Djukic, Marija

[["dc.bibliographiccitation.firstpage","630"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","636"],["dc.bibliographiccitation.volume","259"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Neubieser, Katja"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Schmidt, Holger"],["dc.date.accessioned","2018-11-07T09:11:41Z"],["dc.date.available","2018-11-07T09:11:41Z"],["dc.date.issued","2012"],["dc.description.abstract","Presence of BB-specific antibodies in the cerebrospinal fluid (CSF) with evidence of their intrathecal production in conjunction with the white cell count in the CSF and typical clinical symptoms is the traditional diagnostic gold standard of Lyme neuroborreliosis (LNB). Few data are available on the CSF lactate concentration in European adults with the diagnosis of acute LNB. The objective of the study was to investigate the CSF changes during acute LNB. Routine CSF parameters [leukocyte count, protein, lactate and albumin concentrations, CSF/serum quotients of albumin (Q(Alb)), IgG, IgA and IgM, and oligoclonal IgG bands] and the Borrelia burgdorferi (BB)-specific antibody index were retrospectively studied in relation to the clinical presentation in patients diagnosed with acute LNB. A total of 118 patients with LNB were categorized into the following groups according to their symptoms at presentation; group 1: polyradiculoneuritis (Bannwarth's syndrome), group 2: isolated facial palsy and group 3: predominantly meningitic course of the disease. In addition to the CSF of patients with acute LNB, CSF of 19 patients with viral meningitis (VM) and 3 with neurolues (NL) were analyzed. There were 97 patients classified with definite LNB, and 21 as probable LNB. Neck stiffness and fever were reported by 15.3% of patients. Most of these patients were younger than 50 years. Polyradiculoneuritis was frequently found in patients older than 50 years. Lymphopleocytosis was found in all patients. Only 5 patients had a CSF lactate >= 3.5 mmol/l, and the mean CSF lactate level was not elevated (2.1 +/- A 0.6 mmol/l). The patients with definite LNB had significantly higher lactate levels than patients with probable LNB. Elevated lactate levels were accompanied by fever and headache. In the Reiber nomograms, intrathecal immunoglobulin synthesis was found for IgM in 70.2% followed by IgG in 19.5%. Isoelectric focussing detected an intrathecal IgG synthesis in 83 patients (70.3%). Elevated BB AIs in the CSF were found in 97 patients (82.2%). Patients with VM showed lower CSF protein concentration and CSF/serum quotients of albumin than LNB patients. In acute LNB, all patients had elevated cerebrospinal fluid (CSF) leukocyte counts. In contrast to infections by other bacteria, CSF lactate was lower than 3.5 mmol/l in all but 5 patients. The CSF findings did not differ between polyradiculoneuritis, facial palsy, and meningitis. The CSF in LNB patients strongly differed from CSF in VM patients with respect to protein concentration and the CSF/serum albumin quotient."],["dc.identifier.doi","10.1007/s00415-011-6221-8"],["dc.identifier.isi","000302489400004"],["dc.identifier.pmid","21898139"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8098"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26777"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","15"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Fluids and Barriers of the CNS"],["dc.bibliographiccitation.lastpage","5"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Bunkowski, Stephanie"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2017-09-07T11:44:33Z"],["dc.date.available","2017-09-07T11:44:33Z"],["dc.date.issued","2016"],["dc.description.abstract","Background The composition of the cerebrospinal fluid (CSF) is not homogeneous, and concentrations of proteins from different origins diverge among ventricular, cisternal and lumbar CSF fractions. Concentrations of blood-derived proteins increase and of brain-derived proteins decrease from ventricular to lumbar fractions. We studied whether the origin of the CSF portion analysed may affect results in CSF analysis for dementia. Methods In 16 geriatric patients with suspected normal pressure hydrocephalus [age 82.5 (76/87) years; median (25th/75th percentile)] a lumbar spinal tap of 40 ml was performed. The CSF was sequentially collected in 8 fractions of 5 ml with the 1st fraction corresponding to lumbar CSF, the 8th to cisterna magna-near CSF. Fractions were analysed for total protein, albumin, Tau protein (Tau), phosphorylated Tau (pTau), Amyloid beta 1–42 (Aβ1–42), Amyloid beta 1–40 (Aβ1–40), and the Aβ1–42/Aβ1–40 ratio. Results The concentrations of total protein and albumin increased from cisternal to lumbar fractions due to diffusion-related accumulation from blood to CSF with significantly higher concentrations in fraction 1 compared to fraction 8. The concentrations of Tau showed a non-significant trend towards decreased values in lumbar samples, and pTau was slightly, but significantly decreased in the lumbar fraction 1 [26.5 (22.5/35.0) pg/ml] compared to the cistern-near fraction 8 [27.0 (24.2/36.3) pg/ml] (p = 0.02, Wilcoxon signed rank test). Aβ1-42, Aβ1-40, and the Aβ1-42/Aβ1-40 ratio remained almost constant. Conclusions According to the flow-related diverging dynamics of blood-derived and brain-derived proteins in CSF, the concentrations of Tau and pTau tended to be lower in lumbar compared to cisternal CSF fractions after a spinal tap of 40 ml. The differences reached statistical significance for pTau only. The small differences will not