Happe, Svenja

[["dc.bibliographiccitation.firstpage","1401"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1406"],["dc.bibliographiccitation.volume","254"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Kundmueller, Lotte"],["dc.contributor.author","Reichelt, Doris"],["dc.contributor.author","Husstedt, Ingo-W."],["dc.contributor.author","Evers, Stefan"],["dc.date.accessioned","2018-11-07T10:58:13Z"],["dc.date.available","2018-11-07T10:58:13Z"],["dc.date.issued","2007"],["dc.description.abstract","Background The lifetime prevalence of restless legs syndrome (RLS) is about 10 % in the general population. The association of RLS with HIV infection is unknown. We aimed to investigate the prevalence of RLS in HIV positive patients and to define predictors. Methods A standardized questionnaire was presented to 228 HIV infected patients of the HIV outpatient clinic at the Department of Neurology,University of Munster, Germany. 129 patients (57% recall; 15% female, 44 +/- 9 years; mean CD4(+) cell count 333 +/- 274/mu l, 82% under highly active antiretroviral treatment) were included in the statistical analysis. 100 age- and sex-matched controls (20 % female, 42 +/- 13 years) were recruited from waiting relatives of surgical patients. Beside demographic and disease-specific data, the questionnaire included the diagnostic questions for RLS and the RLS severity scale by the International RLS Study Group. Diagnosis of RLS was confirmed by experienced neurologists. Results 33.3% of the HIV infected patients and 7% of the controls (p < 0.001) fulfilled the diagnostic criteria for RLS. The mean RLS severity score was higher in HIV infected patients (19.5 +/- 7.2) than in controls (7.3 +/- 1.5; p < 0.001) and correlated inversely with the CD4(+) cell count (r = -0.381; p = 0.024) and the BMI (r = -0.548; p < 0.001) but not with other disease-specific factors. Conclusions HIV infected patients show a significantly higher prevalence rate for RLS than the general population. The HIV infection itself with its immunological changes and involvement of the central nervous system may predispose for a risk of RLS in HIV infected patients."],["dc.identifier.doi","10.1007/s00415-007-0563-2"],["dc.identifier.isi","000250442500015"],["dc.identifier.pmid","17934881"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50430"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.title","Comorbidity of restless legs syndrome and HIV infection"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","646"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","652"],["dc.bibliographiccitation.volume","257"],["dc.contributor.author","Boentert, Matthias"],["dc.contributor.author","Dziewas, Rainer"],["dc.contributor.author","Heidbreder, Anna"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Kleffner, Ilka"],["dc.contributor.author","Evers, Stefan"],["dc.contributor.author","Young, Peter"],["dc.date.accessioned","2018-11-07T08:44:39Z"],["dc.date.available","2018-11-07T08:44:39Z"],["dc.date.issued","2010"],["dc.description.abstract","To investigate the prevalence of fatigue, daytime sleepiness, reduced sleep quality, and restless legs syndrome (RLS) in a large cohort of patients with Charcot-Marie-Tooth disease (CMT) and their impact on health-related quality of life (HRQoL). Participants of a web-based survey answered the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index, the Multidimensional Fatigue Inventory, and, if the diagnostic criteria of RLS were met, the International RLS Severity Scale. Diagnosis of RLS was affirmed in screen-positive patients by means of a standardized telephone interview. HRQoL was assessed by using the SF-36 questionnaire. Age- and sex-matched control subjects were recruited from waiting relatives of surgical outpatients. 227 adult self-reported CMT patients answered the above questionnaires, 42.9% were male, and 57.1% were female. Age ranged from 18 to 78 years. Compared to controls (n = 234), CMT patients reported significantly higher fatigue, a higher extent and prevalence of daytime sleepiness and worse sleep quality. Prevalence of RLS was 18.1% in CMT patients and 5.6% in controls (p = 0.001). RLS severity was correlated with worse sleep quality and reduced HRQoL. Women with CMT were affected more often and more severely by RLS than male patients. With regard to fatigue, sleep quality, daytime sleepiness, RLS prevalence, RLS severity, and HRQoL, we did not find significant differences between genetically distinct subtypes of CMT. HRQoL is reduced in CMT patients which may be due to fatigue, sleep-related symptoms, and RLS in particular. Since causative treatment for CMT is not available, sleep-related symptoms should be recognized and treated in order to improve quality of life."],["dc.identifier.doi","10.1007/s00415-009-5390-1"],["dc.identifier.isi","000276254900022"],["dc.identifier.pmid","19937049"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6748"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20248"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Fatigue, reduced sleep