Gruber, Rudolf Matthias

[["dc.bibliographiccitation.artnumber","189"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Molecular and Clinical Oncology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Hoene, Georg"],["dc.contributor.author","Gruber, Rudolf"],["dc.contributor.author","Leonhard, Johanna"],["dc.contributor.author","Wiechens, Bernhard"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.date.accessioned","2021-08-12T07:46:07Z"],["dc.date.available","2021-08-12T07:46:07Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.3892/mco.2021.2351"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88623"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","2049-9469"],["dc.relation.issn","2049-9450"],["dc.title","Combined quality of life and posttraumatic growth evaluation during follow‑up care of patients suffering from oral squamous cell carcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","ONS411"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Neurosurgery"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Schaller, Bernhard J."],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.contributor.author","Merten, Hans-Albert"],["dc.contributor.author","Kruschat, Thomas"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Buchfelder, Michael"],["dc.contributor.author","Ludwig, H.-C."],["dc.date.accessioned","2018-11-07T10:55:32Z"],["dc.date.available","2018-11-07T10:55:32Z"],["dc.date.issued","2005"],["dc.description.abstract","OBJECTIVE: Piezoelectric surgery represents an innovative, ultrasonic surgery technique for performing a safe and effective osteotomy or osteoplasty that contrasts with the traditional hard and soft tissue management methods with rotating instruments. METHODS: Because of its physical and mechanical properties, the definitive clinical advantage of piezoelectric bone surgery with regard to precision cutting lies in the sparing of vital neurovascular bundles or general soft tissue and better visualization of the surgical field, thus suggesting its great safety. Piezoelectric bone surgery has been previously described only in oral and maxillofacial operative procedures in adults. RESULTS: Five children between the age of 6 and 84 months were operated on for craniosynostosis, tethered cord, and an extraconal intraorbital tumor. The usefulness of piezoelectric bone surgery during neurosurgical procedures is presented for these cases. This technique is especially recommended when there are anatomic difficulties because of poor intraoperative visibility or the presence of delicate anatomic structures. CONCLUSION: The present preliminary report (comprising illustrative case reports) demonstrates and introduces for the first time the utility of piezoelectric bone surgery in cranial base and spinal surgery in children. Until now, there has been no documented neurosurgical experience of this technique even in adults."],["dc.identifier.doi","10.1227/01.NEU.0000176700.77461.C9"],["dc.identifier.isi","000208209000069"],["dc.identifier.pmid","16234663"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49806"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0148-396X"],["dc.title","PIEZOELECTRIC BONE SURGERY: A REVOLUTIONARY TECHNIQUE FOR MINIMALLY INVASIVE SURGERY IN CRANIAL BASE AND SPINAL SURGERY? TECHNICAL NOTE"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","580"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Craniofacial Surgery"],["dc.bibliographiccitation.lastpage","587"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Kramer, Franz-Josef"],["dc.contributor.author","Gruber, Rudolf"],["dc.contributor.author","Fialka, Florian"],["dc.contributor.author","Sinikovic, Branko"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-11-07T11:15:37Z"],["dc.date.available","2018-11-07T11:15:37Z"],["dc.date.issued","2008"],["dc.description.abstract","Children with orofacial clefts (OFC) at preschool ages may have to tolerate psychosocial disadvantages due to their altered speech and facial appearance probably affecting their quality of life (QoL) and family functioning. In 147 children with OFC aged between 5 and 6 years and their families, the QoL and family functioning were analyzed using the KINDL questionnaire for measuring health-related QoL in children and impact on family scale. The KINDL scores were lowest in the dimension self-esteem. In all dimensions, the KINDL scores of children were higher than those of the parents suggesting a superior QoL than the care-givers estimated (P < 0.001). In affected families, the impact on family scale dimensions personal impact and impact on coping strategies were found highest. Families having children with isolated cleft lip or cleft lip and palate had higher impacts on coping strategies when compared with children having isolated cleft palate (P < 0.041). The impact for siblings (P < 0.02) was found highest in patients with cleft lip and palate. In all examined dimensions, children with OFC perceived a higher QoL than their caregivers expected. However, self-esteem seems to be problematic in all types of OFC and in both genders. Knowledge of potential impacts related to the type of cleft and the gender of the patient will probably facilitate health care professionals to identify children and families at high risk to experience a reduced QoL and may help to offer specific support and treatment