Bürgers, Ralf

[["dc.bibliographiccitation.firstpage","4580"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Polymers"],["dc.bibliographiccitation.volume","14"],["dc.contributor.affiliation","Hampe, Tristan; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Liersch, Julia; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Wiechens, Bernhard; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Wassmann, Torsten; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Schubert, Andrea; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Alhussein, Mohammad; 3Molecular Phytopathology and Mycotoxin Research, University of Göttingen, 37077 Göttingen, Germany"],["dc.contributor.affiliation","Bürgers, Ralf; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Krohn, Sebastian; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany"],["dc.contributor.author","Hampe, Tristan"],["dc.contributor.author","Liersch, Julia"],["dc.contributor.author","Wiechens, Bernhard"],["dc.contributor.author","Wassmann, Torsten"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Alhussein, Mohammad"],["dc.contributor.author","Bürgers, Ralf"],["dc.contributor.author","Krohn, Sebastian"],["dc.date.accessioned","2022-12-01T08:31:46Z"],["dc.date.available","2022-12-01T08:31:46Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:12:02Z"],["dc.description.abstract","This study aimed to investigate the release of common monomers from conventional (Dialog Vario, Enamel Plus HFO) and UDMA-based indirect veneering composites (VITA VM LC, GC Gradia). Ten cylindrical samples of each material were prepared (n = 40), immersed in HPLC grade water, and incubated for 24 h in an incubation shaker at 37 °C and 112 rpm. Extraction was performed following ISO 10993-12 and monomers were detected and quantified by HPLC-MS/MS. In all the samples, urethane dimethacrylate (UDMA) and bisphenol A (BPA) were quantifiable. Compared to water blanks, BPA levels were only elevated in the eluates from conventional composites. In all other samples, concentrations were in the range of extraneous BPA and were therefore clinically irrelevant. Low concentrations of Bisphenol A-glycidyl methacrylate (BisGMA) were found in one BPA-free composite and in both conventional materials. Statistical analyses showed that BPA-free materials released significantly less BisGMA and no BPA, while UDMA elution was comparable to elution from conventional materials. All measured concentrations were below reported effective cytotoxic concentrations. Considering these results, the substitution of BPA-derivatives with UDMA might be beneficial since BPA-associated adverse effects are ruled out. Further studies should be enrolled to test the biocompatibility of UDMA on cells of the oral environment."],["dc.description.sponsorship","German Society for Prosthodontics and Material Sciences (DGPro)"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3390/polym14214580"],["dc.identifier.pii","polym14214580"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118262"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","2073-4360"],["dc.title","A Pilot Study on Monomer and Bisphenol A (BPA) Release from UDMA-Based and Conventional Indirect Veneering Composites"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1070"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Healthcare"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Wiechens, Bernhard; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany; schwea@gmx.de (S.P.); tristan.hampe@med.uni-goettingen.de (T.H.); torsten.wassmann@med.uni-goettingen.de (T.W.); nikolaus.gersdorff@med.uni-goettingen.de (N.G.); ralf.buergers@med.uni-goettingen.de (R.B.)"],["dc.contributor.affiliation","Paschereit, Svea; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany; schwea@gmx.de (S.P.); tristan.hampe@med.uni-goettingen.de (T.H.); torsten.wassmann@med.uni-goettingen.de (T.W.); nikolaus.gersdorff@med.uni-goettingen.de (N.G.); ralf.buergers@med.uni-goettingen.de (R.B.)"],["dc.contributor.affiliation","Hampe, Tristan; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany; schwea@gmx.de (S.P.); tristan.hampe@med.uni-goettingen.de (T.H.); torsten.wassmann@med.uni-goettingen.de (T.W.); nikolaus.gersdorff@med.uni-goettingen.de (N.G.); ralf.buergers@med.uni-goettingen.de (R.B.)"],["dc.contributor.affiliation","Wassmann, Torsten; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany; schwea@gmx.de (S.P.); tristan.hampe@med.uni-goettingen.de (T.H.); torsten.wassmann@med.uni-goettingen.de (T.W.); nikolaus.gersdorff@med.uni-goettingen.de (N.G.); ralf.buergers@med.uni-goettingen.de (R.B.)"],["dc.contributor.affiliation","Gersdorff, Nikolaus; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany; schwea@gmx.de (S.P.); tristan.hampe@med.uni-goettingen.de (T.H.); torsten.wassmann@med.uni-goettingen.de (T.W.); nikolaus.gersdorff@med.uni-goettingen.de (N.G.); ralf.buergers@med.uni-goettingen.de (R.B.)"],["dc.contributor.affiliation","Bürgers, Ralf; 1Department of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany; schwea@gmx.de (S.P.); tristan.hampe@med.uni-goettingen.de (T.H.); torsten.wassmann@med.uni-goettingen.de (T.W.); nikolaus.gersdorff@med.uni-goettingen.de (N.G.); ralf.buergers@med.uni-goettingen.de (R.B.)"],["dc.contributor.author","Wiechens, Bernhard"],["dc.contributor.author","Paschereit, Svea"],["dc.contributor.author","Hampe, Tristan"],["dc.contributor.author","Wassmann, Torsten"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.contributor.author","Bürgers, Ralf"],["dc.date.accessioned","2022-07-01T07:35:32Z"],["dc.date.available","2022-07-01T07:35:32Z"],["dc.date.issued","2022"],["dc.date.updated","2022-07-08T12:20:30Z"],["dc.description.abstract","Splint