Anker, Stefan Dietmar

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Circulation: Heart Failure"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Emmens, Johanna E."],["dc.contributor.author","ter Maaten, Jozine M."],["dc.contributor.author","Damman, Kevin"],["dc.contributor.author","van Veldhuisen, Dirk J."],["dc.contributor.author","de Boer, Rudolf A."],["dc.contributor.author","Struck, Joachim"],["dc.contributor.author","Bergmann, Andreas"],["dc.contributor.author","Sama, Iziah E."],["dc.contributor.author","Streng, Koen W."],["dc.contributor.author","Anker, Stefan D."],["dc.contributor.author","Dickstein, Kenneth"],["dc.contributor.author","Lang, Chim C."],["dc.contributor.author","Metra, Marco"],["dc.contributor.author","Samani, Nilesh J."],["dc.contributor.author","Ng, Leong L."],["dc.contributor.author","Voors, Adriaan A."],["dc.date.accessioned","2020-12-10T18:37:58Z"],["dc.date.available","2020-12-10T18:37:58Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1161/CIRCHEARTFAILURE.118.005544"],["dc.identifier.eissn","1941-3297"],["dc.identifier.issn","1941-3289"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77153"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Proenkephalin, an Opioid System Surrogate, as a Novel Comprehensive Renal Marker in Heart Failure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2128"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Journal of the American College of Cardiology"],["dc.bibliographiccitation.lastpage","2136"],["dc.bibliographiccitation.volume","70"],["dc.contributor.author","Bayes-Genis, Antoni"],["dc.contributor.author","Núñez, Julio"],["dc.contributor.author","Zannad, Faiez"],["dc.contributor.author","Ferreira, João Pedro"],["dc.contributor.author","Anker, Stefan D."],["dc.contributor.author","Cleland, John G."],["dc.contributor.author","Dickstein, Kenneth"],["dc.contributor.author","Filippatos, Gerasimos"],["dc.contributor.author","Lang, Chim C."],["dc.contributor.author","Ng, Leong L."],["dc.contributor.author","Ponikowski, Piotr"],["dc.contributor.author","Samani, Nilesh J."],["dc.contributor.author","van Veldhuisen, Dirk J."],["dc.contributor.author","Zwinderman, Aeilko H."],["dc.contributor.author","Metra, Marco"],["dc.contributor.author","Lupón, Josep"],["dc.contributor.author","Voors, Adriaan A."],["dc.date.accessioned","2020-12-10T14:24:44Z"],["dc.date.available","2020-12-10T14:24:44Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.jacc.2017.08.057"],["dc.identifier.issn","0735-1097"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72336"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The PCSK9-LDL Receptor Axis and Outcomes in Heart Failure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","627"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","634"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Voors, Adriaan A."],["dc.contributor.author","Ouwerkerk, Wouter"],["dc.contributor.author","Zannad, Faiez"],["dc.contributor.author","van Veldhuisen, Dirk J."],["dc.contributor.author","Samani, Nilesh J."],["dc.contributor.author","Ponikowski, Piotr"],["dc.contributor.author","Ng, Leong L."],["dc.contributor.author","Metra, Marco"],["dc.contributor.author","ter Maaten, Jozine M."],["dc.contributor.author","Lang, Chim C."],["dc.contributor.author","Hillege, Hans L."],["dc.contributor.author","van der Harst, Pim"],["dc.contributor.author","Filippatos, Gerasimos"],["dc.contributor.author","Dickstein, Kenneth"],["dc.contributor.author","Cleland, John G."],["dc.contributor.author","Anker, Stefan D."],["dc.contributor.author","Zwinderman, Aeilko H."],["dc.date.accessioned","2020-12-10T14:06:23Z"],["dc.date.available","2020-12-10T14:06:23Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1002/ejhf.785"],["dc.identifier.issn","1388-9842"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69873"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Development and validation of multivariable models to predict mortality and hospitalization in patients with heart failure"],["dc.title.alternative","Mortality and hospitalization models in heart failure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","877"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","886"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Suzuki, Toru"],["dc.contributor.author","Yazaki, Yoshiyuki"],["dc.contributor.author","Voors, Adriaan A."],["dc.contributor.author","Jones, Donald J.L."],["dc.contributor.author","Chan, Daniel