Hoffmann, Marion

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Friedrich, Carsten"],["dc.contributor.author","Kuehn, Alexander"],["dc.contributor.author","Zimmermann, Martin"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Kuehnle, Ingrid"],["dc.contributor.author","Nowak, Johannes"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Schrappe, Martin"],["dc.contributor.author","Escherich, Gabriele"],["dc.contributor.author","Burkhardt, Birgit"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2018-11-07T10:13:06Z"],["dc.date.available","2018-11-07T10:13:06Z"],["dc.date.issued","2016"],["dc.format.extent","55"],["dc.identifier.isi","000379749000210"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40369"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","17th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Liverpool, ENGLAND"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","HIGH-GRADE GLIOMA ARISING IN SURVIVORS OF PEDIATRIC ACUTE LYMPHOBLASTIC MALIGNANCIES: A COOPERATIVE ANALYSIS OF THE GERMAN HIT-HGG/-GBM AND ALL-BFM/COALL STUDIES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Clinical Neuroradiology"],["dc.contributor.author","Hohm, Annika"],["dc.contributor.author","Karremann, Michael"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Vandergrift, Lindsey A."],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Stock, Annika"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Pham, Mirko"],["dc.contributor.author","Nowak, Johannes"],["dc.date.accessioned","2022-01-11T14:05:23Z"],["dc.date.available","2022-01-11T14:05:23Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Purpose Recent research identified histone H3 K27M mutations to be associated with a dismal prognosis in pediatric diffuse midline glioma (pDMG); however, data on detailed MRI characteristics with respect to H3 K27 mutation status and molecular subgroups (H3.1 and H3.3 K27M mutations) are limited. Methods Standardized magnetic resonance imaging (MRI) parameters and epidemiologic data of 68 pDMG patients (age <18 years) were retrospectively reviewed and compared in a) H3 K27M mutant versus H3 K27 wildtype (WT) tumors and b) H3.1 versus H3.3 K27M mutant tumors. Results Intracranial gliomas ( n  = 58) showed heterogeneous phenotypes with isointense to hyperintense signal in T2-weighted images and frequent contrast enhancement. Hemorrhage and necrosis may be present. Comparing H3 K27M mutant to WT tumors, there were significant differences in the following parameters: i) tumor localization ( p  = 0.001), ii) T2 signal intensity ( p  = 0.021), and iii) T1 signal homogeneity ( p  = 0.02). No significant imaging differences were found in any parameter between H3.1 and H3.3 K27M mutant tumors; however, H3.1 mutant tumors occurred at a younger age ( p  = 0.004). Considering spinal gliomas ( n  = 10) there were no significant imaging differences between the analyzed molecular groups. Conclusion With this study, we are the first to provide detailed MR imaging data on H3 K27M mutant pDMG with respect to molecular subgroup status in a large patient cohort. Our findings may support diagnosis and future targeted therapeutic trials of pDMG within the framework of the radiogenomics concept."],["dc.description.abstract","Abstract Purpose Recent research identified histone H3 K27M mutations to be associated with a dismal prognosis in pediatric diffuse midline glioma (pDMG); however, data on detailed MRI characteristics with respect to H3 K27 mutation status and molecular subgroups (H3.1 and H3.3 K27M mutations) are limited. Methods Standardized magnetic resonance imaging (MRI) parameters and epidemiologic data of 68 pDMG patients (age <18 years) were retrospectively reviewed and compared in a) H3 K27M mutant versus H3 K27 wildtype (WT) tumors and b) H3.1 versus H3.3 K27M mutant tumors. Results Intracranial gliomas ( n  = 58) showed heterogeneous phenotypes with isointense to hyperintense signal in T2-weighted images and frequent contrast enhancement. Hemorrhage and necrosis may be present. Comparing H3 K27M mutant to WT tumors, there were significant differences in the following parameters: i) tumor localization ( p  = 0.001), ii) T2 signal intensity ( p  = 0.021), and iii) T1 signal homogeneity ( p  = 0.02). No significant imaging differences were found in any parameter between H3.1 and H3.3 K27M mutant tumors; however, H3.1 mutant tumors occurred at a younger age ( p  = 0.004). Considering spinal gliomas ( n  = 10) there were no significant imaging differences between the analyzed molecular groups. Conclusion With this study, we are the first to provide detailed MR imaging data on H3 K27M mutant pDMG with respect to molecular subgroup status in a large patient