Wetz, Anna Julienne

[["dc.bibliographiccitation.firstpage","58"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Anaesthesia and Intensive Care"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Wetz, A. J."],["dc.contributor.author","Richardt, E. M."],["dc.contributor.author","Schotola, H."],["dc.contributor.author","Bauer, M."],["dc.contributor.author","Bräuer, A."],["dc.date.accessioned","2020-12-10T18:38:26Z"],["dc.date.available","2020-12-10T18:38:26Z"],["dc.date.issued","2017"],["dc.description.abstract","Acute kidney injury (AKI) is frequently observed after cardiac surgery (CS) with cardiopulmonary bypass (CPB). Multiple mechanisms underlie this phenomenon, including CPB-dependent haemolysis. Haemoglobin is released during haemolysis, and free haemoglobin (frHb) causes tubular cell injury after exceeding the binding capacity of haptoglobin (Hp). The objective of this study was to investigate the influence of perioperative changes in frHb and Hp levels on the incidence of CS-associated (CSA) AKI. After receiving local ethics committee approval and obtaining informed consent from our patients, we analysed the data pertaining to 154 patients undergoing CPB surgery. We recorded frHb and Hp concentrations pre-, intra- and postoperatively and defined AKI using the Kidney Disease Improving Global Outcomes (KDIGO) classification. We observed that frHb levels increased significantly during surgery and then decreased at ten hours thereafter and that Hp levels decreased during surgery and remained at low levels until the first postoperative day. We noted a moderate negative correlation between frHb and Hp levels. AKI was identified in 45.5% of patients; however, there was no significant difference in frHb or Hp levels between patients with and without AKI. We did not observe a relationship between frHb or Hp levels and CSA AKI and thus could not confirm the hypothesis that patients with higher baseline Hp concentrations experience a lower incidence of AKI than patients with lower baseline Hp concentrations."],["dc.identifier.doi","10.1177/0310057X1704500109"],["dc.identifier.eissn","1448-0271"],["dc.identifier.isi","000392257300009"],["dc.identifier.issn","0310-057X"],["dc.identifier.pmid","28072936"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77317"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Australian Soc Anaesthetists"],["dc.relation.issn","1448-0271"],["dc.relation.issn","0310-057X"],["dc.title","Haptoglobin and free haemoglobin during cardiac surgery-is there a link to acute kidney injury?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","587"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Anaesthesia and Intensive Care"],["dc.bibliographiccitation.lastpage","592"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Popov, A. F."],["dc.contributor.author","Schotola, Hanna"],["dc.contributor.author","Wetz, Anna J."],["dc.contributor.author","Bergmann, I."],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Bauer, M."],["dc.contributor.author","Braeuer, Anselm"],["dc.date.accessioned","2020-12-10T18:38:26Z"],["dc.date.available","2020-12-10T18:38:26Z"],["dc.date.issued","2016"],["dc.description.abstract","At the end of cardiopulmonary bypass, there are invariably several hundred millilitres of residual pump blood in the reservoir, which can either be re-transfused or discarded. The objective of this prospective observational study was to investigate the quality of the residual pump blood, focusing on plasma free haemoglobin (pfHb) and blood cell counts. Fifty-one consecutive patients were included in the study. Forty-nine units of residual pump blood and 58 units of transfused red blood cell (RBC) concentrates were analysed. The mean preoperative pfHb of the patients was 0.057 +/- 0.062 g/l, which increased gradually to 0.55 +/- 0.36 g/l on arrival in the intensive care unit postoperatively. On the first postoperative day, the mean pfHb had returned to within the normal range. Our data showed that haemoglobin, haematocrit, and erythrocyte counts of residual pump blood were approximately 40% of the values in standardised RBC concentrates. Plasma free haemoglobin was significantly higher in residual pump blood compared to RBC concentrates, and nearly twice as high as the pfHb in patient blood samples taken contemporaneously. Our findings indicate that residual pump blood pfHb levels are markedly higher compared to patients' blood and RBC concentrates, but that its administration does not significantly increase patients' pfHb levels."],["dc.identifier.doi","10.1177/0310057X1604400519"],["dc.identifier.eissn","1448-0271"],["dc.identifier.isi","000390616500010"],["dc.identifier.issn","0310-057X"],["dc.identifier.pmid","27608341"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77316"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Australian Soc Anaesthetists"],["dc.relation.issn","1448-0271"],["dc.relation.issn","0310-057X"],["dc.title","The Effects of Residual Pump Blood on Patient Plasma Free Haemoglobin Levels Post Cardiac Surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","406"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Anaesthesist"],["dc.bibliographiccitation.lastpage","414"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Braeuer, Anselm"],["dc.contributor.author","Brandes, Ivo Florian"],["dc.contributor.author","Perl, Tal Naggan"],["dc.contributor.author","Wetz, Anna J."],["dc.contributor.author","Bauer, M."],["dc.date.accessioned","2018-11-07T09:40:39Z"],["dc.date.available","2018-11-07T09:40:39Z"],["dc.date.issued","2014"],["dc.description.abstract","Prewarming is a useful and effective measure to reduce perioperative hypothermia. Due to A 23(3) of the German Infektionsschutzgesetz (Gesetz zur Verhutung und Bekampfung von Infektionskrankheiten beim Menschen, Infection Act, act on protection and prevention of infectious diseases in man) and the recommendations of the Hospital Hygiene and Infection Prevention Committee of the Robert Koch Institute, implementation of prewarming is clearly recommended. There are several technically satisfactory and practicable devices available allowing prewarming on the normal hospital ward, in the preoperative holding area or in the induction room of the operating theater (OR) The implementation of prewarming requires additional equipment and training of staff. Using a locally adapted concept for the implementation of prewarming does not lead to inefficiency in the perioperative process. In contrast, the implementation can help to achieve stable arrival times for patients in the OR."],["dc.identifier.doi","10.1007/s00101-014-2316-9"],["dc.identifier.isi","000336326100006"],["dc.identifier.pmid","24691948"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33550"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-055X"],["dc.relation.issn","0003-2417"],["dc.title","Prewarming. Yesterday's luxury, today's minimum requirements"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]