Buhl, Timo

[["dc.bibliographiccitation.firstpage","231"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","240"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Cevik, Naciye"],["dc.contributor.author","Schill, Tillmann"],["dc.contributor.author","Worm, Margitta"],["dc.contributor.author","Mahler, Vera"],["dc.contributor.author","Weisshaar, Elke"],["dc.contributor.author","Vieluf, Dieter"],["dc.contributor.author","Pfützner, Wolfgang"],["dc.contributor.author","Löffler, Harald"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-04-14T08:30:05Z"],["dc.date.available","2021-04-14T08:30:05Z"],["dc.date.issued","2021"],["dc.description.abstract","Summary Background The association of atopic dermatitis (AD) and allergic contact dermatitis has been a matter of considerable uncertainty. Study results range from lack of any association to increased sensitization for multiple allergens, but fail to identify consistent allergen associations. Objective We studied a large patch test cohort of patients stratified by their atopic skin diathesis using the Erlangen Atopy Score (EAS), independent of active skin disease. Methods Retrospective multi‐center data analysis from five departments of dermatology in Germany with 4,509 patients. Patients were grouped as “no atopic skin diathesis” (n = 2,165) and “atopic skin diathesis” (n = 1,743), according to EAS. Results Significantly more individuals with atopic skin diathesis showed at least one positive patch test reaction to the baseline series compared to individuals without atopic skin diathesis (49.1 % vs. 38.3 %). In logistic regression analyses, atopic skin diathesis was associated with a significantly higher risk of sensitization to methylchloroisothiazolinone/methylisothiazolinone (OR 2.383) and methylisothiazolinone (OR 1.891), thiuram mix (OR 1.614), as well as nickel (OR 1.530), cobalt (OR 1.683), and chromium (OR 2.089). Conclusions Atopic skin diathesis proved to be the most important intrinsic risk factor for contact sensitization to few, specific allergens. Past or present AD was a less relevant variable."],["dc.identifier.doi","10.1111/ddg.14341"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83096"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","Atopic skin diathesis rather than atopic dermatitis is associated with specific contact allergies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1488"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","1490"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Olbricht, Nadja"],["dc.contributor.author","Kromer, Christian"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-04-14T08:22:55Z"],["dc.date.available","2021-04-14T08:22:55Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1111/ddg.14244"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80736"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","Effective treatment of atopic dermatitis with dupilumab in an HIV‐positive patient"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","83"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","International Archives of Allergy and Immunology"],["dc.bibliographiccitation.lastpage","88"],["dc.bibliographiccitation.volume","178"],["dc.contributor.author","Saleh, Mohamed M."],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2020-12-10T18:37:51Z"],["dc.date.available","2020-12-10T18:37:51Z"],["dc.date.issued","2019"],["dc.description.abstract","Background: Natural rubber latex (NRL) allergy is commonly diagnosed according to medical history, skin allergy tests, and serological analyses. However, skin tests are increasingly being abandoned because of (i) their time-consuming nature, (ii) latex preparations for skin tests being not commercially available, and (iii) the use of in-house prepared test solutions is becoming ever more difficult due to increasing regulatory hurdles. In this light, we have evaluated differences in the profiles of current and former patients with suspected latex allergy. Methods: Sera of skin test-positive patients from a historic cohort (1995–2001, n = 149 patients) and currently (2014–2015, n = 48 patients) were simultaneously analyzed for specific IgE to latex by ImmunoCAP. If the serological screening was positive (≥0.35 kU/L), component-resolved diagnostics including profilins and cross-reactive carbohydrate determinants (CCDs) were performed. Results: In contrast to 88% (131/149) of the skin test-positive patients from the 1990s, only 51.1% (24/47) of the current cohort were found positive for specific IgE to latex. While 48.3% (72/149) of the patients had a convincing positive history in the 1990s, current skin test-positive patients rarely reported a relevant medical history (8.5%, 4/47). Specific IgE levels to latex were significantly higher in former patients with suspected latex allergy (p \\u0026lt; 0.001) than in former sensitized individuals without allergy. However, this significant difference was lost in current allergic and sensitized patients with positive skin tests. Conclusion: Sensitization profiles in patients with latex allergy have changed significantly over the