Czerny, Claus-Peter

[["dc.bibliographiccitation.journal","Frontiers in Veterinary Science"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Roller, Marco"],["dc.contributor.author","Hansen, Sören"],["dc.contributor.author","Knauf-Witzens, Tobias"],["dc.contributor.author","Oelemann, Walter M. R."],["dc.contributor.author","Czerny, Claus-Peter"],["dc.contributor.author","Abd El Wahed, Ahmed"],["dc.contributor.author","Goethe, Ralph"],["dc.date.accessioned","2021-04-14T08:30:11Z"],["dc.date.available","2021-04-14T08:30:11Z"],["dc.date.issued","2020"],["dc.description.abstract","Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of paratuberculosis (ParaTB or Johne's disease), a contagious, chronic and typically fatal enteric disease of domestic and non-domestic ruminants. Clinically affected animals present wasting and emaciation. However, MAP can also infect non-ruminant animal species with less specific signs. Zoological gardens harbor various populations of diverse animal species, which are managed on limited space at higher than natural densities. Hence, they are predisposed to endemic trans-species pathogen distribution. Information about the incidence and prevalence of MAP infections in zoological gardens and the resulting potential threat to exotic and endangered species are rare. Due to unclear pathogenesis, chronicity of disease as well as the unknown cross-species accuracy of diagnostic tests, diagnosis and surveillance of MAP and ParaTB is challenging. Differentiation between uninfected shedders of ingested bacteria; subclinically infected individuals; and preclinically diseased animals, which may subsequently develop clinical signs after long incubation periods, is crucial for the interpretation of positive test results in animals and the resulting consequences in their management. This review summarizes published data from the current literature on occurrence of MAP infection and disease in susceptible and affected zoo animal species as well as the applied diagnostic methods and measures. Clinical signs indicative for ParaTB, pathological findings and reports on detection, transmission and epidemiology in zoo animals are included. Furthermore, case reports were re-evaluated for incorporation into accepted consistent terminologies and case definitions."],["dc.identifier.doi","10.3389/fvets.2020.572724"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83135"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","2297-1769"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Mycobacterium avium Subspecies paratuberculosis Infection in Zoo Animals: A Review of Susceptibility and Disease Process"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","493"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Viruses"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Ahsendorf, Henrike"],["dc.contributor.author","Gan, Li"],["dc.contributor.author","Eltom, Kamal"],["dc.contributor.author","Abd El Wahed, Ahmed"],["dc.contributor.author","Hotop, Sven-Kevin"],["dc.contributor.author","Roper, Rachel"],["dc.contributor.author","Beutling, Ulrike"],["dc.contributor.author","Broenstrup, Mark"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Hoelzle, Ludwig"],["dc.contributor.author","Czerny, Claus-Peter"],["dc.date.accessioned","2019-07-09T11:51:50Z"],["dc.date.available","2019-07-09T11:51:50Z"],["dc.date.issued","2019"],["dc.description.abstract","The vaccinia virus (VACV) A27 protein and its homologs, which are found in a large number of members of the genus Orthopoxvirus (OPXV), are targets of viral neutralization by host antibodies. We have mapped six binding sites (epitopes #1A: aa 32-39, #1B: aa 28-33, #1C: aa 26-31, #1D: 28-34, #4: aa 9-14, and #5: aa 68-71) of A27 specific monoclonal antibodies (mAbs) using peptide arrays. MAbs recognizing epitopes #1A-D and #4 neutralized VACV Elstree in a complement dependent way (50% plaque-reduction: 12.5-200 µg/mL). Fusion of VACV at low pH was blocked through inhibition of epitope #1A. To determine the sequence variability of the six antigenic sites, 391 sequences of A27 protein homologs available were compared. Epitopes #4 and #5 were conserved among most of the OPXVs, while the sequential epitope complex #1A-D was more variable and, therefore, responsible for species-specific epitope characteristics. The accurate and reliable mapping of defined epitopes on immuno-protective proteins such as the A27 of VACV enables phylogenetic studies and insights into OPXV evolution as well as to pave the way to the development of safer vaccines and chemical or biological antivirals."],["dc.identifier.doi","10.3390/v11060493"],["dc.identifier.pmid","31146446"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16205"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60022"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","630"],["dc.title","Species-Specific Conservation of Linear Antigenic Sites on Vaccinia Virus A27 Protein Homologs of Orthopoxviruses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1007"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Microorganisms"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Okuni, Julius Boniface"],["dc.contributor.author","Hansen, Sören"],["dc.contributor.author","Eltom, Kamal H."],["dc.contributor.author","Eltayeb, ElSagad"],["dc.contributor.author","Amanzada, Ahmad"],["dc.contributor.author","Omega, Joseph Amesa"],["dc.contributor.author","Czerny, Claus Peter"],["dc.contributor.author","Abd El