Happe, Svenja

[["dc.bibliographiccitation.firstpage","646"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","652"],["dc.bibliographiccitation.volume","257"],["dc.contributor.author","Boentert, Matthias"],["dc.contributor.author","Dziewas, Rainer"],["dc.contributor.author","Heidbreder, Anna"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Kleffner, Ilka"],["dc.contributor.author","Evers, Stefan"],["dc.contributor.author","Young, Peter"],["dc.date.accessioned","2018-11-07T08:44:39Z"],["dc.date.available","2018-11-07T08:44:39Z"],["dc.date.issued","2010"],["dc.description.abstract","To investigate the prevalence of fatigue, daytime sleepiness, reduced sleep quality, and restless legs syndrome (RLS) in a large cohort of patients with Charcot-Marie-Tooth disease (CMT) and their impact on health-related quality of life (HRQoL). Participants of a web-based survey answered the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index, the Multidimensional Fatigue Inventory, and, if the diagnostic criteria of RLS were met, the International RLS Severity Scale. Diagnosis of RLS was affirmed in screen-positive patients by means of a standardized telephone interview. HRQoL was assessed by using the SF-36 questionnaire. Age- and sex-matched control subjects were recruited from waiting relatives of surgical outpatients. 227 adult self-reported CMT patients answered the above questionnaires, 42.9% were male, and 57.1% were female. Age ranged from 18 to 78 years. Compared to controls (n = 234), CMT patients reported significantly higher fatigue, a higher extent and prevalence of daytime sleepiness and worse sleep quality. Prevalence of RLS was 18.1% in CMT patients and 5.6% in controls (p = 0.001). RLS severity was correlated with worse sleep quality and reduced HRQoL. Women with CMT were affected more often and more severely by RLS than male patients. With regard to fatigue, sleep quality, daytime sleepiness, RLS prevalence, RLS severity, and HRQoL, we did not find significant differences between genetically distinct subtypes of CMT. HRQoL is reduced in CMT patients which may be due to fatigue, sleep-related symptoms, and RLS in particular. Since causative treatment for CMT is not available, sleep-related symptoms should be recognized and treated in order to improve quality of life."],["dc.identifier.doi","10.1007/s00415-009-5390-1"],["dc.identifier.isi","000276254900022"],["dc.identifier.pmid","19937049"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6748"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20248"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Fatigue, reduced sleep quality and restless legs syndrome in Charcot-Marie-Tooth disease: a web-based survey"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1955"],["dc.bibliographiccitation.journal","Frontiers in psychology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Steinig, Jana"],["dc.contributor.author","Bazan, Ariane"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Antonetti, Sarah"],["dc.contributor.author","Shevrin, Howard"],["dc.date.accessioned","2019-07-09T11:44:47Z"],["dc.date.available","2019-07-09T11:44:47Z"],["dc.date.issued","2017"],["dc.description.abstract","Primary and secondary processes are the foundational axes of the Freudian mental apparatus: one horizontally as a tendency to associate, the primary process, and one vertically as the ability for perspective taking, the secondary process. Primary process mentation is not only supposed to be dominant in the unconscious but also, for example, in dreams. The present study tests the hypothesis that the mental activity during REM-sleep has more characteristics of the primary process, while during non-REM-sleep more secondary process operations take place. Because the solving of a rebus requires the ability to non-contexually condensate the literal reading of single stimuli into a new one, rebus solving is a primary process operation by excellence. In a replication of the dream-rebus study of Shevrin and Fisher (1967), a rebus, which consisted of an image of a comb (German: \"Kamm\") and an image of a raft (German: \"Floß\"), resulting in the German rebus word \"kampflos\" (Engl.: without a struggle), was flashed subliminally (at 1 ms) to 20 participants before going to sleep. Upon consecutive awakenings participants were asked for a dream report, free associations and an image description. Based on objective association norms, there were significantly more conceptual associations referring to Kamm and Floß indexing secondary process mentation when subjects were awakened from non-REM sleep as compared to REM-awakenings. There were not significantly more rebus associations referring to kampflos indexing primary process mentation when awakened from REM-sleep as compared to non-REM awakenings. However, when the associations were scored on the basis of each subject's individual norms, there was a rebus effect with more idiosyncratic rebus associations in awakenings after REM than after non-REM-sleep. Our results support the general idea that REM-sleep is characterized by primary process thinking, while non-REM-sleep mentation follows the rules of the secondary process."],["dc.identifier.doi","10.3389/fpsyg.2017.01955"],["dc.identifier.pmid","29209244"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14900"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59095"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-1078"],["dc.relation.issn","1664-1078"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Processing of a Subliminal Rebus during Sleep: Idiosyncratic Primary versus Secondary Process Associations upon Awakening from REM- versus Non-REM-Sleep."