Kirchhoff, Frank

[["dc.bibliographiccitation.firstpage","229"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Aquatic Geochemistry"],["dc.bibliographiccitation.lastpage","254"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Dietzel, M."],["dc.contributor.author","Kirchhoff, T."],["dc.date.accessioned","2018-11-07T09:43:09Z"],["dc.date.available","2018-11-07T09:43:09Z"],["dc.date.issued","2002"],["dc.description.abstract","Ground waters in North Hesse (Germany) are conspicuous by high amounts of dissolved inorganic carbon (DIC) at low pH. The DIC is received from the uptake of soil CO2 and CO2 of volcanic origin and the subsequent dissolution of Triassic and Permian limestone and dolomites. The volcanic CO2 is related to Miocene basaltic magma which has liberated gaseous CO2 during the breakthrough to Triassic and Permian sediments. The volcanic CO2 (-6 <δ(CCO2)-C-13<-3&PTSTHOUSND;, PDB) was trapped within pore spaces and intra- and intergranulares of Permian evaporites and Triassic sandstones and was stored within such reservoirs until recent times. The uptake of volcanic CO2 occurs as ground water migrates through such reservoirs. The C-13/C-12-signatures of the DIC indicate mixture of soil-CO2 and CO2 of volcanic origin for the dissolution of marine limestone and dolomites. The obtained two types for CO2 of volcanic origin with δC-13(CO 2)-values of -10&PLUSMN;3 and +2&PLUSMN;2&PTSTHOUSND; can be explained by diffusion of CO2 through micropores, faults, and interfaces of solids. This mobilisation of CO2 is accompanied with a kinetic fractionation of &AP;9&PTSTHOUSND;. C-13-depleted CO2 is liberated from the reservoir, whereas (CO2)-C-13 is accumulated in the residue."],["dc.identifier.doi","10.1023/B:AQUA.0000003724.43004.1e"],["dc.identifier.isi","000186608600002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34116"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Kluwer Academic Publ"],["dc.relation.issn","1380-6165"],["dc.title","Stable isotope ratios and the evolution of acidulous ground water"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5473"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","5480"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Lalo, Ulyana"],["dc.contributor.author","Pankratov, Yuri"],["dc.contributor.author","Wichert, Sven P."],["dc.contributor.author","Rossner, Moritz J."],["dc.contributor.author","North, R. Alan"],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Verkhratsky, Alexei"],["dc.date.accessioned","2018-11-07T11:15:02Z"],["dc.date.available","2018-11-07T11:15:02Z"],["dc.date.issued","2008"],["dc.description.abstract","ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical dissociation. Brain slices were prepared from transgenic mice that express enhanced green fluorescent protein under the control of the human glial fibrillary acidic protein promoter. Astrocytes were studied by whole-cell voltage clamp. Exogenous ATP evoked inward currents in 75 of 81 astrocytes. In the majority (similar to 65%) of cells, ATP-induced responses comprising a fast and delayed component; in the remaining subpopulation of astrocytes, ATP triggered a smoother response with rapid peak and slowly decaying plateau phase. The fast component of the response was sensitive to low concentrations of ATP (with EC50 of similar to 40 nM). All ATP-induced currents were blocked by pyridoxal-phosphate-6-azophenyl- 2',4'- disulfonate (PPADS); they were insensitive to ivermectin. Quantitative real-time PCR demonstrated strong expression of P2X(1) and P2X(5) receptor subunits and some expression of P2X(2) subunit mRNAs. The main properties of the ATP-induced response in cortical astrocytes (high sensitivity to ATP, biphasic kinetics, and sensitivity to PPADS) were very similar to those reported for P2X(1/5) heteromeric receptors studied previously in heterologous expression systems."],["dc.description.sponsorship","Wellcome Trust"],["dc.identifier.doi","10.1523/JNEUROSCI.1149-08.2008"],["dc.identifier.isi","000256066200009"],["dc.identifier.pmid","18495881"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54279"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","P2X(1) and P2X(5) Subunits form the functional P2X receptor in mouse cortical astrocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","9836"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.lastpage","9844"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Iafrate, A. John"],["dc.contributor.author","Carl, Silke"],["dc.contributor.author","Bronson, Scott"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Swigut, Tomek"],["dc.contributor.author","Skowronski, Jacek"],["dc.contributor.author","Kirchhoff, Frank"],["dc.date.accessioned","2022-10-06T13:25:42Z"],["dc.date.available","2022-10-06T13:25:42Z"],["dc.date.issued","2000"],["dc.description.abstract","ABSTRACT\n The multifunctional simian and human immunodeficiency virus (SIV and HIV) Nef proteins are important for virulence. We studied the importance of selected Nef functions using an SIV Nef with mutations in two regions that are required for CD4 downregulation. This Nef mutant is defective for downregulating CD4 and, in addition, for enhancing SIV infectivity and induction of SIV replication from infected quiescent peripheral blood mononuclear cells, but not for other known functions, including downregulation of class I major histocompatibility complex (MHC) cell surface expression. Replication of SIV containing this Nef variant in rhesus monkeys was attenuated early during infection. Subsequent increases in viral load coincided with selection of reversions and second-site compensatory changes in Nef. Our results indicate that the surfaces of Nef that mediate CD4 downregulation and the enhancement of virion infectivity are critical for SIV replication in vivo. Furthermore, these findings indicate that class I MHC downregulation by Nef is not sufficient for SIV virulence early in infection."],["dc.identifier.doi","10.1128/JVI.74.21.9836-9844.2000"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114896"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1098-5514"],["dc.relation.issn","0022-538X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://journals.asm.org/non-commercial-tdm-license"],["dc.title","Disrupting Surfaces of Nef Required for Downregulation of CD4 and for Enhancement of Virion Infectivity Attenuates Simian Immunodeficiency Virus Replication In Vivo"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","253"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Medical Primatology"],["dc.bibliographiccitation.lastpage","262"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Klippert, Antonina"],["dc.contributor.author","Stolte-Leeb, Nicole"],["dc.contributor.author","Neumann, Berit"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Daskalaki, Maria"],["dc.contributor.author","Gawanbacht, Ali"],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.date.accessioned","2021-06-01T10:47:23Z"],["dc.date.available","2021-06-01T10:47:23Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1111/jmp.12186"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85587"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0047-2565"],["dc.title","Frequencies of lymphoid T-follicular helper cells obtained longitudinally by lymph node fine-needle aspiration correlate significantly with viral load in SIV-infected rhesus monkeys"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","108"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Respiratory Physiology & Neurobiology"],["dc.bibliographiccitation.lastpage","114"],["dc.bibliographiccitation.volume","159"],["dc.contributor.author","Winter, Stefan M."],["dc.contributor.author","Hirdinger, Johannes"],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Huelsmann, Swen"],["dc.date.accessioned","2018-11-07T10:57:47Z"],["dc.date.available","2018-11-07T10:57:47Z"],["dc.date.issued","2007"],["dc.description.abstract","We screened transgenic mouse lines with Thy 1.2 promoter-induced expression of fluorescent proteins (FPs) for targeting of respiratory neuronal populations in the medulla oblongata. Respiratory neurons were found to be tagged by FPs within the ventral respiratory column (VRC), the pre-Botzinger complex (preBotC) and the rostral ventral respiratory group (rVRG) interneurons. A subset of neurons in the preBotC, labeled with the enhanced yellow fluorescent protein (EYFP), showed inspiratory activity during whole cell recordings from rhythmic slice preparations. Additionally, a subpopulation of EYFP-labeled preBotC neurons expressed both NK1 - and mu-opioid receptors. Furthermore, the spinal tri.