Frahm, Jens

[["dc.bibliographiccitation.firstpage","730"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Magnetic Resonance in Medicine"],["dc.bibliographiccitation.lastpage","740"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Wang, Xiaoqing"],["dc.contributor.author","Roeloffs, Volkert"],["dc.contributor.author","Klosowski, Jakob"],["dc.contributor.author","Tan, Zhengguo"],["dc.contributor.author","Voit, Dirk"],["dc.contributor.author","Uecker, Martin"],["dc.contributor.author","Frahm, Jens"],["dc.date.accessioned","2018-01-17T13:53:19Z"],["dc.date.accessioned","2020-05-13T11:04:28Z"],["dc.date.available","2018-01-17T13:53:19Z"],["dc.date.available","2020-05-13T11:04:28Z"],["dc.date.issued","2018"],["dc.description.abstract","To develop a model-based reconstruction technique for single-shot T1 mapping with high spatial resolution, accuracy, and precision using an inversion-recovery (IR) fast low-angle shot (FLASH) acquisition with radial encoding."],["dc.identifier.doi","10.1002/mrm.26726"],["dc.identifier.pmid","28603934"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/11736"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.doi","10.1002/mrm.26726"],["dc.relation.issn","1522-2594"],["dc.title","Model-based T1 mapping with sparsity constraints using single-shot inversion-recovery radial FLASH"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Human Neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Schweisfurth, Meike A."],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Schweizer, Renate"],["dc.date.accessioned","2022-10-06T13:26:45Z"],["dc.date.available","2022-10-06T13:26:45Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.3389/fnhum.2014.00658"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115159"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1662-5161"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Individual fMRI maps of all phalanges and digit bases of all fingers in human primary somatosensory cortex"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2138"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","2143"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Schweisfurth, Meike A."],["dc.contributor.author","Schweizer, Renate"],["dc.contributor.author","Frahm, Jens"],["dc.date.accessioned","2022-10-06T13:33:18Z"],["dc.date.available","2022-10-06T13:33:18Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1016/j.neuroimage.2011.03.038"],["dc.identifier.pii","S1053811911003168"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115600"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","1053-8119"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Functional MRI indicates consistent intra-digit topographic maps in the little but not the index finger within the human primary somatosensory cortex"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1066"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Clinical Radiology"],["dc.bibliographiccitation.lastpage","1071"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Joseph, Arun A."],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Unterberg-Buchwald, Christine"],["dc.contributor.author","Merboldt, Klaus-Dietmar"],["dc.contributor.author","Voit, Dirk"],["dc.contributor.author","Steinmetz, M."],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Schaetz, S."],["dc.contributor.author","Zhang, S."],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Sohns, J. M."],["dc.date.accessioned","2018-11-07T09:34:30Z"],["dc.date.available","2018-11-07T09:34:30Z"],["dc.date.issued","2014"],["dc.description.abstract","AIM: To evaluate the potential of real-time phase-contrast flow magnetic resonance imaging (MRI) at 40 ms resolution for the simultaneous determination of blood flow in the ascending aorta (AA) and superior vena cava (SVC) in response to reduced intrathoracic pressure (Mueller manoeuvre). MATERIALS AND METHODS: Through-plane flow was assessed in 20 healthy young subjects using real-time phase-contrast MRI based on highly undersampled radial fast low-angle shot (FLASH) with image reconstruction by regularized non-linear inversion. Haemodynamic alterations (three repetitions per subject = 60 events) were evaluated during normal breathing (10 s), inhalation with nearly closed epiglottis (10 s), and recovery (20 s). RESULTS: Relative to normal breathing and despite interindividual differences, reduced intrathoracic pressure by at least 30 mmHg significantly decreased the initial peak mean velocity (averaged across the lumen) in the AA by -24 +/- 9% and increased the velocity in the SVC by +28 +/- 25% (p < 0.0001, n = 23 successful events). Respective changes in flow volume per heartbeat were -25 +/- 9% in the AA and +49 +/- 44% in the SVC (p < 0.0001, n = 23). Flow parameters returned to baseline during sustained pressure reduction, while the heart rate was elevated by 10% (p < 0.0001) after the start (n = 24) and end (n = 17) of the manoeuvre. CONCLUSIONS: Real-time flow MRI during low intrathoracic pressure non-invasively revealed quantitative haemodynamic adjustments in both the AA and SVC. (C) 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","DFG [LO 1773/1]"],["dc.identifier.doi","10.1016/j.crad.2014.06.004"],["dc.identifier.isi","000342881800013"],["dc.identifier.pmid","25060931"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32184"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co Ltd"],["dc.relation.issn","1365-229X"],["dc.relation.issn","0009-9260"],["dc.title","Real-time phase-contrast flow MRI of haemodynamic changes in the ascending aorta and superior vena cava during Mueller manoeuvre"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","256"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Developmental Cell"],["dc.bibliographiccitation.lastpage","269"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Tuoc, Tran Cong"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Sansom, Stephen N."],["dc.contributor.author","Pitulescu, Mara-Elena"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Livesey, Frederick J."],["dc.contributor.author","Stoykova, Anastassia"],["dc.date.accessioned","2017-09-07T11:44:52Z"],["dc.date.available","2017-09-07T11:44:52Z"],["dc.date.issued","2013"],["dc.description.abstract","Increased cortical size is essential to the enhanced intellectual capacity of primates during mammalian evolution. The mechanisms that control cortical size are largely unknown. Here, we show that mammalian BAF170, a subunit of the chromatin remodeling complex mSWI/SNF, is an intrinsic factor that controls cortical size. We find that conditional deletion of BAF170 promotes indirect neurogenesis by increasing the pool of intermediate progenitors (IPs) and results in an enlarged cortex, whereas cortex-specific BAF170 overexpression results in the opposite phenotype. Mechanistically, BAF170 competes with BAF155 subunit in the BAF complex, affecting euchromatin structure and thereby modulating the binding efficiency of the Pax6/REST-corepressor complex to Pax6 target genes that regulate the generation of IPs and late cortical progenitors. Our findings reveal a molecular mechanism mediated by the mSWI/SNF chromatin-remodeling complex that controls cortical architecture."],["dc.identifier.doi","10.1016/j.devcel.2013.04.005"],["dc.identifier.gro","3150356"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7111"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","1534-5807"],["dc.title","Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and Thickness"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","735"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Cell Science"],["dc.bibliographiccitation.lastpage","744"],["dc.bibliographiccitation.volume","122"],["dc.contributor.author","Wozny, Christian"],["dc.contributor.author","Breustedt, Jörg"],["dc.contributor.author","Wolk, Friederike"],["dc.contributor.author","Varoqueaux, Frédérique"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Zivkovic, Aleksandar R."],["dc.contributor.author","Neeb, Antje"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Schmitz, Dietmar"],["dc.contributor.author","Brose, Nils"],["dc.contributor.author","Ivanovic, Aleksandra"],["dc.date.accessioned","2017-09-07T11:45:27Z"],["dc.date.available","2017-09-07T11:45:27Z"],["dc.date.issued","2009"],["dc.description.abstract","AMPA-type glutamate receptors mediate fast excitatory synaptic transmission in the vertebrate brain. Their surface expression at synapses between neurons is regulated in an activity-dependent and activity-independent manner. The protein machinery that regulates synaptic targeting, anchoring and turnover of AMPA receptors consists of several types of specialized scaffolding proteins. The FERM domain scaffolding proteins 4.1G and 4.1N were previously suggested to act jointly in binding and regulating synaptic trafficking of the AMPA receptor subunits GluR1 and GluR4. To determine the functions of 4.1G and 4.1N in vivo, we generated a mutant mouse line that lacks 4.1G entirely and expresses 4.1N at 22% of wild-type levels. These mice had combined 4.1G and 4.1N protein expression in the hippocampus at 12% of wild-type levels (equivalent to 8-10% of combined GluR1 and GluR4 expression levels). They show a moderate reduction in synaptosomal expression levels of the AMPA receptor subunit GluR1 at 3 weeks of age, but no change in basic glutamatergic synaptic transmission and long-term potentiation in the hippocampus. Our study indicates that 4.1G and 4.1N do not have a crucial role in glutamatergic synaptic transmission and the induction and maintenance of long-term plastic changes in synaptic efficacy."],["dc.identifier.doi","10.1242/jcs.037382"],["dc.identifier.gro","3150376"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7134"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0021-9533"],["dc.subject","Knockout; Mouse; Hippocampus; GluR1; GluR4; Synaptic