","2018-11-07T08:44:15Z"],["dc.date.issued","2005"],["dc.description.abstract","Rifampin, a protein synthesis inhibitor, reduced mortality in a mouse model of meningitis compared to bacteriolytic cephalosporin standard therapy. To assess whether moxifloxacin (known to cause a less rapid bacteriolysis than cephalosporins) can similarly reduce mortality, mice infected with Streptococcus pneumoniae by deep intracerebral injection were treated subcutaneously with either 200 mg/kg of moxifloxacin or ceftriaxone every 8 hours for 5 days (n=49 each). They were then observed for an additional 8 days. Overall mortalities were 35 and 29 in moxifloxacin- and ceftriaxone-treated mice, respectively (p=0.29). Kaplan-Meier survival analysis also revealed no statistically significant differences (p=0.32). Moxifloxacin failed to reduce mortality compared to cephalosporin standard therapy."],["dc.identifier.doi","10.1385/NCC:2:3:325"],["dc.identifier.isi","000231204500015"],["dc.identifier.pmid","16159084"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20158"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Humana Press Inc"],["dc.relation.issn","1541-6933"],["dc.title","Moxifloxacin in experimental Streptococcus pneumoniae cerebritis and meningitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","138"],["dc.bibliographiccitation.journal","Frontiers in Cellular Neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Ribes, Sandra"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Eiffert, Helmut"],["dc.date.accessioned","2018-11-07T09:40:02Z"],["dc.date.available","2018-11-07T09:40:02Z"],["dc.date.issued","2014"],["dc.description.abstract","In healthy individuals, infections of the central nervous system (CNS) are comparatively rare. Based on the ability of microglial cells to phagocytose and kill pathogens and on clinical findings in immunocompromised patients with CNS infections, we hypothesize that an intact microglial function is crucial to protect the brain from infections. Phagocytosis of pathogens by microglial cells can be stimulated by agonists of receptors of the innate immune system. Enhancing this pathway to increase the resistance of the brain to infections entails the risk of inducing collateral damage to the nervous tissue. The diversity of microglial cells opens avenue to selectively stimulate sub-populations responsible for the defence against pathogens without stimulating sub-populations which are responsible for collateral damage to the nervous tissue. Palmitoylethanolamide (PEA), an endogenous lipid, increased phagocytosis of bacteria by microglial cells in vitro without a measurable proinflammatory effect. It was tested clinically apparently without severe side effects. Glatiramer acetate increased phagocytosis of latex beads by microglia and monocytes, and dimethyl fumarate enhanced eliminationof human immunodeficiency virus from infected macrophages without inducing a release of proinflammatory compounds. Therefore, the discovery of compounds which stimulate the elimination of pathogens without collateral damage of neuronal structures appears an achievable goal. PEA and, with limitations, glatiramer acetate and dimethyl fumarate appear promising candidates."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2014"],["dc.identifier.doi","10.3389/fncel.2014.00138"],["dc.identifier.isi","000336242400001"],["dc.identifier.pmid","24904283"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10145"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33420"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Research Foundation"],["dc.relation.issn","1662-5102"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Strategies to increase the activity of microglia as efficient protectors of the brain against infections"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]