Fiala, André

[["dc.bibliographiccitation.artnumber","e1002563"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS Biology"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Gupta, Varun K."],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Bhukel, Anuradha"],["dc.contributor.author","Fulterer, Andreas"],["dc.contributor.author","Ender, Anatoli"],["dc.contributor.author","Mauermann, Stephan F."],["dc.contributor.author","Andlauer, Till F. M."],["dc.contributor.author","Antwi-Adjei, Emmanuel"],["dc.contributor.author","Beuschel, Christine"],["dc.contributor.author","Thriene, Kerstin"],["dc.contributor.author","Maglione, Marta"],["dc.contributor.author","Quentin, Christine"],["dc.contributor.author","Bushow, Rene"],["dc.contributor.author","Schwaerzel, Martin"],["dc.contributor.author","Mielke, Thorsten"],["dc.contributor.author","Madeo, Frank"],["dc.contributor.author","Dengjel, Joern"],["dc.contributor.author","Fiala, Andre"],["dc.contributor.author","Sigrist, Stephan J."],["dc.date.accessioned","2018-11-07T10:09:04Z"],["dc.date.available","2018-11-07T10:09:04Z"],["dc.date.issued","2016"],["dc.description.abstract","Memories are assumed to be formed by sets of synapses changing their structural or functional performance. The efficacy of forming new memories declines with advancing age, but the synaptic changes underlying age-induced memory impairment remain poorly understood. Recently, we found spermidine feeding to specifically suppress age-dependent impairments in forming olfactory memories, providing a mean to search for synaptic changes involved in age-dependent memory impairment. Here, we show that a specific synaptic compartment, the presynaptic active zone (AZ), increases the size of its ultrastructural elaboration and releases significantly more synaptic vesicles with advancing age. These age-induced AZ changes, however, were fully suppressed by spermidine feeding. A genetically enforced enlargement of AZ scaffolds (four gene-copies of BRP) impaired memory formation in young animals. Thus, in the Drosophila nervous system, aging AZs seem to steer towards the upper limit of their operational range, limiting synaptic plasticity and contributing to impairment of memory formation. Spermidine feeding suppresses age-dependent memory impairment by counteracting these age-dependent changes directly at the synapse."],["dc.identifier.doi","10.1371/journal.pbio.1002563"],["dc.identifier.isi","000386128900019"],["dc.identifier.pmid","27684064"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13761"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39590"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1545-7885"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","27"],["dc.bibliographiccitation.journal","Frontiers in Behavioral Neuroscience"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Bellmann, Dennis"],["dc.contributor.author","Richardt, Arnd"],["dc.contributor.author","Freyberger, Robert"],["dc.contributor.author","Nuwal, Nidhi"],["dc.contributor.author","Schwaerzel, Martin"],["dc.contributor.author","Fiala, Andre"],["dc.contributor.author","Stoertkuhl, Klemens F."],["dc.date.accessioned","2018-11-07T08:47:42Z"],["dc.date.available","2018-11-07T08:47:42Z"],["dc.date.issued","2010"],["dc.description.abstract","Olfactory stimulation induces an odor-guided crawling behavior of Drosophila melanogaster larvae characterized by either an attractive or a repellent reaction. In order to understand the underlying processes leading to these orientations we stimulated single olfactory receptor neurons (ORNs) through photo-activation within an intact neuronal network. Using the Gal4-UAS system two light inducible proteins, the light-sensitive cation channel channelrhodopsin-2 (ChR-2) or the light-sensitive adenylyl cyclase (Pac alpha) were expressed in all or in individual ORNs of the larval olfactory system. Blue light stimulation caused an activation of these neurons, ultimately producing the illusion of an odor stimulus. Larvae were tested in a phototaxis assay for their orientation toward or away from the light source. Here we show that activation of Pac alpha expressing ORNs bearing the receptors Or33b or Or45a in blind norpA mutant larvae induces a repellent behavior away from the light. Conversely, photo-activation of the majority of ORNs induces attraction towards the light. Interestingly, in wild type larvae two ligands of Or33b and Or45a, octyl acetate and propionic ethylester, respectively, have been found to cause an escape reaction. Therefore, we combined light and odor stimulation to analyze the function of Or33b and Or45a expressing ORNs. We show that the larval olfactory system contains a designated neuronal pathway for repellent odorants and that activation of a specific class of ORNs already determines olfactory avoidance behavior."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SCHW1410/1-1, SFB 554/A2, STO 283/11-1]"],["dc.identifier.doi","10.3389/fnbeh.2010.00027"],["dc.identifier.isi","000208454700030"],["dc.identifier.pmid","20577637"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7267"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21021"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Res Found"],["dc.relation.issn","1662-5153"],["dc.rights","CC BY-NC 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/3.0"],["dc.title","Optogenetically induced olfactory stimulation in Drosophila larvae reveals the neuronal basis of odor-aversion behavior"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e03895"],["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Andlauer, Till F. M."],["dc.contributor.author","Scholz-Kornehl, Sabrina"],["dc.contributor.author","Tian, Rui"],["dc.contributor.author","Kirchner, Marieluise"],["dc.contributor.author","Babikir, Husam A."],["dc.contributor.author","Depner, Harald"],["dc.contributor.author","Loll, Bernhard"],["dc.contributor.author","Quentin, Christine"],["dc.contributor.author","Gupta, Varun K."],["dc.contributor.author","Holt, Matthew G."],["dc.contributor.author","Dipt, Shubham"],["dc.contributor.author","Cressy, Michael"],["dc.contributor.author","Wahl, Markus C."],["dc.contributor.author","Fiala, Andre"],["dc.contributor.author","Selbach, Matthias"],["dc.contributor.author","Schwaerzel, Martin"],["dc.contributor.author","Sigrist, Stephan J."],["dc.date.accessioned","2018-11-07T09:32:39Z"],["dc.date.available","2018-11-07T09:32:39Z"],["dc.date.issued","2014"],["dc.description.abstract","CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short-and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation."],["dc.identifier.doi","10.7554/eLife.03895"],["dc.identifier.isi","000209685200001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11684"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31798"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elife Sciences Publications Ltd"],["dc.relation.issn","2050-084X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Drep-2 is a novel synaptic protein important for learning and memory"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]