Rehfeldt, Florian

[["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Narayanan, Pratibha"],["dc.contributor.author","Hütte, Meike"],["dc.contributor.author","Kudryasheva, Galina"],["dc.contributor.author","Taberner, Francisco J"],["dc.contributor.author","Lechner, Stefan G"],["dc.contributor.author","Rehfeldt, Florian"],["dc.contributor.author","Gomez-Varela, David"],["dc.contributor.author","Schmidt, Manuela"],["dc.date.accessioned","2020-12-10T18:48:06Z"],["dc.date.available","2020-12-10T18:48:06Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.7554/eLife.32346"],["dc.identifier.eissn","2050-084X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/79015"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4294"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","ACS Sustainable Chemistry & Engineering"],["dc.bibliographiccitation.lastpage","4301"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Huang, Heqin"],["dc.contributor.author","Wang, Xiaojie"],["dc.contributor.author","Rehfeldt, Florian"],["dc.contributor.author","Zhang, Kai"],["dc.date.accessioned","2020-05-18T10:10:36Z"],["dc.date.available","2020-05-18T10:10:36Z"],["dc.date.issued","2018"],["dc.description.abstract","Biological tissues are often highly and multiply heterogeneous in both structure and composition, but the integrity of multiheterogeneity in artificial materials is still a big challenge. Herein, dually heterogeneous hydrogels were constructed with two distinct strategies via dynamic bonds and supramolecular cross-links. The hydrogels showed discontinuous spatial ruptures, and the mechanical behaviors of hydrogels could be tuned. The primary heterogeneity resulted from a nonuniform distribution of dynamic and/or static cross-links. The presence of only primary heterogeneity within hydrogels led to uneven mechanical properties that were represented by discontinuous spatial ruptures during the stretching the hydrogel and therefore caused the necking deformation. Further introduction of the secondary heterogeneity by incorporating anisotropic cellulose nanocrystals (CNC) into the hydrogels allowed the adjustment of the necking phenomenon. Moreover, distinct CNC with diverse surface functionalities exhibited different effects: the “active” CNC with surface-attached dynamic bonds retarded the necking propagation, while the “neutral” CNC without further surface modification promoted the extension of necking points. Thus, the regulation of deformation and fracture mode of hydrogels was achieved by the synergy of dually heterogeneous structure."],["dc.identifier.doi","10.1021/acssuschemeng.7b04738"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/65514"],["dc.language.iso","en"],["dc.title","Dually Heterogeneous Hydrogels via Dynamic and Supramolecular Cross-Links Tuning Discontinuous Spatial Ruptures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","263"],["dc.bibliographiccitation.lastpage","282"],["dc.bibliographiccitation.seriesnr","134"],["dc.contributor.author","Eltzner, Benjamin"],["dc.contributor.author","Hauke, Lara"],["dc.contributor.author","Huckemann, Stephan"],["dc.contributor.author","Rehfeldt, Florian"],["dc.contributor.author","Wollnik, Carina"],["dc.contributor.editor","Salditt, Tim"],["dc.contributor.editor","Egner, Alexander"],["dc.contributor.editor","Luke, D. Russell"],["dc.date.accessioned","2021-04-21T11:15:39Z"],["dc.date.available","2021-04-21T11:15:39Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/978-3-030-34413-9_10"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84280"],["dc.relation","SFB 755: Nanoscale Photonic Imaging"],["dc.relation.crisseries","Topics in Applied Physics"],["dc.relation.doi","10.1007/978-3-030-34413-9"],["dc.relation.eisbn","978-3-030-34413-9"],["dc.relation.isbn","978-3-030-34412-2"],["dc.relation.ispartof","Nanoscale Photonic Imaging"],["dc.relation.ispartofseries","Topics in Applied Physics; 134"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.subject.gro","SFB 755"],["dc.title","A Statistical and Biophysical Toolbox to Elucidate Structure and Formation of Stress Fibers"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Molecular Biology of the Cell"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Rehfeldt, Florian"],["dc.contributor.author","Harada, T."],["dc.contributor.author","Brown, A. E. X."],["dc.contributor.author","Zajac, Allison L."],["dc.contributor.author","Cai, Shenshen"],["dc.contributor.author","Zemel, Assaf"],["dc.contributor.author","Discher, Dennis E."],["dc.date.accessioned","2018-11-07T09:00:13Z"],["dc.date.available","2018-11-07T09:00:13Z"],["dc.date.issued","2011"],["dc.identifier.isi","000305505504181"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24099"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Cell Biology"],["dc.publisher.place","Bethesda"],["dc.relation.conference","Annual Meeting of the American-Society-for-Cell-Biology (ASCB)"],["dc.relation.eventlocation","Denver, CO"],["dc.relation.issn","1059-1524"],["dc.title","Matrix Stiffness Dictates Cytoskeletal Organization and Nuclear Morphology in 2D and 3D."