strategies."],["dc.identifier.doi","10.1097/SCS.0b013e31816aaa43"],["dc.identifier.isi","000256245100005"],["dc.identifier.pmid","18520368"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54405"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1049-2275"],["dc.title","Quality of life and family functioning in children with nonsyndromic orofacial clefts at preschool ages"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","455"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Biomedical Materials Research Part A"],["dc.bibliographiccitation.lastpage","462"],["dc.bibliographiccitation.volume","83A"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Weich, Herbert A."],["dc.contributor.author","Schulz, J."],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.date.accessioned","2018-11-07T10:57:09Z"],["dc.date.available","2018-11-07T10:57:09Z"],["dc.date.issued","2007"],["dc.description.abstract","The aim of the present report was to test a system for controlled release of recombinant human bone morphogenic protein (rhBMP2) incorporated into polylactic acid (PLA) implants. Incorporation of rhBMP2 into the polymer was accomplished by mixing rhBMP2 solution with granular powder of amorphous poly-DL-lactic acid, subsequent lyophilization, and high pressure CO2 treatment at 100 bar. Porous cylindrical implants of 8 mm diameter and 3 mm thickness were fabricated with 100, 200, 400, and 800 mu g BMP2/g polymer and submitted to in vitro testing. Polymer degradation was assessed during immersion of PLA implants into PBS for 176 days by measuring the inherent viscosity at days 0, 99, and 131. BMP2 release was evaluated by immersion of both the lyophilized powder and the implants into cell culture medium for up to 27 days. BMP2 release was assessed using a custom made ELISA. The biological activity of the released growth factor was determined by measuring the induction of alkaline phosphatase (AP) in C2C12 cells. There was a significant retardation in the release of BMP2 from the implants compared to the granular powder. Detectable amounts of BMP2 were found for all concentrations of BMP2 until the end of the observation period. Significant induction of AP was detected by BMP released from the implants after 3, 6, and 9 days. The present in-vitro study has shown that incorporation of rhBMP2 into PLA implants with subsequent slow release of biologically active growth factor is possible. (c) 2007 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/jbm.a.31227"],["dc.identifier.isi","000249989300023"],["dc.identifier.pmid","17477390"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50177"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","1549-3296"],["dc.title","In vitro characterization of a slow release system of polylactic acid and rhBMP2"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1095"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Cranio-Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","1103"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Krohn, Sebastian"],["dc.contributor.author","Thiemann, Charlotte"],["dc.contributor.author","Schulz, Xenia"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Schlottig, Falk"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.date.accessioned","2018-11-07T10:11:07Z"],["dc.date.available","2018-11-07T10:11:07Z"],["dc.date.issued","2016"],["dc.description.abstract","The present study aimed to evaluate primary stability (PS) and osseointegration of dental implants in polylactide [70/30 poly(L-lactide-co-o, L-lactide); (PLDLA)1 modified bone in 30 Goettingen minipigs. Each animal received three implants per jaw quadrant. In a split -mouth design, one side of the maxilla and mandible was randomly allocated to the experimental treatment (PLDLA applied into the drill hole before implantation), while the contralateral sides served as intraindividual controls (no PLDLA applied). The required insertion torque and the implant stability quotient (ISQ) were measured during implantation. ISQ volume density (VD) of new bone formation (NBF), and the bone -implant contact (BIC) were evaluated at the end of the observation period (1, 3, 6, 12, and 24 months, respectively) in six animals each. Across all study groups, the PLDLA treatment resulted in a) a comparable insertion torque, b) an equivalent ISQ c) a reduced BIC, and d) a reduced VD of NBF, as opposed to the untreated controls. In conclusion, the PLDLA treatment did not affect the PS, but rather led to an impaired osseointegration, which was particularly strong in the compact mandibular bone, and decreased in the spongious maxillary bone. PLDLA induced anchoring in spongious bone should be evaluated in further investigations. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","Thommen Medical AG, Grenchen, Switzerland"],["dc.identifier.doi","10.1016/j.jcms.2016.05.025"],["dc.identifier.isi","000381322200029"],["dc.identifier.pmid","27346283"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39987"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Churchill Livingstone"],["dc.relation.issn","1878-4119"],["dc.relation.issn","1010-5182"],["dc.title","Primary stability and osseointegration of dental implants in polylactide modified bone - A pilot study in Goettingen minipigs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","175"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Clinical Oral Implants