quality and restless legs syndrome in Charcot-Marie-Tooth disease: a web-based survey"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1255"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Cephalalgia"],["dc.bibliographiccitation.lastpage","1260"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Rhode, A. M."],["dc.contributor.author","Hoesing, V. G."],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Biehl, K."],["dc.contributor.author","Young, P."],["dc.contributor.author","Evers, Stefan"],["dc.date.accessioned","2018-11-07T10:55:39Z"],["dc.date.available","2018-11-07T10:55:39Z"],["dc.date.issued","2007"],["dc.description.abstract","In order to evaluate a possible association between migraine and restless legs syndrome (RLS), we performed a case-control study on the comorbidity of RLS and migraine. Patients with migraine (n = 411) and 411 sex- and age-matched control subjects were included. Migraine was diagnosed according to International Headache Society criteria, RLS according to the criteria of the International Restless Legs Syndrome Study Group. Furthermore, all patients had to fill out a self-assessment test performance on depression [Beck's Depression Inventory (BDI)]. RLS frequency was significantly higher in migraine patients than in control subjects (17.3% vs. 5.6%, P < 0.001; odds ratio 3.5, confidence interval 2.2, 5.8). In our sample, there was no significant association between migraine and depression as defined by the BDI score (9.6% in migraine vs. 4.0% in control subjects, P = 0.190). Depression was, however, not significantly more frequent in migraine patients with RLS (13.6%) than in migraine patients without RLS (8.7%). In addition, migraine patients with RLS had a significantly higher BDI score. RLS features did not differ significantly between migraine patients with RLS and control subjects with RLS. There is an association between RLS and migraine and, in addition, a co-association with depression. The underlying mechanism, however, remains undetermined and might be related to a dysfunction of dopaminergic metabolism in migraine."],["dc.identifier.doi","10.1111/j.1468-2982.2007.01453.x"],["dc.identifier.isi","000250402900009"],["dc.identifier.pmid","17888079"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49836"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0333-1024"],["dc.title","Comorbidity of migraine and restless legs syndrome - a case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1627"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Neurological Sciences"],["dc.bibliographiccitation.lastpage","1632"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Peikert, Andreas"],["dc.contributor.author","Siegert, Rudolf"],["dc.contributor.author","Evers, Stefan"],["dc.date.accessioned","2018-11-07T10:08:01Z"],["dc.date.available","2018-11-07T10:08:01Z"],["dc.date.issued","2016"],["dc.description.abstract","This study aimed at examining the efficacy of lymphatic drainage (LD) and traditional massage (TM) in the prophylactic treatment of migraine using controlled prospective randomized clinical trial of 64 patients (57 women, 45 +/- 10 years) with migraine with and without aura. Patients were randomized into three groups: LD (n = 21); TM (n = 21); waiting group (WG, n = 22). After a 4-week-baseline, a treatment period of 8 weeks was applied followed by a 4-week observation period. The patients filled in a headache diary continuously; every 4 weeks they filled in the German version of the CES-D and the German version of the Headache Disability Inventory. The main outcome measure was migraine frequency per month. At the end of the observation period, the number of migraine attacks and days decreased in the LD group by 1.8 and 3.1, respectively, in the TM group by 1.3 and 2.4, and in the WG by 0.4 and 0.2, respectively. The differences between LD and WG were significant (p = 0.006 and p = 0.015, respectively) as well as the differences between TM und WG (p = 0.042 and p = 0.016, respectively). There was a significant decrease in the amount of analgesic intake in the LD group compared to the two other groups (p = 0.004). TM and LD resulted in a reduction of migraine attack frequency. The analgesic intake only decreased significantly during LD intervention. Useful effects were identified for LD and TM as compared to WG for the prophylaxis of migraine. LD was more efficacious in some parameters than TM."],["dc.identifier.doi","10.1007/s10072-016-2645-3"],["dc.identifier.isi","000384535200008"],["dc.identifier.pmid","27338942"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39394"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1590-3478"],["dc.relation.issn","1590-1874"],["dc.title","The efficacy of lymphatic drainage and traditional massage in the prophylaxis of migraine: a randomized, controlled parallel group study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Neurological