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Molecular Biology of the Cell"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Wollnik, Carina"],["dc.contributor.author","Kudryasheva, Galina"],["dc.contributor.author","Radwitz, J."],["dc.contributor.author","Rehfeldt, Florian"],["dc.date.accessioned","2018-11-07T09:31:01Z"],["dc.date.available","2018-11-07T09:31:01Z"],["dc.date.issued","2013"],["dc.identifier.isi","000209348700271"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31445"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Cell Biology"],["dc.publisher.place","Bethesda"],["dc.relation.issn","1939-4586"],["dc.relation.issn","1059-1524"],["dc.title","Cytoskeletal Structures in Stem Cells as Mechano-Sensors"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","47"],["dc.bibliographiccitation.journal","BMC Biology"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Paluch, Ewa K."],["dc.contributor.author","Nelson, Celeste M."],["dc.contributor.author","Biais, Nicolas"],["dc.contributor.author","Fabry, Ben"],["dc.contributor.author","Moeller, Jens"],["dc.contributor.author","Pruitt, Beth L."],["dc.contributor.author","Wollnik, Carina"],["dc.contributor.author","Kudryasheva, Galina"],["dc.contributor.author","Rehfeldt, Florian"],["dc.contributor.author","Federle, Walter"],["dc.date.accessioned","2018-11-07T09:54:43Z"],["dc.date.available","2018-11-07T09:54:43Z"],["dc.date.issued","2015"],["dc.description.abstract","Mechanotransduction - how cells sense physical forces and translate them into biochemical and biological responses - is a vibrant and rapidly-progressing field, and is important for a broad range of biological phenomena. This forum explores the role of mechanotransduction in a variety of cellular activities and highlights intriguing questions that deserve further attention."],["dc.identifier.doi","10.1186/s12915-015-0150-4"],["dc.identifier.isi","000357371400001"],["dc.identifier.pmid","26141078"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36599"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1741-7007"],["dc.title","Mechanotransduction: use the force(s)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","303"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","MATCH-COMMUNICATIONS IN MATHEMATICAL AND IN COMPUTER CHEMISTRY"],["dc.bibliographiccitation.lastpage","326"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Altschuh, Joachim"],["dc.contributor.author","Lenoir, Dieter"],["dc.contributor.author","Rehfeldt, Florian"],["dc.contributor.author","Bruggemann, Rainer"],["dc.date.accessioned","2018-11-07T10:03:21Z"],["dc.date.available","2018-11-07T10:03:21Z"],["dc.date.issued","2015"],["dc.description.abstract","We discuss some property-property relationships (PPRs) for the estimation of vapour pressure with regard to their predictive power in terms of accuracy and applicability. Seven different PPRs mostly based on the Clausius-Clapeyron equation are analysed, including for example the method of Mackay or those of Fishtine/Vetere. A data set of 375 compounds was compiled, which contains all required quantities as measured ones. Several criteria are defined to determine the accuracy of the estimation methods. By applying partial order theory, it turns out that two equations by Fishtine/Vetere are optimal, i.e. yield the best estimation results, albeit they are not comparable. According to the main focus of this paper our data set is discussed in terms of chemical structures. Structural elements, such as carbonyl-function, amine-function, halogen substitution etc., were identified, which were suitable to characterize the diversity of a set of organic chemicals. Given the composition of the current data set, it was necessary to reduce the number of structural elements to eight. Finally, we introduce the ad-matrix, describing the quality of an estimation equation with respect to a certain structural element. The numerical differences of the ad-values among different estimation equations are not large. Hence a fuzzy partial order approach was applied to get the best vapour pressure estimation equations with respect to a distinct structural element. Four estimation methods can be recommended, concerning their accuracy with respect to different chemical structures."],["dc.identifier.isi","000353424200002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38441"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Univ Kragujevac, Fac Science"],["dc.relation.issn","0340-6253"],["dc.title","Applicability Domain of Nonlinear Property-Property Relationships - Example: Estimation of Vapour Pressure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2113"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Bernoulli"],["dc.bibliographiccitation.lastpage","2142"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Huckemann, Stephan"],["dc.contributor.author","Kim, Kwang-Rae"],["dc.contributor.author","Munk, Axel"],["dc.contributor.author","Rehfeldt, Florian"],["dc.contributor.author","Sommerfeld, Max"],["dc.contributor.author","Weickert, Joachim"],["dc.contributor.author","Wollnik, Carina"],["dc.date.accessioned","2020-12-10T18:43:58Z"],["dc.date.available","2020-12-10T18:43:58Z"],["dc.date.issued","2016"],["dc.description.abstract","We generalize the SiZer of Chaudhuri and Marron (J. Amer. Statist. Assoc. 94 (1999) 807-823; Ann. Statist. 