Brameier, Markus

[["dc.bibliographiccitation.artnumber","222"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Liedigk, Rasmus"],["dc.contributor.author","Kolleck, Jakob"],["dc.contributor.author","Böker, Kai O."],["dc.contributor.author","Meijaard, Erik"],["dc.contributor.author","Md-Zain, Badrul M."],["dc.contributor.author","Abdul-Latiff, Muhammad A. B."],["dc.contributor.author","Ampeng, Ahmad"],["dc.contributor.author","Lakim, Maklarin"],["dc.contributor.author","Abdul-Patah, Pazil"],["dc.contributor.author","Tosi, Anthony J."],["dc.contributor.author","Brameier, Markus"],["dc.contributor.author","Zinner, Dietmar"],["dc.contributor.author","Roos, Christian"],["dc.date.accessioned","2019-07-09T11:41:52Z"],["dc.date.available","2019-07-09T11:41:52Z"],["dc.date.issued","2015"],["dc.description.abstract","Abstract Background Long-tailed macaques (Macaca fascicularis) are an important model species in biomedical research and reliable knowledge about their evolutionary history is essential for biomedical inferences. Ten subspecies have been recognized, of which most are restricted to small islands of Southeast Asia. In contrast, the common long-tailed macaque (M. f. fascicularis) is distributed over large parts of the Southeast Asian mainland and the Sundaland region. To shed more light on the phylogeny of M. f. fascicularis, we sequenced complete mitochondrial (mtDNA) genomes of 40 individuals from all over the taxon’s range, either by classical PCR-amplification and Sanger sequencing or by DNA-capture and high-throughput sequencing. Results Both laboratory approaches yielded complete mtDNA genomes from M. f. fascicularis with high accuracy and/or coverage. According to our phylogenetic reconstructions, M. f. fascicularis initially diverged into two clades 1.70 million years ago (Ma), with one including haplotypes from mainland Southeast Asia, the Malay Peninsula and North Sumatra (Clade A) and the other, haplotypes from the islands of Bangka, Java, Borneo, Timor, and the Philippines (Clade B). The three geographical populations of Clade A appear as paraphyletic groups, while local populations of Clade B form monophyletic clades with the exception of a Philippine individual which is nested within the Borneo clade. Further, in Clade B the branching pattern among main clades/lineages remains largely unresolved, most likely due to their relatively rapid diversification 0.93-0.84 Ma. Conclusions Both laboratory methods have proven to be powerful to generate complete mtDNA genome data with similarly high accuracy, with the DNA-capture and high-throughput sequencing approach as the most promising and only practical option to obtain such data from highly degraded DNA, in time and with relatively low costs. The application of complete mtDNA genomes yields new insights into the evolutionary history of M. f. fascicularis by providing a more robust phylogeny and more reliable divergence age estimations than earlier studies."],["dc.identifier.doi","10.1186/s12864-015-1437-0"],["dc.identifier.pmid","25887664"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12486"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58534"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Mitogenomic phylogeny of the common long-tailed macaque (Macaca fascicularis fascicularis)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Immunogenetics"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Huchard, Elise"],["dc.contributor.author","Albrecht, Christina"],["dc.contributor.author","Schliehe-Diecks, Susanne"],["dc.contributor.author","Baniel, Alice"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Kappeler, Peter M."],["dc.contributor.author","Brameier, Markus"],["dc.date.accessioned","2018-11-07T09:17:22Z"],["dc.date.available","2018-11-07T09:17:22Z"],["dc.date.issued","2013"],["dc.format.extent","905"],["dc.identifier.doi","10.1007/s00251-013-0737-2"],["dc.identifier.isi","000326923600009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28149"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-1211"],["dc.relation.issn","0093-7711"],["dc.title","Large-scale MHC class II genotyping of a wild lemur population by next generation sequencing (vol 64, pg 895, 2012)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","176"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Evolutionary Biology"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Liedigk, Rasmus"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Brameier, Markus"],["dc.contributor.author","Zinner, Dietmar"],["dc.date.accessioned","2019-07-09T11:40:18Z"],["dc.date.available","2019-07-09T11:40:18Z"],["dc.date.issued","2014"],["dc.description.abstract","Background