Hadaček, Franz

[["dc.bibliographiccitation.firstpage","103"],["dc.bibliographiccitation.journal","Journal of Organometallic Chemistry"],["dc.bibliographiccitation.lastpage","110"],["dc.bibliographiccitation.volume","782"],["dc.contributor.author","Chobot, Vladimir"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Weckwerth, Wolfram"],["dc.contributor.author","Kubicova, Lenka"],["dc.date.accessioned","2018-11-07T09:58:30Z"],["dc.date.available","2018-11-07T09:58:30Z"],["dc.date.issued","2015"],["dc.description.abstract","Anthranilic acid (ANA) and 3-hydroxyanthranilic acid (3-HANA) are kynurenine pathway intermediates of the tryptophan metabolism. A hitherto unemployed method combination, differential pulse voltammetry, mass spectrometry (nano-ESI MS), deoxyribose degradation and iron(II) autoxidation assays has been employed for studying of their redox chemistry and their interactions with iron(II) and iron(III) ions. Both acids inhibited the Fenton reaction by iron chelation and ROS scavenging in the deoxyribose degradation assay. In the iron(II) autoxidation assay, anthranilic acid showed antioxidant effects, whereas 3-hydroxyanthranilic acid exhibited apparent pro-oxidant activity. The differential pulse voltammograms of free metabolites and their iron(II) coordination complexes reflected these properties. Nano-ESI MS confirmed ANA and 3-HANA as efficient iron(II) chelators, both of which form coordination complexes of ligand:iron(II) ratio 1:1, 2:1, and 3:1. In addition, nano-ESI MS analyses of the oxidation effects by hydroxyl radical attack identified 3-HANA as strikingly more susceptible than ANA. 3-HANA susceptibility to oxidation may explain its decreased concentrations in the reaction mixture. The presented observations can add to explaining why 3-HANA levels decrease in patients with some neurological and other diseases which can often associated with elevated concentrations of ROS. (C) 2015 The Authors. Published by Elsevier B.V."],["dc.description.sponsorship","Austrian Science Fund (FWF) [P24630-B21]"],["dc.identifier.doi","10.1016/j.jorganchem.2015.01.005"],["dc.identifier.isi","000351637900016"],["dc.identifier.pmid","25892823"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37375"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Sa"],["dc.publisher.place","Lausanne"],["dc.relation.conference","7th International Symposium on Bioorganometallic Chemistry"],["dc.relation.eventlocation","Vienna, AUSTRIA"],["dc.relation.issn","1872-8561"],["dc.relation.issn","0022-328X"],["dc.title","Iron chelation and redox chemistry of anthranilic acid and 3-hydroxyanthranilic acid: A comparison of two structurally related kynurenine pathway metabolites to obtain improved insights into their potential role in neurological disease development"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","476"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Antioxidants"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Kubicova, Lenka"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Bachmann, Gert"],["dc.contributor.author","Weckwerth, Wolfram"],["dc.contributor.author","Chobot, Vladimir"],["dc.date.accessioned","2020-12-10T18:46:56Z"],["dc.date.available","2020-12-10T18:46:56Z"],["dc.date.issued","2019"],["dc.description.sponsorship","Austrian Science Fund"],["dc.identifier.doi","10.3390/antiox8100476"],["dc.identifier.eissn","2076-3921"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17062"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78593"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","2076-3921"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Coordination Complex Formation and Redox Properties of Kynurenic and Xanthurenic Acid Can Affect Brain Tissue Homeodynamics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3917"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","19"],["dc.contributor.affiliation","Chobot, Vladimir; \t\t \r\n\t\t Division of Molecular Systems Biology, Department of Ecogenomics and Systems Biology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria, vladimir.chobot@univie.ac.at"],["dc.contributor.affiliation","Hadacek, Franz; \t\t \r\n\t\t Department of Plant Biochemistry, Albrecht-von-Haller Institut, Georg-August-Universität Göttingen, Justus-von-Liebig-Weg 11, D-37077 Göttingen, Germany, franz.hadacek@biologie.uni-goettingen.de"],["dc.contributor.affiliation","Bachmann, Gert; \t\t \r\n\t\t Division of Molecular Systems Biology, Department of Ecogenomics and Systems Biology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria, gert.bachmann@univie.ac.at"],["dc.contributor.affiliation","Weckwerth, Wolfram; \t\t \r\n\t\t Division of Molecular Systems Biology, Department of Ecogenomics and Systems Biology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria, wolfram.weckwerth@univie.ac.at"],["dc.contributor.affiliation","Kubicova, Lenka; \t\t \r\n\t\t Division of Molecular Systems Biology, Department of Ecogenomics and Systems Biology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria, lenka.kubicova@univie.ac.at"],["dc.contributor.author","Chobot, Vladimir"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Bachmann, Gert"],["dc.contributor.author","Weckwerth, Wolfram"],["dc.contributor.author","Kubicova, Lenka"],["dc.date.accessioned","2020-12-10T18:47:08Z"],["dc.date.available","2020-12-10T18:47:08Z"],["dc.date.issued","2018"],["dc.date.updated","2022-09-05T08:11:57Z"],["dc.description.sponsorship","Austrian