Schuldiner, Maya

[["dc.bibliographiccitation.firstpage","4079"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","Journal of Cell Science"],["dc.bibliographiccitation.lastpage","4085"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Aviram, Naama"],["dc.contributor.author","Schuldiner, Maya"],["dc.date.accessioned","2022-07-11T15:07:56Z"],["dc.date.available","2022-07-11T15:07:56Z"],["dc.date.issued","2017-12-15"],["dc.description.abstract","The evolutionary emergence of organelles was a defining process in diversifying biochemical reactions within the cell and enabling multicellularity. However, compartmentalization also imposed a great challenge-the need to import proteins synthesized in the cytosol into their respective sites of function. For example, one-third of all genes encode for proteins that must be targeted and translocated into the endoplasmic reticulum (ER), which serves as the entry site to the majority of endomembrane compartments. Decades of research have set down the fundamental principles of how proteins get from the cytosol into the ER, and recent studies have brought forward new pathways and additional regulators enabling better definition of the rules governing substrate recognition. In this Cell Science at a Glance article and the accompanying poster, we give an overview of our current understanding of the multifaceted and regulated processes of protein targeting and translocation to the ER."],["dc.identifier.doi","10.1242/jcs.204396"],["dc.identifier.pmid","29246967"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112463"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/19"],["dc.language.iso","en"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P11: Zuordnung zellulärer Kontaktstellen und deren Zusammenspiel"],["dc.relation.eissn","1477-9137"],["dc.relation.issn","0021-9533"],["dc.relation.workinggroup","RG Schuldiner (Functional Genomics of Organelles)"],["dc.title","Targeting and translocation of proteins to the endoplasmic reticulum at a glance"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","overview_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1118"],["dc.bibliographiccitation.issue","6407"],["dc.bibliographiccitation.journal","Science"],["dc.bibliographiccitation.lastpage","1122"],["dc.bibliographiccitation.volume","361"],["dc.contributor.author","Hansen, Katja G."],["dc.contributor.author","Aviram, Naama"],["dc.contributor.author","Laborenz, Janina"],["dc.contributor.author","Bibi, Chen"],["dc.contributor.author","Meyer, Maren"],["dc.contributor.author","Spang, Anne"],["dc.contributor.author","Schuldiner, Maya"],["dc.contributor.author","Herrmann, Johannes M."],["dc.date.accessioned","2022-07-04T13:41:59Z"],["dc.date.available","2022-07-04T13:41:59Z"],["dc.date.issued","2018"],["dc.description.abstract","The majority of organellar proteins are translated on cytosolic ribosomes and must be sorted correctly to function. Targeting routes have been identified for organelles such as peroxisomes and the endoplasmic reticulum (ER). However, little is known about the initial steps of targeting of mitochondrial proteins. In this study, we used a genome-wide screen in yeast and identified factors critical for the intracellular sorting of the mitochondrial inner membrane protein Oxa1. The screen uncovered an unexpected path, termed ER-SURF, for targeting of mitochondrial membrane proteins. This pathway retrieves mitochondrial proteins from the ER surface and reroutes them to mitochondria with the aid of the ER-localized chaperone Djp1. Hence, cells use the expanse of the ER surfaces as a fail-safe to maximize productive mitochondrial protein targeting."],["dc.identifier.doi","10.1126/science.aar8174"],["dc.identifier.pmid","30213914"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112381"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/40"],["dc.language.iso","en"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P11: Zuordnung zellulärer Kontaktstellen und deren Zusammenspiel"],["dc.relation.eissn","1095-9203"],["dc.relation.issn","0036-8075"],["dc.relation.workinggroup","RG Schuldiner (Functional Genomics of Organelles)"],["dc.title","An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]