Klinger, Hans-Michael

[["dc.bibliographiccitation.firstpage","96"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Knee Surgery Sports Traumatology Arthroscopy"],["dc.bibliographiccitation.lastpage","112"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Spahn, Gunter"],["dc.contributor.author","Hofmann, Gunther O."],["dc.contributor.author","von Engelhardt, Lars Victor"],["dc.contributor.author","Li, Mengxia"],["dc.contributor.author","Neubauer, Henning"],["dc.contributor.author","Klinger, Hans Michael"],["dc.date.accessioned","2018-11-07T09:30:48Z"],["dc.date.available","2018-11-07T09:30:48Z"],["dc.date.issued","2013"],["dc.description.abstract","Both high tibial valgus osteotomy (HTO) and unicompartmental medial knee arthroplasty (UKA) are established methods for the treatment for moderate stages of OA. This is the first global meta-analysis to compare the long-term effects of both methods regarding survival, outcomes and complications of total arthroplasty. Literature research was performed using established medical databases: MEDLINE (via PubMed), EMBASE (via OVID) and the Cochrane register. Criteria for inclusion were as follows: English or German papers, a clinical trial with a clear description of survival, an outcome evaluation using a well-described knee score and a follow-up > 5 years. Statistical analysis was performed using the special meta-analysis software called \"Comprehensive Meta Analysis\" (version 2.0; Biostat, Englewood, NJ, USA). Final meta-analysis after the full-text review included 46 studies about valgus HTO and 43 studies about medial UKA. There were no significant differences between valgus HTO and medial UKA in terms of the number of total required replacements. After a 5- to 8-year follow-up, 91.0% of the valgus HTO patients and 91.5% of medial UKA patients did not need a total replacement. This value was 84.4% for valgus HTOs and 86.9% for medial UKAs after a 9- to 12-year follow-up. Mean survival time to TKA was 9.7 years after valgus HTO and 9.2 years after medial UKA. Clinical outcome was significantly better after medial UKA in a 5- to 12-year follow-up. After more than 12 years, results were comparable in both groups. No significant differences were seen in the complication rates. This meta-analysis aimed to find the advantages and disadvantages of two established methods for the treatment for medial compartment knee osteoarthritis. Valgus HTO is more appropriate for younger patients who accept a slight decrease in their physical activity. Medial UKA is appropriate for older patients obtaining sufficient pain relief but with reduced physical activity. II."],["dc.identifier.doi","10.1007/s00167-011-1751-2"],["dc.identifier.isi","000313047100012"],["dc.identifier.pmid","22076053"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31395"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0942-2056"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The impact of a high tibial valgus osteotomy and unicondylar medial arthroplasty on the treatment for knee osteoarthritis: a meta-analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","145"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Zeitschrift für Orthopädie und Unfallchirurgie"],["dc.bibliographiccitation.lastpage","152"],["dc.bibliographiccitation.volume","149"],["dc.contributor.author","Spahn, Gunter"],["dc.contributor.author","Schiele, R."],["dc.contributor.author","Hofmann, Gunther O."],["dc.contributor.author","Schiltenwolf, M."],["dc.contributor.author","Grifka, J."],["dc.contributor.author","Vaitl, T."],["dc.contributor.author","Schneider, S."],["dc.contributor.author","Liebers, F."],["dc.contributor.author","Klinger, Hans-Michael"],["dc.date.accessioned","2018-11-07T08:58:25Z"],["dc.date.available","2018-11-07T08:58:25Z"],["dc.date.issued","2011"],["dc.description.abstract","Aim: This metaanalysis was performed to evaluate the prevalence of the radiological assessed knee osteoarthritis in the whole community. Materials and Methods: Medical databases (Medline, EMBASE, Cochrane) were searched for the strategy: [\"Osteoarthritis\" and \"Knee\" and \"Prevalence\"]. The deadline for the search was 31.12.2009. Two investigators (first and senior author) independently made the selection from 17 studies (from a total of 1428) according to the inclusion criteria: a cross-sectional study of the whole community, radiological investigation and definition of knee ROA by an established radiological score. Only studies in English or German language were evaluated. Effect sizes (event rate, odds ratio [OR] and confidence interval [CI]) were calculated by the software \"Comprehensive Metaanalysis V2\". Study heterogeneity (I2) was determined accordingly to Higgins. Results: The kappa index for interobserver validity was k = 0.948. All studies judged the grade of osteoarthritis according to the Kellgren-Lawrence (KL) score. For calculation of knee ROA KL grades 2+ were estimated only. The total prevalence of knee ROA was 24.3% (CI 23.4-25.2%). The whole prevalence in male patients was 24.3% (CI 23.4-25.2%); I2 = 59.4 (p = 0.002) and in female patients 32.6% (CI 31.8-33.4%); I2 = 49,1 (p A 0.001). Younger male patients (age 50-) had a prevalence of 5.6 (CI 4.5-6.8). In older patients (80+) the male prevalence was 44.5% (CI 39.6-49.5%). In this age group female patients had a prevalence of 71.6% (CI 67.6-75.3%). The higher prevalence of knee ROA in female patients was significant (OR = 1.8 [1.7-1.9]; I2 = 46.0 [p < 0.001]). The prevalence of knee ROA was higher in male Asians compared with male Caucasians (OR = 1.1, CI 0.9-1.2; p = 0.080) in tendency. This difference was significant in female patients (OR = 2.2; CI 2.0-2.4; p < 0.001). Furthermore another trend was evaluated. Female patients (70-79 years) from the birth-year cohort 1920- had a prevalence of 37.8% (CI 35.9-39.7)%. In contrast female patients from the birth-year cohort 1920 had a prevalence of 62.8% (CI 60.8-64.8%) at 70-79 years. This difference was significant (OR = 2.8; CI 2.5-3.1; p < 0.001). Conclusions: This investigation confirms the high prevalence of knee ROA. The evaluated data may serve as a reference for medical or scientific investigations in the future."],["dc.identifier.doi","10.1055/s-0030-1250531"],["dc.identifier.isi","000289241600002"],["dc.identifier.pmid","21243591"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23636"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Thieme Medical Publ Inc"],["dc.relation.issn","1864-6743"],["dc.relation.issn","1864-6697"],["dc.title","The Prevalence of Radiological Osteoarthritis in Relation to Age, Gender, Birth-Year Cohort, and Ethnic Origins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1553"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Knee Surgery Sports Traumatology Arthroscopy"],["dc.bibliographiccitation.lastpage","1561"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Spahn, Gunter"],["dc.contributor.author","Hofmann, Gunther O."],["dc.contributor.author","Klinger, Hans-Michael"],["dc.date.accessioned","2018-11-07T09:23:08Z"],["dc.date.available","2018-11-07T09:23:08Z"],["dc.date.issued","2013"],["dc.description.abstract","Knee osteoarthritis is one of the most common orthopaedic diseases. Therapeutic options for this disease include conservative treatments and arthroscopic debridement and partial or complete replacement. This meta-analysis aimed to collect and analyse the available information on the effects of arthroscopic joint debridement related to the clinical outcomes, the required conversion to replacement and the factors for patient selection. A search for publications was performed in the PubMed, Cochrane and EMBASE medical databases. The primary search resulted in a total of 1,512 citations. The results from 30 papers were included in this study. The extracted dates were listed in a standardised protocol. The statistical evaluation was performed using Comprehensive Meta-analysis software (V2 Biostat, Englewood, NJ, USA). No randomised study that compared conservative and arthroscopic treatments for knee osteoarthritis was found. Most studies reported middle-term results after arthroscopic operations. The