therapy is widely used in the treatment of myofascial pain, but valid studies on the efficacy of this therapy are rare. The purpose of the present study was to investigate which qualifiable and quantifiable effects of splint therapy are detectable. For this purpose, 29 patients (21 women, mean age 44.6 ± 16 years) diagnosed with myofascial pain (RDC/TMD) were investigated in this prospective clinical trial (10/6/14An). Patients were treated with Michigan splints applied overnight for three months. Before (T1) and after three months of treatment (T2), patients were registered with an electronic ultrasound device with qualitative and quantitative evaluation of the registrations and a qualitative assessment of pain symptoms using a verbal analog scale. Significant differences were found between maximum mouth opening (MMP) (p < 0.001) and right condylar movement (CM) at MMP (p = 0.045). Qualitative assessment revealed that 24 of 29 patients experienced an improvement in pain symptoms, 17 of whom experienced complete remission. The results of the qualitative and quantitative analysis provide indications of the effectiveness of the splint therapy. In addition to quantitative measurements, the ultrasound facebow technique was also able to provide qualitative information."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3390/healthcare10061070"],["dc.identifier.pii","healthcare10061070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112195"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112426"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-581"],["dc.relation.eissn","2227-9032"],["dc.rights","CC BY 4.0"],["dc.title","Changes in Maximum Mandibular Mobility Due to Splint Therapy in Patients with Temporomandibular Disorders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Journal of Oral Sciences"],["dc.bibliographiccitation.volume","129"],["dc.contributor.affiliation","Wiessner, Andreas; 1\r\nDepartment of Prosthodontics\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Frauendorf, Holm; 2\r\nInstitute for Organic and Biomolecular Chemistry\r\nUniversity of Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Alhussein, Mohammad; 3\r\nMolecular Phytopathology and Mycotoxin Research\r\nUniversity of Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Karlovsky, Petr; 3\r\nMolecular Phytopathology and Mycotoxin Research\r\nUniversity of Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Bürgers, Ralf; 1\r\nDepartment of Prosthodontics\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Krohn, Sebastian; 1\r\nDepartment of Prosthodontics\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.author","Hampe, Tristan"],["dc.contributor.author","Wiessner, Andreas"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Alhussein, Mohammad"],["dc.contributor.author","Karlovsky, Petr"],["dc.contributor.author","Bürgers, Ralf"],["dc.contributor.author","Krohn, Sebastian"],["dc.date.accessioned","2022-01-11T14:05:59Z"],["dc.date.available","2022-01-11T14:05:59Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T13:56:37Z"],["dc.description.abstract","Abstract This study aimed to investigate the release of common monomers from two conventional and two bisphenol A (BPA)‐free temporary crown and bridge materials. Cylindrical samples of all materials were prepared (N = 90; five samples for each material and cycle of analysis). All samples were immersed in high‐performance liquid chromatography (HPLC)‐grade water and incubated for 1 h, 12 h, 24 h, and 7 days in an incubation shaker at 37°C and 112 rpm. Extraction was performed in accordance with ISO 10993‐12. Eluted monomers were detected and quantified by HPLC coupled with ultraviolet–visible spectroscopy and mass spectrometry (HPLC‐UV/Vis‐MS). Analysis of BPA was performed by HPLC coupled with ultraviolet–visible spectroscopy (HPLC‐UV/Vis) and positive results were verified by HPLC‐tandem mass spectrometry (HPLC‐MS/MS). Neither bisphenol A‐glycidyl methacrylate (Bis‐GMA) nor BPA was quantifiable in any of the crown and bridge samples investigated in the present study. However, all samples contained triethylene glycol dimethacrylate (TEGDMA) and/or urethane dimethacrylate (UDMA) after 24 h of incubation. Statistical analysis showed that significantly more UDMA was released from the BPA‐free materials than from the conventional materials. All concentrations of UDMA measured were below the effective cytotoxic concentrations previously reported. However, for a few materials, especially BPA‐free temporary crown and bridge materials, the levels of UDMA were above previously reported potentially harmful concentrations for local cells. As BPA‐free materials were introduced as being more biocompatible than materials containing BPA, substitution of Bis‐GMA with UDMA should be further investigated."],["dc.identifier.doi","10.1111/eos.12826"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97798"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","1600-0722"],["dc.relation.issn","0909-8836"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","A comparative in vitro study on monomer release from bisphenol A‐free and conventional temporary crown and bridge materials"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]