Bader, Oliver

[["dc.bibliographiccitation.firstpage","15"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Current Biology : CB"],["dc.bibliographiccitation.lastpage","27"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Carreté, Laia"],["dc.contributor.author","Ksiezopolska, Ewa"],["dc.contributor.author","Pegueroles, Cinta"],["dc.contributor.author","Gómez-Molero, Emilia"],["dc.contributor.author","Saus, Ester"],["dc.contributor.author","Iraola-Guzmán, Susana"],["dc.contributor.author","Loska, Damian"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Fairhead, Cecile"],["dc.contributor.author","Gabaldón, Toni"],["dc.date.accessioned","2019-07-09T11:45:13Z"],["dc.date.available","2019-07-09T11:45:13Z"],["dc.date.issued","2018"],["dc.description.abstract","Candida glabrata is an opportunistic fungal pathogen that ranks as the second most common cause of systemic candidiasis. Despite its genus name, this yeast is more closely related to the model yeast Saccharomyces cerevisiae than to other Candida pathogens, and hence its ability to infect humans is thought to have emerged independently. Moreover, C. glabrata has all the necessary genes to undergo a sexual cycle but is considered an asexual organism due to the lack of direct evidence of sexual reproduction. To reconstruct the recent evolution of this pathogen and find footprints of sexual reproduction, we assessed genomic and phenotypic variation across 33 globally distributed C. glabrata isolates. We cataloged extensive copy-number variation, which particularly affects genes encoding cell-wall-associated proteins, including adhesins. The observed level of genetic variation in C. glabrata is significantly higher than that found in Candida albicans. This variation is structured into seven deeply divergent clades, which show recent geographical dispersion and large within-clade genomic and phenotypic differences. We show compelling evidence of recent admixture between differentiated lineages and of purifying selection on mating genes, which provides the first evidence for the existence of an active sexual cycle in this yeast. Altogether, our data point to a recent global spread of previously genetically isolated populations and suggest that humans are only a secondary niche for this yeast."],["dc.identifier.doi","10.1016/j.cub.2017.11.027"],["dc.identifier.pmid","29249661"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15061"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59185"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/310325/EU//NONCODEVOL"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/642095/EU//OPATHY"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/606786/EU//IMRESFUN"],["dc.relation.issn","1879-0445"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject.ddc","610"],["dc.title","Patterns of Genomic Variation in the Opportunistic Pathogen Candida glabrata Suggest the Existence of Mating and a Secondary Association with Humans."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","112"],["dc.bibliographiccitation.journal","Frontiers in Microbiology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Carreté, Laia"],["dc.contributor.author","Ksiezopolska, Ewa"],["dc.contributor.author","Gómez-Molero, Emilia"],["dc.contributor.author","Angoulvant, Adela"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Fairhead, Cécile"],["dc.contributor.author","Gabaldón, Toni"],["dc.date.accessioned","2019-07-09T11:50:27Z"],["dc.date.available","2019-07-09T11:50:27Z"],["dc.date.issued","2019"],["dc.description.abstract","Candida glabrata is an opportunistic fungal pathogen that currently ranks as the second most common cause of candidiasis. Although the mechanisms underlying virulence and drug resistance in C. glabrata are now starting to be elucidated, we still lack a good understanding of how this yeast adapts during the course of an infection. Outstanding questions are whether the observed genomic plasticity of C. glabrata plays a role during infection, or what levels of genetic variation exist within an infecting clonal population. To shed light onto the genomic variation within infecting C. glabrata populations, we compared the genomes of 11 pairs and one trio of serial clinical isolates, each obtained from a single patient. Our results provide a catalog of genetic variations existing within clonal infecting isolates, and reveal an enrichment of non-synonymous changes in genes encoding cell-wall proteins. Genetic variation and the presence of non-synonymous mutations and copy number variations accumulated within the host, suggest that clonal populations entail a non-negligible level of genetic variation that may reflect selection processes that occur within the human body. As we show here, these genomic changes can underlie phenotypic differences in traits that are relevant for infection."],["dc.identifier.doi","10.3389/fmicb.2019.00112"],["dc.identifier.pmid","30809200"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15942"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59775"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/724173/EU//RETVOLUTION"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/642095/EU//OPATHY"],["dc.relation.issn","1664-302X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]