Wedekind, Dirk

[["dc.bibliographiccitation.firstpage","831"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Neural Transmission"],["dc.bibliographiccitation.lastpage","837"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Wedekind, Dirk"],["dc.contributor.author","Bandelow, Borwin"],["dc.contributor.author","Broocks, Andreas"],["dc.contributor.author","Hajak, Goran"],["dc.contributor.author","Ruther, Eckart"],["dc.date.accessioned","2018-11-07T11:09:47Z"],["dc.date.available","2018-11-07T11:09:47Z"],["dc.date.issued","2000"],["dc.description.abstract","Background. Research on basal HPA axis activity in patients with panic disorder showed inconsistent results. Methods. Basal total plasma, plasma free and salivary cortisol levels were compared in patients with panic disorder (n = 47) and in healthy individuals (n = 23). Correlations between these fractions were calculated. Results. All three basal cortisol fractions were significantly elevated in patients compared to controls. There were significant correlations between all three cortisol fractions. Conclusions. Nonsignificant differences between cortisol levels of patients and healthy controls in previous studies may have been due to inclusion of less severely ill patients or to small sample sizes (96 words)."],["dc.identifier.doi","10.1007/s007020070062"],["dc.identifier.isi","000088415100008"],["dc.identifier.pmid","11005547"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53083"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0300-9564"],["dc.title","Salivary, total plasma and plasma free cortisol in panic disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","169"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Psychiatry Research"],["dc.bibliographiccitation.lastpage","179"],["dc.bibliographiccitation.volume","134"],["dc.contributor.author","Bandelow, Borwin"],["dc.contributor.author","Krause, Jan"],["dc.contributor.author","Wedekind, Dirk"],["dc.contributor.author","Broocks, Andreas"],["dc.contributor.author","Hajak, Goran"],["dc.contributor.author","Ruther, Eckart"],["dc.date.accessioned","2018-11-07T11:08:29Z"],["dc.date.available","2018-11-07T11:08:29Z"],["dc.date.issued","2005"],["dc.description.abstract","Patients with borderline personality disorder (BPD) were have not yet been compared with a healthy control group with regard to traumatic life events during childhood. The patients (n = 66) and controls (n = 109) were investigated using a comprehensive retrospective interview with 203 questions about childhood traumatic life events, parental attitudes, family history of psychiatric disorders and birth risk factors. The frequency of reports of traumatic childhood experiences was significantly higher in patients than in controls, including sexual abuse, violence, separation from parents, childhood illness, and other factors. On a 0- to 10-point \"severe trauma scale,\" patients had significantly more severe traumatic events (mean score = 3.86, SD = 1.77) than control subjects (0.61, SD = 0.93). Only four (6.1%) of the BPD patients, but 67 (61.5%) of the controls did not report any severe traumatic events at all. Compared with controls, patients described the attitude of their parents as significantly more unfavorable in all aspects. Patients reported significantly higher rates of psychiatric disorders in their families in general, especially anxiety disorders, depression, and suicidality. Among birth risk factors, premature birth was reported more often in BPD subjects. In a logistic regression model of all possible etiological factors examined, the following factors showed a significant influence: familial neurotic spectrum disorders, childhood sexual abuse, separation from parents and unfavorable parental rearing styles. The present data support the hypothesis that the etiology of BPD is multifactorial and that familial psychiatric disorders and sexual abuse are contributing factors. © 2005 Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.psychres.2003.07.008"],["dc.identifier.isi","000228935500007"],["dc.identifier.pmid","15840418"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52793"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0165-1781"],["dc.title","Early traumatic life events, parental attitudes, family history, and birth risk factors in patients with borderline personality disorder and healthy controls"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","904"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","The World Journal of Biological