Khadjeh, Sara

[["dc.bibliographiccitation.firstpage","4921"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","4926"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Wimmer, Ernst A."],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.date.accessioned","2018-11-07T09:12:10Z"],["dc.date.available","2018-11-07T09:12:10Z"],["dc.date.issued","2012"],["dc.description.abstract","Evolution often results in morphologically similar solutions in different organisms, a phenomenon known as convergence. However, there is little knowledge of the processes that lead to convergence at the genetic level. The genes of the Hox cluster control morphology in animals. They may also be central to the convergence of morphological traits, but whether morphological similarities also require similar changes in Hox gene function is disputed. In arthropods, body subdivision into a region with locomotory appendages (\"thorax\") and a region with reduced appendages (\"abdomen\") has evolved convergently in several groups, e. g., spiders and insects. In insects, legs develop in the expression domain of the Hox gene Antennapedia (Antp), whereas the Hox genes Ultrabithorax (Ubx) and abdominal-A mediate leg repression in the abdomen. Here, we show that, unlike Antp in insects, the Antp gene in the spider Achaearanea tepidariorum represses legs in the first segment of the abdomen (opisthosoma), and that Antp and Ubx are redundant in the following segment. The down-regulation of Antp in A. tepidariorum leads to a striking 10-legged phenotype. We present evidence from ectopic expression of the spider Antp gene in Drosophila embryos and imaginal tissue that this unique function of Antp is not due to changes in the Antp protein, but likely due to divergent evolution of cofactors, Hox collaborators or target genes in spiders and flies. Our results illustrate an interesting example of convergent evolution of abdominal leg repression in arthropods by altering the role of distinct Hox genes at different levels of their action."],["dc.identifier.doi","10.1073/pnas.1116421109"],["dc.identifier.isi","000302164200046"],["dc.identifier.pmid","22421434"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26887"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Divergent role of the Hox gene Antennapedia in spiders is responsible for the convergent evolution of abdominal limb repression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","453"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Arthropod Structure & Development"],["dc.bibliographiccitation.lastpage","467"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Sprenger, Frederik"],["dc.contributor.author","Prpic, Nikola Michael"],["dc.date.accessioned","2018-11-07T08:37:17Z"],["dc.date.available","2018-11-07T08:37:17Z"],["dc.date.issued","2010"],["dc.description.abstract","The prosoma of spiders bears different gnathal (labrum, chelicerae, pedipalps) and locomotory appendages (legs). In most species these appendages are also used for additional functions, e.g. sensing, mating, and courtship. The opisthosoma is equipped with four pairs of highly specialized appendages. Two pairs of spinnerets are used for silk production and manipulation. The other two pairs of appendages are internalized during development and give rise to a complex respiratory system of book lungs and tracheae. Thus spiders have a number of different appendage types with radically different adult morphologies. Furthermore, all these appendage types display significant additional species specific diversity correlating with a large spectrum of functions of the appendages. Despite this importance of appendage diversity for the evolution of the spiders we know relatively little about the genetic patterning mechanisms producing this diversity of morphology. We review recent advances concerning the developmental genetics of spider appendage diversification, mainly concentrating on open questions and future directions of research. We conclude that the deeper understanding of appendage development and diversity in spiders can contribute significantly not only to evolutionary developmental biology, but also to behavioral biology, speciation research and population genetics, and the study of sexually dimorphic traits. (C) 2010 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.asd.2010.07.007"],["dc.identifier.isi","000285819100007"],["dc.identifier.pmid","20696272"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18496"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1467-8039"],["dc.title","Patterning mechanisms and morphological diversity of spider appendages and their importance for spider evolution"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","235"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","236"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Mohamed, Belal A."],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Sossalla, Samuel T."],["dc.contributor.author","Neef, S."],["dc.contributor.author","Lehnart, Stephan E."