Wahed, Ahmed"],["dc.contributor.author","Ojok, Lonzy"],["dc.date.accessioned","2021-04-14T08:25:03Z"],["dc.date.available","2021-04-14T08:25:03Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3390/microorganisms8071007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81506"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2076-2607"],["dc.title","Paratuberculosis: A Potential Zoonosis and a Neglected Disease in Africa"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","23"],["dc.bibliographiccitation.journal","Journal of Clinical Virology"],["dc.bibliographiccitation.lastpage","27"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Hansen, Sören"],["dc.contributor.author","Faye, Oumar"],["dc.contributor.author","Sanabani, Sabri S."],["dc.contributor.author","Faye, Martin"],["dc.contributor.author","Böhlken-Fascher, Susanne"],["dc.contributor.author","Faye, Ousmane"],["dc.contributor.author","Sall, Amadou A."],["dc.contributor.author","Bekaert, Michaël"],["dc.contributor.author","Weidmann, Manfred"],["dc.contributor.author","Czerny, Claus-Peter"],["dc.contributor.author","Abd El Wahed, Ahmed"],["dc.date.accessioned","2020-12-10T14:25:03Z"],["dc.date.available","2020-12-10T14:25:03Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.jcv.2018.07.001"],["dc.identifier.issn","1386-6532"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72419"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Combination random isothermal amplification and nanopore sequencing for rapid identification of the causative agent of an outbreak"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","117"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Veterinary Sciences"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Roller, Marco"],["dc.contributor.author","Hansen, Sören"],["dc.contributor.author","Böhlken-Fascher, Susanne"],["dc.contributor.author","Knauf-Witzens, Tobias"],["dc.contributor.author","Czerny, Claus-Peter"],["dc.contributor.author","Goethe, Ralph"],["dc.contributor.author","Abd El Wahed, Ahmed"],["dc.date.accessioned","2021-04-14T08:32:27Z"],["dc.date.available","2021-04-14T08:32:27Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3390/vetsci7030117"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17560"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83927"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","2306-7381"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Molecular and Serological Footprints of Mycobacterium avium Subspecies Infections in Zoo Animals"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","676"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Pathogens"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Eltom, Kamal"],["dc.contributor.author","Samy, Abdallah"],["dc.contributor.author","Abd El Wahed, Ahmed"],["dc.contributor.author","Czerny, Claus-Peter"],["dc.date.accessioned","2021-04-14T08:32:30Z"],["dc.date.available","2021-04-14T08:32:30Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3390/pathogens9090676"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17542"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83939"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","2076-0817"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Buffalopox Virus: An Emerging Virus in Livestock and Humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","50"],["dc.bibliographiccitation.journal","Journal of Virological Methods"],["dc.bibliographiccitation.lastpage","53"],["dc.bibliographiccitation.volume","263"],["dc.contributor.author","Hansen, Sören"],["dc.contributor.author","Dill, Veronika"],["dc.contributor.author","Shalaby, Mohamed A."],["dc.contributor.author","Eschbaumer, Michael"],["dc.contributor.author","Böhlken-Fascher, Susanne"],["dc.contributor.author","Hoffmann, Bernd"],["dc.contributor.author","Czerny, Claus-Peter"],["dc.contributor.author","Abd El Wahed, Ahmed"],["dc.date.accessioned","2020-12-10T15:20:09Z"],["dc.date.available","2020-12-10T15:20:09Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.jviromet.2018.10.020"],["dc.identifier.issn","0166-0934"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72571"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Serotyping of foot-and-mouth disease virus using oxford nanopore sequencing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","244"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Veterinary Research"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Shalaby, Mohamed A."],["dc.contributor.author","El-Deeb, Ayman"],["dc.contributor.author","El-Tholoth, Mohamed"],["dc.contributor.author","Hoffmann, Donata"],["dc.contributor.author","Czerny, Claus-Peter"],["dc.contributor.author","Hufert, Frank T."],["dc.contributor.author","Weidmann, Manfred"],["dc.contributor.author","Abd El Wahed, Ahmed"],["dc.date.accessioned","2019-07-09T11:42:52Z"],["dc.date.available","2019-07-09T11:42:52Z"],["dc.date.issued","2016"],["dc.description.abstract","Abstract Background Lumpy skin disease virus (LSDV) is a Capripoxvirus infecting cattle and Buffalos. Lumpy skin disease (LSD) leads to significant economic losses due to hide damage, reduction of milk production, mastitis, infertility and mortalities (10 %). Early detection of the virus is crucial to start appropriate outbreak control measures. Veterinarians rely on the presence of the characteristic clinical signs of LSD. Laboratory diagnostics including virus isolation, sequencing and real-time polymerase chain reaction (PCR) are performed at well-equipped laboratories. In this study, a portable, simple, and rapid recombinase polymerase