C.S."],["dc.contributor.author","Anker, Stefan D."],["dc.contributor.author","Cleland, John G."],["dc.contributor.author","Dickstein, Kenneth"],["dc.contributor.author","Filippatos, Gerasimos"],["dc.contributor.author","Hillege, Hans L."],["dc.contributor.author","Lang, Chim C."],["dc.contributor.author","Ponikowski, Piotr"],["dc.contributor.author","Samani, Nilesh J."],["dc.contributor.author","van Veldhuisen, Dirk J."],["dc.contributor.author","Zannad, Faiez"],["dc.contributor.author","Zwinderman, Aeilko H."],["dc.contributor.author","Metra, Marco"],["dc.contributor.author","Ng, Leong L."],["dc.date.accessioned","2020-12-10T14:06:15Z"],["dc.date.available","2020-12-10T14:06:15Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/ejhf.1338"],["dc.identifier.eissn","1879-0844"],["dc.identifier.issn","1388-9842"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69832"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Association with outcomes and response to treatment of trimethylamine N‐oxide in heart failure: results from BIOSTAT‐CHF"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","923"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","930"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Beusekamp, Joost C."],["dc.contributor.author","Tromp, Jasper"],["dc.contributor.author","van der Wal, Haye H."],["dc.contributor.author","Anker, Stefan D."],["dc.contributor.author","Cleland, John G."],["dc.contributor.author","Dickstein, Kenneth"],["dc.contributor.author","Filippatos, Gerasimos"],["dc.contributor.author","van der Harst, Pim"],["dc.contributor.author","Hillege, Hans L."],["dc.contributor.author","Lang, Chim C."],["dc.contributor.author","Metra, Marco"],["dc.contributor.author","Ng, Leong L."],["dc.contributor.author","Ponikowski, Piotr"],["dc.contributor.author","Samani, Nilesh J."],["dc.contributor.author","van Veldhuisen, Dirk J."],["dc.contributor.author","Zwinderman, Aeilko H."],["dc.contributor.author","Rossignol, Patrick"],["dc.contributor.author","Zannad, Faiez"],["dc.contributor.author","Voors, Adriaan A."],["dc.contributor.author","van der Meer, Peter"],["dc.date.accessioned","2020-12-10T14:06:12Z"],["dc.date.available","2020-12-10T14:06:12Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1002/ejhf.1079"],["dc.identifier.issn","1388-9842"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69818"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Potassium and the use of renin-angiotensin-aldosterone system inhibitors in heart failure with reduced ejection fraction: data from BIOSTAT-CHF"],["dc.title.alternative","Potassium and RAAS inhibitors in HFrEF"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1147"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","1155"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Nauta, Jan F."],["dc.contributor.author","Hummel, Yoran M."],["dc.contributor.author","Tromp, Jasper"],["dc.contributor.author","Ouwerkerk, Wouter"],["dc.contributor.author","van der Meer, Peter"],["dc.contributor.author","Jin, Xuanyi"],["dc.contributor.author","Lam, Carolyn S.P."],["dc.contributor.author","Bax, Jeroen J."],["dc.contributor.author","Metra, Marco"],["dc.contributor.author","Samani, Nilesh J."],["dc.contributor.author","Ponikowski, Piotr"],["dc.contributor.author","Dickstein, Kenneth"],["dc.contributor.author","Anker, Stefan D."],["dc.contributor.author","Lang, Chim C."],["dc.contributor.author","Ng, Leong L."],["dc.contributor.author","Zannad, Faiez"],["dc.contributor.author","Filippatos, Gerasimos S."],["dc.contributor.author","van Veldhuisen, Dirk J."],["dc.contributor.author","van Melle, Joost P."],["dc.contributor.author","Voors, Adriaan A."],["dc.date.accessioned","2020-12-10T14:06:18Z"],["dc.date.available","2020-12-10T14:06:18Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/ejhf.1632"],["dc.identifier.eissn","1879-0844"],["dc.identifier.issn","1388-9842"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16849"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69848"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.lastpage","9"],["dc.contributor.author","Mordi, Ify R."],["dc.contributor.author","Santema, Bernadet T."],["dc.contributor.author","Kloosterman, Mariëlle"],["dc.contributor.author","Choy, Anna-Maria"],["dc.contributor.author","Rienstra, Michiel"],["dc.contributor.author","van Gelder, Isabelle"],["dc.contributor.author","Anker, Stefan D."],["dc.contributor.author","Cleland, John