Emmert, Alexander

[["dc.bibliographiccitation.artnumber","e16712"],["dc.bibliographiccitation.issue","31"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","98"],["dc.contributor.author","Buentzel, Judith"],["dc.contributor.author","Yao, Sha"],["dc.contributor.author","Elakad, Omar"],["dc.contributor.author","Lois, Anna-Maria"],["dc.contributor.author","Brünies, Jana"],["dc.contributor.author","König, Julia"],["dc.contributor.author","Hinterthaner, Marc"],["dc.contributor.author","Danner, Bernhard C."],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Emmert, Alexander"],["dc.contributor.author","Bohnenberger, Hanibal"],["dc.date.accessioned","2019-08-09T06:40:34Z"],["dc.date.available","2019-08-09T06:40:34Z"],["dc.date.issued","2019"],["dc.description.abstract","Molecular characterization of lung cancer specimens after radical surgery offers additional prognostic information and may help to guide adjuvant therapeutic procedures. The transcriptional regulators alpha thalassemia/mental retardation X-linked (ATRX) and death domain-associated protein (DAXX) have recently been described in different cancer entities as a useful prognostic biomarker. This study was initiated to explore their protein expression patterns and prognostic value in patients with operable lung cancer disease.The protein abundance (in the following text also named protein expression) of ATRX and DAXX were analyzed by immunohistochemistry in 194 samples of squamous cell lung carcinoma (SQCLC), 111 samples of pulmonary adenocarcinoma (AC) and 40 samples of small cell lung cancer (SCLC). The protein levels of ATRX and DAXX were correlated with clinicopathological characteristics and patient outcome.ATRX showed strong protein expression in 16.2% of AC, 11.9% of SQCLC, and 42.5% of SCLC. DAXX was highly expressed in 54.9% of AC, 76.2% of SQCLC, and 82.5% of SCLC. Immunostaining of both ATRX and DAXX were seen in 14.4% of AC, 11.3% of SQCLC, and 42.5% of SCLC. High protein expression of ATRX was a favorable prognostic marker for patients with AC (hazard ratio 0.38, P = .02). Sub-group analyses showed a significant correlation between ATRX and the clinical stage of SQCLC and SCLC. Histological grading and ATRX were also significantly associated in cases of SQCLC.The presence of ATRX and DAXX are correlated with lung cancer histology. Strong ATRX protein expression is associated with a significantly longer overall survival in patients with AC."],["dc.description.sponsorship","Open-Access-Publikationafonds 2019"],["dc.identifier.doi","10.1097/MD.0000000000016712"],["dc.identifier.pmid","31374064"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16343"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62353"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1536-5964"],["dc.relation.issn","0025-7974"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Expression and prognostic impact of alpha thalassemia/mental retardation X-linked and death domain-associated protein in human lung cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4603"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Anticancer Research"],["dc.bibliographiccitation.lastpage","4612"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","BUENTZEL, JUDITH"],["dc.contributor.author","HEINZ, JUDITH"],["dc.contributor.author","BLECKMANN, ANNALEN"],["dc.contributor.author","BAUER, CHRISTOPH"],["dc.contributor.author","RÖVER, CHRISTIAN"],["dc.contributor.author","BOHNENBERGER, HANIBAL"],["dc.contributor.author","SAHA, SHEKHAR"],["dc.contributor.author","HINTERTHANER, MARC"],["dc.contributor.author","BARAKI, HASSINA"],["dc.contributor.author","KUTSCHKA, INGO"],["dc.contributor.author","EMMERT, ALEXANDER"],["dc.date.accessioned","2020-12-10T18:43:04Z"],["dc.date.available","2020-12-10T18:43:04Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.21873/anticanres.13640"],["dc.identifier.eissn","1791-7530"],["dc.identifier.issn","0250-7005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78183"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Sarcopenia as Prognostic Factor in Lung Cancer Patients: A Systematic Review and Meta-analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e1847"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The International Journal of Medical Robotics and Computer Assisted Surgery"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Buentzel, Judith"],["dc.contributor.author","Heinz, Judith"],["dc.contributor.author","Hinterthaner, Marc"],["dc.contributor.author","Schöndube, Friedrich A."],["dc.contributor.author","Straube, Carmen"],["dc.contributor.author","Roever, Christian"],["dc.contributor.author","Emmert, Alexander"],["dc.date.accessioned","2020-12-10T14:07:09Z"],["dc.date.available","2020-12-10T14:07:09Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1002/rcs.v13.4"],["dc.identifier.issn","1478-5951"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70138"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Robotic versus thoracoscopic thymectomy: The current evidence"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e85"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","International Journal of Surgery. Oncology"],["dc.bibliographiccitation.lastpage","5"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Saha, Shekhar"],["dc.contributor.author","Yao, Sha"],["dc.contributor.author","Elakad, Omar"],["dc.contributor.author","Lois, Anna-Maria"],["dc.contributor.author","Henric-Petri, Hannah"],["dc.contributor.author","Buentzel, Judith"],["dc.contributor.author","Hinterthaner, Marc"],["dc.contributor.author","Danner, Bernhard C."],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Emmert, Alexander"],["dc.contributor.author","Bohnenberger, Hanibal"],["dc.date.accessioned","2020-06-09T11:55:48Z"],["dc.date.accessioned","2021-10-27T13:22:15Z"],["dc.date.available","2020-06-09T11:55:48Z"],["dc.date.available","2021-10-27T13:22:15Z"],["dc.date.issued","2020"],["dc.description.abstract","Background: UDP-glucose-6-dehydrogenase (UGDH) plays an important role in the production of hyaluronic acid, an extracellular matrix component that is responsible for the promotion of normal cellular growth and migration. Increased levels of UGDH have been linked to the progression of epithelial cancers, such as those of the breast, colon and prostate. Therefore we aimed to analyze if the expression