amplification (RPA) assay for the detection of LSDV-genome for the use on farms was developed. Results The LSDV RPA assay was performed at 42 °C and detected down to 179 DNA copies/reaction in a maximum of 15 min. Unspecific amplification was observed with neither LSDV-negative samples (n = 12) nor nucleic acid preparations from orf virus, bovine papular stomatitis virus, cowpoxvirus, Peste des petits ruminants and Blue tongue virus (serotypes 1, 6 and 8). The clinical sensitivity of the LSDV RPA assay matched 100 % (n = 22) to real-time PCR results. In addition, the LSDV RPA assay detected sheep and goat poxviruses. Conclusion The LSDV RPA assay is a rapid and sensitive test that could be implemented in field or at quarantine stations for the identification of LSDV infected case."],["dc.identifier.doi","10.1186/s12917-016-0875-5"],["dc.identifier.pmid","27806722"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13902"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58768"],["dc.language.iso","en"],["dc.rights.access","openAccess"],["dc.rights.holder","The Author(s)."],["dc.title","Recombinase polymerase amplification assay for rapid detection of lumpy skin disease virus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","123"],["dc.bibliographiccitation.lastpage","136"],["dc.bibliographiccitation.seriesnr","2142"],["dc.contributor.author","Hansen, Sören"],["dc.contributor.author","Faye, Oumar"],["dc.contributor.author","Sanabani, Sabri S."],["dc.contributor.author","Faye, Martin"],["dc.contributor.author","Böhlken-Fascher, Susanne"],["dc.contributor.author","Faye, Ousmane"],["dc.contributor.author","Sall, Amadou Alpha"],["dc.contributor.author","Bekaert, Michaël"],["dc.contributor.author","Weidmann, Manfred"],["dc.contributor.author","Czerny, Claus-Peter"],["dc.contributor.author","Abd El Wahed, Ahmed"],["dc.contributor.editor","Kobinger, Gary"],["dc.contributor.editor","Racine, Trina"],["dc.date.accessioned","2021-06-02T10:44:21Z"],["dc.date.available","2021-06-02T10:44:21Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/978-1-0716-0581-3_11"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87005"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Springer US"],["dc.publisher.place","New York, NY"],["dc.relation.crisseries","Methods in Molecular Biology"],["dc.relation.eisbn","978-1-0716-0581-3"],["dc.relation.isbn","978-1-0716-0580-6"],["dc.relation.ispartof","Methods in Molecular Biology"],["dc.relation.ispartof","Zika Virus : Methods and Protocols"],["dc.relation.ispartofseries","Methods in Molecular Biology; 2142"],["dc.title","Zika Virus Amplification Using Strand Displacement Isothermal Method and Sequencing Using Nanopore Technology"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","3648"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Hansen, Sören"],["dc.contributor.author","Hotop, Sven-Kevin"],["dc.contributor.author","Faye, Oumar"],["dc.contributor.author","Ndiaye, Oumar"],["dc.contributor.author","Böhlken-Fascher, Susanne"],["dc.contributor.author","Pessôa, Rodrigo"],["dc.contributor.author","Hufert, Frank"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Frank, Ronald"],["dc.contributor.author","Czerny, Claus-Peter"],["dc.contributor.author","Schmidt-Chanasit, Jonas"],["dc.contributor.author","Sanabani, Sabri S."],["dc.contributor.author","Sall, Amadou A."],["dc.contributor.author","Niedrig, Matthias"],["dc.contributor.author","Brönstrup, Mark"],["dc.contributor.author","Fritz, Hans-Joachim"],["dc.contributor.author","Abd El Wahed, Ahmed"],["dc.date.accessioned","2019-07-09T11:50:13Z"],["dc.date.available","2019-07-09T11:50:13Z"],["dc.date.issued","2019"],["dc.description.abstract","Zika virus (ZIKV) is a mosquito-borne flavivirus. Homologous proteins of different flaviviruses display high degrees of sequence identity, especially within subgroups. This leads to extensive immunological cross-reactivity and corresponding problems for developing a ZIKV-specific serological assay. In this study, peptide microarrays were employed to identify individual ZIKV antibody targets with promise in differential diagnosis. A total of 1643 overlapping oligopeptides were synthesized and printed onto glass slides. Together, they encompass the full amino acid sequences of ZIKV proteomes of African, Brazilian, USA, and French Polynesian origins. The resulting ZIKV scanning microarray chips were used to screen three pools of sera from recent Zika outbreaks in Senegal and Cape Verde, in Brazil, and from overseas travelers returning to the EU. Together with a mixed pool of well characterized, archived sera of patients suffering from infections by dengue, yellow fever, tick-borne encephalitis, and West Nile viruses, a total of 42 sera went into the study. Sixty-eight antibody target regions were identified. Most of which were hitherto unknown. Alignments and sequence comparisons revealed 13 of which could be classified as bona fide ZIKV-specific. These identified antibody target regions constitute a founding set of analytical tools for serological discrimination of ZIKV from other flaviviruses."],["dc.identifier.doi","10.1038/s41598-019-40224-2"],["dc.identifier.pmid","30842564"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15882"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59723"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","630"],["dc.title","Diagnosing Zika virus infection against a background of other flaviviruses: Studies in high resolution serological analysis."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]