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","230"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","237"],["dc.bibliographiccitation.volume","257"],["dc.contributor.author","Hoegl, Birgit"],["dc.contributor.author","Garcia-Borreguero, Diego"],["dc.contributor.author","Kohnen, Ralf"],["dc.contributor.author","Ferini-Strambi, Luigi"],["dc.contributor.author","Hadjigeorgiou, Georgios M."],["dc.contributor.author","Hornyak, Magdolna"],["dc.contributor.author","de Weerd, A. L."],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Stiasny-Kolster, Karin"],["dc.contributor.author","Gschliesser, Viola"],["dc.contributor.author","Egatz, Renata"],["dc.contributor.author","Frauscher, Birgit"],["dc.contributor.author","Benes, Heike"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Hening, Wayne A."],["dc.contributor.author","Allen, Richard P."],["dc.date.accessioned","2018-11-07T08:46:22Z"],["dc.date.available","2018-11-07T08:46:22Z"],["dc.date.issued","2010"],["dc.description.abstract","The European Restless Legs Syndrome (RLS) Study Group performed the first multi-center, long-term study systematically evaluating RLS augmentation under levodopa treatment. This prospective, open-label 6-month study was conducted in six European countries and included 65 patients (85% treatment naive) with idiopathic RLS. Levodopa was flexibly up-titrated to a maximum dose of 600 mg/day. Presence of augmentation was diagnosed independently by two international experts using established criteria. In addition to the augmentation severity rating scale (ASRS), changes in RLS severity (International RLS severity rating scale (IRLS), clinical global impression (CGI)) were analyzed. Sixty patients provided evaluable data, 35 completed the trial and 25 dropped out. Augmentation occurred in 60% (36/60) of patients, causing 11.7% (7/60) to drop out. Median time to occurrence of augmentation was 71 days. The mean maximum dose of levodopa was 311 mg/day (SD: 105). Patients with augmentation compared to those without were significantly more likely to be on higher doses of levodopa (a parts per thousand yen300 mg, 83 vs. 54%, P = 0.03) and to show less improvement of symptom severity (IRLS, P = 0.039). Augmentation was common with levodopa, but could be tolerated by most patients during this 6-month trial. Patients should be followed over longer periods to determine if dropout rates increase with time."],["dc.description.sponsorship","Pharmacia (now Pfizer) USA"],["dc.identifier.doi","10.1007/s00415-009-5299-8"],["dc.identifier.isi","000274251700011"],["dc.identifier.pmid","19756826"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6747"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20677"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: results of a prospective multi-center study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","762"],["dc.bibliographiccitation.journal","Brain"],["dc.bibliographiccitation.lastpage","770"],["dc.bibliographiccitation.volume","133"],["dc.contributor.author","Bachmann, Cornelius G."],["dc.contributor.author","Rolke, Roman"],["dc.contributor.author","Scheidt, Uta"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Sommer, Martin"],["dc.contributor.author","Pavlakovic, Goran"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Treede, Rolf-Detlef"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T08:45:14Z"],["dc.date.available","2018-11-07T08:45:14Z"],["dc.date.issued","2010"],["dc.description.abstract","This study aimed to assess thermal and mechanical perception and pain thresholds in primary idiopathic restless legs syndrome and secondary restless legs syndrome associated with small fibre neuropathy. Twenty-one patients (age: 53.4 +/- 8.4, n = 3, male) with primary restless legs syndrome and 13 patients (age: 63.0 +/- 8.2, n = 1, male) with secondary restless legs syndrome associated with small fibre neuropathy were compared with 20 healthy subjects (age: 58.0 +/- 7.0; n = 2, male). Differential diagnosis of secondary restless legs syndrome associated with small fibre neuropathy was based on clinical symptoms and confirmed with skin biopsies in all patients. A comprehensive quantitative sensory testing protocol encompassing thermal and mechanical detection and pain thresholds, as devised by the German Research Network on Neuropathic Pain, was performed on the clinically more affected foot between 2 pm and 1 am when restless legs syndrome symptoms were present in all patients. Patients with primary restless legs syndrome showed hyperalgesia to blunt pressure (P < 0.001), pinprick (P < 0.001) and vibratory hyperaesthesia (P < 0.001). Patients with secondary restless legs syndrome associated with small fibre neuropathy showed thermal hypoaesthesia to cold (A delta-fibre mediated) and warm (C-fibre mediated) (all P < 0.001) and hyperalgesia to pinprick (P < 0.001). Static mechanical hyperalgesia in primary and secondary restless legs syndrome is consistent with the concept of central disinhibition of nociceptive pathways, which might be induced by conditioning afferent input from damaged small fibre neurons in secondary restless legs syndrome."],["dc.identifier.doi","10.1093/brain/awq026"],["dc.identifier.isi","000276046000012"],["dc.identifier.pmid","20194142"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6232"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20388"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0006-8950"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Thermal hypoaesthesia differentiates secondary restless legs syndrome associated with small fibre neuropathy from primary restless legs syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1365"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1371"],["dc.bibliographiccitation.volume","255"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Vennemann, Mechthild"],["dc.contributor.author","Evers, Stefan"],["dc.contributor.author","Berger, Klaus"],["dc.date.accessioned","2018-11-07T11:11:37Z"],["dc.date.available","2018-11-07T11:11:37Z"],["dc.date.issued","2008"],["dc.description.abstract","Study objectives Restless legs syndrome (RLS) is a frequent sleep disorder with a prevalence of 5 % to 15 % in Caucasion populations. Dopaminergic treatment is known to reduce sensorimotor RLS symptoms and is approved for RLS, but not all patients ask for treatment. About 2 % to 3 % of patients presenting to a primary care physician require RLS-specific treatment. The overall treatment preference of RLS sufferers, however, is still unknown. The aim of this study was to assess the prevalence and treatment preference in patients with previously diagnosed and those with yet undiagnosed RLS in a population-based survey in Germany. Design and setting Cross-sectional health survey with face-to-face interviews with 1312 participants in the Dortmund Health Study. RLS was assessed with standardized, validated questions addressing the four minimal diagnostic criteria for RLS defined by the International Restless Legs Syndrome Study Group. Participants Participants were aged 25 to 75 years and were randomly selected from the city register. Results The overall prevalence of individuals with a known doctor diagnosis of RLS was 2.3 %. In addition, 6.5 % fulfilled the four minimal criteria but did not know about this diagnosis yielding an overall prevalence of 8.8 %. Prevalence was higher in women (10.2 %) and German descendents (9.2 %) compared to men (7.1 %) and migrants (6.7 %). Almost 60 % of all RLS cases reported symptoms at least once a week. 33.3 % of cases with a known RLS diagnosis and 14.1 % with an unknown diagnosis had an RLS treatment wish. The latter is determined by knowledge of the diagnosis, daily symptoms, diabetes and sleep disturbance. Conclusion About every fourth RLS case knows about the diagnosis and overall every fifth RLS case wishes medication to effectively reduce symptoms, corresponding to 1.6 % of the whole study population."],["dc.identifier.doi","10.1007/s00415-008-0922-7"],["dc.identifier.isi","000259980900012"],["dc.identifier.pmid","18575924"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6741"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53478"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Treatment wish of individuals with known and unknown restless legs syndrome in the community"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2294"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","New England Journal of Medicine"],["dc.bibliographiccitation.lastpage","2296"],["dc.bibliographiccitation.volume","359"],["dc.contributor.author","Crozier, Thomas A."],["dc.contributor.author","Karimdadian, Desiree"],["dc.contributor.author","Happe, Svenja"],["dc.date.accessioned","2018-11-07T11:08:59Z"],["dc.date.available","2018-11-07T11:08:59Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1056/NEJMc0806664"],["dc.identifier.isi","000260994000032"],["dc.identifier.pmid","19020334"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6262"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52917"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Massachusetts Medical Soc"],["dc.relation.issn","0028-4793"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Restless Legs Syndrome and Spinal Anesthesia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","304"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","European Neurology"],["dc.bibliographiccitation.lastpage","309"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Bunten, Sabine"],["dc.date.accessioned","2018-11-07T09:14:47Z"],["dc.date.available","2018-11-07T09:14:47Z"],["dc.date.issued","2012"],["dc.description.abstract","Unilateral facial weakness is common. Transcranial magnetic stimulation (TMS) allows identification of a conduction failure at the level of the canalicular portion of the facial nerve and may help to confirm the diagnosis. Methods: We retrospectively analyzed 216 patients with the diagnosis of peripheral facial palsy. The electrophysiological investigations included the blink reflex, preauricular electrical stimulation and the response to TMS at the labyrinthine part of the canalicular proportion of the facial nerve within 3 days after symptom onset. Results: A similar reduction or loss of the TMS amplitude (p < 0.005) of the affected side was seen in each patient group. Of the 216 patients (107 female, mean age 49.7 +/- 18.0 years), 193 were diagnosed with Bell's palsy. Test results of the remaining patients led to the diagnosis of infectious [including herpes simplex, varicella zoster infection and borreliosis (n = 13)] and noninfectious [including diabetes and neoplasma (n = 10)] etiology. Conclusions: A conduction block in TMS supports the diagnosis of peripheral facial palsy without being specific for Bell's palsy. Significance: These data shed light on the TMS-based diagnosis of peripheral facial palsy, an ability to localize the site of lesion within the Fallopian channel regardless of the underlying pathology. Copyright (C) 2012 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000341624"],["dc.identifier.isi","000311042800008"],["dc.identifier.pmid","23051862"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9080"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27502"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","S. Karger