Science Fund"],["dc.identifier.doi","10.3390/ijms19123917"],["dc.identifier.eissn","1422-0067"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78657"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Antioxidant Properties and the Formation of Iron Coordination Complexes of 8-Hydroxyquinoline"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5850"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","Molecules"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Chobot, Vladimir"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Bachmann, Gert"],["dc.contributor.author","Weckwerth, Wolfram"],["dc.contributor.author","Kubicova, Lenka"],["dc.date.accessioned","2021-04-14T08:27:20Z"],["dc.date.available","2021-04-14T08:27:20Z"],["dc.date.issued","2020"],["dc.description.sponsorship","Austrian Science Fund"],["dc.identifier.doi","10.3390/molecules25245850"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82251"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","MDPI"],["dc.relation.eissn","1420-3049"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","In Vitro Evaluation of Pro- and Antioxidant Effects of Flavonoid Tricetin in Comparison to Myricetin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","111"],["dc.bibliographiccitation.journal","Journal of Organometallic Chemistry"],["dc.bibliographiccitation.lastpage","115"],["dc.bibliographiccitation.volume","782"],["dc.contributor.author","Kubicova, Lenka"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Weckwerth, Wolfram"],["dc.contributor.author","Chobot, Vladimir"],["dc.date.accessioned","2018-11-07T09:58:31Z"],["dc.date.available","2018-11-07T09:58:31Z"],["dc.date.issued","2015"],["dc.description.abstract","The tryptophan metabolite, quinolinic (2,3-pyridinedicarboxylic) acid, is known as an endogenous neurotoxin. Quinolinic acid can form coordination complexes with iron or copper. The effects of quinolinic acid on reactive oxygen species production in the presence of iron or copper were explored by a combination of chemical assays, classical site-specific and ascorbic acid-free variants of the deoxyribose degradation assay, and mass spectrometry (ESI-MS). Quinolinic acid showed evident antioxidant activity in chemical assays, but the effect was more pronounced in the presence of copper as transition metal catalyst than in presence of iron. Nano-ESI-MS confirmed the ability of quinolinic acid to form coordination complexes with iron(II) or copper(II) and quinolinic acid stability against oxidative attack by hydroxyl radicals. The results illustrate a highly milieu-dependent quinolinic acid chemistry when it enters reactions as competitive ligand. (C) 2015 The Authors. Published by Elsevier B.V."],["dc.description.sponsorship","Austrian Science Fund (FWF) [P24630-B21]"],["dc.identifier.doi","10.1016/j.jorganchem.2015.01.030"],["dc.identifier.isi","000351637900017"],["dc.identifier.pmid","25892824"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13843"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37376"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Sa"],["dc.publisher.place","Lausanne"],["dc.relation.conference","7th International Symposium on Bioorganometallic Chemistry"],["dc.relation.eventlocation","Vienna, AUSTRIA"],["dc.relation.issn","1872-8561"],["dc.relation.issn","0022-328X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effects of endogenous neurotoxin quinolinic acid on reactive oxygen species production by Fenton reaction catalyzed by iron or copper"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1986"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Chobot, Vladimir"],["dc.contributor.author","Hadacek, Franz"],["dc.contributor.author","Bachmann, Gert"],["dc.contributor.author","Weckwerth, Wolfram"],["dc.contributor.author","Kubicova, Lenka"],["dc.date.accessioned","2018-11-07T10:04:51Z"],["dc.date.available","2018-11-07T10:04:51Z"],["dc.date.issued","2016"],["dc.description.abstract","The flavanol (+/-)-catechin shows an OH group but no 4-keto group on ring C (C3), and no conjugation between ring A and B. The related flavanone (+)-eriodictyol has a keto group on C4 but no 3-OH group on ring C. (+)-Taxifolin, another flavanone, has an OH on C3 and a keto group on C4 of the C ring. Deoxyribose degradation assay systems, with hydrogen peroxide and ascorbic acid either added or omitted, were performed in variants in which Fe(III) was added in a complex with ethylenediaminetetraacetic acid (EDTA). In combination with differential pulse voltammetry (DVP), the specific redox-chemical contributions of the ring A m-dihydroxyl groups could be explored more specifically in addition to those of the traditionally investigated o-dihydroxyl groups of ring B."],["dc.description.sponsorship","Austrian Science Fund (FWF) [P24630-B21]"],["dc.identifier.doi","10.3390/ijms17121986"],["dc.identifier.isi","000392280500030"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14313"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38785"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mdpi Ag"],["dc.relation.issn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Pro- and Antioxidant Activity of Three Selected Flavan Type Flavonoids: Catechin, Eriodictyol and Taxifolin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]