Sciences"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Peikert, Andreas"],["dc.contributor.author","Siegert, Rudolf"],["dc.contributor.author","Evers, Stefan"],["dc.date.accessioned","2018-11-07T10:08:01Z"],["dc.date.available","2018-11-07T10:08:01Z"],["dc.date.issued","2016"],["dc.format.extent","1753"],["dc.identifier.doi","10.1007/s10072-016-2657-z"],["dc.identifier.isi","000384535200029"],["dc.identifier.pmid","27412032"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39395"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1590-3478"],["dc.relation.issn","1590-1874"],["dc.title","The efficacy of lymphatic drainage and traditional massage in the prophylaxis of migraine: a randomized, controlled parallel group study (vol 37, pg 1627, 2016)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1174"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Fischer, S."],["dc.contributor.author","Heese, C."],["dc.contributor.author","Reichelt, D."],["dc.contributor.author","Gruneberg, U."],["dc.contributor.author","Freund, M."],["dc.contributor.author","Kloska, S."],["dc.contributor.author","Evers, Stefan"],["dc.contributor.author","Husstedt, I. W."],["dc.date.accessioned","2018-11-07T09:46:50Z"],["dc.date.available","2018-11-07T09:46:50Z"],["dc.date.issued","2002"],["dc.description.abstract","Highly active antiretroviral therapy (HAART) has resulted in a reduction of morbidity and mortality in HIV-associated cerebral opportunistic infection. Before HAART, up to 50% of all HIV-infected patients in Europe developed cerebral toxoplasmosis, an encephalitis caused by reactivation of Toxoplasma gondii infection. Although potent therapeutical options exist the prognosis is still poor. We describe the course of 36 AIDS patients with cerebral toxoplasmosis and present a review of clinical signs, diagnosis, therapy, and survival times. The main criteria for differential diagnosis from other secondary neuromanifestations such as primary CNS lymphoma, progressive multifocal leukencephalopathy, abscesses, and ischemic infarctions are described. Indications and problems of stereotactic biopsy are discussed."],["dc.identifier.doi","10.1007/s00115-002-1416-y"],["dc.identifier.isi","000180045100006"],["dc.identifier.pmid","12486567"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34977"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0028-2804"],["dc.title","HIV-associated cerebral toxoplasmosis - review and retrospective analysis of 36 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1365"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1371"],["dc.bibliographiccitation.volume","255"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Vennemann, Mechthild"],["dc.contributor.author","Evers, Stefan"],["dc.contributor.author","Berger, Klaus"],["dc.date.accessioned","2018-11-07T11:11:37Z"],["dc.date.available","2018-11-07T11:11:37Z"],["dc.date.issued","2008"],["dc.description.abstract","Study objectives Restless legs syndrome (RLS) is a frequent sleep disorder with a prevalence of 5 % to 15 % in Caucasion populations. Dopaminergic treatment is known to reduce sensorimotor RLS symptoms and is approved for RLS, but not all patients ask for treatment. About 2 % to 3 % of patients presenting to a primary care physician require RLS-specific treatment. The overall treatment preference of RLS sufferers, however, is still unknown. The aim of this study was to assess the prevalence and treatment preference in patients with previously diagnosed and those with yet undiagnosed RLS in a population-based survey in Germany. Design and setting Cross-sectional health survey with face-to-face interviews with 1312 participants in the Dortmund Health Study. RLS was assessed with standardized, validated questions addressing the four minimal diagnostic criteria for RLS defined by the International Restless Legs Syndrome Study Group. Participants Participants were aged 25 to 75 years and were randomly selected from the city register. Results The overall prevalence of individuals with a known doctor diagnosis of RLS was 2.3 %. In addition, 6.5 % fulfilled the four minimal criteria but did not know about this diagnosis yielding an overall prevalence of 8.8 %. Prevalence was higher in women (10.2 %) and German descendents (9.2 %) compared to men (7.1 %) and migrants (6.7 %). Almost 60 % of all RLS cases reported symptoms at least once a week. 33.3 % of cases with a known RLS diagnosis and 14.1 % with an unknown diagnosis had an RLS treatment wish. The latter is determined by knowledge of the diagnosis, daily symptoms, diabetes and sleep disturbance. Conclusion About every fourth RLS case knows about the diagnosis and overall every fifth RLS case wishes medication to effectively reduce symptoms, corresponding to 1.6 % of the whole study population."],["dc.identifier.doi","10.1007/s00415-008-0922-7"],["dc.identifier.isi","000259980900012"],["dc.identifier.pmid","18575924"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6741"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53478"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Treatment wish of individuals with known and unknown restless legs syndrome in the community"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","689"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Neurology