Gruber, Oliver

[["dc.bibliographiccitation.artnumber","e94973"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Schilbach, Leonhard"],["dc.contributor.author","Müller, Veronika I."],["dc.contributor.author","Hoffstaedter, Felix"],["dc.contributor.author","Clos, Mareike"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Eickhoff, Simon B."],["dc.contributor.editor","Marinazzo, Daniele"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2014"],["dc.description.abstract","Alterations of social cognition and dysfunctional interpersonal expectations are thought to play an important role in the etiology of depression and have, thus, become a key target of psychotherapeutic interventions. The underlying neurobiology, however, remains elusive. Based upon the idea of a close link between affective and introspective processes relevant for social interactions and alterations thereof in states of depression, we used a meta-analytically informed network analysis to investigate resting-state functional connectivity in an introspective socio-affective (ISA) network in individuals with and without depression. Results of our analysis demonstrate significant differences between the groups with depressed individuals showing hyperconnectivity of the ISA network. These findings demonstrate that neurofunctional alterations exist in individuals with depression in a neural network relevant for introspection and socio-affective processing, which may contribute to the interpersonal difficulties that are linked to depressive symptomatology."],["dc.identifier.doi","10.1371/journal.pone.0094973"],["dc.identifier.gro","3150741"],["dc.identifier.pmid","24759619"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11609"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7531"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","public"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Meta-Analytically Informed Network Analysis of Resting State fMRI Reveals Hyperconnectivity in an Introspective Socio-Affective Network in Depression"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2931"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","2942"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Poeppl, Timm B."],["dc.contributor.author","Müller, Veronika I."],["dc.contributor.author","Hoffstaedter, Felix"],["dc.contributor.author","Bzdok, Danilo"],["dc.contributor.author","Laird, Angela R."],["dc.contributor.author","Fox, Peter T."],["dc.contributor.author","Langguth, Berthold"],["dc.contributor.author","Rupprecht, Rainer"],["dc.contributor.author","Sorg, Christian"],["dc.contributor.author","Riedl, Valentin"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Eickhoff, Simon B."],["dc.date.accessioned","2017-09-07T11:47:52Z"],["dc.date.available","2017-09-07T11:47:52Z"],["dc.date.issued","2016"],["dc.description.abstract","Major depressive disorder (MDD) involves impairment in cognitive and interpersonal functioning. The right temporoparietal junction (RTPJ) is a key brain region subserving cognitive-attentional and social processes. Yet, findings on the involvement of the RTPJ in the pathophysiology of MDD have so far been controversial. Recent connectivity-based parcellation data revealed a topofunctional dualism within the RTPJ, linking its anterior and posterior part (aRTPJ/pRTPJ) to antagonistic brain networks for attentional and social processing, respectively. Comparing functional resting-state connectivity of the aRTPJ and pRTPJ in 72 MDD patients and 76 well-matched healthy controls, we found a seed (aRTPJ/pRTPJ) × diagnosis (MDD/controls) interaction in functional connectivity for eight regions. Employing meta-data from a large-scale neuroimaging database, functional characterization of these regions exhibiting differentially altered connectivity with the aRTPJ/pRTPJ revealed associations with cognitive (dorsolateral prefrontal cortex, parahippocampus) and behavioral (posterior medial frontal cortex) control, visuospatial processing (dorsal visual cortex), reward (subgenual anterior cingulate cortex, medial orbitofrontal cortex, posterior cingulate cortex), as well as memory retrieval and social cognition (precuneus). These findings suggest that an imbalance in connectivity of subregions, rather than disturbed connectivity of the RTPJ as a whole, characterizes the connectional disruption of the RTPJ in MDD. This imbalance may account for key symptoms of MDD in cognitive, emotional, and social domains. Hum Brain Mapp 37:2931-2942, 2016. © 2016 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/hbm.23217"],["dc.identifier.gro","3150740"],["dc.identifier.pmid","27090056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7529"],["dc.language.iso","en"],["dc.notes.status","public"],["dc.relation.issn","1065-9471"],["dc.subject","connectivity; depression; functional magnetic resonance imaging; major depressive disorder; resting state; right temporoparietal junction"],["dc.title","Imbalance in subregional connectivity of the right temporoparietal junction in major depression"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","291"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","American Journal of Psychiatry"],["dc.bibliographiccitation.lastpage","298"],["dc.bibliographiccitation.volume","173"],["dc.contributor.author","Bludau, Sebastian"],["dc.contributor.author","Bzdok, Danilo"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Kohn, Nils"],["dc.contributor.author","Riedl, Valentin"],["dc.contributor.author","Sorg, Christian"],["dc.contributor.author","Palomero-Gallagher, Nicola"],["dc.contributor.author","Mueller, Veronika I."],["dc.contributor.author","Hoffstaedter, Felix"],["dc.contributor.author","Amunts, Katrin"],["dc.contributor.author","Eickhoff, Simon B."],["dc.date.accessioned","2018-11-07T10:17:05Z"],["dc.date.available","2018-11-07T10:17:05Z"],["dc.date.issued","2016"],["dc.description.abstract","Objective: The heterogeneous human frontal pole has been identified as a node in the dysfunctional network of major depressive disorder. The contribution of the medial (socio-affective) versus lateral (cognitive) frontal pole to major depression pathogenesis is currently unclear. The authors performed morphometric comparison of the micro-structurally informed subdivisions of human frontal pole between depressed patients and comparison subjects using both uni- and multivariate statistics. Method: Multisite voxel- and region-based morphometric MRI analysis was conducted in 73 depressed patients and 73 matched comparison subjects without psychiatric history. Frontal pole volume was first compared between depressed patients and comparison subjects by subdivision-wise classical morphometric analysis. In a second approach, frontal pole volume was compared by subdivision-naive multivariate searchlight analysis based on support vector machines. Results: Subdivision-wise morphometric analysis found a significantly smaller medial frontal pole in depressed patients, with a negative correlation of disease severity and duration. Histologically uninformed multivariate voxel-wise statistics provided converging evidence for structural aberrations specific to the microstructurally defined medial area of the frontal pole in depressed patients. Conclusions: Across disparate methods, subregion specificity in the left medial frontal pole volume indepressed patients was demonstrated. Indeed, the frontal pole was shown to structurally and functionally connect to other key regions in major depression pathology, such as the anterior cingulate cortex and the amygdala via the uncinate fasciculus. Present and previous findings consolidate the left medial portion of the frontal pole as particularly altered in major depression."],["dc.identifier.doi","10.1176/appi.ajp.2015.15030349"],["dc.identifier.isi","000375289200014"],["dc.identifier.pmid","26621569"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41161"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Psychiatric Publishing, Inc"],["dc.relation.issn","1535-7228"],["dc.relation.issn","0002-953X"],["dc.title","Medial Prefrontal Aberrations in Major Depressive Disorder Revealed by Cytoarchitectonically Informed Voxel-Based Morphometry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]