G."],["dc.contributor.author","Dickstein, Kenneth"],["dc.contributor.author","Filippatos, Gerasimos"],["dc.contributor.author","van der Harst, Pim"],["dc.contributor.author","Hillege, Hans L."],["dc.contributor.author","Metra, Marco"],["dc.contributor.author","Ng, Leong L."],["dc.contributor.author","Ouwerkerk, Wouter"],["dc.contributor.author","Ponikowski, Piotr"],["dc.contributor.author","Samani, Nilesh J."],["dc.contributor.author","van Veldhuisen, Dirk J."],["dc.contributor.author","Zwinderman, Aeilko H."],["dc.contributor.author","Zannad, Faiez"],["dc.contributor.author","Voors, Adriaan A."],["dc.contributor.author","Lang, Chim C."],["dc.date.accessioned","2019-07-09T11:51:01Z"],["dc.date.available","2019-07-09T11:51:01Z"],["dc.date.issued","2019"],["dc.description.abstract","BACKGROUND: In patients with heart failure with reduced ejection fraction (HFrEF) on sub-optimal doses of beta-blockers, it is conceivable that changes in heart rate following treatment intensification might be important regardless of underlying heart rhythm. We aimed to compare the prognostic significance of both achieved heart rate and change in heart rate following beta-blocker uptitration in patients with HFrEF either in sinus rhythm (SR) or atrial fibrillation (AF). METHODS: We performed a post hoc analysis of the BIOSTAT-CHF study. We evaluated 1548 patients with HFrEF (mean age 67 years, 35% AF). Median follow-up was 21 months. Patients were evaluated at baseline and at 9 months. The combined primary outcome was all-cause mortality and heart failure hospitalisation stratified by heart rhythm and heart rate at baseline. RESULTS: Despite similar changes in heart rate and beta-blocker dose, a decrease in heart rate at 9 months was associated with reduced incidence of the primary outcome in both SR and AF patients [HR per 10 bpm decrease-SR: 0.83 (0.75-0.91), p < 0.001; AF: 0.89 (0.81-0.98), p = 0.018], whereas the relationship was less strong for achieved heart rate in AF [HR per 10 bpm higher-SR: 1.26 (1.10-1.46), p = 0.001; AF: 1.08 (0.94-1.23), p = 0.18]. Achieved heart rate at 9 months was only prognostically significant in AF patients with high baseline heart rates (p for interaction 0.017 vs. low). CONCLUSIONS: Following beta-blocker uptitration, both achieved and change in heart rate were prognostically significant regardless of starting heart rate in SR, however, they were only significant in AF patients with high baseline heart rate."],["dc.identifier.doi","10.1007/s00392-018-1409-x"],["dc.identifier.pmid","30610382"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16029"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59857"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/242209/EU//BIOSTAT-CHF"],["dc.relation.issn","1861-0692"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2102"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","2111"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Hoes, Martijn F."],["dc.contributor.author","Tromp, Jasper"],["dc.contributor.author","Ouwerkerk, Wouter"],["dc.contributor.author","Bomer, Nils"],["dc.contributor.author","Oberdorf‐Maass, Silke U."],["dc.contributor.author","Samani, Nilesh J."],["dc.contributor.author","Ng, Leong L."],["dc.contributor.author","Lang, Chim C."],["dc.contributor.author","van der Harst, Pim"],["dc.contributor.author","Hillege, Hans"],["dc.contributor.author","Anker, Stefan D."],["dc.contributor.author","Metra, Marco"],["dc.contributor.author","van Veldhuisen, Dirk J."],["dc.contributor.author","Voors, Adriaan A."],["dc.contributor.author","van der Meer, Peter"],["dc.date.accessioned","2019-12-16T11:32:41Z"],["dc.date.accessioned","2021-10-27T13:21:56Z"],["dc.date.available","2019-12-16T11:32:41Z"],["dc.date.available","2021-10-27T13:21:56Z"],["dc.date.issued","2019"],["dc.description.abstract","AIMS: Cathepsin D is a ubiquitous lysosomal protease that is primarily secreted due to oxidative stress. The role of circulating cathepsin D in heart failure (HF) is unknown. The aim of this study is to determine the association between circulating cathepsin D levels and clinical outcomes in patients with HF and to investigate the biological settings that induce the release of cathepsin D in HF. METHODS AND RESULTS: Cathepsin D levels were studied in 2174 patients with HF from the BIOSTAT-CHF index study. Results were validated in 1700 HF patients from the BIOSTAT-CHF validation cohort. The primary combined outcome was all-cause mortality and/or HF hospitalizations. Human pluripotent stem