Schnabel, Viktor

[["dc.bibliographiccitation.firstpage","528"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","530"],["dc.bibliographiccitation.volume","20"],["dc.contributor.affiliation","Julius, Katharina; 1\r\nDepartment of Dermatology\r\nVenereology\r\nand Allergology\r\nUniversity Medical Center\r\nGöttingen Germany"],["dc.contributor.affiliation","Kromer, Christian; 1\r\nDepartment of Dermatology\r\nVenereology\r\nand Allergology\r\nUniversity Medical Center\r\nGöttingen Germany"],["dc.contributor.affiliation","Schnabel, Viktor; 1\r\nDepartment of Dermatology\r\nVenereology\r\nand Allergology\r\nUniversity Medical Center\r\nGöttingen Germany"],["dc.contributor.affiliation","Vlahova, Lyubomira; 1\r\nDepartment of Dermatology\r\nVenereology\r\nand Allergology\r\nUniversity Medical Center\r\nGöttingen Germany"],["dc.contributor.affiliation","Kitz, Julia; 2\r\nInstitute of Pathology\r\nUniversity Medical Center\r\nGöttingen Germany"],["dc.contributor.affiliation","Schön, Michael P.; 1\r\nDepartment of Dermatology\r\nVenereology\r\nand Allergology\r\nUniversity Medical Center\r\nGöttingen Germany"],["dc.contributor.affiliation","Sahlmann, Carsten‐Oliver; 4\r\nInstitute of Nuclear Medicine\r\nUniversity Medical Center\r\nGöttingen Germany"],["dc.contributor.author","Julius, Katharina"],["dc.contributor.author","Kromer, Christian"],["dc.contributor.author","Schnabel, Viktor"],["dc.contributor.author","Vlahova, Lyubomira"],["dc.contributor.author","Kitz, Julia"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Sahlmann, Carsten‐Oliver"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2022-04-01T10:03:27Z"],["dc.date.available","2022-04-01T10:03:27Z"],["dc.date.issued","2022"],["dc.date.updated","2022-06-14T21:15:08Z"],["dc.identifier.doi","10.1111/ddg.14737"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106172"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.rights.uri","http://creativecommons.org/licenses/by-nc/4.0/"],["dc.title","Response of metastatic acral melanoma with exon 11 BRAF G469A mutation to BRAF/MEK inhibition"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Cancer Research and Clinical Oncology"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Schnabel, Viktor"],["dc.contributor.author","Kromer, Christian"],["dc.contributor.author","Bauer-Büntzel, Christoph"],["dc.contributor.author","Richter, Annika"],["dc.contributor.author","Bremmer, Felix"],["dc.contributor.author","Kück, Fabian"],["dc.contributor.author","Julius, Katharina"],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Schön, Michael P."],["dc.date.accessioned","2022-02-01T10:31:54Z"],["dc.date.available","2022-02-01T10:31:54Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Purpose Melanocytic nevi in lymph nodes (NNs) are an important histological differential diagnosis of initial sentinel lymph node (SN) metastasis in melanoma. Our aim was to associate NN in SNs with clinicopathologic features and survival rates in 1, 250 patients with SN biopsy for melanoma. Methods To compare patients with present and absent NN, we used Fisher's exact test, Mann–Whitney U test, and multivariate logistic regression models in this retrospective observational study based on a prospectively maintained institutional database. Results NN prevalence in axillary, cervical, and groin SNs was 16.5%, 19.4%, and 9.8%, respectively. NN were observed in combination with all growth patterns of melanoma, but more frequently when the primary was histologically associated with a cutaneous nevus. We observed a decreasing NN prevalence with increasing SN metastasis diameter. Multiple logistic regression determined a significantly increased NN probability for SNs of the neck or axilla, for individuals with ≥ 50 cutaneous nevi, midline primary melanomas, and for individuals who reported non-cutaneous malignancies in their parents. Cancer in parents was also significantly more frequently reported by melanoma patients who had more than 50 cutaneous nevi. In SN-negative patients, NN indicated a tendency for slightly lower melanoma-specific survival. Conclusions We found a highly significant association between NN diagnosis and multiple cutaneous nevi and provided circumstantial evidence that cutaneous nevi in the drainage area of lymph nodes are particularly important. The trend toward lower melanoma-specific survival in SN-negative patients with NN suggests that careful differentiation of SN metastases is important."],["dc.description.abstract","Abstract Purpose Melanocytic nevi in lymph nodes (NNs) are an important histological differential diagnosis of initial sentinel lymph node (SN) metastasis in melanoma. Our aim was to associate NN in SNs with clinicopathologic features and survival rates in 1, 250 patients with SN biopsy for melanoma. Methods To compare patients with present and absent NN, we used Fisher's exact test, Mann–Whitney U test, and multivariate logistic regression models in this retrospective observational study based on a prospectively maintained institutional database. Results NN prevalence in axillary, cervical, and groin SNs was 16.5%, 19.4%, and 9.8%, respectively. NN were observed in combination with all growth patterns of melanoma, but more frequently when the primary was histologically associated with a cutaneous nevus. We observed a decreasing NN prevalence with increasing SN metastasis diameter. Multiple logistic regression determined a significantly increased NN probability for SNs of the neck or axilla, for individuals with ≥ 50 cutaneous nevi, midline primary melanomas, and for individuals who reported non-cutaneous malignancies in their parents. Cancer in parents was also significantly more frequently reported by melanoma patients who had more than 50 cutaneous nevi. In SN-negative patients, NN indicated a tendency for slightly lower melanoma-specific survival. Conclusions We found a highly significant association between NN diagnosis and multiple cutaneous nevi and provided circumstantial evidence that cutaneous nevi in the drainage area of lymph nodes are particularly important. The trend toward lower melanoma-specific survival in SN-negative patients with NN suggests that careful differentiation of SN metastases is important."],["dc.identifier.doi","10.1007/s00432-021-03894-y"],["dc.identifier.pii","3894"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98974"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","1432-1335"],["dc.relation.issn","0171-5216"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Melanocytic nevi in sentinel lymph nodes: association with cutaneous nevi and clinical relevance in patients with cutaneous melanomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

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