Jung, Wolfram

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[["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Journal of Clinical Oncology"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Straka, Christian"],["dc.contributor.author","Vogel, Martin"],["dc.contributor.author","Mueller, Juergen"],["dc.contributor.author","Kropff, Martin H."],["dc.contributor.author","Metzner, Bernd"],["dc.contributor.author","Langer, Christian"],["dc.contributor.author","Sayer, Herbert G."],["dc.contributor.author","Jung, Wolfram"],["dc.contributor.author","Duerk, Heinz Albert"],["dc.contributor.author","Wandt, Hannes"],["dc.contributor.author","Bassermann, Florian"],["dc.contributor.author","Gramatzki, Martin"],["dc.contributor.author","Roesler, Wolf"],["dc.contributor.author","Knop, Stefan"],["dc.contributor.author","Wolf, Hans-Heinrich"],["dc.contributor.author","Brugger, Wolfram"],["dc.contributor.author","Engelhardt, Monika Martha"],["dc.contributor.author","Fischer, Thomas"],["dc.contributor.author","Einsele, Hermann"],["dc.date.accessioned","2018-11-07T09:57:07Z"],["dc.date.available","2018-11-07T09:57:07Z"],["dc.date.issued","2015"],["dc.identifier.isi","000358036901824"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37095"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Clinical Oncology"],["dc.publisher.place","Alexandria"],["dc.relation.conference","Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)"],["dc.relation.eventlocation","Chicago, IL"],["dc.relation.issn","1527-7755"],["dc.relation.issn","0732-183X"],["dc.title","Results from two phase III studies of bortezomib (BTZ) consolidation vs observation (OBS) post-transplant in patients (pts) with newly diagnosed multiple myeloma (NDMM)."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","558"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Blood"],["dc.bibliographiccitation.lastpage","565"],["dc.bibliographiccitation.volume","111"],["dc.contributor.author","Hoster, Eva"],["dc.contributor.author","Dreyling, Martin H."],["dc.contributor.author","Klapper, Wolfram"],["dc.contributor.author","Gisselbrecht, Christian"],["dc.contributor.author","van Hoof, Achiel"],["dc.contributor.author","Kluin-Nelemans, Hanneke C."],["dc.contributor.author","Pfreundschuh, Michael"],["dc.contributor.author","Reiser, Marcel"],["dc.contributor.author","Metzner, Bernd"],["dc.contributor.author","Einsele, Hermann"],["dc.contributor.author","Peter, Norma"],["dc.contributor.author","Jung, Wolfram"],["dc.contributor.author","Woermann, Bernhard"],["dc.contributor.author","Ludwig, Wolf-Dieter"],["dc.contributor.author","Duehrsen, Ulrich"],["dc.contributor.author","Eimermacher, Hartmut"],["dc.contributor.author","Wandt, Hannes"],["dc.contributor.author","Hasford, Joerg"],["dc.contributor.author","Hiddemann, Wolfgang"],["dc.contributor.author","Unterhalt, Michael"],["dc.date.accessioned","2018-11-07T11:19:06Z"],["dc.date.available","2018-11-07T11:19:06Z"],["dc.date.issued","2008"],["dc.description.abstract","There is no generally established prognostic index for patients with mantle cell lymphoma (MCL), because the International Prognostic Index (IPI) and Follicular Lymphoma International Prognostic Index (FLIPI) have been developed for diffuse large cell and follicular lymphoma patients, respectively. Using data of 455 advanced stage MCL patients treated within 3 clinical trials, we examined the prognostic relevance of IPI and FLIPI and derived a new prognostic index (MCL international prognostic index, MIPI) of overall survival (OS). Statistical methods included Kaplan-Meier estimates and the log-rank test for evaluating IPI and FLIPI and multiple Cox regression for developing the MIPI. IPI and FLIPI showed poor separation of survival curves. According to the MIPI, patients were classified into low risk (44% of patients, median OS not reached), intermediate risk (35%, 51 months), and high risk groups (21%, 29 months), based on the 4 independent prognostic factors: age, performance status, lactate dehydrogenase (LDH), and leukocyte count. Cell proliferation (Ki-67) was exploratively analyzed as an important biologic marker and showed strong additional prognostic relevance. The MIPI is the first prognostic index particularly suited for MCL patients and may serve as an important tool to facilitate risk-adapted treatment decisions in patients with advanced stage MCL."],["dc.identifier.doi","10.1182/blood-2007-06-095331"],["dc.identifier.isi","000252458700025"],["dc.identifier.pmid","17962512"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55190"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Hematology"],["dc.relation.issn","0006-4971"],["dc.title","A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