results of these studies showed excellent or good outcomes in more than 60 % of all patients. These results were correlated with a significant increase in the knee scores from baseline to follow-up; the standardised difference in means was 2.3 (CI 95 % 1.5-3.0, p < 0.001). The required conversion rate to replacement increased as the follow-up interval increased. The rates were as follows: 1 year-6.1 % (CI 95 %, 2.1-16.6 %), 2 years-16.8 % (CI 95 %, 10.2-26.3 %), 3 years-21.7 % (CI 95 %, 15.5-29.1 %) and 4 years-34.1 % (CI 95 %, 22.8-47.6 %). The mean survival time was 42.7 (CI 95 %, 14.5-71.1) months. Numerous factors influenced the outcome, including the radiological stage of the osteoarthritis and individual patient factors (e.g. time of history of osteoarthritis, weight and smoking). The local knee findings, such as axial dysalignment, missing effusion and massive crepitus, were also correlated with patient outcome. Arthroscopic joint debridement is a potential and sufficient treatment for knee osteoarthritis in a middle-term time interval. This procedure results in an excellent or good outcome in approximately 60 % of patients in approximately 5 years. Systematic review of studies, Level III."],["dc.identifier.doi","10.1007/s00167-012-2169-1"],["dc.identifier.isi","000320672600014"],["dc.identifier.pmid","22893268"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29510"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1433-7347"],["dc.relation.issn","0942-2056"],["dc.title","The effects of arthroscopic joint debridement in the knee osteoarthritis: results of a meta-analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","565"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Knee Surgery Sports Traumatology Arthroscopy"],["dc.bibliographiccitation.lastpage","573"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Spahn, Gunter"],["dc.contributor.author","Kahl, Enrico"],["dc.contributor.author","Mueckley, Thomas"],["dc.contributor.author","Hofmann, Gunther O."],["dc.contributor.author","Klinger, Hans Michael"],["dc.date.accessioned","2018-11-07T11:14:47Z"],["dc.date.available","2018-11-07T11:14:47Z"],["dc.date.issued","2008"],["dc.description.abstract","Both mechanical shavers and radiofrequency-based devices are used to treat symptomatic partial thickness chondral lesions. Controversy exists as to which mode of treatment provides better outcomes. The purpose of this study was to compare clinical results after bipolar radiofrequency-based chondroplasty (RFC) to mechanical shaver debridement (MSD). Patients (n = 60) included in the study presented with knee pain associated with a medial meniscus tear and idiopathic ICRS grade III defect of the medial femoral condyle. Patients who had osteoarthritis, grade II or higher cartilage defects of the tibial joint surface, the lateral compartment, or the femoro-patellar joint, or had previously undergone surgery on the affected knee were excluded. Patients underwent partial meniscectomy; during the procedure, they were randomly assigned to receive bipolar RFC (Paragon, ArthroCare Corporation, Austin, TX) or MSD (Full radius resector LR 4.85 x 12.5 cm), Arthrex, Naples, FL). Postoperatively, the same physiotherapist provided instructions for a daily 2-h home training program consisting of isometric, isotonic, and leg lifting exercises; patients were provided the option of using crutches. Clinical outcomes were assessed using the Tegner score, visual analogue scale (VAS) score, and Knee and Osteoarthritis Outcome Score (KOOS) assessment, which consists of five principal domains including pain, symptoms, function in daily living (ADL), and knee related quality of life (QOL), where a score of 0 indicates extreme symptoms and 100 represents no symptoms. Age and time from injury onset did not differ significantly between the RFC and MSD groups (43 +/- 10 vs. 44 +/- 9 years, P = 0.732; 8 +/- 3 vs. 7 +/- 4 months, P = 0.279). No complications or adverse events were observed. Preoperatively, mean (+/- SD) scores for all KOOS principal domains were < 20 and did not differ significantly (P > 0.05) between treatment groups. Post-operatively, the RFC patients returned to activity significantly earlier than MSD patients (17 +/- 7 vs. 22 +/- 6 days, P = 0.002). VAS pain scores at 6 h, 24 h, 6 weeks, and 1 year were significantly ( P < 0.001) lower for the RFC group than for the MSD group ( 4 +/- 2, 2 +/- 0.5, 2 +/- 1, 2 +/- 1 vs. 8 +/- 1, 4 +/- 1, 4 +/- 1, 3 +/- 1, respectively). At 1 year, RFC patients had significantly better Tegner score (4.1 +/- 0.8 vs. 2.8 +/- 0.6, P < 0.001) and KOOS domain scores for pain, symptoms, ADL, QOL, respectively (81.1 +/- 8, vs. 59.4 +/- 12.8; 80.7 +/- 7.5 vs. 59.6 +/- 7.5; 81.5 +/- 6.5 vs. 60.1 +/- 6.9; 80 +/- 10 vs. 61.3 +/- 12.5; P < 0.001) than MSD patients. Significantly fewer RFC patients (2% vs 23%, p = 0.026) reported using NSAIDS for knee pain at 1 year. Patients undergoing radiofrequency-based chondroplasty for ICRS grade III medial femoral condyle chondral lesions in conjunction with partial meniscectomy had significantly better clinical outcomes through 1 year than patients with similar pathology receiving chondral debridement using the mechanical shaver."],["dc.identifier.doi","10.1007/s00167-008-0506-1"],["dc.identifier.isi","000256322000006"],["dc.identifier.pmid","18327566"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54218"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0942-2056"],["dc.title","Arthroscopic knee chondroplasty using a bipolar radiofrequency-based device compared to mechanical shaver: results of a prospective, randomized, controlled study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S235"],["dc.bibliographiccitation.journal","Osteoarthritis and Cartilage"],["dc.bibliographiccitation.lastpage","S236"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Spahn, Gunter"],["dc.contributor.author","Klinger, Hans-Michael"],["dc.contributor.author","Baums, M."],["dc.contributor.author","Pinkepank, Ulrich"],["dc.contributor.author","Hofmann, Gunther O."],["dc.date.accessioned","2018-11-07T08:52:52Z"],["dc.date.available","2018-11-07T08:52:52Z"],["dc.date.issued","2011"],["dc.identifier.isi","000209001600529"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22273"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.publisher.place","Oxford"],["dc.relation.issn","1522-9653"],["dc.relation.issn","1063-4584"],["dc.title","RESULTS OF SUBJECTIVE ( CLINICAL) AND OBJECTIVE EVALUATION (NIRS-MEASUREMENTS) OF CARTILAGE LESIONS IN KNEE ARTHROSCOPY"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S73"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Arthroscopy The Journal of Arthroscopic and Related Surgery"],["dc.bibliographiccitation.lastpage","S80"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Spahn, Gunter"],["dc.contributor.author","Klinger, Hans Michael"],["dc.contributor.author","Mueckley, Thomas"],["dc.contributor.author","Hofmann, Gunther O."],["dc.date.accessioned","2018-11-07T08:39:29Z"],["dc.date.available","2018-11-07T08:39:29Z"],["dc.date.issued","2010"],["dc.description.abstract","Purpose: This randomized study was undertaken to compare the effectiveness of simple mechanical debridement and 50 degrees C controlled bipolar chondroplasty. Methods: A total of 60 patients who had a grade III articular cartilage defect of the medial femoral condyle were included. After randomization, 30 patients underwent simple debridement of articular cartilage defects, which was performed with a mechanical shaver (mechanical shaver debridement [MSD] group). The remaining patients underwent thermal chondroplasty, which was performed with a temperature-controlled bipolar device with a constant thermo-application of a maximum of 50 degrees C (radiofrequency-based chondroplasty [RFC] group). All patients underwent partial (n = 41) or subtotal (n = 19) meniscectomy. Follow-up was undertaken 4 years postoperatively. Results: No significant differences between the preoperative findings for the 2 groups were observed. One patient from the MSD group had died, and one female patient in the RFC group was lost to follow-up. A total of 18 patients had undergone