Hadaček, Franz

[["dc.bibliographiccitation.firstpage","103"],["dc.bibliographiccitation.journal","Journal of Organometallic Chemistry"],["dc.bibliographiccitation.lastpage","110"],["dc.bibliographiccitation.volume","782"],["dc.contributor.author","Chobot, Vladimir"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Weckwerth, Wolfram"],["dc.contributor.author","Kubicova, Lenka"],["dc.date.accessioned","2018-11-07T09:58:30Z"],["dc.date.available","2018-11-07T09:58:30Z"],["dc.date.issued","2015"],["dc.description.abstract","Anthranilic acid (ANA) and 3-hydroxyanthranilic acid (3-HANA) are kynurenine pathway intermediates of the tryptophan metabolism. A hitherto unemployed method combination, differential pulse voltammetry, mass spectrometry (nano-ESI MS), deoxyribose degradation and iron(II) autoxidation assays has been employed for studying of their redox chemistry and their interactions with iron(II) and iron(III) ions. Both acids inhibited the Fenton reaction by iron chelation and ROS scavenging in the deoxyribose degradation assay. In the iron(II) autoxidation assay, anthranilic acid showed antioxidant effects, whereas 3-hydroxyanthranilic acid exhibited apparent pro-oxidant activity. The differential pulse voltammograms of free metabolites and their iron(II) coordination complexes reflected these properties. Nano-ESI MS confirmed ANA and 3-HANA as efficient iron(II) chelators, both of which form coordination complexes of ligand:iron(II) ratio 1:1, 2:1, and 3:1. In addition, nano-ESI MS analyses of the oxidation effects by hydroxyl radical attack identified 3-HANA as strikingly more susceptible than ANA. 3-HANA susceptibility to oxidation may explain its decreased concentrations in the reaction mixture. The presented observations can add to explaining why 3-HANA levels decrease in patients with some neurological and other diseases which can often associated with elevated concentrations of ROS. (C) 2015 The Authors. Published by Elsevier B.V."],["dc.description.sponsorship","Austrian Science Fund (FWF) [P24630-B21]"],["dc.identifier.doi","10.1016/j.jorganchem.2015.01.005"],["dc.identifier.isi","000351637900016"],["dc.identifier.pmid","25892823"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37375"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Sa"],["dc.publisher.place","Lausanne"],["dc.relation.conference","7th International Symposium on Bioorganometallic Chemistry"],["dc.relation.eventlocation","Vienna, AUSTRIA"],["dc.relation.issn","1872-8561"],["dc.relation.issn","0022-328X"],["dc.title","Iron chelation and redox chemistry of anthranilic acid and 3-hydroxyanthranilic acid: A comparison of two structurally related kynurenine pathway metabolites to obtain improved insights into their potential role in neurological disease development"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","476"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Antioxidants"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Kubicova, Lenka"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Bachmann, Gert"],["dc.contributor.author","Weckwerth, Wolfram"],["dc.contributor.author","Chobot, Vladimir"],["dc.date.accessioned","2020-12-10T18:46:56Z"],["dc.date.available","2020-12-10T18:46:56Z"],["dc.date.issued","2019"],["dc.description.sponsorship","Austrian Science Fund"],["dc.identifier.doi","10.3390/antiox8100476"],["dc.identifier.eissn","2076-3921"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17062"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78593"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","2076-3921"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Coordination Complex Formation and Redox Properties of Kynurenic and Xanthurenic Acid Can Affect Brain Tissue Homeodynamics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","138"],["dc.bibliographiccitation.journal","Frontiers in Ecology and Evolution"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Drage, Sigrid"],["dc.contributor.author","Mitter, Birgit"],["dc.contributor.author","Engelmeier, Doris"],["dc.contributor.author","Chobot, Vladimir"],["dc.contributor.author","Gorfer, Markus"],["dc.contributor.author","Muchugi, Alice"],["dc.contributor.author","Jamnadass, Ramni H."],["dc.contributor.author","Sessitsch, Angela"],["dc.contributor.author","Hadacek, Franz"],["dc.date.accessioned","2019-07-09T11:44:42Z"],["dc.date.available","2019-07-09T11:44:42Z"],["dc.date.issued","2017"],["dc.description.abstract","The African pepper bark tree,Warburgia ugandensis, accumulates antimicrobial drimane sesquiterpenes in all of its organs. One hypothesis states that plant defense compounds determine endophyte community structure. Another hypothesis suggests that they just facilitate the endophytic lifestyle by exerting a balanced antagonism. To explore this, a representative selection of endophytic bacterial and fungal isolates from this tree species was assayed together with six non-endophytic strains to determine their tolerance and susceptibility to the root and leaf extract fraction containing high and low drimane sesquiterpene amounts respectively. Inhibitory effects were explored by assessing both growth and growth efficiency, the latter of which relates respiratory activity to growth. The