-eminal nucleus, the lateral reticular nucleus (LRT) and the hypoglossal nucleus demonstrated intense EYFP expression whereas other regions of the medulla were devoid of neuronal EYFP labeling (e.g. the nucleus ambiguous). In conclusion, Thy 1.2-FP transgenic mice will facilitate the functional analysis of respiratory-related neurons in the medulla and improve the three dimensional analysis of cells contributing to this important neuronal circuit. (c) 2007 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.resp.2007.05.009"],["dc.identifier.isi","000250604200013"],["dc.identifier.pmid","17616445"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50333"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1569-9048"],["dc.title","Transgenic expression of fluorescent proteins in respiratory neurons"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1358"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","1365"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Grass, D."],["dc.contributor.author","Pawlowski, P. G."],["dc.contributor.author","Hirrlinger, Johannes"],["dc.contributor.author","Papadopoulos, Nestoras"],["dc.contributor.author","Richter, Diethelm W."],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Hulsmann, S."],["dc.date.accessioned","2018-11-07T10:51:10Z"],["dc.date.available","2018-11-07T10:51:10Z"],["dc.date.issued","2004"],["dc.description.abstract","A population of neurons in the caudal medulla generates the rhythmic activity underlying breathing movements. Although this neuronal network has attracted great attention for studying neuronal aspects of synaptic transmission, functions of glial cells supporting this neuronal activity remain unclear. To investigate the role of astrocytes in the respiratory network, we applied electrophysiological and immunohistochemical techniques to characterize astrocytes in regions involved in the generation and transmission of rhythmic activity. In the ventral respiratory group and the hypoglossal nucleus (XII) of acutely isolated brainstem slices, we analyzed fluorescently labeled astrocytes obtained from TgN(GFAP-EGFP) transgenic mice with the whole-cell voltage-clamp technique. Three subpopulations of astrocytes could be discerned by their distinct membrane current profiles. A first group of astrocytes was characterized by nonrectifying, symmetrical and voltage-independent potassium currents and a robust glutamate transporter response to D-aspartate. A second group of astrocytes showed additional A-type potassium currents, whereas a third group, identified by immunolabeling for the glial progenitor marker NG2, expressed outwardly rectifying potassium currents, smaller potassium inward currents, and only minimal D-aspartate-induced transporter currents. Astrocytes of all groups showed kainate-induced inward currents. We conclude that most of the astrocytes serve as a buffer system of excess extracellular glutamate and potassium; however, a distinct cell population (NG2-positive, A-type potassium currents) may play an important role for network plasticity."],["dc.identifier.doi","10.1523/JNEUROSCI.4022-03.2004"],["dc.identifier.isi","000188896100012"],["dc.identifier.pmid","14960607"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48825"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Diversity of functional astroglial properties in the respiratory network"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","267"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Virology"],["dc.bibliographiccitation.lastpage","272"],["dc.bibliographiccitation.volume","183"],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Voss, Gerald"],["dc.contributor.author","Nick, Sigrid"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Coulibaly, Cheick"],["dc.contributor.author","Frank, Ronald"],["dc.contributor.author","Jentsch, Klaus-Dieter"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.date.accessioned","2022-10-06T13:32:39Z"],["dc.date.available","2022-10-06T13:32:39Z"],["dc.date.issued","1991"],["dc.identifier.doi","10.1016/0042-6822(91)90139-3"],["dc.identifier.pii","0042682291901393"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115433"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0042-6822"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Antibody response to the negative regulatory factor (nef) in experimentally infected macaques: Correlation with viremia, disease progression, and seroconversion to structural viral proteins"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1371"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.lastpage","16"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Joas, Simone"],["dc.contributor.author","Parrish, Erica H."],["dc.contributor.author","Gnanadurai, Clement