The evolutionary history of the Old World monkey tribe Papionini comprising the genera Macaca, Mandrillus, Cercocebus, Lophocebus, Theropithecus, Rungwecebus and Papio is still matter of debate. Although the African Papionini (subtribe Papionina) are generally considered to be the sister lineage to the Asian Papionini (subtribe Macacina), previous studies based on morphological data, nuclear or mitochondrial sequences have shown contradictory phylogenetic relationships among and within both subtribes. To further elucidate the phylogenetic relationships among papionins and to estimate divergence ages we generated mitochondrial genome data and combined them with previously published sequences. Results Our mitochondrial gene tree comprises 33 papionins representing all genera of the tribe except Rungwecebus. In contrast to most previous studies, the obtained phylogeny suggests a division of the Papionini into three main mitochondrial clades with similar ages: 1) Papio, Theropithecus, Lophocebus; 2) Mandrillus, Cercocebus; and 3) Macaca; the Mandrillus + Cercocebus clade appears to be more closely related to Macaca than to the other African Papionini. Further, we find paraphyletic relationships within the Mandrillus + Cercocebus clade as well as in Papio. Relationships among Theropithecus, Lophocebus and Papio remain unresolved. Divergence ages reveal initial splits within the three mitochondrial clades around the Miocene/Pliocene boundary and differentiation of Macaca species groups occurred on a similar time scale as those found between genera of the subtribe Papionina. Conclusion Due to the largely well-resolved mitochondrial phylogeny, our study provides new insights into the evolutionary history of the Papionini. Results show some contradictory relationships in comparison to previous analyses, notably the paraphyly within the Cercocebus + Mandrillus clade and three instead of only two major mitochondrial clades. Divergence ages among species groups of macaques are similar to those among African Papionini genera, suggesting that diversification of the mitochondrial genome is of a similar magnitude in both subtribes. However, since our mitochondrial tree represents just a single gene tree that most likely does not reflect the true species tree, extensive nuclear sequence data is required to illuminate the true species phylogeny of papionins and to trace possible ancient hybridization events among lineages."],["dc.identifier.doi","10.1186/s12862-014-0176-1"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58141"],["dc.language.iso","en"],["dc.title","Mitogenomics of the Old World monkey tribe Papionini"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","American Journal of Physical Anthropology"],["dc.bibliographiccitation.lastpage","10"],["dc.bibliographiccitation.volume","147"],["dc.contributor.author","Yang, Mouyu"],["dc.contributor.author","Yang, Yeqin"],["dc.contributor.author","Cui, Duoying"],["dc.contributor.author","Fickenscher, Gisela"],["dc.contributor.author","Zinner, Dietmar"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Brameier, Markus"],["dc.date.accessioned","2022-10-06T13:34:37Z"],["dc.date.available","2022-10-06T13:34:37Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1002/ajpa.21618"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115954"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0002-9483"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Population genetic structure of Guizhou snub-nosed monkeys (Rhinopithecus brelichi) as inferred from mitochondrial control region sequences, and comparison with R. roxellana and R. bieti"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3239"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","The Journal of Immunology"],["dc.bibliographiccitation.lastpage","3246"],["dc.bibliographiccitation.volume","192"],["dc.contributor.author","Kono, Azumi"],["dc.contributor.author","Brameier, Markus"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Suzuki, Shingo"],["dc.contributor.author","Shigenari, Atsuko"],["dc.contributor.author","Kametani, Yoshie"],["dc.contributor.author","Kitaura, Kazutaka"],["dc.contributor.author","Matsutani, Takaji"],["dc.contributor.author","Suzuki, Ryuji"],["dc.contributor.author","Inoko, Hidetoshi"],["dc.contributor.author","Shiina, Takashi"],["dc.date.accessioned","2022-10-06T13:26:52Z"],["dc.date.available","2022-10-06T13:26:52Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.4049/jimmunol.1302745"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115186"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1550-6606"],["dc.relation.issn","0022-1767"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Genomic