Schuldiner, Maya

[["dc.bibliographiccitation.firstpage","395"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Developmental Cell"],["dc.bibliographiccitation.lastpage","409"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Eisenberg-Bord, Michal"],["dc.contributor.author","Shai, Nadav"],["dc.contributor.author","Schuldiner, Maya"],["dc.contributor.author","Bohnert, Maria"],["dc.date.accessioned","2022-07-11T15:02:22Z"],["dc.date.available","2022-07-11T15:02:22Z"],["dc.date.issued","2016"],["dc.description.abstract","Membrane contact sites enable interorganelle communication by positioning organelles in close proximity using molecular \"tethers.\" With a growing understanding of the importance of contact sites, the hunt for new contact sites and their tethers is in full swing. Determining just what is a tether has proven challenging. Here, we aim to delineate guidelines that define the prerequisites for categorizing a protein as a tether. Setting this gold standard now, while groups from different disciplines are beginning to explore membrane contact sites, will enable efficient cooperation in the growing field and help to realize a great collaborative opportunity to boost its development."],["dc.identifier.doi","10.1016/j.devcel.2016.10.022"],["dc.identifier.pmid","27875684"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112461"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/4"],["dc.language.iso","en"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P11: Zuordnung zellulärer Kontaktstellen und deren Zusammenspiel"],["dc.relation.eissn","1878-1551"],["dc.relation.issn","1534-5807"],["dc.relation.workinggroup","RG Bohnert (Lipid Droplet Kommunikation)"],["dc.relation.workinggroup","RG Schuldiner (Functional Genomics of Organelles)"],["dc.title","A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","overview_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1469"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Biochimica et Biophysica Acta. Molecular Cell Research"],["dc.bibliographiccitation.lastpage","1480"],["dc.bibliographiccitation.volume","1864"],["dc.contributor.author","Eisenberg-Bord, Michal"],["dc.contributor.author","Schuldiner, Maya"],["dc.date.accessioned","2022-07-11T15:10:27Z"],["dc.date.available","2022-07-11T15:10:27Z"],["dc.date.issued","2017-09"],["dc.description.abstract","Mitochondria, cellular metabolic hubs, perform many essential processes and are required for the production of metabolites such as ATP, iron-sulfur clusters, heme, amino acids and nucleotides. To fulfill their multiple roles, mitochondria must communicate with all other organelles to exchange small molecules, ions and lipids. Since mitochondria are largely excluded from vesicular trafficking routes, they heavily rely on membrane contact sites. Contact sites are areas of close proximity between organelles that allow efficient transfer of molecules, saving the need for slow and untargeted diffusion through the cytosol. More globally, multiple metabolic pathways require coordination between mitochondria and additional organelles and mitochondrial activity affects all other cellular entities and vice versa. Therefore, uncovering the different means of mitochondrial communication will allow us a better understanding of mitochondria and may illuminate disease processes that occur in the absence of proper cross-talk. In this review we focus on how mitochondria interact with all other organelles and emphasize how this communication is essential for mitochondrial and cellular homeostasis. This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann."],["dc.identifier.doi","10.1016/j.bbamcr.2017.04.012"],["dc.identifier.pmid","28433686"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112464"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/91"],["dc.language.iso","en"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P11: Zuordnung zellulärer Kontaktstellen und deren Zusammenspiel"],["dc.relation.issn","0167-4889"],["dc.relation.workinggroup","RG Schuldiner (Functional Genomics of Organelles)"],["dc.title","Mitochatting - If only we could be a fly on the cell wall"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","overview_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","2515256418825409"],["dc.bibliographiccitation.journal","Contact"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Eisenberg-Bord, Michal"],["dc.contributor.author","Tsui, Hui S"],["dc.contributor.author","Antunes, Diana"],["dc.contributor.author","Fernández-Del-Río, Lucía"],["dc.contributor.author","Bradley, Michelle C."],["dc.contributor.author","Dunn, Cory D"],["dc.contributor.author","Nguyen, Theresa P. T."],["dc.contributor.author","Rapaport, Doron"],["dc.contributor.author","Clarke, Catherine F."],["dc.contributor.author","Schuldiner, Maya"],["dc.date.accessioned","2022-07-04T13:56:18Z"],["dc.date.available","2022-07-04T13:56:18Z"],["dc.date.issued","2019-02-22"],["dc.description.abstract","Loss of the endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) complex