Bertsch, Hans P.

[["dc.bibliographiccitation.firstpage","101"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Archives of Dermatological Research"],["dc.bibliographiccitation.lastpage","105"],["dc.bibliographiccitation.volume","300"],["dc.contributor.author","Mössner, Rotraut"],["dc.contributor.author","Thaci, Diamant"],["dc.contributor.author","Mohr, Johannes"],["dc.contributor.author","Pätzold, Sylvie"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.contributor.author","Krüger, Ullrich"],["dc.contributor.author","Reich, Kristian"],["dc.date.accessioned","2018-11-07T11:17:20Z"],["dc.date.available","2018-11-07T11:17:20Z"],["dc.date.issued","2008"],["dc.description.abstract","Infliximab is a monoclonal antibody directed against TNF-alpha. It has been approved for use in rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriatic arthritis and plaque-type psoriasis. In case reports, positive effects on pustular variants of psoriasis have also been reported. However, paradoxically, manifestation of pustular psoriasis and plaque-type psoriasis has been reported in patients treated with TNF antagonists including infliximab for other indications. Here, we report on 5 patients with chronic plaque-type psoriasis who developed palmoplantar pustulosis during or after discontinuation of infliximab therapy. In two of the five cases, manifestation of palmoplantar pustulosis was not accompanied by worsening of plaque-type psoriasis. Possibly, site-specific factors or a differential contribution of immunological processes modulated by TNF inhibitors to palmoplantar pustulosis and plaque-type psoriasis may have played a role."],["dc.identifier.doi","10.1007/s00403-008-0831-8"],["dc.identifier.isi","000253573300001"],["dc.identifier.pmid","18239925"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3520"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54781"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","0340-3696"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Manifestation of palmoplantar pustulosis during or after infliximab therapy for plaque-type psoriasis: report on five cases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1433"],["dc.bibliographiccitation.issue","36"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","94"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Satzger, Imke"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Voelker, Bernward"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Gutzmer, Ralf"],["dc.contributor.author","Starz, Hans"],["dc.date.accessioned","2018-11-07T09:51:53Z"],["dc.date.available","2018-11-07T09:51:53Z"],["dc.date.issued","2015"],["dc.description.abstract","The objective of this study was to analyze different types of nodal basin recurrence after sentinel lymph node biopsy (SLNB) for melanoma.Patients and Methods: Kaplan-Meier estimates and the Cox proportional hazards model were used to study 2653 patients from 3 German melanoma centers retrospectively.The estimated 5-year negative predictive value of SLNB was 96.4%. The estimated false-negative (FN) rates after 1, 2, 3, 5, and 10 years were 2.5%, 4.6%, 6.4%, 8.7%, and 12.6%, respectively. Independent factors associated with false negativity were older age, fewer SLNs excised, and head or neck location of the primary tumor. Compared with SLN-positive patients, the FNs had a significantly lower survival. In SLN-positive patients undergoing completion lymphadenectomy (CLND), the 5-year nodal basin recurrence rate was 18.3%. The recurrence rates for axilla, groin, and neck were 17.2%, 15.5%, and 44.1%, respectively. Significant factors predicting local relapse after CLND were older age, head, or neck location of the primary tumor, ulceration, deeper penetration of the metastasis into the SLN, tumor-positive CLND, and >2 lymph node metastases. All kinds of nodal relapse were associated with a higher prevalence of in-transit metastases.The FN rate after SLNB steadily increases over the observation period and should, therefore, be estimated by the Kaplan-Meier method. False-negativity is associated with fewer SLNs excised. The beneficial effect of CLND on nodal basin disease control varies considerably across different risk groups. This should be kept in mind about SLN-positive patients when individual decisions on prophylactic CLND are taken."],["dc.identifier.doi","10.1097/MD.0000000000001433"],["dc.identifier.isi","000369531900012"],["dc.identifier.pmid","26356697"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13119"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36000"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1536-5964"],["dc.relation.issn","0025-7974"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma A Retrospective Multicenter Study in 2653 Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","127"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Dermatology"],["dc.bibliographiccitation.lastpage","130"],["dc.bibliographiccitation.volume","225"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Buhl, Timo"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Holzkamp, Ricarda"],["dc.date.accessioned","2018-11-07T09:14:44Z"],["dc.date.available","2018-11-07T09:14:44Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1159/000342181"],["dc.identifier.isi","000311760700006"],["dc.identifier.pmid","23018645"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9077"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27488"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","S. Karger AG"],["dc.relation.eissn","1421-9832"],["dc.relation.issn","1018-8665"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Squamomelanocytic Tumor of the Nail Unit Metastasizing to a Sentinel Lymph Node: A Dermoscopic and Histologic Investigation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1714"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Annals of Surgical Oncology"],["dc.bibliographiccitation.lastpage","1721"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.contributor.author","Bardzik, Pavel"],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Helms, Hans-Joachim"],["dc.contributor.author","Meller, Johannes"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.date.accessioned","2018-11-07T09:25:38Z"],["dc.date.available","2018-11-07T09:25:38Z"],["dc.date.issued","2013"],["dc.description.abstract","The value of a preoperative lymphoscintigraphy in melanoma patients with clinically evident regional lymph node metastases has not been studied. Therapeutic lymph node dissection (TLND) is regarded as the clinical standard, but the appropriate extent of TLND is controversial in all lymphatic basins. Of the 115 consecutive patients with surgery on palpable lymph node metastases, 34 received a pre-operative lymphoscintigraphy. Lymphatic drainage to a second nodal basin outside the clinically involved basin was found in 15 cases. In 13 patients, the ectopic tumor-draining lymph nodes were excised as in a sentinel node biopsy. The lymph nodes from the TLND specimens were postoperatively separated and classified as either radioactive or non-radioactive. A total of 493 lymph nodes were examined pathologically. The largest macrometastasis maintained the ability to take up radiotracer in 77% of cases. Radioactively labeled lymph nodes carried a higher risk of being involved with metastasis. The proportions of tumor involvement for radioactive and non-radioactive lymph nodes were 44.5 and 16.9%, respectively (P=0.00002). Of the 13 ectopic nodal basins surgically explored, six harbored clinically occult metastases. In patients undergoing TLND for palpable metastases, tumor-draining lymph nodes in a second, ectopic nodal basin should be excised, because they could be affected by occult metastasis. With respect to radioactive lymph nodes situated within the nodal basin of the macrometastasis but beyond the borders of a less-radical lymphadenectomy, further studies are needed."],["dc.identifier.doi","10.1245/s10434-012-2841-1"],["dc.identifier.isi","000317308200043"],["dc.identifier.pmid","23314605"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10335"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30107"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1068-9265"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Individualized Surgery: Gamma-Probe-Guided Lymphadenectomy in Patients with Clinically Enlarged Lymph Node Metastases from Melanomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]