Sequence Analysis of the MHC Class I G/F Segment in Common Marmoset (\n Callithrix jacchus\n )"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","895"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Immunogenetics"],["dc.bibliographiccitation.lastpage","913"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Huchard, Elise"],["dc.contributor.author","Albrecht, Christina"],["dc.contributor.author","Schliehe-Diecks, Susanne"],["dc.contributor.author","Baniel, Alice"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Kappeler, Peter M."],["dc.contributor.author","Brameier, Markus"],["dc.date.accessioned","2017-09-07T11:48:24Z"],["dc.date.available","2017-09-07T11:48:24Z"],["dc.date.issued","2012"],["dc.description.abstract","The critical role of major histocompatibility complex (MHC) genes in disease resistance, along with their putative function in sexual selection, reproduction and chemical ecology, make them an important genetic system in evolutionary ecology. Studying selective pressures acting on MHC genes in the wild nevertheless requires population-wide genotyping, which has long been challenging because of their extensive polymorphism. Here, we report on large-scale genotyping of the MHC class II loci of the grey mouse lemur (Microcebus murinus) from a wild population in western Madagascar. The second exons from MHC-DRB and -DQB of 772 and 672 individuals were sequenced, respectively, using a 454 sequencing platform, generating more than 800,000 reads. Sequence analysis, through a stepwise variant validation procedure, allowed reliable typing of more than 600 individuals. The quality of our genotyping was evaluated through three independent methods, namely genotyping the same individuals by both cloning and 454 sequencing, running duplicates, and comparing parent-offspring dyads; each displaying very high accuracy. A total of 61 (including 20 new) and 60 (including 53 new) alleles were detected at DRB and DQB genes, respectively. Both loci were non-duplicated, in tight linkage disequilibrium and in Hardy-Weinberg equilibrium, despite the fact that sequence analysis revealed clear evidence of historical selection. Our results highlight the potential of 454 sequencing technology in attempts to investigate patterns of selection shaping MHC variation in contemporary populations. The power of this approach will nevertheless be conditional upon strict quality control of the genotyping data."],["dc.identifier.doi","10.1007/s00251-012-0649-6"],["dc.identifier.gro","3150796"],["dc.identifier.pmid","22948859"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8796"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7588"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.issn","0093-7711"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Large-scale MHC class II genotyping of a wild lemur population by next generation sequencing"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","195"],["dc.bibliographiccitation.issue","7517"],["dc.bibliographiccitation.journal","Nature"],["dc.bibliographiccitation.lastpage","201"],["dc.bibliographiccitation.volume","513"],["dc.contributor.author","Carbone, Lucia"],["dc.contributor.author","Harris, R. Alan"],["dc.contributor.author","Gnerre, Sante"],["dc.contributor.author","Veeramah, Krishna R."],["dc.contributor.author","Lorente-Galdos, Belen"],["dc.contributor.author","Huddleston, John"],["dc.contributor.author","Meyer, Thomas J."],["dc.contributor.author","Herrero, Javier"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Aken, Bronwen"],["dc.contributor.author","Anaclerio, Fabio"],["dc.contributor.author","Archidiacono, Nicoletta"],["dc.contributor.author","Baker, Carl"],["dc.contributor.author","Barrell, Daniel"],["dc.contributor.author","Batzer, Mark A."],["dc.contributor.author","Beal, Kathryn"],["dc.contributor.author","Blancher, Antoine"],["dc.contributor.author","Bohrson, Craig L."],["dc.contributor.author","Brameier, Markus"],["dc.contributor.author","Campbell, Michael S."],["dc.contributor.author","Capozzi, Oronzo"],["dc.contributor.author","Casola, Claudio"],["dc.contributor.author","Chiatante, Giorgia"],["dc.contributor.author","Cree, Andrew"],["dc.contributor.author","Damert, Annette"],["dc.contributor.author","de Jong, Pieter J."],["dc.contributor.author","Dumas, Laura"],["dc.contributor.author","Fernandez-Callejo, Marcos"],["dc.contributor.author","Flicek, Paul"],["dc.contributor.author","Fuchs, Nina