Bodemer, Walter Wolfgang

[["dc.bibliographiccitation.firstpage","132"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neoplasia"],["dc.bibliographiccitation.lastpage","142"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Tarantul, V."],["dc.contributor.author","Nikolaev, A."],["dc.contributor.author","Hannig, H."],["dc.contributor.author","Kalmyrzaev, B."],["dc.contributor.author","Muchoyan, I."],["dc.contributor.author","Maximov, V."],["dc.contributor.author","Nenasheva, V."],["dc.contributor.author","Dubovaya, V."],["dc.contributor.author","Hunsmann, G."],["dc.contributor.author","Bodemer, W."],["dc.date.accessioned","2019-07-09T11:40:45Z"],["dc.date.available","2019-07-09T11:40:45Z"],["dc.date.issued","2001"],["dc.description.abstract","Several novel, differentially transcribed genes were identified in one centroblastic and one immunoblastic HIV-associated B-cell non-Hodgkin's lymphoma (BNHL) by subtractive cloning. In both lymphomas, we detected an upregulated transcription of several mitochondrial genes. In the centroblastic B-NHL, we found a high level transcription of nuclear genes including the interferon-inducible gene (INF-ind), the immunoglobulin light chain gene (IgL), the set oncogene, and several unknown genes. The data obtained on upregulated expression of the genes in human B-NHL of HIV-infected patients considerably overlap with those obtained earlier for the B-NHL of simian immunodeficiency virus-infected monkeys. In the centroblastic lymphoma, one transcript revealed a fusion of the 3'-untranslated region of the set gene and the C-terminal region of the IgL gene. This chimeric sequence was confirmed by a site-directed polymerase chain reaction performed with total cDNA and genomic DNA. The expected amplification product was obtained in both cases pointing to a genomic rearrangement. The IgL-set fusion sequence was not found in cDNA preparations and genomic DNA of the immunoblastic HIV-associated B-NHL. Further studies are necessary to determine whether these genes contribute to lymphoma development or can be used as therapeutic targets."],["dc.identifier.doi","10.1038/sj.neo.7900137"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11236"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58238"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Detection of Abundantly Transcribed Genes and Gene Translocation in Human Immunodeficiency Virus-Associated Non—Hodgkin's Lymphoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]