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Toischer, Karl"],["dc.date.accessioned","2018-11-07T09:57:24Z"],["dc.date.available","2018-11-07T09:57:24Z"],["dc.date.issued","2015"],["dc.identifier.isi","000366200402357"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37149"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1879-0844"],["dc.relation.issn","1388-9842"],["dc.title","Does leaky ryanodine receptors play any role in maladaptive remodeling after chronic mechanical stress in mice?"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4285"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of Clinical Investigation"],["dc.bibliographiccitation.lastpage","4296"],["dc.bibliographiccitation.volume","127"],["dc.contributor.author","Toischer, Karl"],["dc.contributor.author","Zhu, Wuqiang"],["dc.contributor.author","Hünlich, Mark"],["dc.contributor.author","Mohamed, Belal A."],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Reuter, Sean P."],["dc.contributor.author","Schäfer, Katrin"],["dc.contributor.author","Ramanujam, Deepak"],["dc.contributor.author","Engelhardt, Stefan"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2021-06-01T10:47:52Z"],["dc.date.available","2021-06-01T10:47:52Z"],["dc.date.issued","2017"],["dc.description.abstract","Induction of the cell cycle is emerging as an intervention to treat heart failure. Here, we tested the hypothesis that enhanced cardiomyocyte renewal in transgenic mice expressing cyclin D2 would be beneficial during hemodynamic overload. We induced pressure overload by transthoracic aortic constriction (TAC) or volume overload by aortocaval shunt in cyclin D2–expressing and WT mice. Although cyclin D2 expression dramatically improved survival following TAC, it did not confer a survival advantage to mice following aortocaval shunt. Cardiac function decreased following TAC in WT mice, but was preserved in cyclin D2–expressing mice. On the other hand, cardiac structure and function were compromised in response to aortocaval shunt in both WT and cyclin D2–expressing mice. The preserved function and improved survival in cyclin D2–expressing mice after TAC was associated with an approximately 50% increase in cardiomyocyte number and exaggerated cardiac hypertrophy, as indicated by increased septum thickness. Aortocaval shunt did not further impact cardiomyocyte number in mice expressing cyclin D2. Following TAC, cyclin D2 expression attenuated cardiomyocyte hypertrophy, reduced cardiomyocyte apoptosis, fibrosis, calcium/calmodulin–dependent protein kinase IIδ phosphorylation, brain natriuretic peptide expression, and sustained capillarization. Thus, we show that cyclin D2–induced cardiomyocyte renewal reduced myocardial remodeling and dysfunction after pressure overload but not after volume overload."],["dc.identifier.doi","10.1172/JCI81870"],["dc.identifier.gro","3142324"],["dc.identifier.pmid","29083322"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85743"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/192"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | D01: Erholung aus der Herzinsuffizienz – Einfluss von Fibrose und Transkriptionssignatur"],["dc.relation","SFB 1002 | D04: Bedeutung der Methylierung von RNA (m6A) und des Histons H3 (H3K4) in der Herzinsuffizienz"],["dc.relation","SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle"],["dc.relation.eissn","1558-8238"],["dc.relation.issn","0021-9738"],["dc.relation.workinggroup","RG Hasenfuß (Transition zur Herzinsuffizienz)"],["dc.relation.workinggroup","RG Schäfer (Translationale Vaskuläre Biologie)"],["dc.relation.workinggroup","RG Toischer (Kardiales Remodeling)"],["dc.title","Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Internist"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Vidal, Ramon"],["dc.contributor.author","Capece, V."],["dc.contributor.author","Lbik, D."],["dc.contributor.author","Mohamed, B."],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.contributor.author","Sossalla, Samuel T."],["dc.contributor.author","Fischer, A."],["dc.contributor.author","Bonn, Stefan"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Toischer, Karl"],["dc.date.accessioned","2018-11-07T10:15:52Z"],["dc.date.available","2018-11-07T10:15:52Z"],["dc.date.issued","2016"],["dc.format.extent","S61"],["dc.identifier.isi","000375417500120"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40903"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","1432-1289"],["dc.relation.issn","0020-9554"],["dc.title","Of mice and men - a direct comparison of signaling in pressure overload induced hypertrophy and failure"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Internist"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Lbik, D."],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Mohamed, Belal A."],["dc.contributor.author","Halder, R."],["dc.contributor.author","Fischer, A."