Kühn, Julius

[["dc.bibliographiccitation.firstpage","243"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Psychophysiology"],["dc.bibliographiccitation.lastpage","244"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Kuhn, J."],["dc.contributor.author","Albrecht, B."],["dc.contributor.author","Klein, C."],["dc.contributor.author","Plihal, W."],["dc.date.accessioned","2018-11-07T10:33:23Z"],["dc.date.available","2018-11-07T10:33:23Z"],["dc.date.issued","2002"],["dc.identifier.isi","000183921400108"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44596"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hogrefe & Huber Publishers"],["dc.publisher.place","Gottingen"],["dc.relation.issn","2151-2124"],["dc.relation.issn","0269-8803"],["dc.title","CNV characteristics of emotional processing in subjects with anomalous experiences"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2408"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","The Journal of Immunology"],["dc.bibliographiccitation.lastpage","2420"],["dc.bibliographiccitation.volume","199"],["dc.contributor.author","Bertocci, Barbara"],["dc.contributor.author","Lecoeuche, Damiana"],["dc.contributor.author","Sterlin, Delphine"],["dc.contributor.author","Kühn, Julius"],["dc.contributor.author","Gaillard, Baptiste"],["dc.contributor.author","De Smet, Annie"],["dc.contributor.author","Lembo, Frederique"],["dc.contributor.author","Bole-Feysot, Christine"],["dc.contributor.author","Cagnard, Nicolas"],["dc.contributor.author","Fadeev, Tatiana"],["dc.contributor.author","Dahan, Auriel"],["dc.contributor.author","Weill, Jean-Claude"],["dc.contributor.author","Reynaud, Claude-Agnès"],["dc.date.accessioned","2020-12-10T18:47:42Z"],["dc.date.available","2020-12-10T18:47:42Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.4049/jimmunol.1700708"],["dc.identifier.eissn","1550-6606"],["dc.identifier.issn","0022-1767"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78853"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","812"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The journal of nutrition health & aging"],["dc.bibliographiccitation.lastpage","818"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Noreik, M."],["dc.contributor.author","Kuhn, J."],["dc.contributor.author","Hardenacke, K."],["dc.contributor.author","Lenartz, D."],["dc.contributor.author","Bauer, A."],["dc.contributor.author","Buehrle, C. P."],["dc.contributor.author","Haeussermann, P."],["dc.contributor.author","Hellmich, Martin"],["dc.contributor.author","Klosterkoetter, J."],["dc.contributor.author","Wiltfang, J."],["dc.contributor.author","Maarouf, M."],["dc.contributor.author","Freund, H.-J."],["dc.contributor.author","Visser-Vandewalle, V."],["dc.contributor.author","Sturm, V."],["dc.contributor.author","Schulz, R.-J."],["dc.date.accessioned","2018-11-07T09:50:54Z"],["dc.date.available","2018-11-07T09:50:54Z"],["dc.date.issued","2015"],["dc.description.abstract","The progression of Alzheimer's disease (AD) is associated with impaired nutritional status. New methods, such as deep brain stimulation (DBS), are currently being tested to decrease the progression of AD. DBS is an approved method in the treatment of Parkinson's disease, and its suitability for the treatment of AD patients is currently under experimental investigation. To evaluate the advantages and disadvantages of this new treatment, it is important to assess potential side effects of DBS regarding the nucleus basalis of Meynert; this new treatment is thought to positively affect cognition and might counteract the deterioration of nutritional status and progressive weight loss observed in AD. This study aims to assess the nutritional status of patients with AD before receiving DBS of the nucleus basalis of Meynert and after 1 year, and to analyze potential associations between changes in cognition and nutritional status. A 1-year phase I proof-of-concept study. The Department of Psychiatry and Psychotherapy at the University of Cologne. We assessed a consecutive sample of patients with mild to moderate AD (n=6) who fulfilled the inclusion criteria and provided written informed consent. Intervention: Bilateral low-frequency DBS of the nucleus basalis of Meynert. Nutritional status was assessed using a modified Mini Nutritional