affect clinical interpretation of markers of dementia in the vast majority of cases."],["dc.identifier.doi","10.1186/s12987-016-0039-9"],["dc.identifier.gro","3151687"],["dc.identifier.pmid","27581842"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13876"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8505"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","2045-8118"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Small cisterno-lumbar gradient of phosphorylated Tau protein in geriatric patients with suspected normal pressure hydrocephalus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","208"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neuroinflammation"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Sostmann, Nadine"],["dc.contributor.author","Bertsch, Thomas"],["dc.contributor.author","Mecke, Marianne"],["dc.contributor.author","Nessler, Stefan"],["dc.contributor.author","Manig, Anja"],["dc.contributor.author","Hanisch, Uwe-Karsten"],["dc.contributor.author","Triebel, Jakob"],["dc.contributor.author","Bollheimer, L. C."],["dc.contributor.author","Sieber, Cornel"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2019-07-09T11:40:54Z"],["dc.date.available","2019-07-09T11:40:54Z"],["dc.date.issued","2015"],["dc.description.abstract","Background Meningoencephalitis caused by Escherichia coli is associated with high rates of mortality and risk of neurological sequelae in newborns and infants and in older or immunocompromised adults. A high prevalence of neurological disorders has been observed in geriatric populations at risk of hypovitaminosis D. Methods In vivo, we studied the effects of vitamin D3 on survival and the host’s immune response in experimental bacterial meningoencephalitis in mice after intracerebral E. coli infection. To produce different systemic vitamin D3 concentrations, mice received a low, standard, or high dietary vitamin D3 supplementation. Bacterial titers in blood, spleen, and brain homogenates were determined. Leukocyte infiltration was assessed by histological scores, and tissue cytokine or chemokine concentrations were measured. Results Mice fed a diet with low vitamin D3 concentration died earlier than control animals after intracerebral infection. Vitamin D deficiency did not inhibit leukocyte recruitment into the subarachnoid space and did not lead to an increased density of bacteria in blood, spleen, or brain homogenates. The release of proinflammatory interleukin (IL)-6 was decreased and the release of anti-inflammatory IL-10 was increased in mice fed a diet with high vitamin D3 supplementation. Conclusion Our observations suggest a detrimental role of vitamin D deficiency in bacterial central nervous system infections. Vitamin D may exert immune regulatory functions."],["dc.identifier.doi","10.1186/s12974-014-0208-1"],["dc.identifier.pmid","25563481"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11473"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58294"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.holder","Marija Djukic et al.; licensee BioMed Central Ltd."],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","174"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neuroinflammation"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Erbguth, Frank"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2022-08-04T12:03:57Z"],["dc.date.available","2022-08-04T12:03:57Z"],["dc.date.issued","2022-07-06"],["dc.date.updated","2022-07-25T11:18:55Z"],["dc.description.abstract","The cerebrospinal fluid (CSF) space is convoluted. CSF flow oscillates with a net flow from the ventricles towards the cerebral and spinal subarachnoid space. This flow is influenced by heartbeats, breath, head or body movements as well as the activity of the ciliated epithelium of the plexus and ventricular ependyma. The shape of the CSF space and the CSF flow preclude rapid equilibration of cells, proteins and smaller compounds between the different parts of the compartment. In this review including reinterpretation of previously published data we illustrate, how anatomical and (patho)physiological conditions can influence routine CSF analysis. Equilibration of the components of the CSF depends on the size of the molecule or particle, e.g., lactate is distributed in the CSF more homogeneously than proteins or cells. The concentrations of blood-derived compounds usually increase from the ventricles to the lumbar CSF space, whereas the concentrations of brain-derived compounds usually decrease. Under special conditions, in particular when distribution is impaired, the rostro-caudal gradient of blood-derived compounds can be reversed. In the last century, several researchers attempted to define typical CSF findings for the diagnosis of several inflammatory diseases based on routine parameters. Because of the high spatial and temporal variations, findings considered typical of certain CNS diseases often are absent in parts of or even in the entire CSF compartment. In CNS infections, identification of the pathogen by culture, antigen detection or molecular methods is essential for diagnosis."],["dc.identifier.citation","Journal of Neuroinflammation. 