cohort. Our findings may support diagnosis and future targeted therapeutic trials of pDMG within the framework of the radiogenomics concept."],["dc.identifier.doi","10.1007/s00062-021-01120-3"],["dc.identifier.pii","1120"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97653"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","1869-1447"],["dc.relation.issn","1869-1439"],["dc.title","Magnetic Resonance Imaging Characteristics of Molecular Subgroups in Pediatric H3 K27M Mutant Diffuse Midline Glioma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","215"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.lastpage","224"],["dc.bibliographiccitation.volume","194"],["dc.contributor.author","Seidel, Clemens"],["dc.contributor.author","von Bueren, André O."],["dc.contributor.author","Bojko, Sabrina"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Kortmann, Rolf‑D."],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2020-12-10T14:08:04Z"],["dc.date.available","2020-12-10T14:08:04Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00066-017-1218-6"],["dc.identifier.eissn","1439-099X"],["dc.identifier.issn","0179-7158"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70366"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Konkomitante Radiochemotherapie mit Temozolomid vs. konkomitante Cisplatin-basierte Radiochemotherapie"],["dc.title.alternative","Concurrent radiotherapy with temozolomide vs. concurrent radiotherapy with a cisplatinum-based polychemotherapy regimen. Acute toxicity in pediatric high-grade glioma patients"],["dc.title.subtitle","Akuttoxizität bei Kindern mit hochmalignen Gliomen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Mueller, Klaus"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Seidel, Clemens"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Kordes, Uwe"],["dc.contributor.author","Sander, Annette"],["dc.contributor.author","Roessler, Jochen"],["dc.contributor.author","Graf, Norbert"],["dc.contributor.author","Scheithauer, Heike"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.date.accessioned","2018-11-07T09:39:22Z"],["dc.date.available","2018-11-07T09:39:22Z"],["dc.date.issued","2014"],["dc.format.extent","120"],["dc.identifier.isi","000337924200462"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33263"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","16th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Singapore, SINGAPORE"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","SALVAGE TREATMENT OF PROGRESSIVE NON-PONTINE PEDIATRIC HIGH-GRADE GLIOMAS BY RE-IRRADIATION: PRELIMINARY EXPERIENCES FROM THE GERMAN HIT-HGG STUDY GROUP"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","123"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","131"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Karremann, Michael"],["dc.contributor.author","Gielen, Gerrit H"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Wiese, Maria"],["dc.contributor.author","Colditz, Niclas"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Claviez, Alexander"],["dc.contributor.author","van Vuurden, Dannis G"],["dc.contributor.author","von Bueren, André O"],["dc.contributor.author","Gessi, Marco"],["dc.contributor.author","Kühnle, Ingrid"],["dc.contributor.author","Hans, Volkmar H"],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Waha, Andreas"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Kramm, Christof M"],["dc.date.accessioned","2020-12-10T18:19:37Z"],["dc.date.available","2020-12-10T18:19:37Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1093/neuonc/nox149"],["dc.identifier.eissn","1523-5866"],["dc.identifier.issn","1522-8517"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75312"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Eyrich, Matthias"],["dc.contributor.author","Graf, Norbert"],["dc.contributor.author","Rutkowski, Stefan"],["dc.contributor.author","Fruehwald, Michael C."],["dc.contributor.author","Faber, Joerg"],["dc.contributor.author","Kramm, Christof"],["dc.date.accessioned","2018-11-07T09:39:19Z"],["dc.date.available","2018-11-07T09:39:19Z"],["dc.date.issued","2014"],["dc.format.extent","42"],["dc.identifier.isi","000337924200158"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33253"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","16th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Singapore, SINGAPORE"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","CENTRALLY REVIEWED GLIOMATOSIS CEREBRI IN CHILDREN AND ADOLESCENTS: A RETROSPECITVE ANALYSIS FROM THE HIT-HGG DATABASE"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","von Bueren, Andre