Assessment, bioelectrical impedance analysis, a completed 3-day food diary, and analysis of serum levels of vitamin B12 and folate. With a normal body mass index (BMI) at baseline (mean 23.75 kg/m(2)) and after 1 year (mean 24.59 kg/m(2)), all but one patient gained body weight during the period of the pilot study (mean 2.38 kg, 3.81% of body weight). This was reflected in a mainly stable or improved body composition, assessed by bioelectrical impedance analysis, in five of the six patients. Mean energy intake increased from 1534 kcal/day (min 1037, max 2370) at baseline to 1736 kcal/day (min 1010, max 2663) after 1 year, leading to the improved fulfillment of energy needs in four patients. The only nutritional factors that were associated with changes in cognition were vitamin B12 level at baseline (Spearman's rho = 0.943, p = 0.005) and changes in vitamin B12 level (Spearman's rho = -0.829, p = 0.042). Patients with AD that received DBS of the nucleus basalis of Meynert demonstrated a mainly stable nutritional status within a 1-year period. Whether DBS is causative regarding these observations must be investigated in additional studies."],["dc.description.sponsorship","Marga and Walter Boll foundation; Medtronic Europe SARL"],["dc.identifier.doi","10.1007/s12603-015-0595-8"],["dc.identifier.isi","000362683900003"],["dc.identifier.pmid","26412285"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35803"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1760-4788"],["dc.relation.issn","1279-7707"],["dc.title","Changes in nutritional status after deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's disease - Results of a phase I study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","ra66"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","434"],["dc.bibliographiccitation.journal","Science Signaling"],["dc.bibliographiccitation.lastpage","15"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Kühn, Julius"],["dc.contributor.author","Wong, Leo E."],["dc.contributor.author","Pirkuliyeva, Sona"],["dc.contributor.author","Schulz, Kathrin"],["dc.contributor.author","Schwiegk, Claudia"],["dc.contributor.author","Fünfgeld, Kevser Gencalp"],["dc.contributor.author","Keppler, Selina"],["dc.contributor.author","Batista, Facundo D."],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Habeck, Michael"],["dc.contributor.author","Becker, Stefan"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Wienands, Jürgen"],["dc.date.accessioned","2017-09-07T11:44:50Z"],["dc.date.available","2017-09-07T11:44:50Z"],["dc.date.issued","2016"],["dc.description.abstract","The adaptor molecule Cbl-interacting protein of 85 kD (CIN85) regulates signaling from a number of cell surface receptors, such as growth factor receptors and antigen receptors on lymphocytes. Because of its multidomain structure, CIN85 is thought to act as a classical adaptor protein that connects functionally distinct components of a given signaling pathway through diverse protein domains. However, we found that in B lymphocytes, CIN85 functions to oligomerize SLP-65, which is the central effector protein of the B cell receptor (BCR). Therefore, CIN85 trimerizes through a carboxyl-terminal, coiled-coil domain. The multiple Src homology 3 (SH3) domains of trimeric CIN85 molecules associated with multiple SLP- 65 molecules, which recruited further CIN85 trimers, thereby perpetuating the oligomerization process. Formation of this oligomeric signaling complex in resting B cells rendered the cells poised for the efficient initiation of intracellular signaling upon BCR stimulation. Our data suggest that the functionality of signaling cascades does not rely solely on the qualitative linkage of their various components but requires a critical number of effectors to become concentrated in signaling complexes."],["dc.identifier.doi","10.1126/scisignal.aad6275"],["dc.identifier.gro","3141661"],["dc.identifier.isi","000378944100004"],["dc.identifier.pmid","27353366"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/6564"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: Deutsche Forschungsgemeinschaft [SFB 860, TRR 130]; Max Planck Society"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1937-9145"],["dc.relation.issn","1945-0877"],["dc.title","The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]