revision operations for persistent knee problems: in the MSD group, there were 8 endoprostheses, 4 osteotomies, and 2 revision arthroscopies, whereas in the RFC group, there was 1 replacement, 2 osteotomies, and 1 revision arthroscopy with subtotal medial meniscectomy. The proportion of revisions was significantly higher in the MSD group (P = .006). These patients were excluded from the evaluation. The remaining 40 patients from both groups benefited from the operation. The preoperative Knee Injury and Osteoarthritis Outcome Score (KOOS) was 11.3 points in the MSD group and 15.5 points in the RFC group (P = .279). Patients from the MSD group had a KOOS of 53.2 points at the time of follow-up. In the RFC group the KOOS (71.8 points) was significantly higher (P < .001). Conclusions: Compared with classical mechanical debridement, bipolar radio-frequency currently appears to be the superior method for achieving a good midterm result. Level of Evidence: Level I, randomized controlled trial."],["dc.identifier.doi","10.1016/j.arthro.2010.02.030"],["dc.identifier.isi","000281434100010"],["dc.identifier.pmid","20810095"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19007"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","0749-8063"],["dc.title","Four-Year Results From a Randomized Controlled Study of Knee Chondroplasty With Concomitant Medial Meniscectomy: Mechanical Debridement Versus Radiofrequency Chondroplasty"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","269"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Physikalische Medizin Rehabilitationsmedizin Kurortmedizin"],["dc.bibliographiccitation.lastpage","279"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Spahn, Gunter"],["dc.contributor.author","Schiele, R."],["dc.contributor.author","Hofmann, Gunther O."],["dc.contributor.author","Schiltenwolf, M."],["dc.contributor.author","Grifka, J."],["dc.contributor.author","Vaitl, T."],["dc.contributor.author","Scheidler, S."],["dc.contributor.author","Liebers, F."],["dc.contributor.author","Seidler, S."],["dc.contributor.author","Klinger, Hans-Michael"],["dc.date.accessioned","2018-11-07T08:49:16Z"],["dc.date.available","2018-11-07T08:49:16Z"],["dc.date.issued","2011"],["dc.description.abstract","Introduction: This metaanalysis was performed to evaluate the event rate of radiological knee osteoarthritis (ER ROA) after knee injuries (minimum 10 year follow-up). Furthermore was aimed to compare the ROA after knee injury with the ROA within the normal population. Materials and methods: At deadline 28.2.2010 was performed a systematic PubMed recherche by 2 independent investigators. The search strategy was (MeSH): [knee] and [osteoarthritis] and [special injury]. Furthermore the normal ROA was evaluated for the \"normal population\". Criteria for inclusion were papers in German or English language, minimum follow-up and clear-defined radiological osteoarthritis grading accordingly to the Kellgren-Lawrence (KL) scale. A KL-grade of 2 + was accepted as manifest radiological knee osteoarthritis. The relative risk of ROA was calculated in fixed effect model and is expressed as relative risk (odd ratio OR (CI 95 %)). Results: A total of 1 428 publications were found as result of the search the keywords [osteoarthritis] and [knee] and prevalence]. A total of 18 publications were included in the metaanalysis. The ROA of the \"normal population\" without adjustment to sex or age was 27.1 (CI 95 % 26.6-27.7) %. The ROA after ACL-injury was 42.0 (CI 95% 39.844.2) %. Compared with the normal population increases an ACL-injury the ROA significantly (OR = 2.5 (CI 95% 2.3-2.7), p < 0.001). Patients after PCL-injury have a higher risk of ROA in tendency (OR= 1.3 (CI 95% 0.8-1.9), p = 0.263. Fractures near the knee joint increases the risk of ROA in tendency (OR = 1.2 (CI 95% 1.0-1.3), p = 0.05). Conclusions: Knee joint injuries are doubtless risk factors for an increased ROA. The most traumatologic outcome studies don't address the ROA. The most default of most studies is the lack of information about sex or age adjusted ROA. In