that resides in contact sites between the yeast ER and mitochondria leads to impaired respiration; however, the reason for that is not clear. We find that in ERMES null mutants, there is an increase in the level of mRNAs encoding for biosynthetic enzymes of coenzyme Q6 (CoQ6), an essential electron carrier of the mitochondrial respiratory chain. We show that the mega complexes involved in CoQ6 biosynthesis (CoQ synthomes) are destabilized in ERMES mutants. This, in turn, affects the level and distribution of CoQ6 within the cell, resulting in reduced mitochondrial CoQ6. We suggest that these outcomes contribute to the reduced respiration observed in ERMES mutants. Fluorescence microscopy experiments demonstrate close proximity between the CoQ synthome and ERMES, suggesting a spatial coordination. The involvement of the ER-mitochondria contact site in regulation of CoQ6 biogenesis highlights an additional level of communication between these two organelles."],["dc.identifier.doi","10.1177/2515256418825409"],["dc.identifier.pmid","30937424"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112382"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/52"],["dc.language.iso","en"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P11: Zuordnung zellulärer Kontaktstellen und deren Zusammenspiel"],["dc.relation.eissn","2515-2564"],["dc.relation.workinggroup","RG Schuldiner (Functional Genomics of Organelles)"],["dc.rights","CC BY-NC 4.0"],["dc.title","The Endoplasmic Reticulum-Mitochondria Encounter Structure Complex Coordinates Coenzyme Q Biosynthesis"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","196"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The FEBS Journal"],["dc.bibliographiccitation.lastpage","210"],["dc.bibliographiccitation.volume","284"],["dc.contributor.author","Eisenberg-Bord, Michal"],["dc.contributor.author","Schuldiner, Maya"],["dc.date.accessioned","2022-07-11T15:04:09Z"],["dc.date.available","2022-07-11T15:04:09Z"],["dc.date.issued","2017"],["dc.description.abstract","Mitochondria have crucial functions in the cell, including ATP generation, iron-sulfur cluster biogenesis, nucleotide biosynthesis, and amino acid metabolism. All of these functions require tight regulation on mitochondrial activity and homeostasis. As mitochondria biogenesis is controlled by the nucleus and almost all mitochondrial proteins are encoded by nuclear genes, a tight communication network between mitochondria and the nucleus has evolved, which includes signaling cascades, proteins which are dual-localized to the two compartments, and sensing of mitochondrial products by nuclear proteins. All of these enable a crosstalk between mitochondria and the nucleus that allows the 'ground control' to get information on mitochondria's status. Such information facilitates the creation of a cellular balance of mitochondrial status with energetic needs. This communication also allows a transcriptional response in case mitochondrial function is impaired aimed to restore mitochondrial homeostasis. As mitochondrial dysfunction is related to a growing number of genetic diseases as well as neurodegenerative conditions and aging, elucidating the mechanisms governing the mitochondrial/nuclear communication should progress a better understanding of mitochondrial dysfunctions."],["dc.identifier.doi","10.1111/febs.13778"],["dc.identifier.pmid","27283924"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112462"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/90"],["dc.language.iso","en"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P11: Zuordnung zellulärer Kontaktstellen und deren Zusammenspiel"],["dc.relation.eissn","1742-4658"],["dc.relation.issn","1742-464X"],["dc.relation.workinggroup","RG Schuldiner (Functional Genomics of Organelles)"],["dc.title","Ground control to major TOM: mitochondria-nucleus communication"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","overview_ja"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Wang, Yaxi"],["dc.contributor.author","Yuan, Peihua"],["dc.contributor.author","Tripathi, Ashutosh"],["dc.contributor.author","Rodriguez, Martin"],["dc.contributor.author","Lönnfors, Max"],["dc.contributor.author","Eisenberg-Bord, Michal"],["dc.contributor.author","Schuldiner, Maya"],["dc.contributor.author","Bankaitis, Vytas A."],["dc.date.accessioned","2022-07-11T12:29:59Z"],["dc.date.available","2022-07-11T12:29:59Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1101/696336"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112458"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/86"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P11: Zuordnung zellulärer Kontaktstellen und deren Zusammenspiel"],["dc.relation.workinggroup","RG Schuldiner (Functional Genomics of Organelles)"],["dc.title","Non-Canonical Regulation of Phosphatidylserine Metabolism by a Phosphatidylinositol Transfer Protein and a Phosphatidylinositol 4-OH Kinase"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]