28 (2000) 408-428) for the detection of shape parameters of densities on the real line to the case of circular data. It turns out that only the wrapped Gaussian kernel gives a symmetric, strongly Lipschitz semi-group satisfying \"circular\" causality, that is, not introducing possibly artificial modes with increasing levels of smoothing. Some notable differences between Euclidean and circular scale space theory are highlighted. Based on this, we provide an asymptotic theory to make inference about the persistence of shape features. The resulting circular mode persistence diagram is applied to the analysis of early mechanically-induced differentiation in adult human stem cells from their actin-myosin filament structure. As a consequence, the circular SiZer based on the wrapped Gaussian kernel (WiZer) allows the verification at a controlled error level of the observation reported by Zemel et al. (Nat. Phys. 6 (2010) 468-473): Within early stem cell differentiation, polarizations of stem cells exhibit preferred directions in three different micro-environments."],["dc.identifier.doi","10.3150/15-BEJ722"],["dc.identifier.gro","3141600"],["dc.identifier.isi","000376814400007"],["dc.identifier.issn","1350-7265"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78282"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","DOI-Import GROB-394"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation","RTG 2088: Research Training Group 2088 Discovering structure in complex data: Statistics meets Optimization and Inverse Problems"],["dc.relation.eissn","1573-9759"],["dc.relation.issn","1350-7265"],["dc.title","The circular SiZer, inferred persistence of shape parameters and application to early stem cell differentiation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","233001"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Journal of Physics D Applied Physics"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Prabhune, Meenakshi"],["dc.contributor.author","Rehfeldt, Florian"],["dc.contributor.author","Schmidt, Christoph F."],["dc.date.accessioned","2018-11-07T10:22:43Z"],["dc.date.available","2018-11-07T10:22:43Z"],["dc.date.issued","2017"],["dc.description.abstract","Molecularly generated forces are essential for most activities of biological cells, but also for the maintenance of steady state or homeostasis. To quantitatively understand cellular dynamics in migration, division, or mechanically guided differentiation, it will be important to exactly measure stress fields within the cell and the extracellular matrix. Traction force microscopy and related techniques have been established to determine the stress transmitted from adherent cells to their substrates. However, different approaches are needed to directly assess the stress generated inside the cell. This has recently led to the development of novel molecular force sensors. In this topical review, we briefly mention methods used to measure cell-external forces, and then summarize and explain different designs for the measurement of cell-internal forces with their respective advantages and disadvantages."],["dc.identifier.doi","10.1088/1361-6463/aa6e1e"],["dc.identifier.isi","000401485800001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42323"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Iop Publishing Ltd"],["dc.relation.issn","1361-6463"],["dc.relation.issn","0022-3727"],["dc.title","Molecular force sensors to measure stress in cells"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1600810"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Macromolecular Rapid Communications"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Huang, Heqin"],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Wang, X."],["dc.contributor.author","Rehfeldt, Florian"],["dc.contributor.author","Zhang, Kai"],["dc.date.accessioned","2018-11-07T10:22:58Z"],["dc.date.accessioned","2020-05-18T08:18:54Z"],["dc.date.available","2018-11-07T10:22:58Z"],["dc.date.available","2020-05-18T08:18:54Z"],["dc.date.issued","2017"],["dc.description.abstract","A kind of novel heterogeneous composite hydrogel with dynamic nanocrosslinkers is designed, which is built via the preorganized host-guest interaction on the surface of cellulose nanocrystals. The reversible beta-cyclodextrin/adamantane conjunctions and their gradual dissociation on the nanocrystal-polymer interface guarantee the compressibility and stretchability of the composite hydrogels. While the sacrificed toughening mechanism can be rebuilt in the as-prepared hydrogels, it fails to be regenerated in the swollen hydrogels. This fact is originally due to the extreme mechanical contrast between rigid nanocrystals and the flexible polymer phase. This heterogeneity is largely amplified by the swelling process: poly-mer chains are prestretched between nanocrosslinkers and generate residual stress on the dynamic nanocrystalpoly-mer interface. Thus, this swelling-induced heterogeneity resists the reassociation of the sacrificed beta-cyclodextrin/adamantane complexes. Furthermore, the unstable nanocrystalpolymer interface induces the crack propagate along the nanocrosslinker surface, which remarkably retards the crack propagation during the stretch."],["dc.identifier.doi","10.1002/marc.201600810"],["dc.identifier.isi","000403816200001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42372"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1022-1336"],["dc.relation.issn","1521-3927"],["dc.title","Robust Heterogeneous Hydrogels with Dynamic Nanocrystal-Polymer Interface"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]