Voigt, Niels

[["dc.bibliographiccitation.firstpage","77"],["dc.bibliographiccitation.lastpage","96"],["dc.contributor.author","Heijman, Jordi"],["dc.contributor.author","Molina, Cristina E."],["dc.contributor.author","Voigt, Niels"],["dc.contributor.editor","Thomas, Dierk"],["dc.contributor.editor","Remme, Carol Ann"],["dc.date.accessioned","2019-02-19T14:23:43Z"],["dc.date.available","2019-02-19T14:23:43Z"],["dc.date.issued","2018"],["dc.description.abstract","In cardiomyocytes voltage-gated Ca2+ channels are major players in cardiac cellular electrophysiology and cellular excitation-contraction coupling. Accordingly, Ca2+ channel dysfunction contributes to the development of cardiac arrhythmias and impaired cardiac contractile function. In addition, Ca2+ entry through voltage-gated Ca2+ channels is an important regulator of gene transcription and cardiac cellular metabolism. In order to fulfil these tasks reliably, Ca2+ channels are highly regulated by specific subunit compositions and various signaling pathways. This chapter provides an overview of the role of voltage-gated Ca2+ channels in cardiac cellular electrophysiology and summarizes their molecular composition, biophysical properties, and regulatory mechanisms, with a special focus on L-type Ca2+ channels."],["dc.identifier.doi","10.1007/978-3-319-77812-9_4"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57587"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/233"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.publisher","Springer"],["dc.publisher.place","Cham"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A13: Bedeutung einer gestörten zytosolischen Calciumpufferung bei der atrialen Arrhythmogenese bei Patienten mit Herzinsuffizienz (HF)"],["dc.relation.crisseries","Cardiac and Vascular Biology"],["dc.relation.isbn","978-3-319-77811-2"],["dc.relation.isbn","978-3-319-77812-9"],["dc.relation.ispartof","Channelopathies in Heart Disease"],["dc.relation.ispartofseries","Cardiac and Vascular Biology"],["dc.relation.issn","2509-7830"],["dc.relation.issn","2509-7849"],["dc.relation.workinggroup","RG Voigt (Molecular Pharmacology)"],["dc.title","Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology"],["dc.type","book_chapter"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]