Puls, Miriam

[["dc.bibliographiccitation.firstpage","703"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.lastpage","712"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Lubos, Edith"],["dc.contributor.author","Boekstegers, Peter"],["dc.contributor.author","von Bardeleben, Ralph Stephan"],["dc.contributor.author","Ouarrak, Taoufik"],["dc.contributor.author","Butter, Christian"],["dc.contributor.author","Zuern, Christine S."],["dc.contributor.author","Bekeredjian, Raffi"],["dc.contributor.author","Sievert, Horst"],["dc.contributor.author","Nickenig, Georg"],["dc.contributor.author","Eggebrecht, Holger"],["dc.contributor.author","Senges, Jochen"],["dc.contributor.author","Schillinger, Wolfgang"],["dc.date.accessioned","2018-11-07T10:18:07Z"],["dc.date.available","2018-11-07T10:18:07Z"],["dc.date.issued","2016"],["dc.description.abstract","Aims The transcatheter mitral valve interventions (TRAMI) registry was established in order to assess safety and efficacy of catheter-based mitral valve interventional techniques in Germany, and prospectively enrolled 828 MitraClip patients (median age 76 years, median log. EuroSCORE I 20.0%) between August 2010 and July 2013. We present the 1-year outcome in this MitraClip cohort-which is the largest published to date. Methods and results Seven forty-nine patients (90.5%) were available for 1-year follow-up and included in the following analyses. Mortality, major adverse cardiovascular event rates, and New York Heart Association (NYHA) classes were recorded. Predictors of 1-year mortality were identified by multivariate analysis using a Cox regression model with stepwise forward selection. The 1-year mortality was 20.3%. At 1 year, 63.3% of TRAMI patients pertained to NYHA functional classes I or II (compared with 11.0% at baseline), and self-rated health status (on EuroQuol visual analogue scale) also improved significantly by 10 points. Importantly, a significant proportion of patients regained the complete independence in self-care after MitraClip implantation (independence in 74.0 vs. 58.6% at baseline, P = 0.005). Predictors of 1-year mortality were NYHA class IV (hazard ratio, HR 1.62, P = 0.02), anaemia (HR 2.44, P = 0.02), previous aortic valve intervention (HR 2.12, P = 0.002), serum creatinine >= 1.5 mg/dL (HR 1.77, P = 0.002), peripheral artery disease (HR 2.12, P = 0.0003), left ventricular ejection fraction, <30% (HR 1.58, P = 0.01), severe tricuspid regurgitation (HR 1.84, P = 0.003), and procedural failure (defined as operator-reported failure, conversion to surgery, failure of clip placement, or residual post-procedural severe mitral regurgitation) (HR 4.36, P < 0.0001). Conclusions Treatment of significant MR with MitraClip resulted in significant clinical improvements in a high proportion of TRAMI patients after 12 months. In the TRAMI cohort, the failure of procedural success exhibited the highest hazard ratio concerning the prediction of 1-year mortality."],["dc.identifier.doi","10.1093/eurheartj/ehv627"],["dc.identifier.isi","000371251900016"],["dc.identifier.pmid","26614824"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14155"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41363"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","One-year outcomes and predictors of mortality after MitraClip therapy in contemporary clinical practice: results from the German transcatheter mitral valve interventions registry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]