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Toischer, Karl"],["dc.date.accessioned","2018-11-07T10:15:52Z"],["dc.date.available","2018-11-07T10:15:52Z"],["dc.date.issued","2016"],["dc.format.extent","S51"],["dc.identifier.isi","000375417500098"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40906"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","1432-1289"],["dc.relation.issn","0020-9554"],["dc.title","Maximal resolution of the heart transcriptome with cell type specific profiling"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","389"],["dc.contributor.author","Woelfer, M."],["dc.contributor.author","Noack, C."],["dc.contributor.author","Tiburcy, Malte"],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Chebbok, E."],["dc.contributor.author","Hasenfuss, G. H."],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.contributor.author","Toischer, Karl"],["dc.contributor.author","Zelarayan, Laura Cecilia"],["dc.date.accessioned","2018-11-07T10:19:01Z"],["dc.date.available","2018-11-07T10:19:01Z"],["dc.date.issued","2016"],["dc.format.extent","S38"],["dc.identifier.isi","000398368200155"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41576"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","82nd Annual Meeting of the German-Society-for-Exerimental-and-Clinical-Pharmacology-and-Toxicology (DGPT) / 18th Annual Meeting of the Network-Clinical-Pharmacology-Germany (VKliPha)"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","1432-1912"],["dc.relation.issn","0028-1298"],["dc.title","The Insulin-like growth factor binding protein 5 (IGFBP5) - a potential developmental gene is regulated upon cardiac stress"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Mechanisms of Development"],["dc.bibliographiccitation.volume","126"],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Prpic-Schaeper, Nikola-Michael"],["dc.date.accessioned","2018-11-07T08:27:24Z"],["dc.date.available","2018-11-07T08:27:24Z"],["dc.date.issued","2009"],["dc.format.extent","S255"],["dc.identifier.doi","10.1016/j.mod.2009.06.671"],["dc.identifier.isi","000270034900748"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16199"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","16th Annual Conference of the International-Society-of-Development-Biologists"],["dc.relation.eventlocation","Edinburgh, SCOTLAND"],["dc.relation.issn","0925-4773"],["dc.title","Role of Hox genes in walking leg morphology specification in insects and spiders"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","273"],["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.lastpage","274"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Mohamed, Belal A."],["dc.contributor.author","Richter, C."],["dc.contributor.author","Neef, S."],["dc.contributor.author","Lbik, D."],["dc.contributor.author","Khadjeh, Sara"],["dc.contributor.author","Sossalla, Samuel T."],["dc.contributor.author","Lehnart, Stephan Elmar"],["dc.contributor.author","Luther, S."],["dc.contributor.author","Hasenfuss, Gerd"],["dc.contributor.author","Toischer, Karl"],["dc.date.accessioned","2018-11-07T10:14:44Z"],["dc.date.available","2018-11-07T10:14:44Z"],["dc.date.issued","2016"],["dc.format.extent","423"],["dc.identifier.isi","000377107502228"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40675"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","Congress of the European-Society-of-Cardiology (ESC)"],["dc.relation.eventlocation","Rome, ITALY"],["dc.relation.issn","1879-0844"],["dc.relation.issn","1388-9842"],["dc.title","Role of sarcoplasmic reticulum calcium leak in heart failure"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","47"],["dc.bibliographiccitation.journal","Journal of Molecular and Cellular Cardiology"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Woelfer, M."],["dc.contributor.author","Iyer, L.M."],["dc.contributor.author","Chebbock, E."],["dc.contributor.author","Khadjeh, S."],["dc.contributor.author","Raad, F."],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.contributor.author","Zelarayan, L.C."],["dc.date.accessioned","2022-03-01T11:45:25Z"],["dc.date.available","2022-03-01T11:45:25Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.yjmcc.2018.05.139"],["dc.identifier.pii","S0022282818303006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103321"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0022-2828"],["dc.title","IGFBP5 controls human cardiac cell commitment and interferes with cardiomyocyte differentiation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]