susceptibility of the tested strains showed considerable variation and the obtained patterns did not allow a clear distinction between root and leaf endophytes as well as endophytes and non-endophytes. In addition, all strains were also assayed against juglone, an antimicrobial and redox-active aromatic naphthoquinone. A comparison of differential pulse voltammograms and efficacy in variants of the deoxyribose degradation assay revealed that drimane sesquiterpenes possess anti- and pro-oxidant activities that compare to those of juglone. Leaf endophytes showed higher resistance to oxidative stress than root endophytes, quite contrary to the actual exposure. The obtained results support the notion that structural diverse plant defense compounds can contribute to a balanced antagonismagainst but not to structuring of endophyte communities. Oxidative stress seems to be involved in generating this effect albeit it cannot explain it alone."],["dc.identifier.doi","10.3389/fevo.2017.00138"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14872"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59072"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","2296-701X"],["dc.relation.issn","2296-701X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Antimicrobial Drimane Sesquiterpenes Contribute to Balanced Antagonism but Do Not Structure Bacterial and Fungal Endophytes in the African Pepper Bark Tree Warburgia ugandensis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11830"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.lastpage","11841"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Chobot, Vladimir"],["dc.contributor.author","Kubicova, Lenka"],["dc.contributor.author","Bachmann, Gert"],["dc.contributor.author","Hadacek, Franz"],["dc.date.accessioned","2018-11-07T09:23:55Z"],["dc.date.available","2018-11-07T09:23:55Z"],["dc.date.issued","2013"],["dc.description.abstract","Some antioxidants have been shown to possess additional pro-oxidant effects. Diverse methodologies exist for studying redox properties of synthetic and natural chemicals. The latter are substantial components of our diet. Exploration of their contribution to life-extending or -compromising effects is mandatory. Among reactive oxygen species (ROS), hydroxyl radical ((OH)-O-center dot) is the most damaging species. Due to its short half-life, the assay has to contain a specific generation system. Plants synthesize flavonoids, phenolic compounds recognized as counter-agents to coronary heart disease. Their antioxidant activities are affected by their hydroxylation patterns. Moreover, in the plant, they mainly occur as glycosides. We chose three derivatives, quercetin, luteolin, and rutin, in attempts to explore their redox chemistry in contrasting hydrogen peroxide environments. Initial addition of hydrogen peroxide in high concentration or gradual development constituted a main factor affecting their redox chemical properties, especially in case of quercetin. Our study exemplifies that a combination of a chemical assay (deoxyribose degradation) with an electrochemical method (square-wave voltammetry) provides insightful data. The ambiguity of the tested flavonoids to act either as anti- or pro-oxidant may complicate categorization, but probably contributed to their evolution as components of a successful metabolic system that benefits both producer and consumer."],["dc.description.sponsorship","Austrian Science Fund (FWF) [P24630-B21]"],["dc.identifier.doi","10.3390/ijms140611830"],["dc.identifier.isi","000320772500063"],["dc.identifier.pmid","23736691"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9484"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29698"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mdpi Ag"],["dc.relation.issn","1422-0067"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Versatile Redox Chemistry Complicates Antioxidant Capacity Assessment: Flavonoids as Milieu-Dependent Anti- and Pro-Oxidants"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3917"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","19"],["dc.contributor.affiliation","Chobot, Vladimir; \t\t \r\n\t\t Division of Molecular Systems Biology, Department of Ecogenomics and Systems Biology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria, vladimir.chobot@univie.ac.at"],["dc.contributor.affiliation","Hadacek, Franz; \t\t \r\n\t\t Department of Plant Biochemistry, Albrecht-von-Haller Institut, Georg-August-Universität Göttingen, Justus-von-Liebig-Weg 11, D-37077 Göttingen, Germany, franz.hadacek@biologie.uni-goettingen.de"],["dc.contributor.affiliation","Bachmann, Gert; \t\t \r\n\t\t Division of Molecular Systems Biology, Department of Ecogenomics and Systems Biology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria, gert.bachmann@univie.ac.at"],["dc.contributor.affiliation","Weckwerth, Wolfram; \t\t \r\n\t\t Division of Molecular Systems Biology, Department of Ecogenomics and Systems Biology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria, wolfram.weckwerth@univie.ac.at"],["dc.contributor.affiliation","Kubicova, Lenka; \t\t \r\n\t\t Division of Molecular Systems Biology, Department of Ecogenomics and Systems