Psychiatry"],["dc.bibliographiccitation.lastpage","913"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Wedekind, Dirk"],["dc.contributor.author","Broocks, Andreas"],["dc.contributor.author","Weiss, Nina"],["dc.contributor.author","Engel, Kirsten"],["dc.contributor.author","Neubert, Karin"],["dc.contributor.author","Bandelow, Borwin"],["dc.date.accessioned","2018-11-07T08:38:05Z"],["dc.date.available","2018-11-07T08:38:05Z"],["dc.date.issued","2010"],["dc.description.abstract","Objectives. Regular aerobic exercise (running) has been shown to be superior to a pill placebo in the treatment of panic disorder. Combined drug and exercise treatment has not been investigated in randomized controlled studies to date. Methods. This is a randomized, 10-week, controlled, parallel group, pilot study. A total of 75 outpatients with panic disorder with or without agoraphobia (DSM-IV and ICD-10) received either (1) exercise plus paroxetine 40 mg/day (n = 21), (2) relaxation plus paroxetine (n = 17), (3) exercise plus pill placebo (n = 20), or (4) relaxation plus pill placebo (n = 17). Changes in the Panic and Agoraphobia Scale (P&A), and the Clinical Global Impression Scale (CGI) underwent repeated measure analysis. Results. Effects sizes were large for all groups (d = 1.53-3.87), however not significantly different. Paroxetine-treated patients were significantly more improved than placebo-treated patients. On the CGI, patients in the exercise groups (plus paroxetine or placebo) had a trend toward better improvement compared to relaxation (P = 0.06). Response and remission rates were higher in the paroxetine compared to pill placebo groups. Conclusions. While paroxetine was superior to placebo, aerobic exercise did not differ from relaxation training in most efficacy measures."],["dc.description.sponsorship","GlaxoSmithKline"],["dc.identifier.doi","10.3109/15622975.2010.489620"],["dc.identifier.isi","000282191400008"],["dc.identifier.pmid","20602575"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18686"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.relation.issn","1562-2975"],["dc.title","A randomized, controlled trial of aerobic exercise in combination with paroxetine in the treatment of panic disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Wedekind, Dirk"],["dc.contributor.author","Broocks, Andreas"],["dc.contributor.author","Weiss, N."],["dc.contributor.author","Rotter-Glattkowski, P."],["dc.contributor.author","Engel, Katharina"],["dc.contributor.author","Neubert, K."],["dc.contributor.author","Bandelow, Borwin"],["dc.date.accessioned","2018-11-07T10:57:26Z"],["dc.date.available","2018-11-07T10:57:26Z"],["dc.date.issued","2007"],["dc.format.extent","510"],["dc.identifier.isi","000253318801496"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50250"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0028-2804"],["dc.title","Controlled study for effectiveness of sport vs. relaxation training in combination with paroxetine vs. Placebo in the treatment of the panic disorder"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","153"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","164"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Broocks, Andreas"],["dc.contributor.author","Meyer, T."],["dc.contributor.author","Opitz, M."],["dc.contributor.author","Bartmann, U."],["dc.contributor.author","Hillmer-Vogel, U."],["dc.contributor.author","George, A."],["dc.contributor.author","Pekrun, G."],["dc.contributor.author","Wedekind, Dirk"],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Bandelow, Borwin"],["dc.date.accessioned","2018-11-07T10:39:09Z"],["dc.date.available","2018-11-07T10:39:09Z"],["dc.date.issued","2003"],["dc.description.abstract","Blunted neuroendocrine and physiological responses to the selective 5-HT1A receptor agonist, ipsapirone, have been observed in patients with panic disorder and/or agoraphobia (PDA). In order to examine whether this hyporesponsiveness to ipsapirone is modified by pharmacological or non-pharmacological therapeutic interventions, challenges with an oral dose of ipsapirone (0.3 mg/kg) and placebo were performed in patients with PDA before and after 10 weeks of treatment with clomipramine, aerobic exercise and placebo. Before treatment, administration of ipsapirone was followed by significant increases of cortisol, anxiety and other psychopathological symptoms in comparison to the placebo challenge. In addition, a significant decrease of body temperature was observed. After the 10-week treatment period, the psychological responses to ipsapirone were significantly reduced in the clornipramine and the exercise group. In contrast, there was a non-significant trend towards higher cortisol responses after clornipramine