Buhl, Timo

[["dc.bibliographiccitation.firstpage","350"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","360"],["dc.bibliographiccitation.volume","82"],["dc.contributor.affiliation","Reich, Anna; 1\r\nDepartment of Dermatology, Venereology and Allergology\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Wilke, Annika; 2\r\nLower Saxony Institute of Occupational Dermatology\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Gediga, Günther; 4\r\nDepartment of Dermatology, Environmental Medicine and Health Theory\r\nUniversity of Osnabrück\r\nOsnabrück Germany"],["dc.contributor.affiliation","Baurecht, Hansjörg; 6\r\nDepartment of Dermatology, Allergology and Venereology\r\nUniversity Hospital Schleswig‐Holstein\r\nKiel Germany"],["dc.contributor.affiliation","Rodríguez, Elke; 6\r\nDepartment of Dermatology, Allergology and Venereology\r\nUniversity Hospital Schleswig‐Holstein\r\nKiel Germany"],["dc.contributor.affiliation","Jakasa, Ivone; 8\r\nLaboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology\r\nUniversity of Zagreb\r\nZagreb Croatia"],["dc.contributor.affiliation","Geier, Johannes; 2\r\nLower Saxony Institute of Occupational Dermatology\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Mempel, Martin; 1\r\nDepartment of Dermatology, Venereology and Allergology\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Buhl, Timo; 1\r\nDepartment of Dermatology, Venereology and Allergology\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Weidinger, Stephan; 6\r\nDepartment of Dermatology, Allergology and Venereology\r\nUniversity Hospital Schleswig‐Holstein\r\nKiel Germany"],["dc.contributor.affiliation","Kezic, Sanja; 10\r\nCoronel Institute of Occupational Health\r\nAmsterdam University Medical Center\r\nAmsterdam The Netherlands"],["dc.contributor.affiliation","John, Swen M.; 2\r\nLower Saxony Institute of Occupational Dermatology\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Schön, Michael P.; 1\r\nDepartment of Dermatology, Venereology and Allergology\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.author","Reich, Anna"],["dc.contributor.author","Wilke, Annika"],["dc.contributor.author","Gediga, Günther"],["dc.contributor.author","Baurecht, Hansjörg"],["dc.contributor.author","Rodríguez, Elke"],["dc.contributor.author","Jakasa, Ivone"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Mempel, Martin"],["dc.contributor.author","Buhl, Timo"],["dc.contributor.author","Weidinger, Stephan"],["dc.contributor.author","Kezic, Sanja"],["dc.contributor.author","John, Swen M."],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Brans, Richard"],["dc.date.accessioned","2020-12-10T18:27:14Z"],["dc.date.available","2020-12-10T18:27:14Z"],["dc.date.issued","2020"],["dc.date.updated","2022-02-09T13:21:55Z"],["dc.description.abstract","Abstract Background Metal work apprentices (MWAs) frequently develop work‐related hand eczema (HE). Objectives To evaluate the effect of health education on incidence of work‐related HE in MWAs and to assess confounding factors. Materials/methods In a prospective controlled intervention study, 131 MWAs received educational training on prevention of HE, whereas 172 MWAs and 118 office work apprentices served as controls. At baseline and during three yearly follow‐ups, questionnaires were completed and hands were examined. Saliva samples were collected for assessment of filaggrin (FLG) null mutations and an explorative genome‐wide association study (GWAS), and levels of various cytokines were assessed from stratum corneum samples. Results The 2‐year and 3‐year incidence of HE in the metalwork control group was 20.9% and 32.6%, respectively, which was significantly higher than in the intervention group (odds ratio [OR] 2.63, 95% confidence interval [CI] 1.31 to 5.28, P < .01 and OR 3.47, 95% CI 1.88 to 6.40, P < .0001). The knowledge score was higher in unaffected MWAs (P < .05). Other factors significantly associated with developing HE in MWAs were smoking cigarettes (P < .01) and FLG mutations (P < .001). No significant associations were found regarding epidermal cytokine levels and GWAS. Conclusions Health education is effective in primary prevention of HE in MWAs. Individual factors should be considered in targeted counseling."],["dc.description.sponsorship","Volkswagen Foundation http://dx.doi.org/10.13039/501100001663"],["dc.identifier.doi","10.1111/cod.13502"],["dc.identifier.eissn","1600-0536"],["dc.identifier.issn","0105-1873"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76278"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","Blackwell Publishing Ltd"],["dc.relation.eissn","1600-0536"],["dc.relation.issn","0105-1873"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."],["dc.title","Health education decreases incidence of hand eczema in metal work apprentices: Results of a controlled intervention