future long-term follow-ups for evaluation of the age and sex adjusted ROA are needed for better understanding the progression a \"post-traumatic osteoarthritis\"."],["dc.identifier.doi","10.1055/s-0031-1291253"],["dc.identifier.isi","000298398600003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21415"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0940-6689"],["dc.title","The Relative Risk of Knee Osteoarthritis after Knee Injuries - Results of a Metaanalysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","272"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Zeitschrift für Orthopädie und Unfallchirurgie"],["dc.bibliographiccitation.lastpage","279"],["dc.bibliographiccitation.volume","150"],["dc.contributor.author","Spahn, Gunter"],["dc.contributor.author","Klinger, Hans-Michael"],["dc.contributor.author","Harth, P."],["dc.contributor.author","Hofmann, Gunther O."],["dc.date.accessioned","2018-11-07T09:09:34Z"],["dc.date.available","2018-11-07T09:09:34Z"],["dc.date.issued","2012"],["dc.description.abstract","Aim: High tibial osteotomy (HTO) has been established as an effective method for the treatment of unicondylar knee osteoarthritis. This study was undertaken to quantify the potential for restoration of cartilage lesions or defects after HTO in relation to different cartilage treatment modalities. Control arthroscopy was undertaken to identify the cartilage lesions within the knee joint 1.5 years after medial opening wedge osteotomy. Material and Method: A total of 135 patients (72 male and 63 female) had undergone medial-opening high tibial osteotomy and arthroscopy. The mean age at operation was 48.8 (36 to 65) years. All HTO were fixed with an angle-stable, mobile spacer-containing plate (HTO-Platte, Konigsee, Deutschland). All HTO were combined with a simultaneous arthroscopy. Grade III cartilage lesions had undergone either shaving or temperature-controlled chondroplasty (Paragon ArthroW Austin, TX, USA). In some case these cartilage lesions had remained untreated. Control arthroscopy and removal of the implants was performed 1.5 years after HTO. The cartilage lesions were graded accordingly to the ICRS guidelines (International Cartilage Repair Society). Results: The KOOS at HTO was 49.9 (SD 10.6) points. We observed at follow-up a mean increase from 66.1 (SD 28.8, 95% CI: 61.2-71.1) points. The KOOS at follow-up was 16.1 (SD 29.8) points. There was no delayed union of the HTO space. Before HTO the varus angle Was 10.4 degrees (SD 3.9 range 5 to 20 degrees). The correction angle was 13.6 degrees (SD 4.4, 95% CI: 12.9-14.4 degrees). Finally we determined a valgus angle of-3.2 degrees (SD 1.8 minimum 0 degrees varus, maximum -6 degrees valgus. The clinical outcome (KOOS) significantly (p<0.001) correlated (R = 0.605) with the extension of valgisation. Patients with a valgus angle of 3 degrees and more had the best outcome. Of the grade III lesions 40.4% in the medial femoral condyle and 62.3% in the medial tibial plateau increased to grade II or I lesions. In 13.1% of the medial femoral condyle and 8.5% of medial tibial plateau cases we found complete (grade IV) defects at control arthroscopy. The highest rate of regenerations was detected after temperature-controlled chondroplasty. The worst results were produced after mechanical debridement. Microfracturing of complete defects produced regeneration in about 2/3 in the medial femoral condyle and about 1/3 in the medial tibial plateau. No increase was observed within the lateral or patello-femoral compartment. No correlation was seen between cartilage regeneration and outcome. The extension of valgisation did not influence the cartilage regeneration. Conclusions: The main effect of the HTO is the shift of the weight-bearing line from the arthritic compartment to the opposite femorotibial healthy one. In addition, HTO also produces a partial restoration of cartilage lesions. Deep cartilage lesions (grade III) restore in about 60% of the cases after HTO. The worst restoration is found after mechanical shaving. This method should be avoided in the future. The