Biology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria, lenka.kubicova@univie.ac.at"],["dc.contributor.author","Chobot, Vladimir"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Bachmann, Gert"],["dc.contributor.author","Weckwerth, Wolfram"],["dc.contributor.author","Kubicova, Lenka"],["dc.date.accessioned","2020-12-10T18:47:08Z"],["dc.date.available","2020-12-10T18:47:08Z"],["dc.date.issued","2018"],["dc.date.updated","2022-09-05T08:11:57Z"],["dc.description.sponsorship","Austrian Science Fund"],["dc.identifier.doi","10.3390/ijms19123917"],["dc.identifier.eissn","1422-0067"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78657"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Antioxidant Properties and the Formation of Iron Coordination Complexes of 8-Hydroxyquinoline"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5850"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","Molecules"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Chobot, Vladimir"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Bachmann, Gert"],["dc.contributor.author","Weckwerth, Wolfram"],["dc.contributor.author","Kubicova, Lenka"],["dc.date.accessioned","2021-04-14T08:27:20Z"],["dc.date.available","2021-04-14T08:27:20Z"],["dc.date.issued","2020"],["dc.description.sponsorship","Austrian Science Fund"],["dc.identifier.doi","10.3390/molecules25245850"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82251"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","MDPI"],["dc.relation.eissn","1420-3049"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","In Vitro Evaluation of Pro- and Antioxidant Effects of Flavonoid Tricetin in Comparison to Myricetin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","111"],["dc.bibliographiccitation.journal","Journal of Organometallic Chemistry"],["dc.bibliographiccitation.lastpage","115"],["dc.bibliographiccitation.volume","782"],["dc.contributor.author","Kubicova, Lenka"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Weckwerth, Wolfram"],["dc.contributor.author","Chobot, Vladimir"],["dc.date.accessioned","2018-11-07T09:58:31Z"],["dc.date.available","2018-11-07T09:58:31Z"],["dc.date.issued","2015"],["dc.description.abstract","The tryptophan metabolite, quinolinic (2,3-pyridinedicarboxylic) acid, is known as an endogenous neurotoxin. Quinolinic acid can form coordination complexes with iron or copper. The effects of quinolinic acid on reactive oxygen species production in the presence of iron or copper were explored by a combination of chemical assays, classical site-specific and ascorbic acid-free variants of the deoxyribose degradation assay, and mass spectrometry (ESI-MS). Quinolinic acid showed evident antioxidant activity in chemical assays, but the effect was more pronounced in the presence of copper as transition metal catalyst than in presence of iron. Nano-ESI-MS confirmed the ability of quinolinic acid to form coordination complexes with iron(II) or copper(II) and quinolinic acid stability against oxidative attack by hydroxyl radicals. The results illustrate a highly milieu-dependent quinolinic acid chemistry when it enters reactions as competitive ligand. (C) 2015 The Authors. Published by Elsevier B.V."],["dc.description.sponsorship","Austrian Science Fund (FWF) [P24630-B21]"],["dc.identifier.doi","10.1016/j.jorganchem.2015.01.030"],["dc.identifier.isi","000351637900017"],["dc.identifier.pmid","25892824"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13843"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37376"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Sa"],["dc.publisher.place","Lausanne"],["dc.relation.conference","7th International Symposium on Bioorganometallic Chemistry"],["dc.relation.eventlocation","Vienna, AUSTRIA"],["dc.relation.issn","1872-8561"],["dc.relation.issn","0022-328X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effects of endogenous neurotoxin quinolinic acid on reactive oxygen species production by Fenton reaction catalyzed by iron or copper"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1986"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Chobot, Vladimir"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Bachmann, Gert"],["dc.contributor.author","Weckwerth, Wolfram"],["dc.contributor.author","Kubicova, Lenka"],["dc.date.accessioned","2018-11-07T10:04:51Z"],["dc.date.available","2018-11-07T10:04:51Z"],["dc.date.issued","2016"],["dc.description.abstract","The flavanol (+/-)-catechin shows an OH group but no 4-keto group on ring C (C3), and no conjugation between ring A and B. The related flavanone (+)-eriodictyol has a keto group on C4 but no 3-OH group on ring C. (+)-Taxifolin, another flavanone, has an OH on C3 and a keto group on C4 of the C ring. Deoxyribose degradation assay systems, with hydrogen peroxide and ascorbic acid either added or omitted, were performed in variants in which Fe(III) was added in a complex with ethylenediaminetetraacetic acid (EDTA). In combination with differential pulse voltammetry (DVP), the specific redox-chemical contributions of the ring A m-dihydroxyl groups could be explored more specifically in addition to those of the traditionally investigated o-dihydroxyl groups of ring B."],["dc.description.sponsorship","Austrian Science Fund (FWF) [P24630-B21]"],["dc.identifier.doi","10.3390/ijms17121986"],["dc.identifier.isi","000392280500030"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14313"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38785"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mdpi Ag"],["dc.relation.issn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Pro- and Antioxidant Activity of Three Selected Flavan Type Flavonoids: Catechin, Eriodictyol and Taxifolin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","20023"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Molecules"],["dc.bibliographiccitation.lastpage","20033"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Chobot, Vladimir"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Kubicova, Lenka"],["dc.date.accessioned","2018-11-07T09:31:50Z"],["dc.date.available","2018-11-07T09:31:50Z"],["dc.date.issued","2014"],["dc.description.abstract","Iron is an essential co-factor for many enzymes that catalyze electron transfer reactions. It is well known that so-called \"poorly liganded\" iron can increase ROS concentrations and trigger oxidative stress that is capable of initiating apoptosis. Conversely, controlled ROS production has been recognized as an integral part of cellular signaling. Elevated ROS concentrations are associated with aging, inflammatory and degenerative diseases. Anti-aging properties have been attributed especially to antioxidant phenolic plant metabolites that represent food additives in our diet. Consequently, this study explores the effects of flavonoids (quercetin and rutin), several phenolic acids (caffeic, chlorogenic, and protocatechuic acid), and the alkaloid caffeine on iron(II) autoxidation and ROS production in comparison to the standard antioxidants ascorbic acid and Trolox. The iron(II) autoxidation assay was carried out in pH 6.0 (plant apoplast and inflamed human tissue) and 7.4 (cell cytoplasm and human blood plasma). The obtained results accentuate phenolic acids as the more specific antioxidants compared to ascorbic acid and Trolox. Flavonoid redox chemistry depends more on the chemical milieu, specifically on pH. In vivo, the presence of iron cannot be ruled out and \"wrongly\" or \"poorly\" complexed iron has been pointed out as causative agent of various age-related diseases."],["dc.description.sponsorship","Austrian Science Fund (FWF) [P24630-B21]"],["dc.identifier.doi","10.3390/molecules191220023"],["dc.identifier.isi","000346793200042"],["dc.identifier.pmid","25470272"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11713"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31621"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mdpi Ag"],["dc.relation.issn","1420-3049"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effects of Selected Dietary Secondary Metabolites on Reactive Oxygen Species Production Caused by Iron(II) Autoxidation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","21328"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.lastpage","21338"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Kubicova, Lenka"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Chobot, Vladimir"],["dc.date.accessioned","2018-11-07T09:17:50Z"],["dc.date.available","2018-11-07T09:17:50Z"],["dc.date.issued","2013"],["dc.description.abstract","Quinolinic acid (2,3-pyridinedicarboxylic acid, QUIN) is a well-known neurotoxin. Consequently, QUIN could produce reactive oxygen species (ROS). ROS are generated in reactions catalyzed by transition metals, especially iron (Fe). QUIN can form coordination complexes with iron. A combination of differential pulse voltammetry, deoxyribose degradation and Fe(II) autoxidation assays was used for explorating ROS formation in redox reactions that are catalyzed by iron in QUIN-Fe complexes. Differential pulse voltammetry showed an anodic shift of the iron redox potential if iron was liganded by QUIN. In the H2O2/FeCl3/ascorbic acid variant of the deoxyribose degradation assay, the dose-response curve was U-shaped. In the FeCl3/ascorbic acid variant, QUIN unambiguously showed antioxidant effects. In the Fe(II) autoxidation assay, QUIN decreased the rate of ROS production caused by Fe(II) oxidation. Our study confirms that QUIN toxicity may be caused by ROS generation via the Fenton reaction. This, however, applies only for unnaturally high concentrations that were used in attempts to provide support for the neurotoxic effect. In lower concentrations, we show that by liganding iron, QUIN affects the Fe(II)/Fe(III) ratios that are beneficial to homeostasis. Our results support the notion that redox chemistry can contribute to explaining the hormetic dose-response effects."],["dc.description.sponsorship","Austrian Science Fund (FWF) [P24630-B21]"],["dc.identifier.doi","10.3390/ijms141121328"],["dc.identifier.isi","000328624400009"],["dc.identifier.pmid","24232578"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9483"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28264"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mdpi Ag"],["dc.relation.issn","1422-0067"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Quinolinic Acid: Neurotoxin or Oxidative Stress Modulator?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]