AG"],["dc.relation.eissn","1421-9913"],["dc.relation.issn","0014-3022"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Electrical and Transcranial Magnetic Stimulation of the Facial Nerve: Diagnostic Relevance in Acute Isolated Facial Nerve Palsy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","21"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neuropsychobiology"],["dc.bibliographiccitation.lastpage","27"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Klosch, G."],["dc.contributor.author","Zeitlhofer, J."],["dc.date.accessioned","2018-11-07T10:52:58Z"],["dc.date.available","2018-11-07T10:52:58Z"],["dc.date.issued","2004"],["dc.description.abstract","Objectives: Recent reports have led to the hypothesis of a central nervous system involvement in myasthenia gravis (MG). As the central cholinergic system also plays an important role in sleep/wake rhythms and in the regulation of REM sleep, sleep perception and dreaming may be altered in MG patients. Patients and Methods: Seventeen consecutive patients with MG (mean age 49.5 +/- 13.6 years) and 14 healthy controls (mean age 50.5 +/- 16.0 years) were investigated by means of the Self-Rating Depression Scale, Self-Rating Anxiety Scale, Quality of Life Index, Pittsburgh Sleep Quality Index, and Epworth Sleepiness Scale as well as a self-rating questionnaire for sleep and awakening quality and dreaming for 2 weeks. Results: Subjective sleep and awakening quality and sleep efficiency were reduced (p < 0.05), and the number of nocturnal awakenings (p = 0.02) as well as dream recall frequency ( p = 0.02) were increased in patients with MG. Patients reported more often body-related and tactile sensations during dreaming ( p = 0.001) and dreamed less often visually (p = 0.04). Dream content, emotions, and dream sources did not differ between both groups. Whereas the number of awakenings was related to dream recall frequency in healthy controls, no such a relationship was found in the patient group. Conclusion: There is no clear evidence for the arousal-retrieval model of dream recall in patients with MG, but more for the continuity hypothesis of dreaming. Other factors such as the functional state of the brain, possibly related to a central cholinergic involvement in MG or its anticholinesterase treatment, may be important in explaining dream recall in this patient group. Copyright (C) 2004 S. Karger AG, Basel."],["dc.identifier.doi","10.1159/000077937"],["dc.identifier.isi","000221802600005"],["dc.identifier.pmid","15179016"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49237"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0302-282X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Perception of dreams and subjective sleep quality in patients with myasthenia gravis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","73"],["dc.bibliographiccitation.journal","Health and Quality of Life Outcomes"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Scholz, Hanna"],["dc.contributor.author","Benes, Heike"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Bengel, Juergen"],["dc.contributor.author","Kohnen, Ralf"],["dc.contributor.author","Hornyak, Magdolna"],["dc.date.accessioned","2018-11-07T08:51:41Z"],["dc.date.available","2018-11-07T08:51:41Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Restless legs syndrome (RLS) is a chronic disorder with substantial impact on quality of life similar to that seen in diabetes mellitus or osteoarthritis. Little is known about the psychological characteristics of RLS patients although psychological factors may contribute to unfavourable treatment outcome. Methods: In an observational cross-sectional design, we evaluated the psychological features of 166 consecutive RLS patients from three outpatient clinics, by means of the Symptom Checklist 90-R (SCL-90-R) questionnaire. Additionally, the Beck Depression Inventory-II (BDI-II) and the International RLS Severity Scale (IRLS) were measured. Both treated and untreated patients were included, all patients sought treatment. Results: Untreated patients (n = 69) had elevated but normal scores on the SCL-90-R Global Severity Index (GSI; p = 0.002) and on the sub-scales somatisation (p < 0.001), compulsivity (p = 0.003), depression (p = 0.02), and anxiety (p = 0.004) compared with a German representative sample. In the treated group, particularly in those patients who were dissatisfied with their actual treatment (n = 62), psychological distress was higher than in the untreated group with elevated scores for the GSI (p = 0.03) and the sub-scales compulsivity (p = 0.006), depression (p = 0.012), anxiety (p = 0.031), hostility (p = 0.013), phobic anxiety (p = 0.024), and paranoid ideation (p = 0.012). Augmentation, the most serious side effect of dopaminergic, i.e. first-line treatment of RLS, and loss of efficacy were accompanied with the highest psychological distress, as seen particularly in the normative values of the sub-scales compulsivity and anxiety. Generally, higher RLS severity was correlated with higher psychological impairment (p < 0.001). Conclusion: Severely affected RLS patients show psychological impairment in multiple psychological domains which has to be taken into account in the treatment regimen."],["dc.identifier.doi","10.1186/1477-7525-9-73"],["dc.identifier.isi","000295806600001"],["dc.identifier.pmid","21933380"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6985"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21994"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1477-7525"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Psychological distress of patients suffering from restless legs syndrome: a cross-sectional study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]