best restoration was found in deep lesions after thermochondroplasty. Furthermore, in about half of the patients with complete (grade IV) defects, microfracturing caused the formation of fibrocartilaginous regenerates. This procedure should always be performed if possible."],["dc.identifier.doi","10.1055/s-0031-1298388"],["dc.identifier.isi","000305675300019"],["dc.identifier.pmid","22729374"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26293"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Thieme Medical Publ Inc"],["dc.relation.issn","1864-6697"],["dc.title","Cartilage Regeneration after High Tibial Osteotomy. Results of an Arthroscopic Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Osteoarthritis and Cartilage"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Spahn, Gunter"],["dc.contributor.author","Hofmann, Gunther O."],["dc.contributor.author","Klinger, Hans-Michael"],["dc.date.accessioned","2018-11-07T08:52:52Z"],["dc.date.available","2018-11-07T08:52:52Z"],["dc.date.issued","2011"],["dc.format.extent","S156"],["dc.identifier.isi","000209001600365"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22274"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.publisher.place","Oxford"],["dc.relation.issn","1522-9653"],["dc.relation.issn","1063-4584"],["dc.title","THE RELATIVE RISK OF KNEE OSTEOARTHRITIS AFTER KNEE INJURIES. RESULTS OF A METAANALYSIS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","355"],["dc.bibliographiccitation.issue","5-6"],["dc.bibliographiccitation.journal","BIOMEDIZINISCHE TECHNIK"],["dc.bibliographiccitation.lastpage","359"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Spahn, Gunter"],["dc.contributor.author","Plettenberg, Holger"],["dc.contributor.author","Nagel, Horst"],["dc.contributor.author","Kahl, Enrico"],["dc.contributor.author","Klinger, Hans Michael"],["dc.contributor.author","Guenther, Manfred"],["dc.contributor.author","Mueckley, Thomas"],["dc.contributor.author","Hofmann, Gunther O."],["dc.date.accessioned","2018-11-07T10:30:53Z"],["dc.date.available","2018-11-07T10:30:53Z"],["dc.date.issued","2006"],["dc.description.abstract","This study evaluated the efficiency of Karl Fischer titration and coulometry for measurement of water content in small intact and defective cartilage specimens. Cartilage from the main weight-bearing zone of the medial condyle of 38 fresh sheep knees was used. Of these, 20 condyles had an intact cartilage, while defects (14 grade 1 and 4 grade 11) were found in the rest. The mechanical hardness was determined as Shore A. Cartilage specimens of approximately 5 mg were analyzed in special devices for moisture measurement and then continuously heated up to 105 degrees C. The actual measurement was performed in an electric cell (coulometry). An electrode was laminated with hygroscopic phosphorus pentoxide. In the electrochemical reaction, H and 0 are liberated from the electrode. The requirement for electric energy correlates with the amount of water in the specimen. The water content in intact cartilage was 66.9%. Grade 1 (72.6%) and grade 11 (77.8%) defects had significantly higher water content. Significantly higher and faster spontaneous evaporation was observed in cartilage defects at room temperature. The water content and spontaneous water evaporation correlated with significantly lower mechanical hardness. The experimental design (combined method of thermo-gravimetry, Karl Fischer titration, and coulometry) was sufficient for evaluating the water content in small cartilage specimens. It is also possible to measure the temperature-dependent water liberation from cartilage specimens."],["dc.identifier.doi","10.1515/BMT.2006.069"],["dc.identifier.isi","000243178900013"],["dc.identifier.pmid","17155872"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43969"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Walter De Gruyter & Co"],["dc.relation.issn","0013-5585"],["dc.title","Karl Fischer titration and coulometry for measurement of water content in small cartilage specimens"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]