last 2 decades. Discrimination between NRL sensitization and clinical allergy remains a diagnostic challenge. Our data highlight the need for a combination of all 3 criteria, i.e., patient history, skin test, and analysis of specific IgE, for a correct diagnosis of latex allergy."],["dc.identifier.doi","10.1159/000492191"],["dc.identifier.eissn","1423-0097"],["dc.identifier.issn","1018-2438"],["dc.identifier.pmid","30212836"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77113"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","S. Karger AG"],["dc.relation.eissn","1423-0097"],["dc.relation.issn","1018-2438"],["dc.rights","https://www.karger.com/Services/SiteLicenses"],["dc.title","Profile Shift in Latex Sensitization over the Last 20 Years"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","332"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","337"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Beutner, Caroline"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Schröder, Silke Sabina"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-04-14T08:30:05Z"],["dc.date.available","2021-04-14T08:30:05Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Background Allergy evaluation by patch testing with povidone‐iodine (PVP‐I) or iodine remains challenging, because current patch test preparations frequently lead to false‐positive or irritant skin reactions. Objectives To investigate different preparations for iodine patch tests and to assess their clinical relevance with repeated open application tests (ROATs). Methods We monocentrically analyzed 95 patients with suspected allergy to disinfectants in retrospect who underwent parallel iodine patch testing with four preparations: PVP‐I 2% aq., 5% aq., 10% aq., and iodine 0.5% pet. Results In 27 of 95 patients (28.4%), we found positive reactions to one of the four test preparations. After ROATs in 22 of these 27 positively tested individuals, only one patient was diagnosed with iodine allergy. In contrast, 31 of 95 patients (32.6%) showed irritant or questionable patch‐test reactions on day 2 (D2) and/or D3 and/or D7 to one or more test preparations. Testing with PVP‐I 2% aq. resulted in the lowest number of doubtful skin reactions while detecting the single allergic patient. Conclusion PVP‐I 2% aq. was found to be the optimal patch‐test preparation. In general, iodine allergy appears to be substantially overestimated, and positive patch test responses to iodine should prompt an urgent ROAT for confirmation before diagnosing iodine allergy."],["dc.description.abstract","Highlights Almost all antiseptics have irritant properties. Patch testing with povidone‐iodine (PVP‐iodine) 10% aq. regularly results in a high number of false‐positive and irritant reactions. Testing with PVP‐iodine 2% aq. seems to be an adequate. Relevance confirmation by repeated open application tests (ROATs) after positive patch tests with PVP‐iodine is strongly recommended. image"],["dc.description.sponsorship","ProjektDEAL"],["dc.identifier.doi","10.1111/cod.13760"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83098"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","Blackwell Publishing Ltd"],["dc.relation.eissn","1600-0536"],["dc.relation.issn","0105-1873"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."],["dc.title","Improving povidone‐iodine and iodine preparations for patch testing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","907-918"],["dc.bibliographiccitation.journal","Journal of Asthma and Allergy"],["dc.bibliographiccitation.lastpage","918"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Hollstein, Moritz M."],["dc.contributor.author","Matzke, Silke S."],["dc.contributor.author","Lorbeer, Lisa"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Lex, Christiane"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2022-08-02T14:27:56Z"],["dc.date.available","2022-08-02T14:27:56Z"],["dc.date.issued","2022"],["dc.description.abstract","Allergies against Hymenoptera venoms are a major cause of severe anaphylaxis. Risk assessment for subjects with suspected allergy is difficult because there are currently no biomarkers that predict the likelihood of high-grade anaphylaxis other than several associated comorbidities."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.2147/JAA.S367272"],["dc.identifier.pmid","35836970"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112597"],["dc.language.iso","en"],["dc.relation.issn","1178-6965"],["dc.rights","CC BY-NC 3.0"],["dc.title","Intracutaneous Skin Tests and Serum IgE Levels Cannot Predict the Grade of Anaphylaxis in Patients with Insect Venom Allergies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","37"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Beutner, Caroline"],["dc.contributor.author","Werchan, Barbora"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Gupta, Sidhi"],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-04-14T08:31:31Z"],["dc.date.available","2021-04-14T08:31:31Z"],["dc.date.issued","2020"],["dc.description.abstract","Summary Background: Sensitization rates to aeroallergens