Kühnle, Ingrid

[["dc.bibliographiccitation.firstpage","851"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Blood"],["dc.bibliographiccitation.lastpage","860"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Rensing-Ehl, Anne"],["dc.contributor.author","Voelkl, Simon"],["dc.contributor.author","Speckmann, Carsten"],["dc.contributor.author","Lorenz, Myriam Ricarda"],["dc.contributor.author","Ritter, Julia"],["dc.contributor.author","Janda, Ales"],["dc.contributor.author","Abinun, Mario"],["dc.contributor.author","Pircher, Hanspeter"],["dc.contributor.author","Bengsch, Bertram"],["dc.contributor.author","Thimme, Robert"],["dc.contributor.author","Fuchs, Ilka"],["dc.contributor.author","Ammann, Sandra"],["dc.contributor.author","Allgaeuer, Andrea"],["dc.contributor.author","Kentouche, Karim"],["dc.contributor.author","Cant, Andrew"],["dc.contributor.author","Hambleton, Sophie"],["dc.contributor.author","da Cunha, Claudia Bettoni"],["dc.contributor.author","Huetker, Sebastian"],["dc.contributor.author","Kuehnle, Ingrid"],["dc.contributor.author","Pekrun, Arnulf"],["dc.contributor.author","Seidel, Markus G."],["dc.contributor.author","Hummel, Michael"],["dc.contributor.author","Mackensen, Andreas"],["dc.contributor.author","Schwarz, Klaus"],["dc.contributor.author","Ehl, Stephan"],["dc.date.accessioned","2018-11-07T09:36:42Z"],["dc.date.available","2018-11-07T09:36:42Z"],["dc.date.issued","2014"],["dc.description.abstract","Accumulation of CD3(+) T-cell receptor (TCR)alpha beta(+)CD4(-)CD8(-) double-negative T cells(DNT) is a hallmark of autoimmune lymphoproliferative syndrome (ALPS). DNT origin and differentiation pathways remain controversial. Here we show that human ALPS DNT have features of terminally differentiated effector memory T cells reexpressing CD45RA(+) (TEMRA), but are CD27(+)CD28(+)KLRG1(-) and do not express the transcription factor T-bet. This unique phenotype was also detected among CD4(+) or CD8(+) ALPS TEMRA cells. T-cell receptor beta deep sequencing revealed a significant fraction of shared CDR3 sequences between ALPS DNT and both CD4(+) and CD8(+) TEMRA cells. Moreover, in ALPS patients with a germ line FAS mutation and somatic loss of heterozygosity, in whom biallelic mutant cells can be tracked by absent Fas expression, Fas-negative T cells accumulated not only among DNT, but also among CD4(+) and CD8(+)TEMRA cells. These data indicate that in human Fas deficiency DNT cannot only derive from CD8(+), but also from CD4(+) T cells. Furthermore, defective Fas signaling leads to aberrant transcriptional programs and differentiation of subsets of CD4(+) and CD8(+) T cells. Accumulation of these cells before their double-negative state appears to be an important early event in the pathogenesis of lymphoproliferation in ALPS patients."],["dc.identifier.doi","10.1182/blood-2014-03-564286"],["dc.identifier.isi","000342620400012"],["dc.identifier.pmid","24894771"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32677"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Hematology"],["dc.relation.issn","1528-0020"],["dc.relation.issn","0006-4971"],["dc.title","Abnormally differentiated CD4(+) or CD8(+) T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","984"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","994"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Hartmann, Franziska"],["dc.contributor.author","Lockmann, Anike"],["dc.contributor.author","Himpel, Okko"],["dc.contributor.author","Kühnle, Ingrid"],["dc.contributor.author","Hensen, Janina"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Thoms, Kai‐Martin"],["dc.date.accessioned","2021-04-14T08:22:56Z"],["dc.date.available","2021-04-14T08:22:56Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1111/ddg.14184_g"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80738"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Orale Propranolol‐ und Neodym:YAG‐Farbstofflaser‐Kombinationstherapie infantiler Hämangiome: eine retrospektive Analyse von 30 Kindern mit 48 Hämangiomen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Brehmer, Franziska"],["dc.contributor.author","Lockmann, Anike"],["dc.contributor.author","Groenemeyer, L.-L."],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","von Fintel, H."],["dc.contributor.author","Kuehnle, Ingrid"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Thoms, Kai Martin"],["dc.date.accessioned","2018-11-07T09:58:42Z"],["dc.date.available","2018-11-07T09:58:42Z"],["dc.date.issued","2015"],["dc.format.extent","97"],["dc.identifier.isi","000360219000277"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37426"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Nd:YAG- and pulsed Colouring Laster-Therapy of 271 infantile Haemangiomas in 149 Children: a retrospective Analysis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e27012"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Pediatric Blood & Cancer"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Kube, Stefanie"],["dc.contributor.author","Vokuhl, Christian"],["dc.contributor.author","Dantonello, Tobias"],["dc.contributor.author","Scheer, Monika"],["dc.contributor.author","Hallmen, Erika"],["dc.contributor.author","Feuchtgruber, Simone"],["dc.contributor.author","Escherich, Gabriele"],["dc.contributor.author","Niggli, Felix"],["dc.contributor.author","Kuehnle, Ingrid"],["dc.contributor.author","von Kalle, Thekla"],["dc.contributor.author","Bielack, Stefan"],["dc.contributor.author","Klingebiel, Thomas"],["dc.contributor.author","Koscielniak, Ewa"],["dc.date.accessioned","2020-12-10T14:07:03Z"],["dc.date.available","2020-12-10T14:07:03Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1002/pbc.v65.6"],["dc.identifier.issn","1545-5009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70112"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Inflammatory myofibroblastic tumors-A retrospective analysis of the Cooperative Weichteilsarkom Studiengruppe"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Clinical Immunology"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Rensing-Ehl, Anne"],["dc.contributor.author","Voelkl, Simon"],["dc.contributor.author","Speckmann, Carsten"],["dc.contributor.author","Lorenz, Myriam Ricarda"],["dc.contributor.author","Ritter, J."],["dc.contributor.author","Janda, Ales"],["dc.contributor.author","Abinun, Mario"],["dc.contributor.author","Pircher, Hanspeter"],["dc.contributor.author","Bengsch, B."],["dc.contributor.author","Thimme, Robert"],["dc.contributor.author","Fuchs, Ilka"],["dc.contributor.author","Ammann, Sandra"],["dc.contributor.author","Allgaeuer, Andrea"],["dc.contributor.author","Kentouche, Karim"],["dc.contributor.author","Cant, A."],["dc.contributor.author","Hambleton, Sophie"],["dc.contributor.author","da Cunha, Claudia Bettoni"],["dc.contributor.author","Huetker, Sebastian"],["dc.contributor.author","Kuehnle, Ingrid"],["dc.contributor.author","Pekrun, Arnulf"],["dc.contributor.author","Seidel, Markus G."],["dc.contributor.author","Hummel, Michael"],["dc.contributor.author","Mackensen, Andreas"],["dc.contributor.author","Schwarz, K."],["dc.contributor.author","Ehl, Stephan"],["dc.date.accessioned","2018-11-07T09:33:54Z"],["dc.date.available","2018-11-07T09:33:54Z"],["dc.date.issued","2014"],["dc.format.extent","S165"],["dc.identifier.isi","000347389100046"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32064"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","16th Biennial Meeting of the European-Society-for-Immunodeficiencies"],["dc.relation.eventlocation","Prague, CZECH REPUBLIC"],["dc.relation.issn","1573-2592"],["dc.relation.issn","0271-9142"],["dc.title","Abnormally Differentiated CD4+OR CD8+T-Cells with Phenotypic and Genetic Features of Double Negative T-Cells in Human FAS Deficiency"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","Kuehn, Alexander"],["dc.contributor.author","Zimmermann, Martin"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Kuehnle, Ingrid"],["dc.contributor.author","Nowak, Johannes"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Schrappe, Martin"],["dc.contributor.author","Escherich, Gabriele"],["dc.contributor.author","Burkhardt, Birgit"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2018-11-07T10:13:06Z"],["dc.date.available","2018-11-07T10:13:06Z"],["dc.date.issued","2016"],["dc.format.extent","55"],["dc.identifier.isi","000379749000210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40369"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","17th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Liverpool, ENGLAND"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","HIGH-GRADE GLIOMA ARISING IN SURVIVORS OF PEDIATRIC ACUTE LYMPHOBLASTIC MALIGNANCIES: A COOPERATIVE ANALYSIS OF THE GERMAN HIT-HGG/-GBM AND ALL-BFM/COALL STUDIES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Pediatric Blood & Cancer"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Scheer, M."],["dc.contributor.author","Hallmen, E."],["dc.contributor.author","Sparber-Sauer, M."],["dc.contributor.author","Vokuhl, C."],["dc.contributor.author","Leuschner, Ivo"],["dc.contributor.author","Hartwig, M."],["dc.contributor.author","Kuhnle, Ingrid"],["dc.contributor.author","Seitz, G."],["dc.contributor.author","Ladenstein, Ruth"],["dc.contributor.author","Niggli, F."],["dc.contributor.author","Gustaf, L."],["dc.contributor.author","Bielack, Stefan S."],["dc.contributor.author","Thomas, Kelly A."],["dc.contributor.author","Koscielniak, Ewa"],["dc.date.accessioned","2018-11-07T10:06:11Z"],["dc.date.available","2018-11-07T10:06:11Z"],["dc.date.issued","2016"],["dc.format.extent","S262"],["dc.identifier.isi","000384818801548"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39040"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1545-5017"],["dc.relation.issn","1545-5009"],["dc.title","Desmoplastic Small Round Cell Tumors (DSRCT) in Children and Adolescents Experience of the CWS Study Group"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","73"],["dc.bibliographiccitation.journal","Journal of Clinical