V."],["dc.contributor.author","Gut, Ivo"],["dc.contributor.author","Gut, Marta"],["dc.contributor.author","Hahn, Matthew W."],["dc.contributor.author","Hernandez-Rodriguez, Jessica"],["dc.contributor.author","Hillier, LaDeana W."],["dc.contributor.author","Hubley, Robert"],["dc.contributor.author","Ianc, Bianca"],["dc.contributor.author","Izsvák, Zsuzsanna"],["dc.contributor.author","Jablonski, Nina G."],["dc.contributor.author","Johnstone, Laurel M."],["dc.contributor.author","Karimpour-Fard, Anis"],["dc.contributor.author","Konkel, Miriam K."],["dc.contributor.author","Kostka, Dennis"],["dc.contributor.author","Lazar, Nathan H."],["dc.contributor.author","Lee, Sandra L."],["dc.contributor.author","Lewis, Lora R."],["dc.contributor.author","Liu, Yue"],["dc.contributor.author","Locke, Devin P."],["dc.contributor.author","Mallick, Swapan"],["dc.contributor.author","Mendez, Fernando L."],["dc.contributor.author","Muffato, Matthieu"],["dc.contributor.author","Nazareth, Lynne V."],["dc.contributor.author","Nevonen, Kimberly A."],["dc.contributor.author","O'Bleness, Majesta"],["dc.contributor.author","Ochis, Cornelia"],["dc.contributor.author","Odom, Duncan T."],["dc.contributor.author","Pollard, Katherine S."],["dc.contributor.author","Quilez, Javier"],["dc.contributor.author","Reich, David"],["dc.contributor.author","Rocchi, Mariano"],["dc.contributor.author","Schumann, Gerald G."],["dc.contributor.author","Searle, Stephen"],["dc.contributor.author","Sikela, James M."],["dc.contributor.author","Skollar, Gabriella"],["dc.contributor.author","Smit, Arian"],["dc.contributor.author","Sonmez, Kemal"],["dc.contributor.author","ten Hallers, Boudewijn"],["dc.contributor.author","Terhune, Elizabeth"],["dc.contributor.author","Thomas, Gregg W. C."],["dc.contributor.author","Ullmer, Brygg"],["dc.contributor.author","Ventura, Mario"],["dc.contributor.author","Walker, Jerilyn A."],["dc.contributor.author","Wall, Jeffrey D."],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Ward, Michelle C."],["dc.contributor.author","Wheelan, Sarah J."],["dc.contributor.author","Whelan, Christopher W."],["dc.contributor.author","White, Simon"],["dc.contributor.author","Wilhelm, Larry J."],["dc.contributor.author","Woerner, August E."],["dc.contributor.author","Yandell, Mark"],["dc.contributor.author","Zhu, Baoli"],["dc.contributor.author","Hammer, Michael F."],["dc.contributor.author","Marques-Bonet, Tomas"],["dc.contributor.author","Eichler, Evan E."],["dc.contributor.author","Fulton, Lucinda"],["dc.contributor.author","Fronick, Catrina"],["dc.contributor.author","Muzny, Donna M."],["dc.contributor.author","Warren, Wesley C."],["dc.contributor.author","Worley, Kim C."],["dc.contributor.author","Rogers, Jeffrey"],["dc.contributor.author","Wilson, Richard K."],["dc.contributor.author","Gibbs, Richard A."],["dc.date.accessioned","2019-07-09T11:40:35Z"],["dc.date.available","2019-07-09T11:40:35Z"],["dc.date.issued","2014-09-11"],["dc.description.abstract","Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Here we present the assembly and analysis of a northern white-cheeked gibbon (Nomascus leucogenys) genome. We describe the propensity for a gibbon-specific retrotransposon (LAVA) to insert into chromosome segregation genes and alter transcription by providing a premature termination site, suggesting a possible molecular mechanism for the genome plasticity of the gibbon lineage. We further show that the gibbon genera (Nomascus, Hylobates, Hoolock and Symphalangus) experienced a near-instantaneous radiation ∼5 million years ago, coincident with major geographical changes in southeast Asia that caused cycles of habitat compression and expansion. Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat."],["dc.identifier.doi","10.1038/nature13679"],["dc.identifier.pmid","25209798"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11090"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58210"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1476-4687"],["dc.rights","CC BY-NC-SA 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-sa/3.0"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Evolution, Molecular"],["dc.subject.mesh","Genome"],["dc.subject.mesh","Hominidae"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Hylobates"],["dc.subject.mesh","Karyotype"],["dc.subject.mesh","Molecular Sequence Data"],["dc.subject.mesh","Phylogeny"],["dc.subject.mesh","Retroelements"],["dc.subject.mesh","Selection, Genetic"],["dc.subject.mesh","Transcription Termination, Genetic"],["dc.title","Gibbon genome and the fast karyotype evolution of small apes."