are rising worldwide. The prevalence is increasing, especially in Western countries. We aimed to investigate (1) sensitization rates and (2) cross‐sensitization patterns in skin prick tests (SPTs) for the most relevant inhaled allergens in central Germany over 20 years, adjusted for regional pollen counts. Patients and Methods: This monocentric study evaluated SPTs for tree pollen, grass pollen and house dust mites (HDMs) in 4,315 patients (including children) with suspected airway allergies, from 1998–2017. Results: Sensitization rates to almost all aeroallergens have increased significantly over time, without relevant changes in regional pollen counts. Current sensitization rates in all our symptomatic patients were highest for grass (55.3 %) and rye pollen (59.6 %), with most pronounced increases in HDM sensitization over time (from 37.8 % to the current figure of 50.1 %). However, a low but consistent proportion of tree‐sensitized patients (3.6–7.8 %) showed isolated positive SPTs to alder and/or hazel pollen without sensitization to birch pollen. Conclusions We demonstrate a significant rise in the total number of sensitized patients as well as increases in cross‐sensitization between closely related allergens. Individuals with unusual mono‐sensitization profiles to common inhaled allergens should be studied in more detail, since these patients are currently excluded from clinical trials for allergen immunotherapy."],["dc.identifier.doi","10.1111/ddg.14312"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83619"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","Sensitization rates to common inhaled allergens in Germany – increase and change patterns over the last 20 years"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.contributor.author","Kreipe, Katharina"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Heinemann, Kim‐Elisabeth"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-06-01T09:42:01Z"],["dc.date.available","2021-06-01T09:42:01Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Background The use of disinfectants is part of the everyday life of people, especially in the medical profession. During the coronavirus disease 2019 (COVID‐19) pandemic, the use of disinfectants continues to increase and is of fundamental importance in infection control. Objectives To determine the frequency of sensitization and the value of patch testing to didecyldimethylammonium chloride (DDAC) and the alcohols ethanol, 1‐propanol, and isopropanol. Methods Clinical patch test data of 145 patients with suspected contact allergy to disinfectants were retrospective analysed. Results Among the 145 patients patch tested with the different alcohols, only one nurse was detected with a possible allergy to 1‐propanol. Additional patch testing in 84 patients with DDAC 0.05% resulted in five patients with weakly positive reactions only, without clinical relevance. Patch testing with DDAC 0.03% showed no positive reactions at all on day 3 readings. Conclusions DDAC and alcohols are rarely responsible for allergic contact dermatitis. The accused products of the patients should be checked for other allergens and further additives with skin‐irritating properties. Individual susceptibility and mishandling of the disinfectants should be considered."],["dc.identifier.doi","10.1111/cod.13844"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85112"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Blackwell Publishing Ltd"],["dc.relation.eissn","1600-0536"],["dc.relation.issn","0105-1873"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","Contact sensitizations to disinfectants containing alcohols or quaternary ammonium compounds are rarely of clinical relevance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","cod.13961"],["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","43"],["dc.bibliographiccitation.volume","86"],["dc.contributor.affiliation","Forkel, Susann; 1\r\nDepartment of Dermatology\r\nVenereology and Allergology, University Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Kreipe, Katharina; 1\r\nDepartment of Dermatology\r\nVenereology and Allergology, University Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Geier, Johannes; 2\r\nLower Saxony Institute of Occupational Dermatology\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Buhl, Timo; 1\r\nDepartment of Dermatology\r\nVenereology and Allergology, University Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.author","Beutner, Caroline"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Kreipe, Katharina"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-10-01T09:57:59Z"],["dc.date.available","2021-10-01T09:57:59Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T13:56:38Z"],["dc.identifier.doi","10.1111/cod.13961"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89962"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","1600-0536"],["dc.relation.issn","0105-1873"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","Contact allergy to topical diclofenac with systemic tolerance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]