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Isar, 81675 Munich, Germany, florian.bassermann@mri.tum.de"],["dc.contributor.affiliation","Metzner, Bernd; \t\t \r\n\t\t Oldenburg University Hospital, 26133 Oldenburg, Germany, bernd.metzner@t-online.de"],["dc.contributor.affiliation","Röllig, Christoph; \t\t \r\n\t\t Dresden Carl Gustav Carus University Hospital, 01307 Dresden, Germany, christoph.roellig@uniklinikum-dresden.de"],["dc.contributor.affiliation","Hertenstein, Bernd; \t\t \r\n\t\t Bremen Municipal Hospital Mitte, 28205 Bremen, Germany, Bernd.Hertenstein@klinikum-bremen-mitte.de"],["dc.contributor.affiliation","Khandanpour, Cyrus; \t\t \r\n\t\t Munster University Hospital, 48149 Munster, Germany, cyrus.khandanpour@ukmuenster.de"],["dc.contributor.affiliation","Dechow, Tobias; \t\t \r\n\t\t Private Oncology Practice, 88212 Ravensburg, Germany, tobias.dechow@onkonet.eu"],["dc.contributor.affiliation","Hebart, Holger; \t\t \r\n\t\t Stauferklinikum, Schwäbisch Gmünd, 73557 Mutlangen, Germany, holger.hebart@kliniken-ostalb.de"],["dc.contributor.affiliation","Jung, Wolfram; \t\t \r\n\t\t Göttingen University Hospital, 37099 Göttingen, Germany, wolfram.jung@med.uni-goettingen.de"],["dc.contributor.affiliation","Theurich, Sebastian; \t\t \r\n\t\t Munich Großhadern University Hospital, 80336 Munich, Germany, sebastian.theurich@med.uni-muenchen.de"],["dc.contributor.affiliation","Maschmeyer, Georg; \t\t \r\n\t\t Ernst von Bergmann Hospital, 14467 Potsdam, Germany, georg.maschmeyer@evbk.de"],["dc.contributor.affiliation","Salwender, Hans; \t\t \r\n\t\t Asklepios Klinikum Altona, 22763 Hamburg, Germany, h.salwender@asklepios.com"],["dc.contributor.affiliation","Hess, Georg; \t\t \r\n\t\t Mainz University Hospital, 55131 Mainz, Germany, georg.hess@unimedizin-mainz.de"],["dc.contributor.affiliation","Bittrich, Max; \t\t \r\n\t\t Division of Hematology and Oncology, Würzburg University Hospital Medical Center, 97080 Würzburg, Germany, bittrich_m@ukw.de"],["dc.contributor.affiliation","Rasche, Leo; \t\t \r\n\t\t Division of Hematology and Oncology, Würzburg University Hospital Medical Center, 97080 Würzburg, Germany, rasche_l@ukw.de"],["dc.contributor.affiliation","Brioli, Annamaria; \t\t \r\n\t\t Jena University Hospital, 07747 Jena, Germany, Annamaria.Brioli@med.uni-jena.de"],["dc.contributor.affiliation","Eckardt, Kai-Uwe; \t\t \r\n\t\t Division of Nephrology and Medical Intensive Care, Charité University Medicine, 10117 Berlin, Germany, kai-uwe.eckardt@charite.de"],["dc.contributor.affiliation","Straka, Christian; \t\t \r\n\t\t Munich Hospital Schwabing, 80804 Munich, Germany, christian.straka@muenchen-klinik.de"],["dc.contributor.affiliation","Held, Swantje; \t\t \r\n\t\t Department of Biostatistics at ClinAssess GmbH, 51379 Leverkusen, Germany, swantje.held@clinassess.de"],["dc.contributor.affiliation","Einsele, Hermann; \t\t \r\n\t\t Division of Hematology and Oncology, Würzburg University Hospital Medical Center, 97080 Würzburg, Germany, Einsele_H@ukw.de"],["dc.contributor.affiliation","Knop, Stefan; \t\t \r\n\t\t Division of Hematology and Oncology, Würzburg University Hospital Medical Center, 97080 Würzburg, Germany, knop_s@ukw.de"],["dc.contributor.author","Bachmann, Friederike"],["dc.contributor.author","Schreder, Martin"],["dc.contributor.author","Engelhardt, Monika"],["dc.contributor.author","Langer, Christian"],["dc.contributor.author","Wolleschak, Denise"],["dc.contributor.author","Mügge, Lars Olof"],["dc.contributor.author","Dürk, Heinz"],["dc.contributor.author","Schäfer-Eckart, Kerstin"],["dc.contributor.author","Blau, Igor Wolfgang"],["dc.contributor.author","Gramatzki, Martin"],["dc.contributor.author","Liebisch, Peter"],["dc.contributor.author","Grube, Matthias"],["dc.contributor.author","v Metzler, Ivana"],["dc.contributor.author","Bassermann, Florian"],["dc.contributor.author","Metzner, Bernd"],["dc.contributor.author","Röllig, Christoph"],["dc.contributor.author","Hertenstein, Bernd"],["dc.contributor.author","Khandanpour, Cyrus"],["dc.contributor.author","Dechow, Tobias"],["dc.contributor.author","Hebart, Holger"],["dc.contributor.author","Jung, Wolfram"],["dc.contributor.author","Theurich, Sebastian"],["dc.contributor.author","Maschmeyer, Georg"],["dc.contributor.author","Salwender, Hans"],["dc.contributor.author","Hess, Georg"],["dc.contributor.author","Bittrich, Max"],["dc.contributor.author","Rasche, Leo"],["dc.contributor.author","Brioli, Annamaria"],["dc.contributor.author","Eckardt, Kai-Uwe"],["dc.contributor.author","Straka, Christian"],["dc.contributor.author","Held, Swantje"],["dc.contributor.author","Einsele, Hermann"],["dc.contributor.author","Knop, Stefan"],["dc.date.accessioned","2021-04-14T08:27:56Z"],["dc.date.available","2021-04-14T08:27:56Z"],["dc.date.issued","2021"],["dc.date.updated","2022-02-09T13:21:16Z"],["dc.description.sponsorship","Wilhelm