and exercise treatment. The hypothermic response to ipsapirone was significantly reduced by clornipramine treatment. In conclusion, our results demonstrate that effective treatment of panic disorder has divergent effects on the psychological, neuroendocrine and temperature responses to ipsapirone. (C) 2003 Elsevier Science B.V./ECNP All rights reserved."],["dc.identifier.doi","10.1016/S0924-977X(02)00177-3"],["dc.identifier.isi","000183090600003"],["dc.identifier.pmid","12729940"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45977"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0924-977X"],["dc.title","5-HT1A responsivity in patients with panic disorder before and after treatment with aerobic exercise, clomipramine or placebo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3518"],["dc.bibliographiccitation.issue","33"],["dc.bibliographiccitation.journal","Current Pharmaceutical Design"],["dc.bibliographiccitation.lastpage","3524"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Wedekind, Dirk"],["dc.contributor.author","Sprute, A."],["dc.contributor.author","Broocks, Andreas"],["dc.contributor.author","Huether, Gerald"],["dc.contributor.author","Engel, Katharina"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Bandelow, Borwin"],["dc.date.accessioned","2018-11-07T11:09:23Z"],["dc.date.available","2018-11-07T11:09:23Z"],["dc.date.issued","2008"],["dc.description.abstract","Introduction: Data on basal hypothalamo-pituitary-adrenomedullary (HPA) function over controlled treatment trials with serotonergic drugs in anxiety disorders are still rare. Methods: 29 patients with panic disorder participating in a 10 week randomized, controlled trial (paroxetine vs. placebo with exercise or relaxation; N=60) collected urine for cortisol excretion over 3 consecutive nights before start and before termination of the treatment episode. Urinary cortisol was measured by radioimmunoassay. Efficacy measures were the Clinical Global Impression Scale (CGI) and the Panic and Agoraphobia Scale (P&A). 83% were female (p<.05 vs. males). 55% received additional aerobic exercise, and 45% relaxation. 55% received paroxetine treatment, and 45% placebo. Significantly fewer males received placebo treatment (p<.05). Results: All subjects improved significantly. Cortisol excretion did not differ between treatment groups or at pre-/post measurements. Females showed a significantly higher variability of cortisol excretion compared to males, at pre-(p<.005) and post (p=.015) assessments. Males displayed a trend to lower basal HPA function at end of treatment (p=.08). HPA variability after treatment showed a trend to be higher in the paroxetine (p=.052) -who clinically improved significantly better-compared to the placebo group. No relationship between HPA activity and treatment response or with exercise was detected. Discussion: HPA function shows significant gender differences, with females having a higher HPA function variability. Future studies on HPA function in treatment trials should address gender and medication effects."],["dc.identifier.doi","10.2174/138161208786848757"],["dc.identifier.isi","000261916400005"],["dc.identifier.pmid","19075728"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52996"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Bentham Science Publ Ltd"],["dc.relation.issn","1381-6128"],["dc.title","Nocturnal Urinary Cortisol Excretion Over a Randomized Controlled Trial with Paroxetine vs. Placebo Combined with Relaxation Training or Aerobic Exercise in Panic Disorder"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","397"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","405"],["dc.bibliographiccitation.volume","254"],["dc.contributor.author","Bandelow, Borwin"],["dc.contributor.author","Torrente, A. C."],["dc.contributor.author","Wedekind, Dirk"],["dc.contributor.author","Broocks, Andreas"],["dc.contributor.author","Hajak, Goran"],["dc.contributor.author","Ruther, Eckart"],["dc.date.accessioned","2018-11-07T10:43:22Z"],["dc.date.available","2018-11-07T10:43:22Z"],["dc.date.issued","2004"],["dc.description.abstract","Objective Childhood traumatic experiences, rearing styles, familial mental disorders and birth risk factors have been associated with the development of social anxiety disorder. Method Patients with social anxiety disorder (n = 50) and healthy controls (n = 120) were investigated using a retrospective interview with 203 questions. Results The frequency of reports of traumatic childhood experiences was significantly higher in patients than in controls, including separation from parents, parents' marital discord, sexual