Research"],["dc.bibliographiccitation.lastpage","182"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.contributor.author","Ludwig, Arwed"],["dc.contributor.author","Merten, Hans-Albert"],["dc.contributor.author","Pippig, Susanne"],["dc.contributor.author","Kramer, Franz-Josef"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-11-07T08:32:56Z"],["dc.date.available","2018-11-07T08:32:56Z"],["dc.date.issued","2009"],["dc.description.abstract","The aim of this study was to test the hypothesis that recombinant human growth and differentiation factor-5 (rhGDF-5) in combination with a beta-tricalcium phosphate (beta-TCP) scaffold material results in superior bone formation in sinus floor augmentations in miniature pigs compared with a particulated autogenous bone graft combined with the scaffold material. Six adult female Goettingen minipigs underwent a maxillary sinus floor augmentation procedure. In a split-mouth design, the sinus floors were augmented with beta-TCP mixed with autogenous cortical bone chips, in a ratio of approximately 1 : 1, on one side. The contralateral test site was augmented using beta-TCP coated with two concentrations of rhGDF-5 (400 mu g rhGDF-5/g beta-TCP or 800 mu g rhGDF-5/g beta-TCP; three animals in each case). Simultaneously, one dental implant was inserted into each sinus floor augmentation. After 12 weeks, a histological and histomorphometric assessment of non-decalcified histological specimens was made. There were significantly higher mean values of volume density of newly formed bone using beta-TCP coated with two concentrations of rhGDF-5 (400 mu g: 32.9%; 800 mu g: 23.9%) than with the corresponding control (autogenous bone/beta-TCP) (14.6%, 12.9%) (P=0.012, P=0.049). The bone-to-implant contact rates (BIC) were significantly enhanced in test sites (400 mu g: 84.2%; 800 mu g: 69.8%) compared with the corresponding control sites (24.8%, 40.8%) (P=.027, P=.045). rhGDF-5 delivered on beta-TCP significantly enhanced bone formation compared with beta-TCP combined with autogenous bone in sinus lift procedures in miniature pigs. To cite this article:Gruber RM, Ludwig A, Merten H-A, Pippig S, Kramer F-J, Schliephake H. Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a pilot study in the Goettingen miniature pig comparing autogenous bone and rhGDF-5. Clin. Oral Impl. Res. 20, 2009; 175-182.doi: 10.1111/j.1600-0501.2008.01628.x."],["dc.description.sponsorship","Scil Technology GmbH"],["dc.identifier.doi","10.1111/j.1600-0501.2008.01628.x"],["dc.identifier.isi","000262509500010"],["dc.identifier.pmid","19077151"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17452"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","0905-7161"],["dc.title","Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a pilot study in the Goettingen miniature pig comparing autogenous bone and rhGDF-5"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","103"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Biomaterials"],["dc.bibliographiccitation.lastpage","110"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Weich, Herbert A."],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Gruber, Rudolf"],["dc.contributor.author","Frahse, Sarah"],["dc.date.accessioned","2018-11-07T11:19:34Z"],["dc.date.available","2018-11-07T11:19:34Z"],["dc.date.issued","2008"],["dc.description.abstract","The aim of the present study was to test the hypothesis that human recombinant bone morphogenic protein 2 (rhBMP-2) implanted in a slow release carrier of polylactic acid (PLA) can repair a non-healing defect in the rat mandible and maintain the thickness of an augmented volume. P-DL-lactic acid discs were produced and loaded with 48 and 96 mu g rhBMP-2 and inserted into non-healing defects of the mandible of 45 wistar rats. Fifteen rats received implants with 96 mu g rhBMP-2 (Group 2), 48 mu g rhBMP-2 (Group 1) and blank implants without BMP (Group 0) each on one side of the mandible. Unfilled defects of the same size on the contralateral sides of the mandibles served as empty controls. After 6, 13 and 26 weeks, implants of each group were retrieved from five animals each and submitted to flat panel detector computed tomography, Bone formation and thickness of augmentation was assessed by computer-assisted histomorphometry. In Group 2 significantly more bone was produced than in Group 1. Implants of Group I induced significantly more bone than the blank controls only after 6 weeks, whereas the difference was not significant after 13 and 26 weeks. Differences between Group 2 and Group I were clearly significant after 26 weeks. The thickness of bone tissue was maintained in Group 2 whereas it decreased in Group I and was negligible in Group 0. It is concluded that the PLA implants with 96 mu g rhBMP-2 were able to bridge a non-healing defect in the rat mandible and maintained the thickness of an augmented volume. However, continuous supply of osteogenic signals appears to be required to compensate for adverse effects during polymer degradation. (c) 2007 Published by Elsevier Ltd."],["dc.identifier.doi","10.1016/j.biomaterials.2007.09.019"],["dc.identifier.isi","000251210600011"],["dc.identifier.pmid","17936352"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6198"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55313"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","0142-9612"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid - An experimental study in rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1618"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery"],["dc.bibliographiccitation.lastpage","1629"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Gruber, Rudolph"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Rau, Anna"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-06-25T07:48:54Z"],["dc.date.available","2018-06-25T07:48:54Z"],["dc.date.issued","2016-10"],["dc.description.abstract","To evaluate the efficacy of grafting materials in lateral and vertical ridge augmentations."],["dc.identifier.doi","10.1016/j.jcms.2016.07.028"],["dc.identifier.pmid","27622971"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15135"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1878-4119"],["dc.title","Clinical efficacy of grafting materials in alveolar ridge augmentation: A systematic review"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","522"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Clinical Oral Implants Research"],["dc.bibliographiccitation.lastpage","529"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.contributor.author","Ludwig, Arwed"],["dc.contributor.author","Merten, Hans-Albert"],["dc.contributor.author","Achilles, Mirjam"],["dc.contributor.author","Poehling, Sylke"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-11-07T11:15:25Z"],["dc.date.available","2018-11-07T11:15:25Z"],["dc.date.issued","2008"],["dc.description.abstract","Aim: The aim of this study was to test the hypothesis that recombinant human growth and differentiation factor-5 (rhGDF-5) enhances bone formation in sinus floor augmentations in miniature pigs. Material and methods: The maxillary sinus floors in 12 adult female Goettingen minipigs were augmented with beta-tricalcium phosphate (beta-TCP) on one side. The contralateral test side was augmented using two concentrations of rhGDF-5 (400 mu g rhGDF-5/g beta-TCP; 800 mu g rhGDF-5/g beta-TCP) delivered on beta-TCP (six animals each). One dental implant was inserted into each sinus floor augmentation. After 4 and 12 weeks, histological and histomorphometric assessment of non-decalcified histological specimens was performed. Results: The results showed significantly higher mean values of volume density (VD) of newly formed bone using the concentration of 400 mu g/g beta-TCP (22.8%) compared with the respective control (8%) after 4 weeks (P=0.05). The bone-to-implant contact rates were also significantly enhanced after 4 weeks between test sites (400 mu g: 41.9%; 800 mu g: 40.6%) and control sites (400 mu g: 7.8%; 800 mu g: 16.4%) (400 mu g: P=0.024; 800 mu g: P=0.048). Conclusion: It is concluded that rhGDF-5 delivered on beta-TCP significantly enhanced early bone formation compared with beta-TCP alone in sinus lift procedures in miniature pigs."],["dc.identifier.doi","10.1111/j.1600-0501.2007.01494.x"],["dc.identifier.isi","000254989200014"],["dc.identifier.pmid","18371105"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54360"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0905-7161"],["dc.title","Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a histological and histomorphometric study in the Goettingen miniature pig"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","68"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neurosurgery. Pediatrics"],["dc.bibliographiccitation.lastpage","71"],["dc.bibliographiccitation.volume","104"],["dc.contributor.author","Kramer, Franz-Josef"],["dc.contributor.author","Ludwig, H.-C."],["dc.contributor.author","Materna, T."],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.contributor.author","Merten, Hans-Albert"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-11-07T10:37:11Z"],["dc.date.available","2018-11-07T10:37:11Z"],["dc.date.issued","2006"],["dc.description.abstract","Frontoorbital advancement has become a standard method both to increase intracranial volume and to improve facial appearance in patients with syndromal or nonsyndromal craniosynostosis. Relevant complications of this procedure include severe hemorrhage and trauma to intracranial, orbital, or facial soft tissues, which mostly arise during the process of bone exposure or osteotomy. To minimize the risk of soft tissue injury and to increase the precision of the osteotomy, the authors applied a piezoelectric osteotome for frontoorbital advancement in 15 patients with craniosynostosis seen consecutively (mean age 11.3 months). They demonstrated that this new device can cut cranial bones using ultrasonic microvibrations created by piezoelectric effects. In all patients, this instrument allowed an easy and precise handling during osteotomy with a reduced amount of trauma to adjacent soft tissues and with no complications. Although the time required for piezoelectric osteotomy was longer compared with conventional techniques, the total operation time remained approximately the same because the preparation requirements are less extensive. Postoperatively, bone regeneration was uneventful. The authors conclude that this new technique of piezoelectric osteotomy is a valuable tool for craniofacial reconstructive surgery in pediatric patients."],["dc.identifier.doi","10.3171/ped.2006.104.1.68"],["dc.identifier.isi","000234676000018"],["dc.identifier.pmid","16509486"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45502"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Neurological Surgeons"],["dc.relation.issn","0022-3085"],["dc.title","Piezoelectric osteotomies in craniofacial procedures: a series of 15 pediatric patients - Technical note"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]