W."],["dc.contributor.author","Lump, Edina"],["dc.contributor.author","Stürzel, Christina M."],["dc.contributor.author","Parrish, Nicholas F."],["dc.contributor.author","Learn, Gerald H."],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Neumann, Berit"],["dc.contributor.author","Rensing, Kerstin Mätz"],["dc.contributor.author","Fuchs, Dietmar"],["dc.contributor.author","Billingsley, James M."],["dc.contributor.author","Bosinger, Steven E."],["dc.contributor.author","Silvestri, Guido"],["dc.contributor.author","Apetrei, Cristian"],["dc.contributor.author","Huot, Nicolas"],["dc.contributor.author","Garcia-Tellez, Thalia"],["dc.contributor.author","Müller-Trutwin, Michaela"],["dc.contributor.author","Hotter, Dominik"],["dc.contributor.author","Sauter, Daniel"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Hahn, Beatrice H."],["dc.contributor.author","Kirchhoff, Frank"],["dc.date.accessioned","2018-11-15T12:52:42Z"],["dc.date.accessioned","2021-10-27T13:13:05Z"],["dc.date.available","2018-11-15T12:52:42Z"],["dc.date.available","2021-10-27T13:13:05Z"],["dc.date.issued","2018"],["dc.description.abstract","HIV-1 causes chronic inflammation and AIDS in humans, whereas related simian immunodeficiency viruses (SIVs) replicate efficiently in their natural hosts without causing disease. It is currently unknown to what extent virus-specific properties are responsible for these different clinical outcomes. Here, we incorporate two putative HIV-1 virulence determinants, i.e., a Vpu protein that antagonizes tetherin and blocks NF-κB activation and a Nef protein that fails to suppress T cell activation via downmodulation of CD3, into a non-pathogenic SIVagm strain and test their impact on viral replication and pathogenicity in African green monkeys. Despite sustained high-level viremia over more than 4 years, moderately increased immune activation and transcriptional signatures of inflammation, the HIV-1-like SIVagm does not cause immunodeficiency or any other disease. These data indicate that species-specific host factors rather than intrinsic viral virulence factors determine the pathogenicity of primate lentiviruses."],["dc.identifier.doi","10.1038/s41467-018-03762-3"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15592"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91749"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2041-1723"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","S1"],["dc.bibliographiccitation.journal","Retrovirology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Koppensteiner, Herwig"],["dc.contributor.author","Höhne, Kristin"],["dc.contributor.author","Gondim, Marcos Vinicius"],["dc.contributor.author","Gobert, Francois-Xavier"],["dc.contributor.author","Widder, Miriam"],["dc.contributor.author","Gundlach, Swantje"],["dc.contributor.author","Heigele, Anke"],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Winkler, Michael"],["dc.contributor.author","Benaroch, Philippe"],["dc.contributor.author","Schindler, Michael"],["dc.date.accessioned","2022-10-06T13:26:11Z"],["dc.date.available","2022-10-06T13:26:11Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1186/1742-4690-10-S1-P42"],["dc.identifier.pii","3514"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115018"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1742-4690"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Nef variants from non-pathogenic lentiviral strains inhibit iron uptake through an AP2-dependent inhibition of transferrin endocytosis"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S23"],["dc.bibliographiccitation.journal","NEURON GLIA BIOLOGY"],["dc.bibliographiccitation.lastpage","S24"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Dibaj, Payam"],["dc.contributor.author","Kaiser, M."],["dc.contributor.author","Hirrlinger, Johannes"],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Neusch, C."],["dc.date.accessioned","2018-11-07T11:07:10Z"],["dc.date.available","2018-11-07T11:07:10Z"],["dc.date.issued","2007"],["dc.identifier.isi","000251708800070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52492"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.publisher.place","New york"],["dc.relation.issn","1740-925X"],["dc.title","Co-enrichment of Kir4.1 and AQP4 channels in spinal cord astrocytes suggests coupling of K+ flux and water transport: swelling experiments using transgenic mouse technology and time lapse 2-photon laser microscopy"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]