cell-derived cardiomyocytes were subjected to hypoxic, pro-inflammatory signalling and stretch conditions. Additionally, cathepsin D expression was inhibited by targeted short hairpin RNAs (shRNA). Higher levels of cathepsin D were independently associated with diabetes mellitus, renal failure and higher levels of interleukin-6 and N-terminal pro-B-type natriuretic peptide (P < 0.001 for all). Cathepsin D levels were independently associated with the primary combined outcome [hazard ratio (HR) per standard deviation (SD): 1.12; 95% confidence interval (CI) 1.02-1.23], which was validated in an independent cohort (HR per SD: 1.23, 95% CI 1.09-1.40). In vitro experiments demonstrated that human stem cell-derived cardiomyocytes released cathepsin D and troponin T in response to mechanical stretch. ShRNA-mediated silencing of cathepsin D resulted in increased necrosis, abrogated autophagy, increased stress-induced metabolism, and increased release of troponin T from human stem cell-derived cardiomyocytes under stress. CONCLUSIONS: Circulating cathepsin D levels are associated with HF severity and poorer outcome, and reduced levels of cathepsin D may have detrimental effects with therapeutic potential in"],["dc.identifier.doi","10.1002/ejhf.1674"],["dc.identifier.eissn","1879-0844"],["dc.identifier.issn","1388-9842"],["dc.identifier.pmid","31797504"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16943"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92055"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.eissn","1879-0844"],["dc.relation.issn","1879-0844"],["dc.relation.issn","1388-9842"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.subject.ddc","610"],["dc.title","The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","260"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","267"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Emmens, Johanna Elisabeth"],["dc.contributor.author","Jones, Donald J.L."],["dc.contributor.author","Cao, Thong H."],["dc.contributor.author","Chan, Daniel C.S."],["dc.contributor.author","Romaine, Simon P.R."],["dc.contributor.author","Quinn, Paulene A."],["dc.contributor.author","Anker, Stefan D."],["dc.contributor.author","Cleland, John G."],["dc.contributor.author","Dickstein, Kenneth"],["dc.contributor.author","Filippatos, Gerasimos"],["dc.contributor.author","Hillege, Hans L."],["dc.contributor.author","Lang, Chim C."],["dc.contributor.author","Ponikowski, Piotr"],["dc.contributor.author","Samani, Nilesh J."],["dc.contributor.author","van Veldhuisen, Dirk J."],["dc.contributor.author","Zannad, Faiz"],["dc.contributor.author","Zwinderman, Aeilko H."],["dc.contributor.author","Metra, Marco"],["dc.contributor.author","de Boer, Rudolf A."],["dc.contributor.author","Voors, Adriaan A."],["dc.contributor.author","Ng, Leong L."],["dc.date.accessioned","2020-12-10T14:06:13Z"],["dc.date.available","2020-12-10T14:06:13Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1002/ejhf.1101"],["dc.identifier.issn","1388-9842"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69821"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Proteomic diversity of high-density lipoprotein explains its association with clinical outcome in patients with heart failure"],["dc.title.alternative","HDL proteomic diversity and clinical outcome in HF"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1291"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","1294"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Yazaki, Yoshiyuki"],["dc.contributor.author","Salzano, Andrea"],["dc.contributor.author","Nelson, Christopher P."],["dc.contributor.author","Voors, Adriaan A."],["dc.contributor.author","Anker, Stefan D."],["dc.contributor.author","Cleland, John G."],["dc.contributor.author","Lang, Chim C."],["dc.contributor.author","Metra, Marco"],["dc.contributor.author","Samani, Nilesh J."],["dc.contributor.author","Ng, Leong L."],["dc.contributor.author","Suzuki, Toru"],["dc.date.accessioned","2020-12-10T14:06:18Z"],["dc.date.available","2020-12-10T14:06:18Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/ejhf.v21.10"],["dc.identifier.eissn","1879-0844"],["dc.identifier.issn","1388-9842"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69846"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Geographical location affects the levels and association of trimethylamine N‐oxide with heart failure mortality in BIOSTAT‐CHF: a post‐hoc analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]