Gollisch, Tim

[["dc.bibliographiccitation.firstpage","4754"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Investigative ophthalmology & visual science"],["dc.bibliographiccitation.lastpage","4767"],["dc.bibliographiccitation.volume","58"],["dc.contributor.author","Bemme, Sebastian"],["dc.contributor.author","Weick, Michael"],["dc.contributor.author","Gollisch, Tim"],["dc.date.accessioned","2019-07-09T11:44:50Z"],["dc.date.available","2019-07-09T11:44:50Z"],["dc.date.issued","2017-09-01"],["dc.description.abstract","Purpose: Phosphene perception is a characteristic side effect of heart rate-reducing medication that acts on hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels. It is hypothesized that these phosphenes are caused by blocking HCN channels in photoreceptors and neurons of the retina, yet the underlying changes in visual signal processing in the retina caused by the HCN channel block are still unknown. Methods: We examined the effects of pharmacologic HCN channel block on the encoding of visual signals in retinal ganglion cells by recording ganglion cell spiking activity from isolated mouse retinas mounted on multielectrode arrays. Spontaneous activity and responses to various visual stimuli were measured before, during, and after administration of 3 μM ivabradine. Results: Retinal ganglion cells generally showed slower response kinetics and reduced sensitivity to high temporal frequencies under ivabradine. Moreover, ivabradine differentially affected the sensitivity of On and Off ganglion cells. On cells showed reduced response gain, whereas Off cells experienced an increase in response threshold. In line with these differential effects, Off cells, in contrast to On cells, also showed reduced baseline activity during visual stimulation and reduced spontaneous activity. Furthermore, Off cells, but not On cells, showed increased burst-like spiking activity in the presence of ivabradine. Conclusions: Our data suggest that pharmacologic HCN channel block in the retina leads to a shift in the relative activity of the On and Off pathways of the retina. We hypothesize that this imbalance may underlie the medication-induced perception of phosphenes."],["dc.identifier.doi","10.1167/iovs.17-21572"],["dc.identifier.pmid","28973319"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14921"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59108"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/724822/EU//CODE4Vision"],["dc.relation.issn","1552-5783"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject.ddc","006"],["dc.subject.ddc","573"],["dc.subject.ddc","612"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Benzazepines"],["dc.subject.mesh","Cardiovascular Agents"],["dc.subject.mesh","Cells, Cultured"],["dc.subject.mesh","Disease Models, Animal"],["dc.subject.mesh","Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels"],["dc.subject.mesh","Mice"],["dc.subject.mesh","Mice, Inbred C57BL"],["dc.subject.mesh","Phosphenes"],["dc.subject.mesh","Potassium Channel Blockers"],["dc.subject.mesh","Retina"],["dc.subject.mesh","Retinal Ganglion Cells"],["dc.title","Differential Effects of HCN Channel Block on On and Off Pathways in the Retina as a Potential Cause for Medication-Induced Phosphene Perception."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","976.e7"],["dc.bibliographiccitation.artnumber","https://creativecommons.org/licenses/by/4.0/"],["dc.bibliographiccitation.firstpage","963"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Neuron"],["dc.bibliographiccitation.volume","101"],["dc.contributor.author","Kühn, Norma Krystyna"],["dc.contributor.author","Gollisch, Tim"],["dc.date.accessioned","2019-07-09T11:50:32Z"],["dc.date.available","2019-07-09T11:50:32Z"],["dc.date.issued","2019"],["dc.description.abstract","Neurons in sensory systems are often tuned to particular stimulus features. During complex naturalistic stimulation, however, multiple features may simultaneously affect neuronal responses, which complicates the readout of individual features. To investigate feature representation under complex stimulation, we studied how direction-selective ganglion cells in salamander retina respond to texture motion where direction, velocity, and spatial pattern inside the receptive field continuously change. We found that the cells preserve their direction preference under this stimulation, yet their direction encoding becomes ambiguous due to simultaneous activation by luminance changes. The ambiguities can be resolved by considering populations of direction-selective cells with different preferred directions. This gives rise to synergistic motion decoding, yielding more information from the population than the summed information from single-cell responses. Strong positive response correlations between cells with different preferred directions amplify this synergy. Our results show how correlated population activity can enhance feature extraction in complex visual scenes."],["dc.identifier.doi","10.1016/j.neuron.2019.01.003"],["dc.identifier.pmid","30709656"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15957"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59790"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/600954/EU//VISUALISE"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/724822/EU//CODE4Vision"],["dc.relation.issn","1097-4199"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","006"],["dc.subject.ddc","573"],["dc.subject.ddc","612"],["dc.title","Activity Correlations between Direction-Selective Retinal Ganglion Cells Synergistically Enhance Motion Decoding from Complex Visual Scenes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]