Schneider-Gold, Christiane

[["dc.bibliographiccitation.firstpage","145"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Movement Disorders"],["dc.bibliographiccitation.lastpage","147"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Hiller, Anja"],["dc.contributor.author","Hagenah, Johann M."],["dc.contributor.author","Djarmati, Ana"],["dc.contributor.author","Hedrich, Katja"],["dc.contributor.author","Reetz, Kathrin"],["dc.contributor.author","Schneider-Gold, Christiane"],["dc.contributor.author","Kress, Wolfgang"],["dc.contributor.author","Muenchau, Alexander"],["dc.contributor.author","Klein, Christine"],["dc.date.accessioned","2018-11-07T11:07:05Z"],["dc.date.available","2018-11-07T11:07:05Z"],["dc.date.issued","2007"],["dc.description.abstract","The phenotypic spectrum of PINK1-associated Parkinsonism was studied in a family with homozygous (n = 4) or heterozygous (n = 3) PINK1 mutations. All homozygous mutation carriers were definitely affected; the heterozygous carriers were asymptomatic but displayed unequivocal signs of probable or possible Parkinsonism. This finding suggests a role not only of homozygous but also of heterozygous PINK1 mutations in the development of parkinsonian signs and underlines the necessity to carefully investigate family members of affected mutation carriers. (C) 2006 Movement Disorder Society."],["dc.identifier.doi","10.1002/mds.21059"],["dc.identifier.isi","000244073400026"],["dc.identifier.pmid","17013904"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52473"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0885-3185"],["dc.title","Phenotypic spectrum of PINK1-associated parkinsonism in 15 mutation carriers from 1 family"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","833"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","ARCHIVES OF NEUROLOGY"],["dc.bibliographiccitation.lastpage","838"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Hedrich, K."],["dc.contributor.author","Hagenah, Johann M."],["dc.contributor.author","Djarmati, A."],["dc.contributor.author","Hiller, A."],["dc.contributor.author","Lohnau, T."],["dc.contributor.author","Lasek, K."],["dc.contributor.author","Grunewald, A."],["dc.contributor.author","Hilker, Ruediger"],["dc.contributor.author","Steinlechner, S."],["dc.contributor.author","Boston, H."],["dc.contributor.author","Kock, N."],["dc.contributor.author","Schneider-Gold, C."],["dc.contributor.author","Kress, W."],["dc.contributor.author","Siebner, Hartwig Roman"],["dc.contributor.author","Binkofski, F."],["dc.contributor.author","Lencer, R."],["dc.contributor.author","Munchau, A."],["dc.contributor.author","Klein, C."],["dc.date.accessioned","2018-11-07T09:42:59Z"],["dc.date.available","2018-11-07T09:42:59Z"],["dc.date.issued","2006"],["dc.description.abstract","Background: Although homozygous mutations in the PTEN-induced putative kinase 1 (PINK1) gene have been unequivocally associated with early-onset Parkinson disease (PD), the role of single heterozygous PINK1 mutations is less clear. Objective: To investigate the role of homozygous and heterozygous PINK1 mutations in a large German pedigree (family W). Design: Mutation analysis of PINK1 and results of standardized neurological and motor examination by 3 independent movement disorder specialists, including blinded video rating. Settings: University of Lubeck. Participants: Twenty family members. Main Outcome Measures: The PINK1 genotype and PD status of all family members. Results: The index patient of family W carried a homozygous nonsense mutation (c.1366C > T; p.Q456X) and presented with a phenotype closely resembling idiopathic PD but with an onset at 39 years of age. The family included a total of 4 affected homozygous members (age, 60-71 years; age at onset, 39-61 years), 6 members with slight or mild signs of PD (affected) and a heterozygous mutation (age, 31-49 years), and 5 unaffected heterozygous mutation carriers (age, 34-44 years). Although none of the heterozygous affected family members was aware of their signs (asymptomatic), the clinical findings were unequivocal and predominantly or exclusively present on their dominant right-hand side, eg, unilaterally reduced or absent arm swing and unilateral rigidity. The heterozygous members were all considerably younger than the affected homozygous mutation carriers. Conclusions: Heterozygous PINK1 mutations may predispose to PD, as was previously suggested by the presence of dopamine hypometabolism in asymptomatic mutation carriers. Long-term follow-up of our large family W provides an excellent opportunity to further evaluate the role of single heterozygous PINK1 mutations later in life, which will have major implications on genetic counseling."],["dc.identifier.doi","10.1001/archneur.63.6.833"],["dc.identifier.isi","000238197600006"],["dc.identifier.pmid","16769864"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34080"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Medical Assoc"],["dc.relation.issn","0003-9942"],["dc.title","Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease Role of a single hit?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]