Sander-Stiftung"],["dc.identifier.doi","10.3390/cancers13061322"],["dc.identifier.eissn","2072-6694"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82455"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","MDPI"],["dc.relation.eissn","2072-6694"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Kinetics of Renal Function during Induction in Newly Diagnosed Multiple Myeloma: Results of Two Prospective Studies by the German Myeloma Study Group DSMM"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","1398"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Haematologica"],["dc.bibliographiccitation.lastpage","1406"],["dc.bibliographiccitation.volume","101"],["dc.contributor.author","Straka, Christian"],["dc.contributor.author","Liebisch, Peter"],["dc.contributor.author","Salwender, Hans"],["dc.contributor.author","Hennemann, Burkhard"],["dc.contributor.author","Metzner, Bernd"],["dc.contributor.author","Knop, Stefan"],["dc.contributor.author","Adler-Reichel, Sigrid"],["dc.contributor.author","Gerecke, Christian"],["dc.contributor.author","Wandt, Hannes"],["dc.contributor.author","Bentz, Martin"],["dc.contributor.author","Bruemmendorf, Tim Hendrik"],["dc.contributor.author","Hentrich, Marcus"],["dc.contributor.author","Pfreundschuh, Michael"],["dc.contributor.author","Wolf, Hans-Heinrich"],["dc.contributor.author","Sezer, Orhan"],["dc.contributor.author","Bargou, Ralf C."],["dc.contributor.author","Jung, Wolfram"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Hertenstein, Bernd"],["dc.contributor.author","Heidemann, Else"],["dc.contributor.author","Bernhard, Helga"],["dc.contributor.author","Lang, Nicola"],["dc.contributor.author","Frickhofen, Norbert"],["dc.contributor.author","Hebart, Holger F."],["dc.contributor.author","Schmidmaier, Ralf"],["dc.contributor.author","Sandermann, Andreas"],["dc.contributor.author","Dechow, Tobias"],["dc.contributor.author","Reichle, Albrecht"],["dc.contributor.author","Schnabel, Brigitte"],["dc.contributor.author","Schaefer-Eckart, Kerstin"],["dc.contributor.author","Langer, Christian"],["dc.contributor.author","Gramatzki, Martin"],["dc.contributor.author","Hinke, Axel"],["dc.contributor.author","Emmerich, Bertold"],["dc.contributor.author","Einsele, Hermann"],["dc.date.accessioned","2018-11-07T10:06:00Z"],["dc.date.available","2018-11-07T10:06:00Z"],["dc.date.issued","2016"],["dc.description.abstract","Autologous transplantation is controversial for older patients with multiple myeloma. The role of age-adjusted high-dose melphalan and the impact of induction chemotherapy cycles is still unclear. A total of 434 patients aged 60-70 years were randomly assigned to 4 cycles of standard anthracycline-based induction chemotherapy or no induction. For all patients, double autologous transplantation after melphalan 140 mg/m(2) (MEL140) was planned. The primary end point was progression-free survival. Of 420 eligible patients, 85% received a first transplant and 69% completed double transplantation. Treatment duration was short with a median of 7.7 months with induction chemotherapy cycles and 4.6 months without induction. On an intention-to-treat basis, median progression-free survival with induction chemotherapy cycles (207 patients) was 21.4 months versus 20.0 months with no induction cycles (213 patients) (hazard ratio 1.04, 95% confidence interval 0.84-1.28; P= 0.36). Per protocol, progression-free survival was 23.7 months versus 23.0 months (P= 0.28). Patients aged 65 years or over (55%) did not have an inferior outcome. Patients with low-risk cytogenetics [absence of del17p13, t(4; 14) and 1q21 gains] showed a favorable overall survival and included the patients with sustained first remission. MEL140 was associated with a low rate of severe mucositis (10%) and treatment-related deaths (1%). Based on hazard ratio, the short treatment arm consisting of mobilization chemotherapy and tandem MEL140 achieved 96% of the progression-free survival, demonstrating its value as an independent component of therapy in older patients with multiple myeloma who are considered fit for autologous transplantation."],["dc.description.sponsorship","Novartis"],["dc.identifier.doi","10.3324/haematol.2016.151860"],["dc.identifier.isi","000392550200016"],["dc.identifier.pmid","27662018"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39010"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ferrata Storti Foundation"],["dc.relation.issn","0390-6078"],["dc.title","Autotransplant with and without induction chemotherapy in older multiple myeloma patients: long-term outcome of a randomized trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]