Happe, Svenja

[["dc.bibliographiccitation.firstpage","646"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","652"],["dc.bibliographiccitation.volume","257"],["dc.contributor.author","Boentert, Matthias"],["dc.contributor.author","Dziewas, Rainer"],["dc.contributor.author","Heidbreder, Anna"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Kleffner, Ilka"],["dc.contributor.author","Evers, Stefan"],["dc.contributor.author","Young, Peter"],["dc.date.accessioned","2018-11-07T08:44:39Z"],["dc.date.available","2018-11-07T08:44:39Z"],["dc.date.issued","2010"],["dc.description.abstract","To investigate the prevalence of fatigue, daytime sleepiness, reduced sleep quality, and restless legs syndrome (RLS) in a large cohort of patients with Charcot-Marie-Tooth disease (CMT) and their impact on health-related quality of life (HRQoL). Participants of a web-based survey answered the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index, the Multidimensional Fatigue Inventory, and, if the diagnostic criteria of RLS were met, the International RLS Severity Scale. Diagnosis of RLS was affirmed in screen-positive patients by means of a standardized telephone interview. HRQoL was assessed by using the SF-36 questionnaire. Age- and sex-matched control subjects were recruited from waiting relatives of surgical outpatients. 227 adult self-reported CMT patients answered the above questionnaires, 42.9% were male, and 57.1% were female. Age ranged from 18 to 78 years. Compared to controls (n = 234), CMT patients reported significantly higher fatigue, a higher extent and prevalence of daytime sleepiness and worse sleep quality. Prevalence of RLS was 18.1% in CMT patients and 5.6% in controls (p = 0.001). RLS severity was correlated with worse sleep quality and reduced HRQoL. Women with CMT were affected more often and more severely by RLS than male patients. With regard to fatigue, sleep quality, daytime sleepiness, RLS prevalence, RLS severity, and HRQoL, we did not find significant differences between genetically distinct subtypes of CMT. HRQoL is reduced in CMT patients which may be due to fatigue, sleep-related symptoms, and RLS in particular. Since causative treatment for CMT is not available, sleep-related symptoms should be recognized and treated in order to improve quality of life."],["dc.identifier.doi","10.1007/s00415-009-5390-1"],["dc.identifier.isi","000276254900022"],["dc.identifier.pmid","19937049"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6748"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20248"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Fatigue, reduced sleep quality and restless legs syndrome in Charcot-Marie-Tooth disease: a web-based survey"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1365"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1371"],["dc.bibliographiccitation.volume","255"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Vennemann, Mechthild"],["dc.contributor.author","Evers, Stefan"],["dc.contributor.author","Berger, Klaus"],["dc.date.accessioned","2018-11-07T11:11:37Z"],["dc.date.available","2018-11-07T11:11:37Z"],["dc.date.issued","2008"],["dc.description.abstract","Study objectives Restless legs syndrome (RLS) is a frequent sleep disorder with a prevalence of 5 % to 15 % in Caucasion populations. Dopaminergic treatment is known to reduce sensorimotor RLS symptoms and is approved for RLS, but not all patients ask for treatment. About 2 % to 3 % of patients presenting to a primary care physician require RLS-specific treatment. The overall treatment preference of RLS sufferers, however, is still unknown. The aim of this study was to assess the prevalence and treatment preference in patients with previously diagnosed and those with yet undiagnosed RLS in a population-based survey in Germany. Design and setting Cross-sectional health survey with face-to-face interviews with 1312 participants in the Dortmund Health Study. RLS was assessed with standardized, validated questions addressing the four minimal diagnostic criteria for RLS defined by the International Restless Legs Syndrome Study Group. Participants Participants were aged 25 to 75 years and were randomly selected from the city register. Results The overall prevalence of individuals with a known doctor diagnosis of RLS was 2.3 %. In addition, 6.5 % fulfilled the four minimal criteria but did not know about this diagnosis yielding an overall prevalence of 8.8 %. Prevalence was higher in women (10.2 %) and German descendents (9.2 %) compared to men (7.1 %) and migrants (6.7 %). Almost 60 % of all RLS cases reported symptoms at least once a week. 33.3 % of cases with a known RLS diagnosis and 14.1 % with an unknown diagnosis had an RLS treatment wish. The latter is determined by knowledge of the diagnosis, daily symptoms, diabetes and sleep disturbance. Conclusion About every fourth RLS case knows about the diagnosis and overall every fifth RLS case wishes medication to effectively reduce symptoms, corresponding to 1.6 % of the whole study population."],["dc.identifier.doi","10.1007/s00415-008-0922-7"],["dc.identifier.isi","000259980900012"],["dc.identifier.pmid","18575924"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6741"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53478"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Treatment wish of individuals with known and unknown restless legs syndrome in the community"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]