Beham, Alexander Wilhelm

[["dc.bibliographiccitation.journal","Frontiers in Neurology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Fuchs, Tina"],["dc.contributor.author","Puellmann, Kerstin"],["dc.contributor.author","Dreyfus, David H."],["dc.contributor.author","Piehler, Armin P."],["dc.contributor.author","Reuter, Björn"],["dc.contributor.author","Schwarzbach, Christopher"],["dc.contributor.author","Willmann, Olaf"],["dc.contributor.author","Yepes, Diego"],["dc.contributor.author","Costina, Victor"],["dc.contributor.author","Findeisen, Peter"],["dc.contributor.author","Mahrt, Jens"],["dc.contributor.author","Wang, Chunlin"],["dc.contributor.author","Han, Jian"],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Neumaier, Michael"],["dc.contributor.author","Kaminski, Wolfgang E."],["dc.date.accessioned","2020-12-10T18:44:32Z"],["dc.date.available","2020-12-10T18:44:32Z"],["dc.date.issued","2019"],["dc.description.abstract","Bacterial meningitis is a life-threatening disease that evokes an intense neutrophil-dominated host response to microbes invading the subarachnoid space. Recent evidence indicates the existence of combinatorial V(D)J immune receptors in neutrophils that are based on the T cell receptor (TCR). Here, we investigated expression of the novel neutrophil TCRαβ-based V(D)J receptors in cerebrospinal fluid (CSF) from human patients with acute-phase bacterial meningitis using immunocytochemical, genetic immunoprofiling, cell biological, and mass spectrometric techniques. We find that the human neutrophil combinatorial V(D)J receptors are rapidly induced in CSF neutrophils during the first hours of bacterial meningitis. Immune receptor repertoire diversity is consistently increased in CSF neutrophils relative to circulating neutrophils and phagocytosis of baits directed to the variable immunoreceptor is enhanced in CSF neutrophils during acute-phase meningitis. Our results reveal that a flexible immune response involving neutrophil V(D)J receptors which enhance phagocytosis is immediately initiated at the site of acute bacterial infection."],["dc.identifier.doi","10.3389/fneur.2019.00307"],["dc.identifier.eissn","1664-2295"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78494"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-2295"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Immediate Neutrophil-Variable-T Cell Receptor Host Response in Bacterial Meningitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0204108"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Fuchs, Tina"],["dc.contributor.author","Hahn, Martin"],["dc.contributor.author","Ries, Lukas"],["dc.contributor.author","Giesler, Sophie"],["dc.contributor.author","Busch, Svenja"],["dc.contributor.author","Wang, Chunlin"],["dc.contributor.author","Han, Jian"],["dc.contributor.author","Schulze, Torsten J."],["dc.contributor.author","Puellmann, Kerstin"],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Kaminski, Wolfgang E."],["dc.contributor.author","Neumaier, Michael"],["dc.contributor.editor","Haziot, Alain"],["dc.date.accessioned","2020-12-10T18:42:09Z"],["dc.date.available","2020-12-10T18:42:09Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1371/journal.pone.0204108"],["dc.identifier.eissn","1932-6203"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15701"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77824"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1002375"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLoS Pathogens"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Puellmann, Kerstin"],["dc.contributor.author","Laird, Rebecca"],["dc.contributor.author","Fuchs, Tina"],["dc.contributor.author","Streich, Roswita"],["dc.contributor.author","Breysach, Caroline"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Oniga, Septimia"],["dc.contributor.author","Peccerella, Teresa"],["dc.contributor.author","Findeisen, Peter"],["dc.contributor.author","Kzhyshkowska, Julia"],["dc.contributor.author","Gratchev, Alexei"],["dc.contributor.author","Schweyer, Stefan"],["dc.contributor.author","Saunders, Bernadette"],["dc.contributor.author","Wessels, Johannes Theodor"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Keane, Joseph"],["dc.contributor.author","Becker, Heinz"],["dc.contributor.author","Ganser, Arnold"],["dc.contributor.author","Neumaier, Michael"],["dc.contributor.author","Kaminski, Wolfgang E."],["dc.date.accessioned","2018-11-07T08:50:08Z"],["dc.date.available","2018-11-07T08:50:08Z"],["dc.date.issued","2011"],["dc.description.abstract","Macrophages play a central role in host defense against mycobacterial infection and anti-TNF therapy is associated with granuloma disorganization and reactivation of tuberculosis in humans. Here, we provide evidence for the presence of a T cell receptor (TCR) alpha beta based recombinatorial immune receptor in subpopulations of human and mouse monocytes and macrophages. In vitro, we find that the macrophage-TCR alpha beta induces the release of CCL2 and modulates phagocytosis. TNF blockade suppresses macrophage-TCR alpha beta expression. Infection of macrophages from healthy individuals with mycobacteria triggers formation of clusters that express restricted TCR V beta repertoires. In vivo, TCR alpha beta bearing macrophages abundantly accumulate at the inner host-pathogen contact zone of caseous granulomas from patients with lung tuberculosis. In chimeric mouse models, deletion of the variable macrophage-TCR alpha beta or TNF is associated with structurally compromised granulomas of pulmonary tuberculosis even in the presence of intact T cells. These results uncover a TNF-regulated recombinatorial immune receptor in monocytes/macrophages and demonstrate its implication in granuloma formation in tuberculosis."],["dc.identifier.doi","10.1371/journal.ppat.1002375"],["dc.identifier.isi","000297337300037"],["dc.identifier.pmid","22114556"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7793"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21628"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1553-7374"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","A TNF-Regulated Recombinatorial Macrophage Immune Receptor Implicated in Granuloma Formation in Tuberculosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]