Immunology"],["dc.bibliographiccitation.lastpage","74"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Rensing-Ehl, Anne"],["dc.contributor.author","Janda, Ales"],["dc.contributor.author","Vach, Werner"],["dc.contributor.author","Gladstone, Beryl P."],["dc.contributor.author","Abinun, Mario"],["dc.contributor.author","Albert, M. H."],["dc.contributor.author","Butler, Karina"],["dc.contributor.author","Cant, A."],["dc.contributor.author","Cseh, Anna-Maria"],["dc.contributor.author","Ebinger, Martin"],["dc.contributor.author","Goldacker, Sigune"],["dc.contributor.author","Hambleton, Sophie"],["dc.contributor.author","Hebart, Holger F."],["dc.contributor.author","Houet, Leonora"],["dc.contributor.author","Kentouche, Karim"],["dc.contributor.author","Kuehnle, Ingrid"],["dc.contributor.author","Lehmberg, Kai"],["dc.contributor.author","Mejstrikova, Ester"],["dc.contributor.author","Niemeyer, C."],["dc.contributor.author","Minkov, Milen"],["dc.contributor.author","Neth, O."],["dc.contributor.author","Dueckers, Gregor"],["dc.contributor.author","Owens, S."],["dc.contributor.author","Richards, M."],["dc.contributor.author","Roesler, J."],["dc.contributor.author","Schilling, Freimut H."],["dc.contributor.author","Schuster, Volker"],["dc.contributor.author","Seidel, Markus G."],["dc.contributor.author","Smisek, Petr"],["dc.contributor.author","Sukova, Martina"],["dc.contributor.author","Svec, Peter"],["dc.contributor.author","Wiesel, Thomas"],["dc.contributor.author","Lorenz, M."],["dc.contributor.author","Schwarz, K."],["dc.contributor.author","Ehl, Stephan"],["dc.contributor.author","Speckmann, Carsten"],["dc.date.accessioned","2018-11-07T09:06:30Z"],["dc.date.available","2018-11-07T09:06:30Z"],["dc.date.issued","2012"],["dc.identifier.isi","000308728900140"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25578"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","15th Biennial Meeting European-Society-for-Immunodeficiency (ESID)"],["dc.relation.eventlocation","Florence, ITALY"],["dc.relation.issn","0271-9142"],["dc.title","WHEN SHOULD THE FAS GENE BE SEQUENCED IN PATIENTS WITH LYMPHOPROLIFERATION AND AUTOIMMUNITY"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","415"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Infection"],["dc.bibliographiccitation.lastpage","418"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Kuehnle, Ingrid"],["dc.date.accessioned","2018-11-07T09:41:44Z"],["dc.date.available","2018-11-07T09:41:44Z"],["dc.date.issued","2014"],["dc.description.abstract","A 13-year-old girl with weight loss and ascites was admitted with suspicion of a malignant disease. Abdominal magnetic resonance imaging indicated extensive peritonitis and showed no evidence of a solid tumor. As a new imaging observation, thoracic computed tomography showed a lymphoma-like infracarinal mass and further enlarged lymph nodes in the pathway of draining lymph ducts. A tuberculin skin test and an interferon-gamma blood test were positive, and the tumor marker CA-125 was elevated. Histology of a peritoneal biopsy showed infectious granulomas with central necrosis, and Mycobacterium tuberculosis could be cultured, leading to the diagnosis of a tuberculous peritonitis. The girl received multi-drug anti-tuberculous treatment and subsequently recovered. At follow-up the peritonitis and the infracarinal mass had vanished. In conclusion, tuberculous peritonitis is a rare but relevant differential diagnosis in peritonitis of unknown origin. Its diagnosis is facilitated by imaging, by tuberculosis skin and blood tests, and by clinical interpretation."],["dc.identifier.doi","10.1007/s15010-013-0521-0"],["dc.identifier.isi","000334899600018"],["dc.identifier.pmid","23955269"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33799"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1439-0973"],["dc.relation.issn","0300-8126"],["dc.title","Tuberculous peritonitis with infracarinal mass and elevated CA-125 in a 13-year-old girl"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1372"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of the European Academy of Dermatology and Venereology"],["dc.bibliographiccitation.lastpage","1379"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Hartmann, F."],["dc.contributor.author","Lockmann, A."],["dc.contributor.author","Grönemeyer, L.-L."],["dc.contributor.author","Haenssle, H.A."],["dc.contributor.author","Zutt, M."],["dc.contributor.author","von Fintel, H."],["dc.contributor.author","Kühnle, I."],["dc.contributor.author","Schön, M.P."],["dc.contributor.author","Thoms, K.-M."],["dc.date.accessioned","2020-12-10T18:28:58Z"],["dc.date.available","2020-12-10T18:28:58Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1111/jdv.14074"],["dc.identifier.issn","0926-9959"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76475"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Nd:YAG and pulsed dye laser therapy in infantile haemangiomas: a retrospective analysis of 271 treated haemangiomas in 149 children"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]