study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","231"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","240"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Cevik, Naciye"],["dc.contributor.author","Schill, Tillmann"],["dc.contributor.author","Worm, Margitta"],["dc.contributor.author","Mahler, Vera"],["dc.contributor.author","Weisshaar, Elke"],["dc.contributor.author","Vieluf, Dieter"],["dc.contributor.author","Pfützner, Wolfgang"],["dc.contributor.author","Löffler, Harald"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-04-14T08:30:05Z"],["dc.date.available","2021-04-14T08:30:05Z"],["dc.date.issued","2021"],["dc.description.abstract","Summary Background The association of atopic dermatitis (AD) and allergic contact dermatitis has been a matter of considerable uncertainty. Study results range from lack of any association to increased sensitization for multiple allergens, but fail to identify consistent allergen associations. Objective We studied a large patch test cohort of patients stratified by their atopic skin diathesis using the Erlangen Atopy Score (EAS), independent of active skin disease. Methods Retrospective multi‐center data analysis from five departments of dermatology in Germany with 4,509 patients. Patients were grouped as “no atopic skin diathesis” (n = 2,165) and “atopic skin diathesis” (n = 1,743), according to EAS. Results Significantly more individuals with atopic skin diathesis showed at least one positive patch test reaction to the baseline series compared to individuals without atopic skin diathesis (49.1 % vs. 38.3 %). In logistic regression analyses, atopic skin diathesis was associated with a significantly higher risk of sensitization to methylchloroisothiazolinone/methylisothiazolinone (OR 2.383) and methylisothiazolinone (OR 1.891), thiuram mix (OR 1.614), as well as nickel (OR 1.530), cobalt (OR 1.683), and chromium (OR 2.089). Conclusions Atopic skin diathesis proved to be the most important intrinsic risk factor for contact sensitization to few, specific allergens. Past or present AD was a less relevant variable."],["dc.identifier.doi","10.1111/ddg.14341"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83096"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","Atopic skin diathesis rather than atopic dermatitis is associated with specific contact allergies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","332"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","337"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Beutner, Caroline"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Schröder, Silke Sabina"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-04-14T08:30:05Z"],["dc.date.available","2021-04-14T08:30:05Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Background Allergy evaluation by patch testing with povidone‐iodine (PVP‐I) or iodine remains challenging, because current patch test preparations frequently lead to false‐positive or irritant skin reactions. Objectives To investigate different preparations for iodine patch tests and to assess their clinical relevance with repeated open application tests (ROATs). Methods We monocentrically analyzed 95 patients with suspected allergy to disinfectants in retrospect who underwent parallel iodine patch testing with four preparations: PVP‐I 2% aq., 5% aq., 10% aq., and iodine 0.5% pet. Results In 27 of 95 patients (28.4%), we found positive reactions to one of the four test preparations. After ROATs in 22 of these 27 positively tested individuals, only one patient was diagnosed with iodine allergy. In contrast, 31 of 95 patients (32.6%) showed irritant or questionable patch‐test reactions on day 2 (D2) and/or D3 and/or D7 to one or more test preparations. Testing with PVP‐I 2% aq. resulted in the lowest number of doubtful skin reactions while detecting the single allergic patient. Conclusion PVP‐I 2% aq. was found to be the optimal patch‐test preparation. In general, iodine allergy appears to be substantially overestimated, and positive patch test responses to iodine should prompt an urgent ROAT for confirmation before diagnosing iodine allergy."],["dc.description.abstract","Highlights Almost all antiseptics have irritant properties. Patch testing with povidone‐iodine (PVP‐iodine) 10% aq. regularly results in a high number of false‐positive and irritant reactions. Testing with PVP‐iodine 2% aq. seems to be an adequate. Relevance confirmation by repeated open application tests (ROATs) after positive patch tests with PVP‐iodine is strongly recommended. image"],["dc.description.sponsorship","ProjektDEAL"],["dc.identifier.doi","10.1111/cod.13760"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83098"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","Blackwell Publishing Ltd"],["dc.relation.eissn","1600-0536"],["dc.relation.issn","0105-1873"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."],["dc.title","Improving povidone‐iodine and iodine preparations for patch testing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","37"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Beutner, Caroline"],["dc.contributor.author","Werchan, Barbora"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Gupta, Sidhi"],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-04-14T08:31:31Z"],["dc.date.available","2021-04-14T08:31:31Z"],["dc.date.issued","2020"],["dc.description.abstract","Summary Background: Sensitization rates to aeroallergens are rising worldwide. The prevalence is