2022 Jul 06;19(1):174"],["dc.identifier.doi","10.1186/s12974-022-02538-3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112646"],["dc.language.iso","en"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Cerebrospinal fluid"],["dc.subject","Blood–CSF barrier"],["dc.subject","Blood–brain barrier"],["dc.subject","Lactate"],["dc.subject","Intrathecal immunoglobulin synthesis"],["dc.subject","CSF flow"],["dc.title","Spatial and temporal variation of routine parameters: pitfalls in the cerebrospinal fluid analysis in central nervous system infections"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","138"],["dc.bibliographiccitation.journal","Frontiers in Cellular Neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Ribes, Sandra"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Eiffert, Helmut"],["dc.date.accessioned","2018-11-07T09:40:02Z"],["dc.date.available","2018-11-07T09:40:02Z"],["dc.date.issued","2014"],["dc.description.abstract","In healthy individuals, infections of the central nervous system (CNS) are comparatively rare. Based on the ability of microglial cells to phagocytose and kill pathogens and on clinical findings in immunocompromised patients with CNS infections, we hypothesize that an intact microglial function is crucial to protect the brain from infections. Phagocytosis of pathogens by microglial cells can be stimulated by agonists of receptors of the innate immune system. Enhancing this pathway to increase the resistance of the brain to infections entails the risk of inducing collateral damage to the nervous tissue. The diversity of microglial cells opens avenue to selectively stimulate sub-populations responsible for the defence against pathogens without stimulating sub-populations which are responsible for collateral damage to the nervous tissue. Palmitoylethanolamide (PEA), an endogenous lipid, increased phagocytosis of bacteria by microglial cells in vitro without a measurable proinflammatory effect. It was tested clinically apparently without severe side effects. Glatiramer acetate increased phagocytosis of latex beads by microglia and monocytes, and dimethyl fumarate enhanced eliminationof human immunodeficiency virus from infected macrophages without inducing a release of proinflammatory compounds. Therefore, the discovery of compounds which stimulate the elimination of pathogens without collateral damage of neuronal structures appears an achievable goal. PEA and, with limitations, glatiramer acetate and dimethyl fumarate appear promising candidates."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2014"],["dc.identifier.doi","10.3389/fncel.2014.00138"],["dc.identifier.isi","000336242400001"],["dc.identifier.pmid","24904283"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10145"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33420"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Research Foundation"],["dc.relation.issn","1662-5102"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Strategies to increase the activity of microglia as efficient protectors of the brain against infections"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2394"],["dc.bibliographiccitation.journal","Brain"],["dc.bibliographiccitation.lastpage","2403"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Mildner, Alexander"],["dc.contributor.author","Schmidt, Hauke"],["dc.contributor.author","Czesnik, Dirk"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Prinz, Marco R."],["dc.date.accessioned","2018-11-07T09:17:35Z"],["dc.date.available","2018-11-07T09:17:35Z"],["dc.date.issued","2006"],["dc.description.abstract","Previous studies have demonstrated a potential role of brain endogenous microglia and meningeal macrophages in inflammation and brain injury during bacterial meningitis. However, the contribution of previously engrafted monocytes and microglia to this process is still unknown. We therefore used genetically labelled bone marrow-derived cells from transgenic mice expressing the green fluorescent protein (GFP) under the chicken beta-actin promoter to deliver fluorescently labelled monocytes to the diseased brain. Approximately 24 hours after Streptococcus pneumoniae infection, GFP-expressing parenchymal microglia changed their morphology to an activated phenotype and upregulated major histocompatibility complex class II molecules. Bacterial meningitis increased the engraftment of GFP(+) monocytes and their differentiation to microglia during the post-inflammatory period, but not during acute meningitis. Importantly, these newly recruited monocytes became an integral part of the pool of parenchymal microglia and contributed to the clearance of damaged tissue by increased lysosomal activity and close location to apoptotic cells. Thus, circulating cells entering the brain such as monocytes/macrophages might provide a potential cellular target for the treatment of the tissue damage following meningitis via peripheral cell therapy."],["dc.identifier.doi","10.1093/brain/awl206"],["dc.identifier.isi","000240679700015"],["dc.identifier.pmid","16891321"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7750"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28202"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0006-8950"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","P33"],["dc.bibliographiccitation.issue","Suppl 1"],["dc.bibliographiccitation.journal","BMC Proceedings"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","König, Fatima B."],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Gerber, Joachim"],["dc.contributor.author","Schweyer, Stefan"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Schreiber, Stefan"],["dc.contributor.author","Rüchel, Reinhardt"],["dc.contributor.author","Schmidth, Holger"],["dc.date.accessioned","2019-07-09T11:42:07Z"],["dc.date.available","2019-07-09T11:42:07Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1186/1753-6561-2-s1-p33"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12879"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58595"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Short-term