Wetz, Anna Julienne

[["dc.bibliographiccitation.firstpage","58"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Anaesthesia and Intensive Care"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Wetz, A. J."],["dc.contributor.author","Richardt, E. M."],["dc.contributor.author","Schotola, H."],["dc.contributor.author","Bauer, M."],["dc.contributor.author","Bräuer, A."],["dc.date.accessioned","2020-12-10T18:38:26Z"],["dc.date.available","2020-12-10T18:38:26Z"],["dc.date.issued","2017"],["dc.description.abstract","Acute kidney injury (AKI) is frequently observed after cardiac surgery (CS) with cardiopulmonary bypass (CPB). Multiple mechanisms underlie this phenomenon, including CPB-dependent haemolysis. Haemoglobin is released during haemolysis, and free haemoglobin (frHb) causes tubular cell injury after exceeding the binding capacity of haptoglobin (Hp). The objective of this study was to investigate the influence of perioperative changes in frHb and Hp levels on the incidence of CS-associated (CSA) AKI. After receiving local ethics committee approval and obtaining informed consent from our patients, we analysed the data pertaining to 154 patients undergoing CPB surgery. We recorded frHb and Hp concentrations pre-, intra- and postoperatively and defined AKI using the Kidney Disease Improving Global Outcomes (KDIGO) classification. We observed that frHb levels increased significantly during surgery and then decreased at ten hours thereafter and that Hp levels decreased during surgery and remained at low levels until the first postoperative day. We noted a moderate negative correlation between frHb and Hp levels. AKI was identified in 45.5% of patients; however, there was no significant difference in frHb or Hp levels between patients with and without AKI. We did not observe a relationship between frHb or Hp levels and CSA AKI and thus could not confirm the hypothesis that patients with higher baseline Hp concentrations experience a lower incidence of AKI than patients with lower baseline Hp concentrations."],["dc.identifier.doi","10.1177/0310057X1704500109"],["dc.identifier.eissn","1448-0271"],["dc.identifier.isi","000392257300009"],["dc.identifier.issn","0310-057X"],["dc.identifier.pmid","28072936"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77317"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Australian Soc Anaesthetists"],["dc.relation.issn","1448-0271"],["dc.relation.issn","0310-057X"],["dc.title","Haptoglobin and free haemoglobin during cardiac surgery-is there a link to acute kidney injury?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","282"],["dc.bibliographiccitation.journal","Journal of Clinical Anesthesia"],["dc.bibliographiccitation.lastpage","289"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Wetz, Anna J."],["dc.contributor.author","Perl, Thorsten"],["dc.contributor.author","Brandes, Ivo Florian"],["dc.contributor.author","Harden, Markus"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Braeuer, Anselm"],["dc.date.accessioned","2018-11-07T10:06:45Z"],["dc.date.available","2018-11-07T10:06:45Z"],["dc.date.issued","2016"],["dc.description.abstract","Study objective: Perioperative hypothermia is a frequently observed phenomenon of general anesthesia and is associated with adverse patient outcome. Recently, a significant influence of core temperature before induction of anesthesia has been reported. However, there are still little existing data on core temperature before induction of anesthesia and no data regarding potential risk factors for developing preoperative hypothermia. The purpose of this investigation was to estimate the incidence of hypothermia before anesthesia and to determine if certain factors predict its incidence. Design/setting/patients: Data from 7 prospective studies investigating core temperature previously initiated at our department were analyzed. Patients undergoing a variety of elective surgical procedures were included. Interventions/measurements: Core temperature was measured before induction of anesthesia with an oral (314 patients), infrared tympanic (143 patients), or tympanic contact thermometer (36 patients). Available potential predictors included American Society of Anesthesiologists status, sex, age, weight, height, body mass index, adipose ratio, and lean body weight. Association with preoperative hypothermia was assessed separately for each predictor using logistic regression. Independent predictors were identified using multivariable logistic regression. Main results: A total of 493 patients were included in the study. Hypothermia was found in 105 patients (21.3%; 95% confidence interval, 17.8%-25.2%). The median core temperature was 36.3 degrees C (25th-75th percentiles, 36.0 degrees C-36.7 degrees C). Two independent factors for preoperative hypothermia were identified: male sex and age (>52 years). Conclusions: As a consequence of the high incidence of hypothermia before anesthesia, measuring core temperature should be mandatory 60 to 120 minutes before induction to identify and provide adequate treatment to hypothermic patients. (C) 2016 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.jclinane.2016.03.065"],["dc.identifier.isi","000384952700058"],["dc.identifier.pmid","27687393"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39155"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1873-4529"],["dc.relation.issn","0952-8180"],["dc.title","Unexpectedly high incidence of hypothermia before induction of anesthesia in elective surgical patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","179"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical and Applied Thrombosis, Hemostasis"],["dc.bibliographiccitation.lastpage","185"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Wand, Saskia"],["dc.contributor.author","Adam, Elisabeth Hannah"],["dc.contributor.author","Wetz, Anna Julienne"],["dc.contributor.author","Meybohm, Patrick"],["dc.contributor.author","Kunze-Szikszay, Nils"],["dc.contributor.author","Zacharowski, Kai"],["dc.contributor.author","Popov, Aron Frederick"],["dc.contributor.author","Moritz, Anton"],["dc.contributor.author","Moldenhauer, Lisa"],["dc.contributor.author","Kaiser, Julia"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Weber, Christian Friedrich"],["dc.date.accessioned","2020-12-10T18:38:30Z"],["dc.date.available","2020-12-10T18:38:30Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1177/1076029617693939"],["dc.identifier.eissn","1938-2723"],["dc.identifier.issn","1076-0296"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77342"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The Prevalence and Clinical Relevance of ASA Nonresponse After Cardiac Surgery: A Prospective Bicentric Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]