Hardeland, Rüdiger

[["dc.bibliographiccitation.firstpage","15858"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.lastpage","15890"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Tan, Dun-Xian"],["dc.contributor.author","Zheng, Xiaodong"],["dc.contributor.author","Kong, Jin"],["dc.contributor.author","Manchester, Lucien C."],["dc.contributor.author","Hardeland, Rüdiger"],["dc.contributor.author","Kim, Seok Joong"],["dc.contributor.author","Xu, X."],["dc.contributor.author","Reiter, Russel J."],["dc.date.accessioned","2018-11-07T09:35:42Z"],["dc.date.available","2018-11-07T09:35:42Z"],["dc.date.issued","2014"],["dc.description.abstract","Melatonin and melatonin isomers exist and/or coexist in living organisms including yeasts, bacteria and plants. The levels of melatonin isomers are significantly higher than that of melatonin in some plants and in several fermented products such as in wine and bread. Currently, there are no reports documenting the presence of melatonin isomers in vertebrates. From an evolutionary point of view, it is unlikely that melatonin isomers do not exist in vertebrates. On the other hand, large quantities of the microbial flora exist in the gut of the vertebrates. These microorganisms frequently exchange materials with the host. Melatonin isomers, which are produced by these organisms inevitably enter the host's system. The origins of melatonin and its isomers can be traced back to photosynthetic bacteria and other primitive unicellular organisms. Since some of these bacteria are believed to be the precursors of mitochondria and chloroplasts these cellular organelles may be the primary sites of melatonin production in animals or in plants, respectively. Phylogenic analysis based on its rate-limiting synthetic enzyme, serotonin N-acetyltransferase (SNAT), indicates its multiple origins during evolution. Therefore, it is likely that melatonin and its isomer are also present in the domain of archaea, which perhaps require these molecules to protect them against hostile environments including extremely high or low temperature. Evidence indicates that the initial and primary function of melatonin and its isomers was to serve as the first-line of defence against oxidative stress and all other functions were acquired during evolution either by the process of adoption or by the extension of its antioxidative capacity."],["dc.identifier.doi","10.3390/ijms150915858"],["dc.identifier.isi","000343109700059"],["dc.identifier.pmid","25207599"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11708"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32448"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mdpi Ag"],["dc.relation.issn","1422-0067"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Fundamental Issues Related to the Origin of Melatonin and Melatonin Isomers during Evolution: Relation to Their Biological Functions"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","23448"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.lastpage","23500"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Angeles Bonmati-Carrion, Maria"],["dc.contributor.author","Arguelles-Prieto, Raquel"],["dc.contributor.author","Jose Martinez-Madrid, Maria"],["dc.contributor.author","Reiter, Russel J."],["dc.contributor.author","Hardeland, Ruediger"],["dc.contributor.author","Angeles Rol, Maria"],["dc.contributor.author","Antonio Madrid, Juan"],["dc.date.accessioned","2018-11-07T09:31:54Z"],["dc.date.available","2018-11-07T09:31:54Z"],["dc.date.issued","2014"],["dc.description.abstract","Currently, in developed countries, nights are excessively illuminated (light at night), whereas daytime is mainly spent indoors, and thus people are exposed to much lower light intensities than under natural conditions. In spite of the positive impact of artificial light, we pay a price for the easy access to light during the night: disorganization of our circadian system or chronodisruption (CD), including perturbations in melatonin rhythm. Epidemiological studies show that CD is associated with an increased incidence of diabetes, obesity, heart disease, cognitive and affective impairment, premature aging and some types of cancer. Knowledge of retinal photoreceptors and the discovery of melanopsin in some ganglion cells demonstrate that light intensity, timing and spectrum must be considered to keep the biological clock properly entrained. Importantly, not all wavelengths of light are equally chronodisrupting. Blue light, which is particularly beneficial during the daytime, seems to be more disruptive at night, and induces the strongest melatonin inhibition. Nocturnal blue light exposure is currently increasing, due to the proliferation of energy-efficient lighting (LEDs) and electronic devices. Thus, the development of lighting systems that preserve the melatonin rhythm could reduce the health risks induced by chronodisruption. This review addresses the state of the art regarding the crosstalk between light and the circadian system."],["dc.identifier.doi","10.3390/ijms151223448"],["dc.identifier.isi","000346797400111"],["dc.identifier.pmid","25526564"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11710"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31631"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mdpi Ag"],["dc.relation.issn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]