therapy with corticosteroids can lead to progressive multifocal leukoencephalopathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","4"],["dc.bibliographiccitation.journal","BMC Pulmonary Medicine"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Larsen, Joerg"],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2018-11-07T09:29:07Z"],["dc.date.available","2018-11-07T09:29:07Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Among a variety of more common differential diagnoses, the aetiology of acute respiratory failure includes Lyme neuroborreliosis. Case presentation: We report an 87-years old huntsman with unilateral phrenic nerve palsy as a consequence of Lyme neuroborreliosis. Conclusion: Although Lyme neuroborreliosis is a rare cause of diaphragmatic weakness, it should be considered in the differential workup because of its potentially treatable nature."],["dc.description.sponsorship","Robert Bosch Foundation; Else Kroner-Fresenius-Stiftung"],["dc.identifier.doi","10.1186/1471-2466-13-4"],["dc.identifier.isi","000314917900001"],["dc.identifier.pmid","23327473"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8527"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30939"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2466"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Unilateral phrenic nerve lesion in Lyme neuroborreliosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","139"],["dc.bibliographiccitation.journal","BMC Neurology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Schmidt, Holger"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Holzgraefe, Manfred"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","von Steinbuechel, Nicole"],["dc.contributor.author","Blocher, Joachim"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.date.accessioned","2018-11-07T09:53:13Z"],["dc.date.available","2018-11-07T09:53:13Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Patients often report neurocognitive difficulties after neuroborreliosis (NB). The frequency and extent of cognitive problems in European patients have been studied incompletely. Methods: Sixty patients received a neurological and neuropsychological work-up 6 months or longer after treatment for proven NB. Quality of life, psychiatric symptom load, and brain atrophy were measured. All results were compared with a group of 30 healthy control persons adapted for age, gender and education being serologically negative for Borrelia burgdorferi senso latu. A cognitive sum score and a global sum score including cognitive, psychological results and quality of life data was calculated for both groups. Results: Patients after NB showed a lower (i.e. more impaired) score on the Scripps Neurological rating scale (SNRS), but the observed neurological deficits were generally mild (mean +/- SD: 97.1 +/- 4.7 vs. 99.1 +/- 2.4, p = 0.02). The mean neuropsychological domain results of the NB group were all within the normal range. However, a lower performance was found for the frontal executive function z-values (mean +/- SD-0.29 +/- 0.60 vs. 0.09 +/- 0.60; p = 0.0059) of NB patients. Comparing the global sum score (mean +/- SD 11.3 +/- 4.2(NB) vs. 14.3 +/- 2.9(control), p = 0.001) and the cognitive sum score of the NB group with those of the control group (mean +/- SD -0.15 +/- 0.42(NB) vs. 0.08 +/- 0.31(control), p = 0.0079), both differences were statistically different. The frequencies of impaired global sum scores and those of the pathological cognitive sum scores (p = 0.07) did not differ statistically. No significant differences were found for health-related quality of life (hrQoL), sleep, psychiatric symptom load, or brain atrophy. Conclusion: The mean cognitive functions of patients after proven NB were in the normal range. However, we were able to demonstrate a lower performance for the domain of frontal executive functions, for the mean cognitive sum score and the global sum score as a sign of subtle but measurable sequelae of neuroborreliosis. Brain atrophy is not a common consequence of neuroborreliosis."],["dc.identifier.doi","10.1186/s12883-015-0386-1"],["dc.identifier.isi","000361446200001"],["dc.identifier.pmid","26286440"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12505"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36286"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2377"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Neurocognitive functions and brain atrophy after proven neuroborreliosis: a case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Geriatrics"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Luley, Marie-Christine"],["dc.contributor.author","Loleit, Tobias"],["dc.contributor.author","Knopf, Elmar"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Criée, Carl-Peter"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2021-04-14T08:31:21Z"],["dc.date.available","2021-04-14T08:31:21Z"],["dc.date.issued","2020"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1186/s12877-020-01804-4"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17596"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83565"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1471-2318"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Training improves the handling of inhaler devices and reduces the severity of symptoms in geriatric patients suffering from chronic-obstructive pulmonary disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]