level of UGDH does also influence patients survival of lung cancer patients. Methods: UGDH expression levels were analyzed by immunohistochemistry in 96 samples of pulmonary adenocarcinoma (AC), 84 cases of squamous cell lung carcinoma (SQCLC) and 33 samples of small cell lung cancer (SCLC) and correlated with clinicopathologic characteristics and patient outcome. Results: UGDH was expressed in 62.5% cases of AC, 70.2% cases of SQCLC, and 48.5% cases of SCLC. In AC, expression of UGDH was significantly associated with lymph node metastasis and worse overall survival of the affected patients. However, UGDH expression had no significant correlation to prognosis in SQCLC or SCLC patients. Conclusions: In our study, expression of UGDH was associated with worse prognosis of patients with pulmonary adenocarcinoma so that expression of UGDH might help to guide treatment decisions. Furthermore, UGDH might present a potential novel drug target in AC as it displays inhibitable catalytic activity."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2020"],["dc.identifier.doi","10.1097/IJ9.0000000000000085"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17377"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92078"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2471-3864"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","UDP-glucose 6-dehydrogenase expression as a predictor of survival in patients with pulmonary adenocarcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e7633"],["dc.bibliographiccitation.issue","35"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","96"],["dc.contributor.author","Emmert, Alexander"],["dc.contributor.author","Straube, Carmen"],["dc.contributor.author","Buentzel, Judith"],["dc.contributor.author","Roever, Christian"],["dc.date.accessioned","2020-12-10T18:20:03Z"],["dc.date.available","2020-12-10T18:20:03Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1097/MD.0000000000007633"],["dc.identifier.issn","0025-7974"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14606"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75450"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-SA 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-sa/4.0"],["dc.title","Robotic versus thoracoscopic lung resection"],["dc.title.alternative","A systematic review and meta-analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0528"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","97"],["dc.contributor.author","Emmert, Alexander"],["dc.contributor.author","Gries, Gereon"],["dc.contributor.author","Wand, Saskia"],["dc.contributor.author","Buentzel, Judith"],["dc.contributor.author","Bräuer, Anselm"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Brandes, Ivo F."],["dc.date.accessioned","2020-12-10T18:20:04Z"],["dc.date.available","2020-12-10T18:20:04Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1097/MD.0000000000010528"],["dc.identifier.issn","0025-7974"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15265"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75454"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/4.0"],["dc.title","Association between perioperative hypothermia and patient outcomes after thoracic surgery"],["dc.title.alternative","A single center retrospective analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e7161"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","96"],["dc.contributor.author","Buentzel, Judith"],["dc.contributor.author","Straube, Carmen"],["dc.contributor.author","Heinz, Judith"],["dc.contributor.author","Roever, Christian"],["dc.contributor.author","Beham, Alexander"],["dc.contributor.author","Emmert, Andreas"],["dc.contributor.author","Hinterthaner, Marc"],["dc.contributor.author","Danner, Bernhard C."],["dc.contributor.author","Emmert, Alexander"],["dc.date.accessioned","2020-12-10T18:20:03Z"],["dc.date.available","2020-12-10T18:20:03Z"],["dc.date.issued","2017"],["dc.description.abstract","Robot-assisted minimally invasive surgery (RVATS) is a relatively new technique applied for thymectomies. Only few studies directly compare RVATS to the mainstay therapy, open surgery (sternotomy). A systematic search of the literature was performed in October 2016. The meta-analysis includes studies comparing robotassisted and open thymectomy regarding operation time, length of hospitalization, intraoperative blood loss, and chest-in-tube days, postoperative complications, reoperation, arrhythmic events, pleural effusion, and postoperative bleeding. Of 626 studies preliminary screened, 7 articles were included. There were no significant differences in comparison of operation time (3.19 minutes [95% confidence interval, 95% CI 112.43 to 106.05]; P=.94), but patients undergoing RVATS spent significantly less time in hospital (4.06 days [95% CI 7.98 to 0.13], P=.046). There were fewer chests-in-tube days (2.50 days [95% CI 15.01 to 10.01]; P=.24) and less intraoperative blood loss (256.84mL [95% CI 627.47 to 113.80]; P=.10) observed in the RVATS group; due to a small number of studies, these results were not statistically significant. There were also less post-operative complications in the RVATS group (12 complications in 209 patients vs 51 complications in 259 patients); however, this difference was not statistical significant (odds ratio 0.27, 95% CI 0.07 – 1.12; P=.06). Patients undergoing RVATS spent less time in hospital than patients treated by open surgery (sternotomy). These patients tended to have less postoperative complications, less intraoperative blood loss, and fewer chest-in-tube days. We found evidence for the safety and feasibility of RVATS compared with open surgery, which has to be further confirmed in randomised controlled trials."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.identifier.doi","10.1097/MD.0000000000007161"],["dc.identifier.gro","630787"],["dc.identifier.issn","0025-7974"],["dc.identifier.pmid","28614249"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14518"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75449"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1536-5964"],["dc.rights","CC BY-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/3.0"],["dc.title","Thymectomy via open surgery or robotic video assisted thoracic surgery: Can a recommendation already be made?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]