Neurosurgery & Psychiatry"],["dc.bibliographiccitation.lastpage","692"],["dc.bibliographiccitation.volume","80"],["dc.contributor.author","Moeddel, G."],["dc.contributor.author","Bunten, Sabine"],["dc.contributor.author","Dobis, C."],["dc.contributor.author","Kovac, S."],["dc.contributor.author","Dogan, M."],["dc.contributor.author","Fischera, M."],["dc.contributor.author","Dziewas, Raineda Cunha"],["dc.contributor.author","Schaebitz, W. R."],["dc.contributor.author","Evers, Stefan"],["dc.contributor.author","Happe, Svenja"],["dc.date.accessioned","2018-11-07T08:29:27Z"],["dc.date.available","2018-11-07T08:29:27Z"],["dc.date.issued","2009"],["dc.description.abstract","The purpose of this study was to investigate the safety and efficacy of intravenous levetiracetam (LEV-iv) in refractory status epilepticus (SE). A retrospective chart review was performed on patients who received LEV-iv for treatment of SE (n = 36) and had failed at least one other antiepileptic drug. LEV-iv (median 3000 mg/day; range 1000-9000) was administered as a bolus loading (500-2000 mg per 30-60 min, n = 30) or as a continuous pump infusion (n = 6). SE was terminated in 69% (\"responders'); 31% (\"non-responders') remained in SE. Factors associated with failure were: dose escalation over 3000 mg/day, lack of bolus loading, treatment latency over 48 h, age over 80 years, non-convulsive SE with coma (\"subtle SE'), periodic lateralised epileptiform discharges (PLEDs) on EEG, acute cerebral lesion and intubation narcosis. SE was terminated in all eight patients without brain lesion (p = 0.033), and in all seven patients with complex partial SE (p = 0.051). Outcome was favourable (ambulatory patients) in 48% (responders) compared with 0% (non-responders), and \"adverse' (death or continuing coma/stupor) in 24% (responders) compared with 100% (non-responders). Mortality was 17% (responders 4%, non-responders 45%). No patient had cardiocirculatory side effects or worsening of SE. Two patients experienced nausea and vomiting during LEV-iv loading, leading to aspiration pneumonia in one. This study suggests that LEV-iv may be a safe and efficacious treatment of SE. Prospective and controlled trials are imperative to confirm these preliminary findings."],["dc.identifier.doi","10.1136/jnnp.2008.145458"],["dc.identifier.isi","000266113500026"],["dc.identifier.pmid","19448097"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16656"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","B M J Publishing Group"],["dc.relation.issn","0022-3050"],["dc.title","Intravenous levetiracetam: a new treatment alternative for refractory status epilepticus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","SLEEP"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Vennemann, Mechthild"],["dc.contributor.author","Evers, Stefan"],["dc.contributor.author","Berger, Klaus"],["dc.date.accessioned","2018-11-07T11:07:35Z"],["dc.date.available","2018-11-07T11:07:35Z"],["dc.date.issued","2007"],["dc.format.extent","A282"],["dc.identifier.isi","246224900822"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52600"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Academy Sleep Medicine"],["dc.publisher.place","Westchester"],["dc.relation.conference","21st Annual Meeting of the Association-Professional-Sleep-Societies"],["dc.relation.eventlocation","Minneapolis, MN"],["dc.relation.issn","0161-8105"],["dc.title","Wish for treatment in individuals with diagnosed and undiagnosed"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","544"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Schmerz"],["dc.bibliographiccitation.lastpage","551"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Hornyak, Magdolna"],["dc.contributor.author","Stiasny-Kolster, Karin"],["dc.contributor.author","Evers, Stefan"],["dc.contributor.author","Happe, Svenja"],["dc.date.accessioned","2018-11-07T08:51:54Z"],["dc.date.available","2018-11-07T08:51:54Z"],["dc.date.issued","2011"],["dc.description.abstract","Pain in the legs belongs to the five most frequent regional pain symptoms. Restless legs syndrome (RLS) presents a particular differential diagnosis for pain in the legs, which is characterized by a nocturnal urge to move the legs often associated with painful sensations in the legs. It is one of the most common neurological disorders and probably the leading cause of nocturnal pain in the legs. In this overview, the diagnosis and therapy of RLS as well as aspects of pain therapy of the disorder are presented. In addition, the differential diagnoses for exclusion of other specific causes of nocturnal pain in the legs are discussed."],["dc.identifier.doi","10.1007/s00482-011-1074-8"],["dc.identifier.isi","000297554100009"],["dc.identifier.pmid","21717211"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22041"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0932-433X"],["dc.title","Restless legs syndrome and nocturnal leg pain. Differential diagnosis and treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]