plasticity"],["dc.title","The function of glutamatergic synapses is not perturbed by severe knockdown of 4.1N and 4.1G expression"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S56"],["dc.bibliographiccitation.journal","Bone Marrow Transplantation"],["dc.bibliographiccitation.lastpage","S57"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Ebell, Wolfram"],["dc.contributor.author","Kuhl, J."],["dc.contributor.author","Sydow, U."],["dc.contributor.author","Strauss, G."],["dc.contributor.author","Kohler, W."],["dc.contributor.author","Baumann, M."],["dc.contributor.author","Weddige-Diedrichs, A."],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Hunneman, H."],["dc.contributor.author","Willichowski, E."],["dc.contributor.author","Gärtner, J."],["dc.contributor.author","Gaedicke, G."],["dc.date.accessioned","2018-11-07T10:50:29Z"],["dc.date.available","2018-11-07T10:50:29Z"],["dc.date.issued","2004"],["dc.identifier.isi","000220850900157"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48663"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","London"],["dc.relation.conference","30th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation/20th Meeting of the EBMT-Nurses-Group/3rd Meeting of the EBMT-Data-Management-Group"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","0268-3369"],["dc.title","Allogeneic transplantation in X-linked, childhood onset, cerebral adrenoleukodystrophy"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","206"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Prosthetic Dentistry"],["dc.bibliographiccitation.lastpage","209"],["dc.bibliographiccitation.volume","119"],["dc.contributor.author","Krohn, Sebastian"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Merboldt, Klaus-Dietmar"],["dc.contributor.author","Wassmann, Torsten"],["dc.contributor.author","Joseph, Arun A."],["dc.contributor.author","Bürgers, Ralf"],["dc.date.accessioned","2021-06-01T10:49:53Z"],["dc.date.available","2021-06-01T10:49:53Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.prosdent.2017.03.022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86447"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0022-3913"],["dc.title","Diagnosis of disk displacement using real-time MRI: Clinical report of two patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","605"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","International Journal of Pharmaceutics"],["dc.bibliographiccitation.lastpage","612"],["dc.bibliographiccitation.volume","475"],["dc.contributor.author","Quodbach, Julian"],["dc.contributor.author","Moussavi, Amir"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Kleinebudde, Peter"],["dc.date.accessioned","2021-06-01T10:49:38Z"],["dc.date.available","2021-06-01T10:49:38Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1016/j.ijpharm.2014.09.021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86361"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0378-5173"],["dc.title","Assessment of disintegrant efficacy with fractal dimensions from real-time MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","209"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Magnetic Resonance Imaging"],["dc.bibliographiccitation.lastpage","215"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Radulovic, Jelena"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:27Z"],["dc.date.available","2017-09-07T11:45:27Z"],["dc.date.issued","2006"],["dc.description.abstract","This magnetic resonance imaging (MRI) study describes mapping of the habenulo-interpeduncular pathway in living mice based on manganese-induced contrast. Six hours after intracerebroventricular microinjection of MnCl2, T1-weighted 3D MRI (2.35 T) at 117 μm isotropic resolution revealed a continuous pattern of anterograde labeling from the habenula via the fasciculus retroflexus to the interpeduncular nucleus. Alternatively, the less invasive systemic administration of MnCl2 allowed for monitoring of the dynamic uptake pattern of respective neural components with even higher reproducibility across animals. Time courses covered the range from 42 min to 24 h after injection. In conclusion, manganese-enhanced MRI may open new ways for functional assessments of the habenulo-interpeduncular system in animal models with cognitive impairment."],["dc.identifier.doi","10.1016/j.mri.2005.10.034"],["dc.identifier.gro","3150377"],["dc.identifier.pmid","16563949"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7135"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0730-725X"],["dc.subject","Habenula; Magnetic resonance imaging; Manganese; Mice; Neural pathways"],["dc.title","Mapping of the habenulo-interpeduncular pathway in living mice using manganese-enhanced 3D MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]