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","77"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Evolutionary Biology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Zinner, Dietmar"],["dc.contributor.author","Kubatko, Laura S."],["dc.contributor.author","Schwarz, Christiane"],["dc.contributor.author","Yang, Mouyu"],["dc.contributor.author","Meyer, Dirk"],["dc.contributor.author","Nash, Stephen D."],["dc.contributor.author","Xing, Jinchuan"],["dc.contributor.author","Batzer, Mark A."],["dc.contributor.author","Brameier, Markus"],["dc.contributor.author","Leendertz, Fabian H."],["dc.contributor.author","Ziegler, Thomas"],["dc.contributor.author","Perwitasari-Farajallah, Dyah"],["dc.contributor.author","Nadler, Tilo"],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Osterholz, Martin"],["dc.date.accessioned","2018-11-28T14:38:55Z"],["dc.date.available","2018-11-28T14:38:55Z"],["dc.date.issued","2011"],["dc.description.abstract","Colobine monkeys constitute a diverse group of primates with major radiations in Africa and Asia. However, phylogenetic relationships among genera are under debate, and recent molecular studies with incomplete taxon-sampling revealed discordant gene trees. To solve the evolutionary history of colobine genera and to determine causes for possible gene tree incongruences, we combined presence/absence analysis of mobile elements with autosomal, X chromosomal, Y chromosomal and mitochondrial sequence data from all recognized colobine genera."],["dc.identifier.doi","10.1186/1471-2148-11-77"],["dc.identifier.pmid","21435245"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56997"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1471-2148"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Nuclear versus mitochondrial DNA: evidence for hybridization in colobine monkeys"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e69504"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Finstermeier, Knut"],["dc.contributor.author","Zinner, Dietmar"],["dc.contributor.author","Brameier, Markus"],["dc.contributor.author","Meyer, Matthias"],["dc.contributor.author","Kreuz, Eva"],["dc.contributor.author","Hofreiter, Michael"],["dc.contributor.author","Roos, Christian"],["dc.date.accessioned","2019-07-09T11:54:25Z"],["dc.date.available","2019-07-09T11:54:25Z"],["dc.date.issued","2013-07-16"],["dc.description.abstract","Primates, the mammalian order including our own species, comprise 480 species in 78 genera. Thus, they represent the third largest of the 18 orders of eutherian mammals. Although recent phylogenetic studies on primates are increasingly built on molecular datasets, most of these studies have focused on taxonomic subgroups within the order. Complete mitochondrial (mt) genomes have proven to be extremely useful in deciphering within-order relationships even up to deep nodes. Using 454 sequencing, we sequenced 32 new complete mt genomes adding 20 previously not represented genera to the phylogenetic reconstruction of the primate tree. With 13 new sequences, the number of complete mt genomes within the parvorder Platyrrhini was widely extended, resulting in a largely resolved branching pattern among New World monkey families. We added 10 new Strepsirrhini mt genomes to the 15 previously available ones, thus almost doubling the number of mt genomes within this clade. Our data allow precise date estimates of all nodes and offer new insights into primate evolution. One major result is a relatively young date for the most recent common ancestor of all living primates which was estimated to 66-69 million years ago, suggesting that the divergence of extant primates started close to the K/T-boundary. Although some relationships remain unclear, the large number of mt genomes used allowed us to reconstruct a robust primate phylogeny which is largely in agreement with previous publications. Finally, we show that mt genomes are a useful tool for resolving primate phylogenetic relationships on various taxonomic levels."],["dc.format.extent","10"],["dc.identifier.doi","10.1371/journal.pone.0069504"],["dc.identifier.fs","599647"],["dc.identifier.pmid","23874967"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9143"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60655"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY-NC 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/3.0"],["dc.title","A Mitogenomic Phylogeny of Living Primates"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]