Geiss‐Friedlander, Ruth

[["dc.bibliographiccitation.firstpage","695"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.lastpage","713"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Kunadt, Marcel"],["dc.contributor.author","Eckermann, Katrin"],["dc.contributor.author","Stuendl, Anne"],["dc.contributor.author","Gong, Jing"],["dc.contributor.author","Russo, Belisa"],["dc.contributor.author","Strauss, Katrin"],["dc.contributor.author","Rai, Surya"],["dc.contributor.author","Kügler, Sebastian"],["dc.contributor.author","Falomir Lockhart, Lisandro"],["dc.contributor.author","Schwalbe, Martin"],["dc.contributor.author","Krumova, Petranka"],["dc.contributor.author","Oliveira, Luis M. A."],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Levin, Johannes"],["dc.contributor.author","Giese, Armin"],["dc.contributor.author","Kruse, Niels"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Geiss‐Friedlander, Ruth"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Freischmidt, Axel"],["dc.contributor.author","Feiler, Marisa S."],["dc.contributor.author","Danzer, Karin M."],["dc.contributor.author","Zweckstetter, Markus"],["dc.contributor.author","Jovin, Thomas M."],["dc.contributor.author","Simons, Mikael"],["dc.contributor.author","Weishaupt, Jochen H."],["dc.contributor.author","Schneider, Anja"],["dc.date.accessioned","2017-09-07T11:44:25Z"],["dc.date.available","2017-09-07T11:44:25Z"],["dc.date.issued","2015"],["dc.description.abstract","Extracellular alpha-Synuclein has been implicated in interneuronal propagation of disease pathology in Parkinson's Disease. How alpha-Synuclein is released into the extracellular space is still unclear. Here, we show that alpha-Synuclein is present in extracellular vesicles in the central nervous system. We find that sorting of alpha-Synuclein in extracellular vesicles is regulated by sumoylation and that sumoylation acts as a sorting factor for targeting of both, cytosolic and transmembrane proteins, to extracellular vesicles. We provide evidence that the SUMO-dependent sorting utilizes the endosomal sorting complex required for transport (ESCRT) by interaction with phosphoinositols. Ubiquitination of cargo proteins is so far the only known determinant for ESCRT-dependent sorting into the extracellular vesicle pathway. Our study reveals a function of SUMO protein modification as a Ubiquitin-independent ESCRT sorting signal, regulating the extracellular vesicle release of alpha-Synuclein. We deciphered in detail the molecular mechanism which directs alpha-Synuclein into extracellular vesicles which is of highest relevance for the understanding of Parkinson's disease pathogenesis and progression at the molecular level. We furthermore propose that sumo-dependent sorting constitutes a mechanism with more general implications for cell biology."],["dc.identifier.doi","10.1007/s00401-015-1408-1"],["dc.identifier.gro","3141916"],["dc.identifier.isi","000352716500007"],["dc.identifier.pmid","25778619"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11731"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2500"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1432-0533"],["dc.relation.issn","0001-6322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]