abuse, familial violence, childhood illness, and other factors. On a 0-10 point 'severe trauma scale' patients had significantly higher mean scores (2.0; SD 1.28) than control subjects (0.82; SD 1.1; p < 0.0001). Only 6 (12 %) of the social phobic patients, but 63 (52.5 %) of the controls did not report any severe traumatic events at all (chi(2) = 24.0; p < 0.0001). Compared to controls, patients described their parents' rearing styles as significantly more unfavourable. Patients reported higher rates of psychiatric disorders in their families in general, in particular anxiety disorders, depression, and suicidality. Birth risk factors did not differ between patients and controls. in a logistic regression model, the highest contribution was noted for familial anxiety disorders. Separation from parents also had a significant, but smaller influence. There was only a trend towards a significant contribution of childhood sexual abuse. Violence in the family, parental rearing styles and birth risk factors did not contribute significantly. Conclusions The present data suggest that the aetiology of social anxiety disorder is multifactorial and that familial mental disorders and separation experiences are the most important contributing factors."],["dc.identifier.doi","10.1007/s00406-004-0521-2"],["dc.identifier.isi","000226092900009"],["dc.identifier.pmid","15538600"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47036"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0940-1334"],["dc.title","Early traumatic life events, parental rearing styles, family history of mental disorders, and birth risk factors in patients with social anxiety disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Psychiatry"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Broocks, Andreas"],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Munzel, U."],["dc.contributor.author","Hajak, Goran"],["dc.contributor.author","Wedekind, Dirk"],["dc.contributor.author","Bandelow, Borwin"],["dc.date.accessioned","2018-11-07T09:29:01Z"],["dc.date.available","2018-11-07T09:29:01Z"],["dc.date.issued","2000"],["dc.format.extent","243S"],["dc.identifier.doi","10.1016/S0924-9338(00)94044-6"],["dc.identifier.isi","000165731700103"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30920"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Editions Scientifiques Medicales Elsevier"],["dc.publisher.place","Paris cedex 15"],["dc.relation.issn","0924-9338"],["dc.title","Responsiveness of central serotonin receptors in panic disorder: Effects of clomipramine treatment and exercise"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","245"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychiatry Research"],["dc.bibliographiccitation.lastpage","250"],["dc.bibliographiccitation.volume","95"],["dc.contributor.author","Bandelow, Borwin"],["dc.contributor.author","Wedekind, Dirk"],["dc.contributor.author","Sandvoss, V."],["dc.contributor.author","Broocks, Andreas"],["dc.contributor.author","Hajak, Goran"],["dc.contributor.author","Pauls, J."],["dc.contributor.author","Peter, H."],["dc.contributor.author","Ruther, Eckart"],["dc.date.accessioned","2018-11-07T10:15:44Z"],["dc.date.available","2018-11-07T10:15:44Z"],["dc.date.issued","2000"],["dc.description.abstract","In patients with panic disorder (n = 23), daytime salivary cortisol levels were determined in 2-h spans on 3 consecutive days and compared with 23 age- and sex-matched healthy controls. Additionally, nocturnal urinary free cortisol levels were measured. Daytime salivary cortisol levels were numerically higher in the patients, although the difference did not reach statistical significance. In a subgroup of 14 patients with higher illness severity las expressed by a score greater than or equal to 22 on the Panic and Agoraphobia Scale), salivary cortisol levels were significantly higher than in the controls. Mean nocturnal urinary cortisol levels were significantly higher in the whole group of patients and also in the more severely ill subgroup when compared with controls. Cortisol elevations seem to be more pronounced during the night and occurred mainly in more severely ill panic patients. (C) 2000 Elsevier Science Ireland Ltd. Al rights reserved."],["dc.identifier.doi","10.1016/S0165-1781(00)00183-9"],["dc.identifier.isi","000089463500007"],["dc.identifier.pmid","10974363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40874"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ireland Ltd"],["dc.relation.issn","0165-1781"],["dc.title","Diurnal variation of cortisol in panic disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]