Oscar"],["dc.contributor.author","Seidel, Clemens"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Bojko, Sabrina"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Kortmann, Rolf-Dieter"],["dc.contributor.author","Kramm, Christof M."],["dc.date.accessioned","2018-11-07T10:13:05Z"],["dc.date.available","2018-11-07T10:13:05Z"],["dc.date.issued","2016"],["dc.format.extent","53"],["dc.identifier.isi","000379749000203"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40367"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.publisher.place","Cary"],["dc.relation.conference","17th International Symposium on Pediatric Neuro-Oncology (ISPNO)"],["dc.relation.eventlocation","Liverpool, ENGLAND"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","ACUTE TOXICITY OF TEMOZOLOMIDE-VERSUS CISPLATIN-BASED RADIOCHEMOTHERAPY IN PEDIATRIC HIGH GRADE GLIOMA: COMPARATIVE ANALYSIS OF PROSPECTIVE, CONSECUTIVE, MULTICENTRIC AND MULTINATIONAL TRIALS OF THE GERMAN HIT-HGG STUDY GROUP"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1963"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Journal of Clinical Oncology"],["dc.bibliographiccitation.lastpage","1972"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Hoffman, Lindsey M."],["dc.contributor.author","Veldhuijzen van Zanten, Sophie E.M."],["dc.contributor.author","Colditz, Niclas"],["dc.contributor.author","Baugh, Joshua"],["dc.contributor.author","Chaney, Brooklyn"],["dc.contributor.author","Hoffmann, Marion"],["dc.contributor.author","Lane, Adam"],["dc.contributor.author","Fuller, Christine"],["dc.contributor.author","Miles, Lili"],["dc.contributor.author","Hawkins, Cynthia"],["dc.contributor.author","Bartels, Ute"],["dc.contributor.author","Bouffet, Eric"],["dc.contributor.author","Goldman, Stewart"],["dc.contributor.author","Leary, Sarah"],["dc.contributor.author","Foreman, Nicholas K."],["dc.contributor.author","Packer, Roger"],["dc.contributor.author","Warren, Katherine E."],["dc.contributor.author","Broniscer, Alberto"],["dc.contributor.author","Kieran, Mark W."],["dc.contributor.author","Minturn, Jane"],["dc.contributor.author","Comito, Melanie"],["dc.contributor.author","Broxson, Emmett"],["dc.contributor.author","Shih, Chie-Schin"],["dc.contributor.author","Khatua, Soumen"],["dc.contributor.author","Chintagumpala, Murali"],["dc.contributor.author","Carret, Anne Sophie"],["dc.contributor.author","Escorza, Nancy Yanez"],["dc.contributor.author","Hassall, Timothy"],["dc.contributor.author","Ziegler, David S."],["dc.contributor.author","Gottardo, Nicholas"],["dc.contributor.author","Dholaria, Hetal"],["dc.contributor.author","Doughman, Renee"],["dc.contributor.author","Benesch, Martin"],["dc.contributor.author","Drissi, Rachid"],["dc.contributor.author","Nazarian, Javad"],["dc.contributor.author","Jabado, Nada"],["dc.contributor.author","Boddaert, Nathalie"],["dc.contributor.author","Varlet, Pascale"],["dc.contributor.author","Giraud, Géraldine"],["dc.contributor.author","Castel, David"],["dc.contributor.author","Puget, Stephanie"],["dc.contributor.author","Jones, Chris"],["dc.contributor.author","Hulleman, Esther"],["dc.contributor.author","Modena, Piergiorgio"],["dc.contributor.author","Giagnacovo, Marzia"],["dc.contributor.author","Antonelli, Manila"],["dc.contributor.author","Pietsch, Torsten"],["dc.contributor.author","Gielen, Gerrit H."],["dc.contributor.author","Jones, David T.W."],["dc.contributor.author","Sturm, Dominik"],["dc.contributor.author","Pfister, Stefan M."],["dc.contributor.author","Gerber, Nicolas U."],["dc.contributor.author","Grotzer, Michael A."],["dc.contributor.author","Pfaff, Elke"],["dc.contributor.author","von Bueren, André O."],["dc.contributor.author","Hargrave, Darren"],["dc.contributor.author","Solanki, Guirish A."],["dc.contributor.author","Jadrijevic Cvrlje, Filip"],["dc.contributor.author","Kaspers, Gertjan J.L."],["dc.contributor.author","Vandertop, William P."],["dc.contributor.author","Grill, Jacques"],["dc.contributor.author","Bailey, Simon"],["dc.contributor.author","Biassoni, Veronica"],["dc.contributor.author","Massimino, Maura"],["dc.contributor.author","Calmon, Raphaël"],["dc.contributor.author","Sanchez, Esther"],["dc.contributor.author","Bison, Brigitte"],["dc.contributor.author","Warmuth-Metz, Monika"],["dc.contributor.author","Leach, James"],["dc.contributor.author","Jones, Blaise"],["dc.contributor.author","van Vuurden, Dannis G."],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Fouladi, Maryam"],["dc.date.accessioned","2020-12-10T18:41:35Z"],["dc.date.available","2020-12-10T18:41:35Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1200/JCO.2017.75.9308"],["dc.identifier.eissn","1527-7755"],["dc.identifier.issn","0732-183X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77619"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]