Kratzke, Manuel

[["dc.bibliographiccitation.firstpage","1318"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The EMBO Journal"],["dc.bibliographiccitation.lastpage","1330"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Glyvuk, Nataliya"],["dc.contributor.author","Tsytsyura, Yaroslav"],["dc.contributor.author","Geumann, Constanze"],["dc.contributor.author","D'Hooge, Rudi"],["dc.contributor.author","Hueve, Jana"],["dc.contributor.author","Kratzke, Manuel"],["dc.contributor.author","Baltes, Jennifer"],["dc.contributor.author","Boening, Daniel"],["dc.contributor.author","Klingauf, Juergen"],["dc.contributor.author","Schu, Peter"],["dc.date.accessioned","2018-11-07T08:43:59Z"],["dc.date.available","2018-11-07T08:43:59Z"],["dc.date.issued","2010"],["dc.description.abstract","Synaptic vesicle recycling involves AP-2/clathrin-mediated endocytosis, but it is not known whether the endosomal pathway is also required. Mice deficient in the tissue-specific AP-1-sigma 1B complex have impaired synaptic vesicle recycling in hippocampal synapses. The ubiquitously expressed AP-1-sigma 1A complex mediates protein sorting between the trans-Golgi network and early endosomes. Vertebrates express three sigma 1 subunit isoforms: A, B and C. The expressions of sigma 1A and sigma 1B are highest in the brain. Synaptic vesicle reformation in cultured neurons from sigma 1B-deficient mice is reduced upon stimulation, and large endosomal intermediates accumulate. The sigma 1B-deficient mice have reduced motor coordination and severely impaired long-term spatial memory. These data reveal a molecular mechanism for a severe human X-chromosome-linked mental retardation. The EMBO Journal (2010) 29, 1318-1330. doi: 10.1038/emboj.2010.15; Published online 4 March 2010"],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SFB 523 A6, SFB 523 B10]"],["dc.identifier.doi","10.1038/emboj.2010.15"],["dc.identifier.isi","000276927000003"],["dc.identifier.pmid","20203623"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20103"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0261-4189"],["dc.title","AP-1/sigma 1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

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