increasing, especially in Western countries. We aimed to investigate (1) sensitization rates and (2) cross‐sensitization patterns in skin prick tests (SPTs) for the most relevant inhaled allergens in central Germany over 20 years, adjusted for regional pollen counts. Patients and Methods: This monocentric study evaluated SPTs for tree pollen, grass pollen and house dust mites (HDMs) in 4,315 patients (including children) with suspected airway allergies, from 1998–2017. Results: Sensitization rates to almost all aeroallergens have increased significantly over time, without relevant changes in regional pollen counts. Current sensitization rates in all our symptomatic patients were highest for grass (55.3 %) and rye pollen (59.6 %), with most pronounced increases in HDM sensitization over time (from 37.8 % to the current figure of 50.1 %). However, a low but consistent proportion of tree‐sensitized patients (3.6–7.8 %) showed isolated positive SPTs to alder and/or hazel pollen without sensitization to birch pollen. Conclusions We demonstrate a significant rise in the total number of sensitized patients as well as increases in cross‐sensitization between closely related allergens. Individuals with unusual mono‐sensitization profiles to common inhaled allergens should be studied in more detail, since these patients are currently excluded from clinical trials for allergen immunotherapy."],["dc.identifier.doi","10.1111/ddg.14312"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83619"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","Sensitization rates to common inhaled allergens in Germany – increase and change patterns over the last 20 years"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.contributor.author","Kreipe, Katharina"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Heinemann, Kim‐Elisabeth"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Fuchs, Thomas"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-06-01T09:42:01Z"],["dc.date.available","2021-06-01T09:42:01Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Background The use of disinfectants is part of the everyday life of people, especially in the medical profession. During the coronavirus disease 2019 (COVID‐19) pandemic, the use of disinfectants continues to increase and is of fundamental importance in infection control. Objectives To determine the frequency of sensitization and the value of patch testing to didecyldimethylammonium chloride (DDAC) and the alcohols ethanol, 1‐propanol, and isopropanol. Methods Clinical patch test data of 145 patients with suspected contact allergy to disinfectants were retrospective analysed. Results Among the 145 patients patch tested with the different alcohols, only one nurse was detected with a possible allergy to 1‐propanol. Additional patch testing in 84 patients with DDAC 0.05% resulted in five patients with weakly positive reactions only, without clinical relevance. Patch testing with DDAC 0.03% showed no positive reactions at all on day 3 readings. Conclusions DDAC and alcohols are rarely responsible for allergic contact dermatitis. The accused products of the patients should be checked for other allergens and further additives with skin‐irritating properties. Individual susceptibility and mishandling of the disinfectants should be considered."],["dc.identifier.doi","10.1111/cod.13844"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85112"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Blackwell Publishing Ltd"],["dc.relation.eissn","1600-0536"],["dc.relation.issn","0105-1873"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","Contact sensitizations to disinfectants containing alcohols or quaternary ammonium compounds are rarely of clinical relevance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","cod.13961"],["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","43"],["dc.bibliographiccitation.volume","86"],["dc.contributor.affiliation","Forkel, Susann; 1\r\nDepartment of Dermatology\r\nVenereology and Allergology, University Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Kreipe, Katharina; 1\r\nDepartment of Dermatology\r\nVenereology and Allergology, University Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Geier, Johannes; 2\r\nLower Saxony Institute of Occupational Dermatology\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Buhl, Timo; 1\r\nDepartment of Dermatology\r\nVenereology and Allergology, University Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.author","Beutner, Caroline"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Kreipe, Katharina"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Buhl, Timo"],["dc.date.accessioned","2021-10-01T09:57:59Z"],["dc.date.available","2021-10-01T09:57:59Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T13:56:38Z"],["dc.identifier.doi","10.1111/cod.13961"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89962"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","1600-0536"],["dc.relation.issn","0105-1873"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","Contact allergy to topical diclofenac with systemic tolerance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]